Topology of a DNA G-quadruplex structure formed in the HIV-1 promoter: A potential target for anti-HIV drug development

Journal of the American Chemical Society

Volumn 136, Issue 14, 2014, Pages 5249-5252

  Amrane, Samir ^a,b   Kerkour, Abdelaziz ^a,b   Bedrat, Amina ^a,b   Vialet, Brune ^a,b   Andreola, Marie Line ^a,c   Mergny, Jean Louis ^a,b  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b INSERM U869   (France)

^c University Victor Segalen   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA SEQUENCES; GENE EXPRESSION; HYDROGEN BONDS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEIC ACIDS; POSITIVE IONS;

DRUG DEVELOPMENT; G-QUADRUPLEX STRUCTURE; GUANINE-TRACTS; HIV-1 GENE EXPRESSION; HYBRID STRUCTURE; NUCLEIC ACID STRUCTURE; POTENTIAL TARGETS; PRIMARY SEQUENCES;

TOPOLOGY;

CYTOSINE; DNA FRAGMENT; GUANINE; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; ACRIDINE DERIVATIVE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BRACO19; GUANINE QUADRUPLEX; LIGAND; VIRUS DNA;

ARTICLE; BINDING SITE; BOMBYX MORI; CIRCULAR DICHROISM; CONFORMATION; DNA BASE COMPOSITION; DNA SEQUENCE; DNA STRUCTURE; DRUG DEVELOPMENT; ELECTROPHORETIC MOBILITY; GENE EXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; IN VITRO STUDY; MUTATION; NATIVE POLYACRYLAMIDE GEL ELECTROPHORESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; CHEMISTRY; DRUG EFFECTS; GENETICS; PROMOTER REGION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACRIDINES; ANTI-HIV AGENTS; DNA, VIRAL; G-QUADRUPLEXES; HIV-1; LIGANDS; PROMOTER REGIONS, GENETIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84897980191     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja501500c     Document Type: Article

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