-
1
-
-
20144364292
-
Prevalence of quadruplexes in the human genome
-
DOI 10.1093/nar/gki609
-
Huppert JL, Balasubramanian S (2005) Prevalence of quadruplexes in the human genome. Nucleic Acids Res 33: 2908-2916. (Pubitemid 41511230)
-
(2005)
Nucleic Acids Research
, vol.33
, Issue.9
, pp. 2908-2916
-
-
Huppert, J.L.1
Balasubramanian, S.2
-
2
-
-
20144369806
-
Highly prevalent putative quadruplex sequence motifs in human DNA
-
DOI 10.1093/nar/gki553
-
Todd AK, Johnston M, Neidle S (2005) Highly prevalent putative quadruplex sequence motifs in human DNA. Nucleic Acids Res 33: 2901-2907. (Pubitemid 41511229)
-
(2005)
Nucleic Acids Research
, vol.33
, Issue.9
, pp. 2901-2907
-
-
Todd, A.K.1
Johnston, M.2
Neidle, S.3
-
3
-
-
0023788886
-
Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis
-
Sen D, Gilbert W (1988) Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis. Nature 334: 364-366.
-
(1988)
Nature
, vol.334
, pp. 364-366
-
-
Sen, D.1
Gilbert, W.2
-
4
-
-
1042268168
-
G-quartets 40 years later: From 5′-GMP to molecular biology and supramolecular chemistry
-
Davis JT (2004) G-quartets 40 years later: from 5′-GMP to molecular biology and supramolecular chemistry. Angew Chem Int Ed Engl 43: 668-698.
-
(2004)
Angew Chem Int Ed Engl
, vol.43
, pp. 668-698
-
-
Davis, J.T.1
-
5
-
-
40249084264
-
Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes
-
DOI 10.1093/nar/gkm1138
-
Eddy J, Maizels N (2008) Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes. Nucleic Acids Res 36: 1321-1333. (Pubitemid 351330947)
-
(2008)
Nucleic Acids Research
, vol.36
, Issue.4
, pp. 1321-1333
-
-
Eddy, J.1
Maizels, N.2
-
6
-
-
33846928449
-
G-quadruplexes in promoters throughout the human genome
-
DOI 10.1093/nar/gkl1057
-
Huppert JL, Balasubramanian S (2007) G-quadruplexes in promoters throughout the human genome. Nucleic Acids Res 35: 406-413. (Pubitemid 46232058)
-
(2007)
Nucleic Acids Research
, vol.35
, Issue.2
, pp. 406-413
-
-
Huppert, J.L.1
Balasubramanian, S.2
-
7
-
-
52449093394
-
Genome-wide computational and expression analyses reveal G-quadruplex DNA motifs as conserved cis-regulatory elements in human and related species
-
Verma A, Halder K, Halder R, Yadav VK, Rawal P, et al. (2008) Genome-wide computational and expression analyses reveal G-quadruplex DNA motifs as conserved cis-regulatory elements in human and related species. J Med Chem 51: 5641-5649.
-
(2008)
J Med Chem
, vol.51
, pp. 5641-5649
-
-
Verma, A.1
Halder, K.2
Halder, R.3
Yadav, V.K.4
Rawal, P.5
-
8
-
-
84891400223
-
Existence and consequences of G-quadruplex structures in DNA
-
Murat P, Balasubramanian S (2013) Existence and consequences of G-quadruplex structures in DNA. Curr Opin Genet Dev 25C: 22-29.
-
(2013)
Curr Opin Genet Dev
, vol.25 C
, pp. 22-29
-
-
Murat, P.1
Balasubramanian, S.2
-
9
-
-
84875464903
-
Quantitative visualization of DNA G-quadruplex structures in human cells
-
Biffi G, Tannahill D, McCafferty J, Balasubramanian S (2013) Quantitative visualization of DNA G-quadruplex structures in human cells. Nat Chem 5: 182-186.
-
(2013)
Nat Chem
, vol.5
, pp. 182-186
-
-
Biffi, G.1
Tannahill, D.2
McCafferty, J.3
Balasubramanian, S.4
-
10
-
-
0037015078
-
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription
-
DOI 10.1073/pnas.182256799
-
Siddiqui-Jain A, Grand CL, Bearss DJ, Hurley LH (2002) Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proc Natl Acad Sci U S A 99: 11593-11598. (Pubitemid 34994444)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.18
, pp. 11593-11598
-
-
Siddiqui-Jain, A.1
Grand, C.L.2
Bearss, D.J.3
Hurley, L.H.4
-
11
-
-
13944272246
-
The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function
-
DOI 10.1158/0008-5472.CAN-04-2910
-
Burger AM, Dai F, Schultes CM, Reszka AP, Moore MJ, et al. (2005) The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res 65: 1489-1496. (Pubitemid 40270178)
-
(2005)
Cancer Research
, vol.65
, Issue.4
, pp. 1489-1496
-
-
Burger, A.M.1
Dai, F.2
Schultes, C.M.3
Reszka, A.P.4
Moore, M.J.5
Double, J.A.6
Neidle, S.7
-
12
-
-
33746916385
-
The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells
-
DOI 10.1158/0008-5472.CAN-06-1581
-
Gomez D, O'Donohue MF, Wenner T, Douarre C, Macadre J, et al. (2006) The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells. Cancer Res 66: 6908-6912. (Pubitemid 44197664)
-
(2006)
Cancer Research
, vol.66
, Issue.14
, pp. 6908-6912
-
-
Gomez, D.1
O'Donohue, M.-F.2
Wenner, T.3
Douarre, C.4
Macadre, J.5
Koebel, P.6
Giraud-Panis, M.-J.7
Kaplan, H.8
Kolkes, A.9
Shin-Ya, K.10
Riou, J.-F.11
-
13
-
-
34247208639
-
Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism
-
DOI 10.1038/sj.bjc.6603691, PII 6603691
-
Phatak P, Cookson JC, Dai F, Smith V, Gartenhaus RB, et al. (2007) Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism. Br J Cancer 96: 1223-1233. (Pubitemid 46625068)
-
(2007)
British Journal of Cancer
, vol.96
, Issue.8
, pp. 1223-1233
-
-
Phatak, P.1
Cookson, J.C.2
Dai, F.3
Smith, V.4
Gartenhaus, R.B.5
Stevens, M.F.G.6
Burger, A.M.7
-
14
-
-
56749151077
-
A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres
-
Rodriguez R, Muller S, Yeoman JA, Trentesaux C, Riou JF, et al. (2008) A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres. J Am Chem Soc 130: 15758-15759.
-
(2008)
J Am Chem Soc
, vol.130
, pp. 15758-15759
-
-
Rodriguez, R.1
Muller, S.2
Yeoman, J.A.3
Trentesaux, C.4
Riou, J.F.5
-
15
-
-
36049045013
-
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect
-
DOI 10.1172/JCI32461
-
Salvati E, Leonetti C, Rizzo A, Scarsella M, Mottolese M, et al. (2007) Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect. J Clin Invest 117: 3236-3247. (Pubitemid 350096981)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.11
, pp. 3236-3247
-
-
Salvati, E.1
Leonetti, C.2
Rizzo, A.3
Scarsella, M.4
Mottolese, M.5
Galati, R.6
Sperduti, I.7
Stevens, M.F.G.8
D'Incalci, M.9
Blasco, M.10
Chiorino, G.11
Bauwens, S.12
Horard, B.13
Gilson, E.14
Stoppacciaro, A.15
Zupi, G.16
Biroccio, A.17
-
16
-
-
77958092097
-
Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines
-
Bejugam M, Gunaratnam M, Muller S, Sanders D, Sewitz S, et al. (2010) Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines. ACS MED CHEM LETT 1: 306-310.
-
(2010)
ACS MED CHEM LETT
, vol.1
, pp. 306-310
-
-
Bejugam, M.1
Gunaratnam, M.2
Muller, S.3
Sanders, D.4
Sewitz, S.5
-
17
-
-
84857163904
-
Small-molecule-induced DNA damage identifies alternative DNA structures in human genes
-
Rodriguez R, Miller KM, Forment JV, Bradshaw CR, Nikan M, et al. (2012) Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol 8: 301-310.
-
(2012)
Nat Chem Biol
, vol.8
, pp. 301-310
-
-
Rodriguez, R.1
Miller, K.M.2
Forment, J.V.3
Bradshaw, C.R.4
Nikan, M.5
-
18
-
-
79961029908
-
DNA secondary structures and epigenetic determinants of cancer genome evolution
-
De S, Michor F (2011) DNA secondary structures and epigenetic determinants of cancer genome evolution. Nat Struct Mol Biol 18: 950-955.
-
(2011)
Nat Struct Mol Biol
, vol.18
, pp. 950-955
-
-
De, S.1
Michor, F.2
-
19
-
-
84864056018
-
Potential G-quadruplex formation at breakpoint regions of chromosomal translocations in cancer may explain their fragility
-
Katapadi VK, Nambiar M, Raghavan SC (2012) Potential G-quadruplex formation at breakpoint regions of chromosomal translocations in cancer may explain their fragility. Genomics 100: 72-80.
-
(2012)
Genomics
, vol.100
, pp. 72-80
-
-
Katapadi, V.K.1
Nambiar, M.2
Raghavan, S.C.3
-
20
-
-
84897029094
-
G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD
-
Gray LT, Vallur AC, Eddy J, Maizels N (2014) G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD. Nat Chem Biol 10: 313-318.
-
(2014)
Nat Chem Biol
, vol.10
, pp. 313-318
-
-
Gray, L.T.1
Vallur, A.C.2
Eddy, J.3
Maizels, N.4
-
21
-
-
77958494782
-
ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner
-
Law MJ, Lower KM, Voon HP, Hughes JR, Garrick D, et al. (2010) ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner. Cell 143: 367-378.
-
(2010)
Cell
, vol.143
, pp. 367-378
-
-
Law, M.J.1
Lower, K.M.2
Voon, H.P.3
Hughes, J.R.4
Garrick, D.5
-
22
-
-
84878122437
-
Pif1 family helicases suppress genome instability at G-quadruplex motifs
-
Paeschke K, Bochman ML, Garcia PD, Cejka P, Friedman KL, et al. (2013) Pif1 family helicases suppress genome instability at G-quadruplex motifs. Nature 497: 458-462.
-
(2013)
Nature
, vol.497
, pp. 458-462
-
-
Paeschke, K.1
Bochman, M.L.2
Garcia, P.D.3
Cejka, P.4
Friedman, K.L.5
-
23
-
-
77955791569
-
G-quadruplex nucleic acids and human disease
-
Wu Y, Brosh RM, Jr. (2010) G-quadruplex nucleic acids and human disease. FEBS J 277: 3470-3488.
-
(2010)
FEBS J
, vol.277
, pp. 3470-3488
-
-
Wu, Y.1
Brosh Jr., R.M.2
-
24
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D,Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144: 646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
25
-
-
79951567895
-
Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma
-
Nambiar M, Goldsmith G, Moorthy BT, Lieber MR, Joshi MV, et al. (2011) Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma. Nucleic Acids Res 39: 936-948.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 936-948
-
-
Nambiar, M.1
Goldsmith, G.2
Moorthy, B.T.3
Lieber, M.R.4
Joshi, M.V.5
-
26
-
-
84886906882
-
G-quadruplex structures formed at the HOX11 breakpoint region contribute to its fragility during t(10;14) translocation in T-cell leukemia
-
Nambiar M, Srivastava M, Gopalakrishnan V, Sankaran SK, Raghavan SC (2013) G-quadruplex structures formed at the HOX11 breakpoint region contribute to its fragility during t(10;14) translocation in T-cell leukemia. Mol Cell Biol 33: 4266-4281.
-
(2013)
Mol Cell Biol
, vol.33
, pp. 4266-4281
-
-
Nambiar, M.1
Srivastava, M.2
Gopalakrishnan, V.3
Sankaran, S.K.4
Raghavan, S.C.5
-
27
-
-
84872578210
-
Fanconi anaemia and the repair of Watson and Crick DNA crosslinks
-
Kottemann MC, Smogorzewska A (2013) Fanconi anaemia and the repair of Watson and Crick DNA crosslinks. Nature 493: 356-363.
-
(2013)
Nature
, vol.493
, pp. 356-363
-
-
Kottemann, M.C.1
Smogorzewska, A.2
-
29
-
-
33745398364
-
Bloom syndrome, genomic instability and cancer: The SOS-like hypothesis
-
Amor-Gueret M (2006) Bloom syndrome, genomic instability and cancer: the SOS-like hypothesis. Cancer Lett 236: 1-12.
-
(2006)
Cancer Lett
, vol.236
, pp. 1-12
-
-
Amor-Gueret, M.1
-
30
-
-
44949114282
-
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability
-
DOI 10.1128/MCB.02210-07
-
Wu Y, Shin-ya K, Brosh RM, Jr. (2008) FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability. Mol Cell Biol 28: 4116-4128. (Pubitemid 351812995)
-
(2008)
Molecular and Cellular Biology
, vol.28
, Issue.12
, pp. 4116-4128
-
-
Wu, Y.1
Kazuo, S.-Y.2
Brosh Jr., R.M.3
-
31
-
-
0032538453
-
The Bloom's syndrome helicase unwinds G4 DNA
-
DOI 10.1074/jbc.273.42.27587
-
Sun H, Karow JK, Hickson ID, Maizels N (1998) The Bloom's syndrome helicase unwinds G4 DNA. J Biol Chem 273: 27587-27592. (Pubitemid 28500481)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.42
, pp. 27587-27592
-
-
Sun, H.1
Karow, J.K.2
Hickson, I.D.3
Maizels, N.4
-
32
-
-
10344256183
-
Defective telomere lagging strand synthesis in cells lacking WRN helicase activity
-
DOI 10.1126/science.1103619
-
Crabbe L, Verdun RE, Haggblom CI, Karlseder J (2004) Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science 306: 1951-1953. (Pubitemid 39627862)
-
(2004)
Science
, vol.306
, Issue.5703
, pp. 1951-1953
-
-
Crabbe, L.1
Verdun, R.E.2
Haggblom, C.I.3
Karlseder, J.4
-
33
-
-
84892717244
-
Loss of DAXX and ATRX are associated with chromosome instability and reduced survival of patients with pancreatic neuroendocrine tumors
-
Marinoni I, Kurrer AS, Vassella E, Dettmer M, Rudolph T, et al. (2014) Loss of DAXX and ATRX are associated with chromosome instability and reduced survival of patients with pancreatic neuroendocrine tumors. Gastroenterology 146: 453-460 e455.
-
(2014)
Gastroenterology
, vol.146
-
-
Marinoni, I.1
Kurrer, A.S.2
Vassella, E.3
Dettmer, M.4
Rudolph, T.5
-
34
-
-
44149094083
-
XPD Helicase Structures and Activities: Insights into the Cancer and Aging Phenotypes from XPD Mutations
-
DOI 10.1016/j.cell.2008.04.030, PII S0092867408005606
-
Fan L, Fuss JO, Cheng QJ, Arvai AS, Hammel M, et al. (2008) XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations. Cell 133: 789-800. (Pubitemid 351715395)
-
(2008)
Cell
, vol.133
, Issue.5
, pp. 789-800
-
-
Fan, L.1
Fuss, J.O.2
Cheng, Q.J.3
Arvai, A.S.4
Hammel, M.5
Roberts, V.A.6
Cooper, P.K.7
Tainer, J.A.8
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