Frequency of TERT promoter mutations in human cancers

Nature Communications

Volumn 4, Issue , 2013, Pages

  Vinagre, João ^a   Almeida, Ana ^a   Pópulo, Helena ^a   Batista, Rui ^a   Lyra, Joana ^a,b   Pinto, Vasco ^a,b   Coelho, Ricardo ^a   Celestino, Ricardo ^a   Prazeres, Hugo ^a,c   Lima, Luis ^a,d,e,f   Melo, Miguel ^g,h   Rocha, Adriana Gaspar Da ^a,b   Preto, Ana ^a,i   Castro, Patrícia ^a   Castro, Ligia ^b,j   Pardal, Fernando ^k   Lopes, José Manuel ^a,b,j   Santos, Lúcio Lara ^d   Reis, Rui Manuel ^l,m   Cameselle Teijeiro, José ⁿ   Sobrinho Simões, Manuel ^a,b,j   Lima, Jorge ^a,b   Máximo, Valdemar ^a,b   Soares, Paula ^a,b   more..

^a UNIVERSITY OF PORTO   (Portugal)

^b University of Porto   (Portugal)

^c Instituto Portugues de Oncologia Francisco Gentil Centro Regional de Oncologia de Coimbra SA   (Portugal)

^d PORTUGUESE ONCOLOGY INSTITUTE   (Portugal)

^e POLYTECHNIC INSTITUTE OF PORTO   (Portugal)

^f Portuguese League Against Cancer (Norte)   (Portugal)

^g CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

^h UNIVERSITY OF COIMBRA   (Portugal)

ⁱ UNIVERSITY OF MINHO   (Portugal)

^j HOSPITAL DE SÃO JOÃO   (Portugal)

^k HOSPITAL DE BRAGA   (Portugal)

^l UNIVERSITY OF MINHO   (Portugal)

^m BARRETOS CANCER HOSPITAL   (Brazil)

ⁿ UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

more..

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; MESSENGER RNA; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

AGE; CANCER; ENZYME; ENZYME ACTIVITY; NERVOUS SYSTEM; REACTIVATION; SKIN; TUMOR;

AGE DISTRIBUTION; ARTICLE; BLADDER CANCER; CANCER CELL CULTURE; CANCER GENETICS; CANCER PATIENT; CENTRAL NERVOUS SYSTEM TUMOR; CONTROLLED STUDY; GENE FREQUENCY; GLIOBLASTOMA; HUMAN; HUMAN CELL; MELANOMA; PROMOTER REGION; PROTEIN EXPRESSION; SOMATIC MUTATION; THYROID CANCER; THYROID FOLLICULAR CARCINOMA;

EID: 84884524540     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3185     Document Type: Article

References (19)

1. Horn, S. et al. TERT promoter mutations in familial and sporadic melanoma. Science 339, 959-961 (2013).
2. Huang, F. W. et al. Highly recurrent TERT promoter mutations in human melanoma. Science 339, 957-959 (2013).
3. Killela, P. J. et al. TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc. Natl Acad. Sci. USA 110, 6021-6026 (2013).
4. Van Raamsdonk, C. D. et al. Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature 457, 599-602 (2009).
5. Populo, H., Vinagre, J., Lopes, J. M. & Soares, P. Analysis of GNAQ mutations, proliferation and MAPK pathway activation in uveal melanomas. Br. J. Ophthalmol. 95, 715-719 (2011).
6. Populo, H., Soares, P., Rocha, A. S., Silva, P. & Lopes, J. M. Evaluation of the mTOR pathway in ocular (uvea and conjunctiva) melanoma. Melanoma Res. 20, 107-117 (2010).
7. Lotsch, D. et al. Prognostic significance of telomerase-associated parameters in glioblastoma: effect of patient age. Neuro. Oncol. 15, 423-432 (2013).
8. Soares, P. et al. Genetic alterations in poorly differentiated and undifferentiated thyroid carcinomas. Curr. Genomics 12, 609-617 (2011).
9. Capezzone, M. et al. Telomere length in neoplastic and nonneoplastic tissues of patients with familial and sporadic papillary thyroid cancer. J. Clin. Endocrinol. Metab. 96, E1852-E1856 (2011).
10. Sanchini, M. A. et al. Relevance of urine telomerase in the diagnosis of bladder cancer. JAMA 294, 2052-2056 (2005). (Pubitemid 41539938)
11. Edge, S. B. et al. AJCC Cancer Staging Manual (Springer, 2010).
12. DeLellis, R. A. L. R., Heitz, P. U. & Eng, C. (eds) World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Endocrine Glands (IARC Press, 2004).
13. Kleihues, P. & Cavenee, W. K. Pathology and Genetics of Tumours of the Nervous System (IARC Press, 2000).
14. Louis, D. N. et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 114, 97-109 2007. (Pubitemid 47103521)
15. Sauter, G. et al. in WHO Classification of Tumors. Pathology and Genetics of Tumors of the Urinary System and Male Genital Organs. (eds Eble, J.N., Sauter, G., Epstein, J.I. & Sesterhenn, I.A.) (IARC Press, 2004).
16. Fletcher, C. D. et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum. Pathol. 33, 459-465 (2002). (Pubitemid 34747864)
17. Soares, P. et al. BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC. Oncogene 22, 4578-4580 (2003). (Pubitemid 36920701)
18. Celestino, R. et al. Molecular alterations and expression of succinate dehydrogenase complex in wild-type KIT/PDGFRA/BRAF gastrointestinal stromal tumors. Eur. J. Hum. Genet. 21, 503-510 (2013).
19. Prazeres, H. et al. Chromosomal, epigenetic and microRNA-mediated inactivation of LRP1B, a modulator of the extracellular environment of thyroid cancer cells. Oncogene 30, 1302-1317 (2011).