Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 39, 2015, Pages E5391-E5400

  Vasilyev, Nikita ^a   Polonskaia, Anna ^b   Darnell, Jennifer C ^c   Darnell, Robert B ^c,d   Patel, Dinshaw J ^b   Serganov, Alexander ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d NEW YORK GENOME CENTER   (United States)

Author keywords

FMRP; Fragile X syndrome; G quadruplex; RGG box; RNA structure

Indexed keywords

ARGININE; FRAGILE X MENTAL RETARDATION PROTEIN; GLYCINE; GUANINE QUADRUPLEX RNA; NUCLEASE; POTASSIUM ION; RNA; UNCLASSIFIED DRUG; FMR1 PROTEIN, HUMAN; GUANINE QUADRUPLEX;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; HYDROGEN BOND; PLASTICITY; PRIORITY JOURNAL; RNA BINDING; CHEMISTRY; CRYSTALLIZATION; GENETICS; HUMAN; MOLECULAR GENETICS; MOLECULAR MODEL; PROTEIN CONFORMATION; PROTEIN FOOTPRINTING; PROTEIN MOTIF;

AMINO ACID MOTIFS; CRYSTALLIZATION; FRAGILE X MENTAL RETARDATION PROTEIN; G-QUADRUPLEXES; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN FOOTPRINTING;

EID: 84942856104     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1515737112     Document Type: Article

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