Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice

Nature

Volumn 530, Issue 7589, 2016, Pages 171-176

  Davies, Benjamin ^a   Hatton, Edouard ^a   Altemose, Nicolas ^a,b   Hussin, Julie G ^a   Pratto, Florencia ^c   Zhang, Gang ^a   Hinch, Anjali Gupta ^a   Moralli, Daniela ^a   Biggs, Daniel ^a   Diaz, Rebeca ^a   Preece, Chris ^a   Li, Ran ^a,b   Bitoun, Emmanuelle ^a   Brick, Kevin ^c   Green, Catherine M ^a   Camerini Otero, R Daniel ^c   Myers, Simon R ^a,b   Donnelly, Peter ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; PROTEIN PRDM9; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; HISTONE LYSINE METHYLTRANSFERASE; PRDM9 PROTEIN, HUMAN; PROTEIN BINDING;

ALLELE; BIOENGINEERING; FERTILITY; GENOME; HYBRID; MAMMAL; PHENOTYPE; PROTEIN; RECOMBINATION; RODENT;

ALLELE; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CHROMOSOME; CONTROLLED STUDY; CORRELATION ANALYSIS; DOUBLE STRANDED DNA BREAK; FERTILITY; GENETIC VARIABILITY; GENOME; HYBRID STERILITY; INFERTILITY; MALE; MEIOSIS; MEIOTIC RECOMBINATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN FUNCTION; SPECIES DIFFERENTIATION; SUBSPECIES; ANIMAL; C57BL MOUSE; CHEMISTRY; CHROMOSOME PAIRING; FEMALE; GENETIC RECOMBINATION; GENETICS; HUMAN; HYBRIDIZATION; METABOLISM; PROTEIN TERTIARY STRUCTURE;

MAMMALIA; MUS;

ALLELES; ANIMALS; BINDING SITES; CHROMOSOME PAIRING; CHROMOSOMES, MAMMALIAN; DNA BREAKS, DOUBLE-STRANDED; FEMALE; GENETIC SPECIATION; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; HYBRIDIZATION, GENETIC; INFERTILITY; MALE; MEIOSIS; MICE; MICE, INBRED C57BL; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; RECOMBINATION, GENETIC; ZINC FINGERS;

EID: 84958073440     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature16931     Document Type: Article

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