The democratization of gene editing: Insights from site-specific cleavage and double-strand break repair

DNA Repair

Volumn 44, Issue , 2016, Pages 6-16

  Jasin, Maria ^a   Haber, James E ^b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b BRANDEIS UNIVERSITY   (United States)

Author keywords

CRISPR Cas9; Double strand break repair; Gene editing; HO endonuclease; Homologous recombination; Homology directed repair; I SceI endonuclease; Nonhomologous end joining

Indexed keywords

ENDONUCLEASE; HO ENDONUCLEASE; I PPOI ENDONUCLEASE; I SCEI ENDONUCLEASE; MEGANUCLEASE I ANII; RESTRICTION ENDONUCLEASE; UNCLASSIFIED DRUG; ZINC FINGER NUCLEASE; BACTERIAL PROTEIN; CAS9 PROTEIN, FRANCISELLA NOVICIDA; DEOXYRIBONUCLEASE; DNA; I-PPO ENDONUCLEASE; MATURASE I-ANII; RNA DIRECTED DNA POLYMERASE; SACCHAROMYCES CEREVISIAE PROTEIN; SCEI PROTEIN, S CEREVISIAE; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; TYPE II SITE SPECIFIC DEOXYRIBONUCLEASE; ZINC FINGER PROTEIN;

BREAK INDUCED REPLICATION; CRISPR CAS SYSTEM; DNA CLEAVAGE; DNA END JOINING REPAIR; DNA REPAIR; DOUBLE STRANDED DNA BREAK; GENE EDITING; GENE TARGETING; HOMOLOGOUS RECOMBINATION; HUMAN; MEIOTIC RECOMBINATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; GENETICS; METABOLISM; MISMATCH REPAIR; PROCEDURES; RECOMBINATION REPAIR;

BACTERIAL PROTEINS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-CAS SYSTEMS; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA; DNA BREAKS, DOUBLE-STRANDED; DNA END-JOINING REPAIR; DNA MISMATCH REPAIR; ENDODEOXYRIBONUCLEASES; ENDONUCLEASES; GENE EDITING; HUMANS; RECOMBINATIONAL DNA REPAIR; RNA-DIRECTED DNA POLYMERASE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION ACTIVATOR-LIKE EFFECTOR NUCLEASES; ZINC FINGERS;

EID: 84973861610     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2016.05.001     Document Type: Review

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