PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice

Science

Volumn 327, Issue 5967, 2010, Pages 836-840

  Baudat, F ^a   Buard, J ^a   Grey, C ^a   Fledel Alon, A ^b   Ober, C ^b   Przeworski, M ^b   Coop, G ^c   De Massy, B ^a  

^a INSTITUTE OF HUMAN GENETICS   (France)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 9; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ALLELE; BIOCHEMISTRY; CYTOLOGY; DNA; GENE EXPRESSION; GENOMICS; HOMINID; RODENT;

ALLELE; ANIMAL EXPERIMENT; ARTICLE; CONSENSUS; DNA BINDING; DNA SEQUENCE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; IN VITRO STUDY; MAMMAL; MEIOSIS; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; SPECIES DIFFERENTIATION; ZINC FINGER MOTIF;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; DNA; DNA BREAKS, DOUBLE-STRANDED; DNA-BINDING PROTEINS; GENOME; GENOME, HUMAN; GENOTYPE; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; MEIOSIS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PHENOTYPE; RECOMBINATION, GENETIC; ZINC FINGERS;

MAMMALIA; MUS;

EID: 76749170346     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1183439     Document Type: Article

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34. E. Brun for technical assistance on PRDM9 in vitro assays, and D. Haddou and F. Arnal for mouse facility service. This study was supported by a grant from CNRS; the Association pour la Recherche sur le Cancer (grant ARC 3939); the Fondation Jerô me Lejeune and the Agence Nationale de la Recherche (grants ANR-06-BLAN-0160-01 and ANR-09-BLAN-0269-01) to B.d.M. C.G. was supported by a grant from Electricitéde France. This research was further was supported by NIH grants HD21244 and HL085197 to C.O., a Sloan Foundation Fellowship to G.C., NIH grant GM83098, American Recovery and Reinvestment Act supplement 03S1, and a Howard Hughes Medical Institute Early Career Scientist Award to M.P. Sequences generated for this study are deposited in GenBank with the following accession numbers: GU216222, GU216223, GU216224, GU216225, GU216226, GU216227, GU216228, GU216229, and GU216230.