Break-induced replication repair of damaged forks induces genomic duplications in human cells

Science

Volumn 343, Issue 6166, 2014, Pages 88-91

  Costantino, Lorenzo ^a   Sotiriou, Sotirios K ^a   Rantala, Juha K ^b,g   Magin, Simon ^c   Mladenov, Emil ^c   Helleday, Thomas ^d   Haber, James E ^e   Iliakis, George ^c   Kallioniemi, Olli P ^f   Halazonetis, Thanos D ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^c UNIVERSITY OF ESSEN MEDICAL SCHOOL   (Germany)

^d KAROLINSKA INSTITUTE   (Sweden)

^e BRANDEIS UNIVERSITY   (United States)

^f UNIVERSITY OF HELSINKI   (Finland)

^g OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN E; DNA DIRECTED DNA POLYMERASE DELTA; POLD3 PROTEIN; POLD4 PROTEIN; UNCLASSIFIED DRUG; DNA DIRECTED DNA POLYMERASE GAMMA; POLD3 PROTEIN, HUMAN;

CANCER; CYTOLOGY; DNA; FUNCTIONAL ROLE; GENE EXPRESSION; GENOMICS; HOMINID; PHYSIOLOGY; YEAST;

ARTICLE; BREAK INDUCED REPLICATION; CELL CYCLE PROGRESSION; DNA REPLICATION; DNA SYNTHESIS; DOUBLE STRANDED DNA BREAK; GENE OVEREXPRESSION; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; BIOSYNTHESIS; CELL CYCLE; DNA REPAIR; GENE DUPLICATION; GENETICS; NEOPLASM; PHYSIOLOGY;

MAMMALIA; SACCHAROMYCETALES;

CELL CYCLE; CYCLIN E; DNA BREAKS, DOUBLE-STRANDED; DNA POLYMERASE III; DNA REPAIR; DNA REPLICATION; GENE DUPLICATION; HUMANS; NEOPLASMS;

EID: 84892743776     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1243211     Document Type: Article

References (30)

1. T. D. Halazonetis, V. G. Gorgoulis, J. Bartek, Science 319, 1352-1355 (2008).
2. R. Di Micco et al., Nature 444, 638-642 (2006).
3. J. Bartkova et al., Nature 444, 633-637 (2006).
4. L. I. Toledo et al., Nat. Struct. Mol. Biol. 18, 721-727 (2011).
5. Materials and methods are available as supplementary materials on Science Online.
6. E. Johansson, S. A. Macneill, Trends Biochem. Sci. 35, 339-347 (2010).
7. L. H. Thompson, D. Schild, Mutat. Res. 477, 131-153 (2001).
8. D. Branzei, M. Foiani, Nat. Rev. Mol. Cell Biol. 11, 208-219 (2010).
9. C. Z. Bachrati, I. D. Hickson, Chromosoma 117, 219-233 (2008).
10. J. R. Lydeard, S. Jain, M. Yamaguchi, J. E. Haber, Nature 448, 820-823 (2007).
11. M. J. McEachern, J. E. Haber, Annu. Rev. Biochem. 75, 111-135 (2006).
12. B. Llorente, C. E. Smith, L. S. Symington, Cell Cycle 7, 859-864 (2008).
13. N. Reynolds, A. Watt, P. A. Fantes, S. A. MacNeill, Curr. Genet. 34, 250-258 (1998).
14. M. Ohtsubo, A. M. Theodoras, J. Schumacher, J. M. Roberts, M. Pagano, Mol. Cell. Biol. 15, 2612-2624 (1995).
15. E. Petermann, M. L. Orta, N. Issaeva, N. Schultz, T. Helleday, Mol. Cell 37, 492-502 (2010).
16. A. C. Bester et al., Cell 145, 435-446 (2011).
17. S. P. Jackson, J. Bartek, Nature 461, 1071-1078 (2009).
18. J. M. Stark, A. J. Pierce, J. Oh, A. Pastink, M. Jasin, Mol. Cell. Biol. 24, 9305-9316 (2004).
19. R. A. Donnianni, L. S. Symington, Proc. Natl. Acad. Sci. U.S.A. 110, 13475-13480 (2013).
20. C. E. Smith, A. F. Lam, L. S. Symington, Mol. Cell. Biol. 29, 1432-1441 (2009).
21. M. McVey, S. E. Lee, Trends Genet. 24, 529-538 (2008).
22. D. P. Kane, M. Shusterman, Y. Rong, M. McVey, PLOS Genet. 8, e1002659 (2012).
23. Q. M. Huang et al., Biochem. Biophys. Res. Commun. 391, 542-546 (2010).
24. C. Payen, R. Koszul, B. Dujon, G. Fischer, PLOS Genet. 4, e1000175 (2008).
25. K. Mizuno, I. Miyabe, S. A. Schalbetter, A. M. Carr, J. M. Murray, Nature 493, 246-249 (2013).
26. A. Malkova, M. L. Naylor, M. Yamaguchi, G. Ira, J. E. Haber, Mol. Cell. Biol. 25, 933-944 (2005).
27. P. J. Stephens et al., Nature 462, 1005-1010 (2009).
28. D. J. McBride et al., J. Pathol. 227, 446-455 (2012).
29. P. J. Campbell et al., Nature 467, 1109-1113 (2010).
30. R. Beroukhim et al., Nature 463, 899-905 (2010).