메뉴 건너뛰기




Volumn 8, Issue 8, 2013, Pages

Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE QUADRUPLEX; LIGAND; NEF PROTEIN;

EID: 84883166324     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073121     Document Type: Article
Times cited : (91)

References (73)
  • 1
    • 77955809107 scopus 로고    scopus 로고
    • Making sense of G-quadruplex and i-motif functions in oncogene promoters
    • doi: 10.1111/j.1742-4658.2010.07759.x
    • Brooks TA, Kendrick S, Hurley L, (2010) Making sense of G-quadruplex and i-motif functions in oncogene promoters. FEBS J 277: 3459-3469. doi:10.1111/j.1742-4658.2010.07759.x. PubMed: 20670278.
    • (2010) FEBS J , vol.277 , pp. 3459-3469
    • Brooks, T.A.1    Kendrick, S.2    Hurley, L.3
  • 2
    • 27144451010 scopus 로고    scopus 로고
    • Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo
    • doi: 10.1038/nsmb982
    • Paeschke K, Simonsson T, Postberg J, Rhodes D, Lipps HJ, (2005) Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo. Nat Struct Mol Biol 12: 847-854. doi:10.1038/nsmb982. PubMed: 16142245.
    • (2005) Nat Struct Mol Biol , vol.12 , pp. 847-854
    • Paeschke, K.1    Simonsson, T.2    Postberg, J.3    Rhodes, D.4    Lipps, H.J.5
  • 4
    • 33846928449 scopus 로고    scopus 로고
    • G-quadruplexes in promoters throughout the human genome
    • 17169996
    • Huppert JL, Balasubramanian S, (2007) G-quadruplexes in promoters throughout the human genome. Nucleic Acids Res 35: 406-413. PubMed: 17169996.
    • (2007) Nucleic Acids Res , vol.35 , pp. 406-413
    • Huppert, J.L.1    Balasubramanian, S.2
  • 5
    • 79953313413 scopus 로고    scopus 로고
    • Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
    • doi: 10.1038/nrd3428
    • Balasubramanian S, Hurley LH, Neidle S, (2011) Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nat Rev Drug Discov 10: 261-275. doi:10.1038/nrd3428. PubMed: 21455236.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 261-275
    • Balasubramanian, S.1    Hurley, L.H.2    Neidle, S.3
  • 6
    • 0031004279 scopus 로고    scopus 로고
    • DNA secondary structures and the evolution of hypervariable tandem arrays
    • doi: 10.1074/jbc.272.14.9517
    • Weitzmann MN, Woodford KJ, Usdin K, (1997) DNA secondary structures and the evolution of hypervariable tandem arrays. J Biol Chem 272: 9517-9523. doi:10.1074/jbc.272.14.9517. PubMed: 9083093.
    • (1997) J Biol Chem , vol.272 , pp. 9517-9523
    • Weitzmann, M.N.1    Woodford, K.J.2    Usdin, K.3
  • 7
    • 0027190015 scopus 로고
    • DNA sequences at immunoglobulin switch region recombination sites
    • doi: 10.1093/nar/21.3.365
    • Dunnick W, Hertz GZ, Scappino L, Gritzmacher C, (1993) DNA sequences at immunoglobulin switch region recombination sites. Nucleic Acids Res 21: 365-372. doi:10.1093/nar/21.3.365. PubMed: 8441648.
    • (1993) Nucleic Acids Res , vol.21 , pp. 365-372
    • Dunnick, W.1    Hertz, G.Z.2    Scappino, L.3    Gritzmacher, C.4
  • 8
    • 0033034413 scopus 로고    scopus 로고
    • High affinity interactions of nucleolin with G-G-paired rDNA
    • doi: 10.1074/jbc.274.22.15908
    • Hanakahi LA, Sun H, Maizels N, (1999) High affinity interactions of nucleolin with G-G-paired rDNA. J Biol Chem 274: 15908-15912. doi:10.1074/jbc.274.22.15908. PubMed: 10336496.
    • (1999) J Biol Chem , vol.274 , pp. 15908-15912
    • Hanakahi, L.A.1    Sun, H.2    Maizels, N.3
  • 9
    • 77958494782 scopus 로고    scopus 로고
    • ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner
    • Law MJ, Lower KM, Voon HP, Hughes JR, Garrick D, et al. (2011) ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner. Cell 143: 367-378.
    • (2011) Cell , vol.143 , pp. 367-378
    • Law, M.J.1    Lower, K.M.2    Voon, H.P.3    Hughes, J.R.4    Garrick, D.5
  • 10
    • 33845352895 scopus 로고    scopus 로고
    • Dynamic roles for G4 DNA in the biology of eukaryotic cells
    • doi: 10.1038/nsmb1171
    • Maizels N, (2006) Dynamic roles for G4 DNA in the biology of eukaryotic cells. Nat Struct Mol Biol 13: 1055-1059. doi:10.1038/nsmb1171. PubMed: 17146462.
    • (2006) Nat Struct Mol Biol , vol.13 , pp. 1055-1059
    • Maizels, N.1
  • 11
    • 80053611613 scopus 로고    scopus 로고
    • G-quadruplex-induced instability during leading-strand replication
    • doi: 10.1038/emboj.2011.316
    • Lopes J, Piazza A, Bermejo R, Kriegsman B, Colosio A, et al. (2011) G-quadruplex-induced instability during leading-strand replication. EMBO J 30: 4033-4046. doi:10.1038/emboj.2011.316. PubMed: 21873979.
    • (2011) EMBO J , vol.30 , pp. 4033-4046
    • Lopes, J.1    Piazza, A.2    Bermejo, R.3    Kriegsman, B.4    Colosio, A.5
  • 12
    • 79951567895 scopus 로고    scopus 로고
    • Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma
    • 20880994
    • Nambiar M, Goldsmith G, Moorthy BT, Lieber MR, Joshi MV, et al. (2010) Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma. Nucleic Acids Res 39: 936-948. PubMed: 20880994.
    • (2010) Nucleic Acids Res , vol.39 , pp. 936-948
    • Nambiar, M.1    Goldsmith, G.2    Moorthy, B.T.3    Lieber, M.R.4    Joshi, M.V.5
  • 13
    • 77955650378 scopus 로고    scopus 로고
    • Mechanisms and implications of transcription blockage by guanine-rich DNA sequences
    • doi: 10.1073/pnas.1007580107
    • Belotserkovskii BP, Liu R, Tornaletti S, Krasilnikova MM, Mirkin SM, et al. (2010) Mechanisms and implications of transcription blockage by guanine-rich DNA sequences. Proc Natl Acad Sci U S A 107: 12816-12821. doi:10.1073/pnas.1007580107. PubMed: 20616059.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 12816-12821
    • Belotserkovskii, B.P.1    Liu, R.2    Tornaletti, S.3    Krasilnikova, M.M.4    Mirkin, S.M.5
  • 14
    • 3042785608 scopus 로고    scopus 로고
    • Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA
    • doi: 10.1101/gad.1200804
    • Duquette ML, Handa P, Vincent JA, Taylor AF, Maizels N, (2004) Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA. Genes Dev 18: 1618-1629. doi:10.1101/gad.1200804. PubMed: 15231739.
    • (2004) Genes Dev , vol.18 , pp. 1618-1629
    • Duquette, M.L.1    Handa, P.2    Vincent, J.A.3    Taylor, A.F.4    Maizels, N.5
  • 15
    • 84861416464 scopus 로고    scopus 로고
    • Quadruplex-single nucleotide polymorphisms (Quad-SNP) influence gene expression difference among individuals
    • doi: 10.1093/nar/gkr1258
    • Baral A, Kumar P, Halder R, Mani P, Yadav VK, et al. (2012) Quadruplex-single nucleotide polymorphisms (Quad-SNP) influence gene expression difference among individuals. Nucleic Acids Res 40: 3800-3811. doi:10.1093/nar/gkr1258. PubMed: 22238381.
    • (2012) Nucleic Acids Res , vol.40 , pp. 3800-3811
    • Baral, A.1    Kumar, P.2    Halder, R.3    Mani, P.4    Yadav, V.K.5
  • 17
    • 47649124369 scopus 로고    scopus 로고
    • G-quadruplexes: targets in anticancer drug design
    • doi: 10.1002/cmdc.200700300
    • Ou TM, Lu YJ, Tan JH, Huang ZS, Wong KY, et al. (2008) G-quadruplexes: targets in anticancer drug design. Chemmedchem 3: 690-713. doi:10.1002/cmdc.200700300. PubMed: 18236491.
    • (2008) Chemmedchem , vol.3 , pp. 690-713
    • Ou, T.M.1    Lu, Y.J.2    Tan, J.H.3    Huang, Z.S.4    Wong, K.Y.5
  • 18
    • 0032497405 scopus 로고    scopus 로고
    • NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA
    • doi: 10.1021/bi981330n
    • Fedoroff OY, Salazar M, Han H, Chemeris VV, Kerwin SM, et al. (1998) NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA. Biochemistry 37: 12367-12374. doi:10.1021/bi981330n. PubMed: 9730808.
    • (1998) Biochemistry , vol.37 , pp. 12367-12374
    • Fedoroff, O.Y.1    Salazar, M.2    Han, H.3    Chemeris, V.V.4    Kerwin, S.M.5
  • 19
    • 0033083378 scopus 로고    scopus 로고
    • Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells
    • 9973212
    • Izbicka E, Wheelhouse RT, Raymond E, Davidson KK, Lawrence RA, et al. (1999) Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells. Cancer Res 59: 639-644. PubMed: 9973212.
    • (1999) Cancer Res , vol.59 , pp. 639-644
    • Izbicka, E.1    Wheelhouse, R.T.2    Raymond, E.3    Davidson, K.K.4    Lawrence, R.A.5
  • 20
    • 44349142304 scopus 로고    scopus 로고
    • Structural basis of DNA quadruplex recognition by an acridine drug
    • doi: 10.1021/ja8016973
    • Campbell NH, Parkinson GN, Reszka AP, Neidle S, (2008) Structural basis of DNA quadruplex recognition by an acridine drug. J Am Chem Soc 130: 6722-6724. doi:10.1021/ja8016973. PubMed: 18457389.
    • (2008) J Am Chem Soc , vol.130 , pp. 6722-6724
    • Campbell, N.H.1    Parkinson, G.N.2    Reszka, A.P.3    Neidle, S.4
  • 21
    • 0037070575 scopus 로고    scopus 로고
    • Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex
    • doi: 10.1021/ja017308q
    • Kim MY, Vankayalapati H, Shin-Ya K, Wierzba K, Hurley LH, (2002) Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex. J Am Chem Soc 124: 2098-2099. doi:10.1021/ja017308q. PubMed: 11878947.
    • (2002) J Am Chem Soc , vol.124 , pp. 2098-2099
    • Kim, M.Y.1    Vankayalapati, H.2    Shin-Ya, K.3    Wierzba, K.4    Hurley, L.H.5
  • 22
    • 70350220557 scopus 로고    scopus 로고
    • Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis
    • doi: 10.1158/0008-5472.CAN-09-1304
    • Drygin D, Siddiqui-Jain A, O'Brien S, Schwaebe M, Lin A, et al. (2009) Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis. Cancer Res 69: 7653-7661. doi:10.1158/0008-5472.CAN-09-1304. PubMed: 19738048.
    • (2009) Cancer Res , vol.69 , pp. 7653-7661
    • Drygin, D.1    Siddiqui-Jain, A.2    O'Brien, S.3    Schwaebe, M.4    Lin, A.5
  • 23
    • 75549083801 scopus 로고    scopus 로고
    • Investigation of mRNA quadruplex formation in Escherichia coli
    • doi: 10.1038/nprot.2009.111
    • Wieland M, Hartig JS, (2009) Investigation of mRNA quadruplex formation in Escherichia coli. Nat Protoc 4: 1632-1640. doi:10.1038/nprot.2009.111. PubMed: 19876023.
    • (2009) Nat Protoc , vol.4 , pp. 1632-1640
    • Wieland, M.1    Hartig, J.S.2
  • 24
    • 84871728994 scopus 로고    scopus 로고
    • Genome-wide study predicts promoter-G4 DNA motifs regulate selective functions in bacteria: radioresistance of D. radiodurans involves G4 DNA-mediated regulation
    • doi: 10.1093/nar/gkt004
    • Beaume N, Pathak R, Yadav VK, Kota S, Misra HS, et al. (2013) Genome-wide study predicts promoter-G4 DNA motifs regulate selective functions in bacteria: radioresistance of D. radiodurans involves G4 DNA-mediated regulation. Nucleic Acids Res 41: 76-89. doi:10.1093/nar/gkt004. PubMed: 23161683.
    • (2013) Nucleic Acids Res , vol.41 , pp. 76-89
    • Beaume, N.1    Pathak, R.2    Yadav, V.K.3    Kota, S.4    Misra, H.S.5
  • 25
    • 33745121203 scopus 로고    scopus 로고
    • Genome-wide prediction of G4 DNA as regulatory motifs: role in Escherichia coli global regulation
    • doi: 10.1101/gr.4508806
    • Rawal P, Kummarasetti VB, Ravindran J, Kumar N, Halder K, et al. (2006) Genome-wide prediction of G4 DNA as regulatory motifs: role in Escherichia coli global regulation. Genome Res 16: 644-655. doi:10.1101/gr.4508806. PubMed: 16651665.
    • (2006) Genome Res , vol.16 , pp. 644-655
    • Rawal, P.1    Kummarasetti, V.B.2    Ravindran, J.3    Kumar, N.4    Halder, K.5
  • 26
    • 0345097633 scopus 로고    scopus 로고
    • The discovery of HIV as the cause of AIDS
    • doi: 10.1056/NEJMp038194
    • Gallo RC, Montagnier L, (2003) The discovery of HIV as the cause of AIDS. N Engl J Med 349: 2283-2285. doi:10.1056/NEJMp038194. PubMed: 14668451.
    • (2003) N Engl J Med , vol.349 , pp. 2283-2285
    • Gallo, R.C.1    Montagnier, L.2
  • 27
    • 84883178009 scopus 로고    scopus 로고
    • HIV and Its Treatment- FDA-Approved Anti-HIV Medications
    • In: Services DoHaH, editor: U.S. Department of Health and Human Services' Guidelines
    • AIDSinfo (2011) HIV and Its Treatment- FDA-Approved Anti-HIV Medications. In: Services DoHaH, editor: U.S. Department of Health and Human Services' Guidelines.
    • (2011) U.S. Department of Health and Human Services' Guidelines
  • 28
    • 79952414942 scopus 로고    scopus 로고
    • Global trends in molecular epidemiology of HIV-1 during 2000-2007
    • doi: 10.1097/QAD.0b013e328342ff93
    • Hemelaar J, Gouws E, Ghys PD, Osmanov S, (2011) Global trends in molecular epidemiology of HIV-1 during 2000-2007. AIDS 25: 679-689. doi:10.1097/QAD.0b013e328342ff93. PubMed: 21297424.
    • (2011) AIDS , vol.25 , pp. 679-689
    • Hemelaar, J.1    Gouws, E.2    Ghys, P.D.3    Osmanov, S.4
  • 29
    • 84883154309 scopus 로고    scopus 로고
    • HIV Sequence Compendium 2008. Los Alamos National Laboratory, Theoretical Biology and Biophysics
    • Los Alamos, New Mexico
    • Kuiken C, Leitner T, Foley B, Hahn B, Marx P, et al. (2008) HIV Sequence Compendium 2008. Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico. LaUR: pp. 08-03719.
    • (2008) LaUR , pp. 08-03719
    • Kuiken, C.1    Leitner, T.2    Foley, B.3    Hahn, B.4    Marx, P.5
  • 30
    • 0028006247 scopus 로고
    • The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages
    • doi: 10.1084/jem.179.1.101
    • Miller MD, Warmerdam MT, Gaston I, Greene WC, Feinberg MB, (1994) The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages. J Exp Med 179: 101-113. doi:10.1084/jem.179.1.101. PubMed: 8270859.
    • (1994) J Exp Med , vol.179 , pp. 101-113
    • Miller, M.D.1    Warmerdam, M.T.2    Gaston, I.3    Greene, W.C.4    Feinberg, M.B.5
  • 31
    • 0027952787 scopus 로고
    • The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes
    • doi: 10.1084/jem.179.1.115
    • Spina CA, Kwoh TJ, Chowers MY, Guatelli JC, Richman DD, (1994) The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes. J Exp Med 179: 115-123. doi:10.1084/jem.179.1.115. PubMed: 7903679.
    • (1994) J Exp Med , vol.179 , pp. 115-123
    • Spina, C.A.1    Kwoh, T.J.2    Chowers, M.Y.3    Guatelli, J.C.4    Richman, D.D.5
  • 32
    • 0033578024 scopus 로고    scopus 로고
    • HIV: a new role for Nef in the spread of HIV
    • doi: 10.1016/S0960-9822(99)80282-6
    • Harris M, (1999) HIV: a new role for Nef in the spread of HIV. Curr Biol 9: R459-R461. doi:10.1016/S0960-9822(99)80282-6. PubMed: 10375524.
    • (1999) Curr Biol , vol.9
    • Harris, M.1
  • 33
    • 0029015330 scopus 로고
    • Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis
    • 7541845
    • Aiken C, Trono D, (1995) Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis. J Virol 69: 5048-5056. PubMed: 7541845.
    • (1995) J Virol , vol.69 , pp. 5048-5056
    • Aiken, C.1    Trono, D.2
  • 34
    • 0031979771 scopus 로고    scopus 로고
    • Grossly defective nef gene sequences in a human immunodeficiency virus type 1-seropositive long-term nonprogressor
    • 9557645
    • Salvi R, Garbuglia AR, Di Caro A, Pulciani S, Montella F, et al. (1998) Grossly defective nef gene sequences in a human immunodeficiency virus type 1-seropositive long-term nonprogressor. J Virol 72: 3646-3657. PubMed: 9557645.
    • (1998) J Virol , vol.72 , pp. 3646-3657
    • Salvi, R.1    Garbuglia, A.R.2    Di Caro, A.3    Pulciani, S.4    Montella, F.5
  • 35
    • 0025743306 scopus 로고
    • Importance of the nef gene for maintenance of high virus loads and for development of AIDS
    • doi: 10.1016/0092-8674(91)90097-I
    • Kestler HW 3rd, Ringler DJ, Mori K, Panicali DL, Sehgal PK, et al. (1991) Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65: 651-662. doi:10.1016/0092-8674(91)90097-I. PubMed: 2032289.
    • (1991) Cell , vol.65 , pp. 651-662
    • Kestler 3rd, H.W.1    Ringler, D.J.2    Mori, K.3    Panicali, D.L.4    Sehgal, P.K.5
  • 36
    • 61949425674 scopus 로고    scopus 로고
    • Strategies for inhibiting function of HIV-1 accessory proteins: a necessary route to AIDS therapy?
    • doi: 10.2174/092986709787002646
    • Richter SN, Frasson I, Palù G, (2009) Strategies for inhibiting function of HIV-1 accessory proteins: a necessary route to AIDS therapy? Curr Med Chem 16: 267-286. doi:10.2174/092986709787002646. PubMed: 19149577.
    • (2009) Curr Med Chem , vol.16 , pp. 267-286
    • Richter, S.N.1    Frasson, I.2    Palù, G.3
  • 37
    • 0142009639 scopus 로고    scopus 로고
    • G-quartets direct assembly of HIV-1 nucleocapsid protein along single-stranded DNA
    • doi: 10.1093/nar/gkg716
    • Lyonnais S, Gorelick RJ, Mergny JL, Le Cam E, Mirambeau G, (2003) G-quartets direct assembly of HIV-1 nucleocapsid protein along single-stranded DNA. Nucleic Acids Res 31: 5754-5763. doi:10.1093/nar/gkg716. PubMed: 14500839.
    • (2003) Nucleic Acids Res , vol.31 , pp. 5754-5763
    • Lyonnais, S.1    Gorelick, R.J.2    Mergny, J.L.3    Le Cam, E.4    Mirambeau, G.5
  • 38
    • 0027533742 scopus 로고
    • Evidence for interstrand quadruplex formation in the dimerization of human immunodeficiency virus 1 genomic RNA
    • doi: 10.1073/pnas.90.8.3393
    • Sundquist WI, Heaphy S, (1993) Evidence for interstrand quadruplex formation in the dimerization of human immunodeficiency virus 1 genomic RNA. Proc Natl Acad Sci U S A 90: 3393-3397. doi:10.1073/pnas.90.8.3393. PubMed: 8475087.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 3393-3397
    • Sundquist, W.I.1    Heaphy, S.2
  • 39
    • 33747860882 scopus 로고    scopus 로고
    • QGRS Mapper: a web-based server for predicting G-quadruplexes in nucleotide sequences
    • doi: 10.1093/nar/gkj467
    • Kikin O, D'Antonio L, Bagga PS, (2006) QGRS Mapper: a web-based server for predicting G-quadruplexes in nucleotide sequences. Nucleic Acids Res 34: W676-W682. doi:10.1093/nar/gkj467. PubMed: 16845096.
    • (2006) Nucleic Acids Res , vol.34
    • Kikin, O.1    D'Antonio, L.2    Bagga, P.S.3
  • 40
    • 0031954686 scopus 로고    scopus 로고
    • Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1
    • 9525605
    • Platt EJ, Wehrly K, Kuhmann SE, Chesebro B, Kabat D, (1998) Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1. J Virol 72: 2855-2864. PubMed: 9525605.
    • (1998) J Virol , vol.72 , pp. 2855-2864
    • Platt, E.J.1    Wehrly, K.2    Kuhmann, S.E.3    Chesebro, B.4    Kabat, D.5
  • 41
    • 0033856458 scopus 로고    scopus 로고
    • Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120
    • doi: 10.1128/JVI.74.18.8358-8367.2000
    • Derdeyn CA, Decker JM, Sfakianos JN, Wu X, O'Brien WA, et al. (2000) Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120. J Virol 74: 8358-8367. doi:10.1128/JVI.74.18.8358-8367.2000. PubMed: 10954535.
    • (2000) J Virol , vol.74 , pp. 8358-8367
    • Derdeyn, C.A.1    Decker, J.M.2    Sfakianos, J.N.3    Wu, X.4    O'Brien, W.A.5
  • 42
    • 73449135109 scopus 로고    scopus 로고
    • Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds
    • doi: 10.1021/cb900195c
    • Emert-Sedlak L, Kodama T, Lerner EC, Dai W, Foster C, et al. (2009) Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds. ACS Chem Biol 4: 939-947. doi:10.1021/cb900195c. PubMed: 19807124.
    • (2009) ACS Chem Biol , vol.4 , pp. 939-947
    • Emert-Sedlak, L.1    Kodama, T.2    Lerner, E.C.3    Dai, W.4    Foster, C.5
  • 43
    • 84857680190 scopus 로고    scopus 로고
    • Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner
    • doi: 10.1371/journal.pone.0032561
    • Narute PS, Smithgall TE, (2012) Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner. PLOS ONE 7: e32561. doi:10.1371/journal.pone.0032561. PubMed: 22393415.
    • (2012) PLOS ONE , vol.7
    • Narute, P.S.1    Smithgall, T.E.2
  • 44
    • 70350547756 scopus 로고    scopus 로고
    • HIV-1 Nef dimerization is required for Nef-mediated receptor downregulation and viral replication
    • doi: 10.1016/j.jmb.2009.09.047
    • Poe JA, Smithgall TE, (2009) HIV-1 Nef dimerization is required for Nef-mediated receptor downregulation and viral replication. J Mol Biol 394: 329-342. doi:10.1016/j.jmb.2009.09.047. PubMed: 19781555.
    • (2009) J Mol Biol , vol.394 , pp. 329-342
    • Poe, J.A.1    Smithgall, T.E.2
  • 45
    • 84872898071 scopus 로고    scopus 로고
    • Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity
    • doi: 10.1016/j.chembiol.2012.11.005
    • Emert-Sedlak LA, Narute P, Shu ST, Poe JA, Shi H, et al. (2013) Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity. Chem Biol 20: 82-91. doi:10.1016/j.chembiol.2012.11.005. PubMed: 23352142.
    • (2013) Chem Biol , vol.20 , pp. 82-91
    • Emert-Sedlak, L.A.1    Narute, P.2    Shu, S.T.3    Poe, J.A.4    Shi, H.5
  • 46
    • 0029881450 scopus 로고    scopus 로고
    • The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase
    • doi: 10.1038/nsb0496-340
    • Grzesiek S, Bax A, Clore GM, Gronenborn AM, Hu JS, et al. (1996) The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase. Nat Struct Biol 3: 340-345. doi:10.1038/nsb0496-340. PubMed: 8599760.
    • (1996) Nat Struct Biol , vol.3 , pp. 340-345
    • Grzesiek, S.1    Bax, A.2    Clore, G.M.3    Gronenborn, A.M.4    Hu, J.S.5
  • 47
    • 0343494918 scopus 로고    scopus 로고
    • Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain
    • doi: 10.1016/S0092-8674(00)81276-3
    • Lee CH, Saksela K, Mirza UA, Chait BT, Kuriyan J, (1996) Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain. Cell 85: 931-942. doi:10.1016/S0092-8674(00)81276-3. PubMed: 8681387.
    • (1996) Cell , vol.85 , pp. 931-942
    • Lee, C.H.1    Saksela, K.2    Mirza, U.A.3    Chait, B.T.4    Kuriyan, J.5
  • 48
    • 0033544383 scopus 로고    scopus 로고
    • The conserved core of human immunodeficiency virus type 1 Nef is essential for association with Lck and for enhanced viral replication in T-lymphocytes
    • doi: 10.1006/viro.1999.9937
    • Cheng H, Hoxie JP, Parks WP, (1999) The conserved core of human immunodeficiency virus type 1 Nef is essential for association with Lck and for enhanced viral replication in T-lymphocytes. Virology 264: 5-15. doi:10.1006/viro.1999.9937. PubMed: 10544125.
    • (1999) Virology , vol.264 , pp. 5-15
    • Cheng, H.1    Hoxie, J.P.2    Parks, W.P.3
  • 49
    • 0032566709 scopus 로고    scopus 로고
    • A K cation-induced conformational switch within a loop spanning segment of a DNA quadruplex containing G-G-G-C repeats
    • doi: 10.1006/jmbi.1998.2031
    • Bouaziz S, Kettani A, Patel DJ, (1998) A K cation-induced conformational switch within a loop spanning segment of a DNA quadruplex containing G-G-G-C repeats. J Mol Biol 282: 637-652. doi:10.1006/jmbi.1998.2031. PubMed: 9737927.
    • (1998) J Mol Biol , vol.282 , pp. 637-652
    • Bouaziz, S.1    Kettani, A.2    Patel, D.J.3
  • 51
    • 78649850820 scopus 로고    scopus 로고
    • How long is too long? Effects of loop size on G-quadruplex stability
    • doi: 10.1093/nar/gkq639
    • Guédin A, Gros J, Alberti P, Mergny JL, (2010) How long is too long? Effects of loop size on G-quadruplex stability. Nucleic Acids Res 38: 7858-7868. doi:10.1093/nar/gkq639. PubMed: 20660477.
    • (2010) Nucleic Acids Res , vol.38 , pp. 7858-7868
    • Guédin, A.1    Gros, J.2    Alberti, P.3    Mergny, J.L.4
  • 52
    • 64549099313 scopus 로고    scopus 로고
    • Circular dichroism and conformational polymorphism of DNA
    • doi: 10.1093/nar/gkp026
    • Kypr J, Kejnovská I, Renciuk D, Vorlícková M, (2009) Circular dichroism and conformational polymorphism of DNA. Nucleic Acids Res 37: 1713-1725. doi:10.1093/nar/gkp026. PubMed: 19190094.
    • (2009) Nucleic Acids Res , vol.37 , pp. 1713-1725
    • Kypr, J.1    Kejnovská, I.2    Renciuk, D.3    Vorlícková, M.4
  • 53
    • 84861382319 scopus 로고    scopus 로고
    • The porphyrin TmPyP4 unfolds the extremely stable G-quadruplex in MT3-MMP mRNA and alleviates its repressive effect to enhance translation in eukaryotic cells
    • 22266651
    • Morris MJ, Wingate KL, Silwal J, Leeper TC, Basu S, (2012) The porphyrin TmPyP4 unfolds the extremely stable G-quadruplex in MT3-MMP mRNA and alleviates its repressive effect to enhance translation in eukaryotic cells. Nucleic Acids Res, 40: 4137-45. PubMed: 22266651.
    • (2012) Nucleic Acids Res , vol.40 , pp. 4137-4145
    • Morris, M.J.1    Wingate, K.L.2    Silwal, J.3    Leeper, T.C.4    Basu, S.5
  • 54
    • 68249156463 scopus 로고    scopus 로고
    • Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands
    • doi: 10.1021/ja902281d
    • Palumbo SL, Ebbinghaus SW, Hurley LH, (2009) Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands. J Am Chem Soc 131: 10878-10891. doi:10.1021/ja902281d. PubMed: 19601575.
    • (2009) J Am Chem Soc , vol.131 , pp. 10878-10891
    • Palumbo, S.L.1    Ebbinghaus, S.W.2    Hurley, L.H.3
  • 55
    • 0035913742 scopus 로고    scopus 로고
    • Selective interactions of cationic porphyrins with G-quadruplex structures
    • doi: 10.1021/ja002179j
    • Han H, Langley DR, Rangan A, Hurley LH, (2001) Selective interactions of cationic porphyrins with G-quadruplex structures. J Am Chem Soc 123: 8902-8913. doi:10.1021/ja002179j. PubMed: 11552797.
    • (2001) J Am Chem Soc , vol.123 , pp. 8902-8913
    • Han, H.1    Langley, D.R.2    Rangan, A.3    Hurley, L.H.4
  • 56
    • 0028302998 scopus 로고
    • Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene
    • 8151761
    • Chowers MY, Spina CA, Kwoh TJ, Fitch NJ, Richman DD, et al. (1994) Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene. J Virol 68: 2906-2914. PubMed: 8151761.
    • (1994) J Virol , vol.68 , pp. 2906-2914
    • Chowers, M.Y.1    Spina, C.A.2    Kwoh, T.J.3    Fitch, N.J.4    Richman, D.D.5
  • 57
    • 84856453839 scopus 로고    scopus 로고
    • The Nef-infectivity enigma: mechanisms of enhanced lentiviral infection
    • doi: 10.2174/157016211798842099
    • Vermeire J, Vanbillemont G, Witkowski W, Verhasselt B, (2011) The Nef-infectivity enigma: mechanisms of enhanced lentiviral infection. Curr HIV Res 9: 474-489. doi:10.2174/157016211798842099. PubMed: 22103831.
    • (2011) Curr HIV Res , vol.9 , pp. 474-489
    • Vermeire, J.1    Vanbillemont, G.2    Witkowski, W.3    Verhasselt, B.4
  • 58
    • 65649089445 scopus 로고    scopus 로고
    • The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression
    • doi: 10.1021/jm900055s
    • Sun D, Hurley LH, (2009) The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression. J Med Chem 52: 2863-2874. doi:10.1021/jm900055s. PubMed: 19385599.
    • (2009) J Med Chem , vol.52 , pp. 2863-2874
    • Sun, D.1    Hurley, L.H.2
  • 59
    • 84857863993 scopus 로고    scopus 로고
    • A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro
    • doi: 10.1093/nar/gkr882
    • Raiber EA, Kranaster R, Lam E, Nikan M, Balasubramanian S, (2012) A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro. Nucleic Acids Res 40: 1499-1508. doi:10.1093/nar/gkr882. PubMed: 22021377.
    • (2012) Nucleic Acids Res , vol.40 , pp. 1499-1508
    • Raiber, E.A.1    Kranaster, R.2    Lam, E.3    Nikan, M.4    Balasubramanian, S.5
  • 60
    • 77957260077 scopus 로고    scopus 로고
    • A novel G-quadruplex motif modulates promoter activity of human thymidine kinase 1
    • doi: 10.1111/j.1742-4658.2010.07814.x
    • Basundra R, Kumar A, Amrane S, Verma A, Phan AT, et al. (2010) A novel G-quadruplex motif modulates promoter activity of human thymidine kinase 1. FEBS J 277: 4254-4264. doi:10.1111/j.1742-4658.2010.07814.x. PubMed: 20849417.
    • (2010) FEBS J , vol.277 , pp. 4254-4264
    • Basundra, R.1    Kumar, A.2    Amrane, S.3    Verma, A.4    Phan, A.T.5
  • 61
    • 14744270743 scopus 로고    scopus 로고
    • Stable secondary structure near the nicking site for adeno-associated virus type 2 Rep proteins on human chromosome 19
    • doi: 10.1128/JVI.79.6.3544-3556.2005
    • Jang MY, Yarborough OH 3rd, Conyers GB, McPhie P, Owens RA, (2005) Stable secondary structure near the nicking site for adeno-associated virus type 2 Rep proteins on human chromosome 19. J Virol 79: 3544-3556. doi:10.1128/JVI.79.6.3544-3556.2005. PubMed: 15731249.
    • (2005) J Virol , vol.79 , pp. 3544-3556
    • Jang, M.Y.1    Yarborough 3rd, O.H.2    Conyers, G.B.3    McPhie, P.4    Owens, R.A.5
  • 62
    • 0030993474 scopus 로고    scopus 로고
    • Bombyx mori single repeat telomeric DNA sequence forms a G-quadruplex capped by base triads
    • doi: 10.1038/nsb0597-382
    • Kettani A, Bouaziz S, Wang W, Jones RA, Patel DJ, (1997) Bombyx mori single repeat telomeric DNA sequence forms a G-quadruplex capped by base triads. Nat Struct Biol 4: 382-389. doi:10.1038/nsb0597-382. PubMed: 9145109.
    • (1997) Nat Struct Biol , vol.4 , pp. 382-389
    • Kettani, A.1    Bouaziz, S.2    Wang, W.3    Jones, R.A.4    Patel, D.J.5
  • 63
    • 33644858313 scopus 로고    scopus 로고
    • Formation of the G-quadruplex and i-motif structures in retinoblastoma susceptibility genes (Rb)
    • doi: 10.1093/nar/gkj485
    • Xu Y, Sugiyama H, (2006) Formation of the G-quadruplex and i-motif structures in retinoblastoma susceptibility genes (Rb). Nucleic Acids Res 34: 949-954. doi:10.1093/nar/gkj485. PubMed: 16464825.
    • (2006) Nucleic Acids Res , vol.34 , pp. 949-954
    • Xu, Y.1    Sugiyama, H.2
  • 64
    • 70450202380 scopus 로고    scopus 로고
    • Giardia telomeric sequence d(TAGGG)4 forms two intramolecular G-quadruplexes in K+ solution: effect of loop length and sequence on the folding topology
    • doi: 10.1021/ja905611c
    • Hu L, Lim KW, Bouaziz S, Phan AT, (2009) Giardia telomeric sequence d(TAGGG)4 forms two intramolecular G-quadruplexes in K+ solution: effect of loop length and sequence on the folding topology. J Am Chem Soc 131: 16824-16831. doi:10.1021/ja905611c. PubMed: 19874015.
    • (2009) J Am Chem Soc , vol.131 , pp. 16824-16831
    • Hu, L.1    Lim, K.W.2    Bouaziz, S.3    Phan, A.T.4
  • 65
    • 70350692142 scopus 로고    scopus 로고
    • Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad
    • doi: 10.1093/nar/gkp630
    • Lim KW, Alberti P, Guédin A, Lacroix L, Riou JF, et al. (2009) Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad. Nucleic Acids Res 37: 6239-6248. doi:10.1093/nar/gkp630. PubMed: 19692585.
    • (2009) Nucleic Acids Res , vol.37 , pp. 6239-6248
    • Lim, K.W.1    Alberti, P.2    Guédin, A.3    Lacroix, L.4    Riou, J.F.5
  • 66
    • 67749124298 scopus 로고    scopus 로고
    • Structure of the human telomere in K+ solution: a stable basket-type G-quadruplex with only two G-tetrad layers
    • doi: 10.1021/ja807503g
    • Lim KW, Amrane S, Bouaziz S, Xu W, Mu Y, et al. (2009) Structure of the human telomere in K+ solution: a stable basket-type G-quadruplex with only two G-tetrad layers. J Am Chem Soc 131: 4301-4309. doi:10.1021/ja807503g. PubMed: 19271707.
    • (2009) J Am Chem Soc , vol.131 , pp. 4301-4309
    • Lim, K.W.1    Amrane, S.2    Bouaziz, S.3    Xu, W.4    Mu, Y.5
  • 67
    • 76349097100 scopus 로고    scopus 로고
    • Human telomeric G-quadruplex: structures of DNA and RNA sequences
    • doi: 10.1111/j.1742-4658.2009.07464.x
    • Phan AT, (2010) Human telomeric G-quadruplex: structures of DNA and RNA sequences. FEBS J 277: 1107-1117. doi:10.1111/j.1742-4658.2009.07464.x. PubMed: 19951353.
    • (2010) FEBS J , vol.277 , pp. 1107-1117
    • Phan, A.T.1
  • 68
    • 84855959280 scopus 로고    scopus 로고
    • Toward a digital gene response: RNA G-quadruplexes with fewer quartets fold with higher cooperativity
    • doi: 10.1021/ja2096255
    • Mullen MA, Assmann SM, Bevilacqua PC, (2012) Toward a digital gene response: RNA G-quadruplexes with fewer quartets fold with higher cooperativity. J Am Chem Soc 134: 812-815. doi:10.1021/ja2096255. PubMed: 22239732.
    • (2012) J Am Chem Soc , vol.134 , pp. 812-815
    • Mullen, M.A.1    Assmann, S.M.2    Bevilacqua, P.C.3
  • 69
    • 80051739988 scopus 로고    scopus 로고
    • A sequence-independent analysis of the loop length dependence of intramolecular RNA G-quadruplex stability and topology
    • doi: 10.1021/bi200805j
    • Zhang AY, Bugaut A, Balasubramanian S, (2011) A sequence-independent analysis of the loop length dependence of intramolecular RNA G-quadruplex stability and topology. Biochemistry 50: 7251-7258. doi:10.1021/bi200805j. PubMed: 21744844.
    • (2011) Biochemistry , vol.50 , pp. 7251-7258
    • Zhang, A.Y.1    Bugaut, A.2    Balasubramanian, S.3
  • 70
    • 76349122184 scopus 로고    scopus 로고
    • Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancer
    • doi: 10.1111/j.1742-4658.2009.07463.x
    • Neidle S, (2010) Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancer. FEBS J 277: 1118-1125. doi:10.1111/j.1742-4658.2009.07463.x. PubMed: 19951354.
    • (2010) FEBS J , vol.277 , pp. 1118-1125
    • Neidle, S.1
  • 71
    • 37049004147 scopus 로고    scopus 로고
    • Targeting telomeres and telomerase
    • doi: 10.1016/j.biochi.2007.07.011
    • De Cian A, Lacroix L, Douarre C, Temime-Smaali N, Trentesaux C, et al. (2008) Targeting telomeres and telomerase. Biochimie 90: 131-155. doi:10.1016/j.biochi.2007.07.011. PubMed: 17822826.
    • (2008) Biochimie , vol.90 , pp. 131-155
    • De Cian, A.1    Lacroix, L.2    Douarre, C.3    Temime-Smaali, N.4    Trentesaux, C.5
  • 72
    • 66549124907 scopus 로고    scopus 로고
    • The structures of quadruplex nucleic acids and their drug complexes
    • doi: 10.1016/j.sbi.2009.04.001
    • Neidle S, (2009) The structures of quadruplex nucleic acids and their drug complexes. Curr Opin Struct Biol 19: 239-250. doi:10.1016/j.sbi.2009.04.001. PubMed: 19487118.
    • (2009) Curr Opin Struct Biol , vol.19 , pp. 239-250
    • Neidle, S.1
  • 73
    • 0034894379 scopus 로고    scopus 로고
    • Structure--function relationships in HIV-1 Nef
    • doi: 10.1093/embo-reports/kve141
    • Geyer M, Fackler OT, Peterlin BM, (2001) Structure--function relationships in HIV-1 Nef. EMBO Rep 2: 580-585. doi:10.1093/embo-reports/kve141. PubMed: 11463741.
    • (2001) EMBO Rep , vol.2 , pp. 580-585
    • Geyer, M.1    Fackler, O.T.2    Peterlin, B.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.