Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression

ACS Chemical Biology

Volumn 11, Issue 1, 2016, Pages 138-148

  Felsenstein, Kenneth M ^a,c   Saunders, Lindsey B ^a   Simmons, John K ^a   Leon, Elena ^a   Calabrese, David R ^a   Zhang, Shuling ^a   Michalowski, Aleksandra ^a   Gareiss, Peter ^b   Mock, Beverly A ^a   Schneekloth, John S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b YALE UNIVERSITY   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 CHLOROPHENYL) 2,3,9 TRIMETHYL 6H THIENO[3,2 F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE 6 ACETIC ACID TERT BUTYL ESTER; GUANINE QUADRUPLEX; MESSENGER RNA; MICRORNA 21; MYC PROTEIN; TRANSCRIPTION FACTOR FKHRL1; MOLECULAR LIBRARY;

ARTICLE; CANCER CELL CULTURE; CYTOTOXICITY; GENE TARGETING; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; MULTIPLE MYELOMA; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; SURFACE PLASMON RESONANCE; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DNA MICROARRAY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IC50; MOLECULAR LIBRARY; PHARMACOLOGY; TUMOR CELL LINE; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL LINE, TUMOR; G-QUADRUPLEXES; GENE EXPRESSION REGULATION; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTO-ONCOGENE PROTEINS C-MYC; SMALL MOLECULE LIBRARIES;

EID: 84954470546     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.5b00577     Document Type: Article

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