The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules

Journal of the American Chemical Society

Volumn 136, Issue 11, 2014, Pages 4172-4185

  Kang, Hyun Jin ^a   Kendrick, Samantha ^b   Hecht, Sidney M ^c   Hurley, Laurence H ^a,b  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXPERIMENTS; GENE EXPRESSION;

ANTAGONISTIC EFFECTS; CIS-REGULATORY ELEMENTS; CONTROL OF GENE EXPRESSION; EQUILIBRIUM MIXTURES; MOLECULAR SWITCHES; PHYSIOLOGICAL CONDITION; TRANSCRIPTIONAL COMPLEXES; TRANSCRIPTIONAL FACTORS;

MOLECULES;

BINDING PROTEIN; GUANINE QUADRUPLEX; HEPATOMA DERIVED GROWTH FACTOR; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; HIGH MOBILITY GROUP B1 PROTEIN; MESSENGER RNA; OLIGOMER; PROTEIN BCL 2; RETINOBLASTOMA BINDING PROTEIN 4; RETINOBLASTOMA BINDING PROTEIN 7; RNA BINDING PROTEIN; SINGLE STRANDED DNA; SINGLE STRANDED RNA; SMALL INTERFERING RNA; STREPTAVIDIN; TRANSCRIPTION FACTOR;

ARTICLE; BREAST CANCER; BROMINATION; CELL PROLIFERATION; CELL STRAIN MCF 7; CHEMOSENSITIZATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA STRUCTURE; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; MOLECULAR CROWDING; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN SECONDARY STRUCTURE; RNA SPLICING; RNA STRUCTURE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

BENZOXAZINES; CELL LINE, TUMOR; CHOLESTANES; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN L; HUMANS; MCF-7 CELLS; PIPERIDINES; PREGNANES; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS;

EID: 84896516232     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja4109352     Document Type: Article

References (33)

1. Brown, R. V.; Hurley, L. H. Biochem. Soc. Trans. 2011, 39, 635
2. Dhakal, S.; Yu, Z.; Konik, R.; Cui, Y.; Koirala, D.; Mao, H. Biophys. J. 2012, 102, 2575
3. Brooks, T. A.; Hurley, L. H. Nat. Rev. Cancer 2009, 9, 849
4. Tomonaga, T.; Levens, D. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 5830
5. Kendrick, S.; Kang, H.-J.; Alam, M. P.; Mdathil, M. M.; Agrawal, P.; Gokhale, V.; Yang, D.; Hecht, S. M.; Hurley, L. H. J. Am. Chem. Soc. 2014.
6. Dethoff, E. A.; Chugh, J.; Mustoe, A. M.; Al-Hashimi, H. M. Nature 2012, 482, 322
7. Dai, J.; Dexheimer, T. S.; Chen, D.; Carver, M.; Ambrus, A.; Jones, R. A.; Yang, D. J. Am. Chem. Soc. 2006, 128, 1096
8. Dexheimer, T. S.; Sun, D.; Fry, M.; Hurley, L. H. In Quadruplex Nucleic Acids; Neidle, S., Ed.; RSCPublishing: Cambridge, 2006, p 180.
9. González, V.; Guo, K.; Hurley, L.; Sun, D. J. Biol. Chem. 2009, 284, 23622
10. Dexheimer, T. S.; Carey, S. S.; Zuohe, S.; Gokhale, V. M.; Hu, X.; Murata, L. B.; Maes, E. M.; Weichsel, A.; Sun, D.; Meuillet, E. J.; Montfort, W. R.; Hurley, L. H. Mol. Cancer Ther. 2009, 8, 1363
11. Michelotti, E. F.; Michelotti, G. A.; Aronsohn, A. I.; Levens, D. Mol. Cell. Biol. 1996, 16, 2350
12. Lee, D.-H.; Lim, M.-H.; Youn, D.-Y.; Jung, S. E.; Ahn, Y. S.; Tsujimoto, Y.; Lee, J.-H. Biochem. Biophys. Res. Commun. 2009, 382, 583
13. Hung, L.-H.; Heiner, M.; Hui, J.; Schreiner, S.; Benes, V.; Bindereif, A. RNA 2008, 14, 284
14. Oberdoerffer, S.; Moita, L. F.; Neems, D.; Freitas, R. P.; Hacohen, N.; Rao, A. Science 2008, 321, 686
15. Grishna, I. Structure-function analysis of heterogeneous nuclear ribonucleoproteins L and LL. Ph.D. Dissertation, Justus-Liebig-Universität, Gießen, Germany, 2010.
16. Cui, Y.; Koirala, D.; Kang, H.; Dhakal, S.; Yangyuoru, P.; Hurley, L. H.; Mao, H. Nucleic Acids Res. 2014, 10.1093/nar/gku185
17. Backe, P. H.; Messias, A. C.; Ravelli, R. B. G.; Sattler, M.; Cusack, S. Structure 2005, 13, 1055
18. Sun, D.; Hurley, L. H. J. Med. Chem. 2009, 52, 2863
19. Christensen, J. J.; Rytting, J. H.; Izatt, R. M. J. Phys. Chem. 1967, 71, 2700
20. Malliavin, T. E.; Gau, J.; Snoussi, K.; Leroy, J.-L. Biophys. J. 2003, 84, 3838
21. Modi, S.; Wani, A. H.; Krishnan, Y. Nucleic Acids Res. 2006, 34, 4354
22. Collin, D.; Gehring, K. J. Am. Chem. Soc. 1998, 120, 4069
23. Fenna, C. P.; Wilkinson, V. J.; Arnold, J. R. P.; Cosstick, R.; Fisher, J. Chem. Commun. (Camb.) 2008, 3567
24. Choi, J.; Majima, T. Photochem. Photobiol. 2013, 89, 513
25. Choi, J.; Kim, S.; Tachikawa, T.; Fujitsuka, M.; Majima, T. J. Am. Chem. Soc. 2011, 133, 16146
26. Rajendran, A.; Nakano, S.; Sugimoto, N. Chem. Commun. (Camb.) 2010, 46, 1299
27. Patel, D. J.; Canuel, L. L. Proc. Natl. Acad. Sci. U.S.A. 1979, 76, 24
28. Lieblein, A. L.; Buck, J.; Schlepckow, K.; Fürtig, B.; Schwalbe, H. Angew. Chem., Int. Ed. 2012, 51, 250
29. Ray, P. S.; Jia, J.; Yao, P.; Majumder, M.; Hatzoglou, M.; Fox, P. L. Nature 2009, 457, 915
30. Preußner, M.; Schreiner, S.; Hung, L.-H.; Porstner, M.; Jack, H.-M.; Benes, V.; Ratsch, G.; Bindereif, A. Nucleic Acids Res. 2012, 40, 5666
31. Biffi, G.; Tannahill, D.; McCafferty, J.; Balasubramanian, S. Nat. Chem 2013, 5, 182
32. Kendrick, S.; Akiyama, Y.; Hecht, S. M.; Hurley, L. H. J. Am. Chem. Soc. 2009, 131, 17667
33. Cheema, S. K.; Mishra, S. K.; Rangnekar, V. M.; Tari, A. M.; Kumar, R.; Lopez-Berestein, G. J. Biol. Chem. 2003, 278, 19995