Short loop length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites

EMBO Journal

Volumn 34, Issue 12, 2015, Pages 1718-1734

  Piazza, Aurèle ^a,d   Adrian, Michael ^b   Samazan, Frédéric ^a   Heddi, Brahim ^b   Hamon, Florian ^c   Serero, Alexandre ^a   Lopes, Judith ^a,e   Teulade Fichou, Marie Paule ^c   Phan, Anh Tuân ^b   Nicolas, Alain ^a  

^a INSTITUT CURIE   (France)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^c CNRS   (France)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

Author keywords

G quadruplex; Genomic instability; Minisatellite; Phen DC3; Pif1

Indexed keywords

GUANINE QUADRUPLEX; PYRIMIDINE; OLIGONUCLEOTIDE;

ARTICLE; BIOINFORMATICS; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DNA SEQUENCE; GENOMIC INSTABILITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; THERMOSTABILITY; BIOLOGY; CHEMICAL STRUCTURE; CIRCULAR DICHROISM; CONFORMATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC ENGINEERING; GENETICS; HEAT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYMERASE CHAIN REACTION; SACCHAROMYCES CEREVISIAE; VARIABLE NUMBER OF TANDEM REPEAT;

CAENORHABDITIS ELEGANS;

CIRCULAR DICHROISM; COMPUTATIONAL BIOLOGY; FLUORESCENCE RESONANCE ENERGY TRANSFER; G-QUADRUPLEXES; GENETIC ENGINEERING; GENOMIC INSTABILITY; HOT TEMPERATURE; MAGNETIC RESONANCE SPECTROSCOPY; MINISATELLITE REPEATS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; POLYMERASE CHAIN REACTION; SACCHAROMYCES CEREVISIAE;

EID: 84930866439     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201490702     Document Type: Article

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