Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex

Journal of Biological Chemistry

Volumn 286, Issue 47, 2011, Pages 41018-41027

  Brown, Robert V ^a   Danford, Forest L ^a   Gokhale, Vijay ^a,b   Hurley, Laurence H ^a,b   Brooks, Tracy A ^a,b  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; DOWN-REGULATION; ELLIPTICINE; G-QUADRUPLEXES; HIGH AFFINITY; HIGHER ORDER; LYMPHOMA CELLS; PROTEIN BINDING; SECONDARY STRUCTURES; SINGLE-STRANDED DNA; UNIQUE FEATURES;

BIOCHEMISTRY; CELL CULTURE; ONCOLOGY; TRANSCRIPTION;

DNA;

ANTINEOPLASTIC AGENT; DNA; DOXORUBICIN; ELLIPTICINE DERIVATIVE; GQC 01; GQC 02; GQC 03; GQC 04; GQC 05; GQC 06; GQC 07; GQC 08; GQC 09; GQC 10; GUANINE QUADRUPLEX; MESSENGER RNA; MYC PROTEIN; NSC 176327; NSC 338258; NSC 86374; QUINDOLINE DERIVATIVE I; SODIUM PROTON EXCHANGE PROTEIN 3; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BURKITT LYMPHOMA; CANCER INHIBITION; CELL STRAIN CA46; CONTROLLED STUDY; DOWN REGULATION; DRUG BINDING SITE; DRUG DETERMINATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TARGETING; HUMAN; HUMAN CELL; LYMPHOMA CELL LINE; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; PROMOTER REGION; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DOWN-REGULATION; ELLIPTICINES; EXONS; G-QUADRUPLEXES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SPACE; LYMPHOMA, NON-HODGKIN; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR TARGETED THERAPY; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-MYC; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER;

EID: 81755172447     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.274720     Document Type: Article

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