Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9

Molecular Cell

Volumn 61, Issue 6, 2016, Pages 895-902

  Anders, Carolin ^a   Bargsten, Katja ^a   Jinek, Martin ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ENDONUCLEASE; ENDONUCLEASE CAS9; ENZYME VARIANT; GUIDE RNA; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CAS9 ENDONUCLEASE STREPTOCOCCUS PYOGENES; DNA; SPACER DNA;

AMINO ACID SUBSTITUTION; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DNA CLEAVAGE; DNA STRAND; ENZYME ENGINEERING; GENOME ANALYSIS; MOLECULAR MODEL; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN MOTIF; STREPTOCOCCUS PYOGENES; CHEMISTRY; CONFORMATION; CRISPR CAS SYSTEM; ENZYME SPECIFICITY; GENETIC ENGINEERING; GENETICS; MUTATION; NUCLEOTIDE MOTIF; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; CRISPR-CAS SYSTEMS; CRYSTALLOGRAPHY, X-RAY; DNA; DNA, INTERGENIC; ENDONUCLEASES; GENETIC ENGINEERING; MUTATION; NUCLEIC ACID CONFORMATION; NUCLEOTIDE MOTIFS; RNA, GUIDE; SUBSTRATE SPECIFICITY;

EID: 84962514403     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2016.02.020     Document Type: Article

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