-
1
-
-
0036240127
-
The mechanism and regulation of chromosomal V(D)J recombination
-
Bassing, C. H., Swat, W. & Alt, F. W. The mechanism and regulation of chromosomal V(D)J recombination. Cell 109, S45-S55 (2002).
-
(2002)
Cell
, vol.109
-
-
Bassing, C.H.1
Swat, W.2
Alt, F.W.3
-
2
-
-
0842303307
-
Unraveling V(D)J recombination: Insights into gene regulation
-
Jung, D. & Alt, F. W. Unraveling V(D)J recombination: insights into gene regulation. Cell 116, 299-311 (2004).
-
(2004)
Cell
, vol.116
, pp. 299-311
-
-
Jung, D.1
Alt, F.W.2
-
3
-
-
0036234455
-
Somatic hypermutation of immunoglobulin genes: Merging mechanisms for genetic diversity
-
Papavasillou, F. N. & Schatz, D. G. Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity. Cell 109, S35-S44 (2002).
-
(2002)
Cell
, vol.109
-
-
Papavasillou, F.N.1
Schatz, D.G.2
-
4
-
-
0036674618
-
AID mismatch repair in antibody diversification
-
Martin, A. & Scharff, M. D. AID and mismatch repair in antibody diversification. Nature Rev. Immunol. 2, 605-614 (2002).
-
(2002)
Nature Rev. Immunol.
, vol.2
, pp. 605-614
-
-
Martin, A.1
Scharff, M.D.2
-
5
-
-
0036152242
-
Mechanism and control of class-switch recombination
-
Manis, J. P., Tian, M. & Alt, F. W. Mechanism and control of class-switch recombination. Trends Immunol. 23, 31-39 (2002).
-
(2002)
Trends Immunol.
, vol.23
, pp. 31-39
-
-
Manis, J.P.1
Tian, M.2
Alt, F.W.3
-
6
-
-
0036212917
-
Molecular mechanism of class switch recombination: Linkage with somatic hypermutation
-
Honjo, T., Kinoshita, K. & Muramatsu, M. Molecular mechanism of class switch recombination: linkage with somatic hypermutation. Annu. Rev. Immunol. 20, 165-196 (2002).
-
(2002)
Annu. Rev. Immunol.
, vol.20
, pp. 165-196
-
-
Honjo, T.1
Kinoshita, K.2
Muramatsu, M.3
-
7
-
-
0031920677
-
Cis-acting sequences that affect somatic hypermutation of Ig genes
-
Storb, U. et al. Cis-acting sequences that affect somatic hypermutation of Ig genes. Immunol. Rev. 162, 153-160 (1998).
-
(1998)
Immunol. Rev.
, vol.162
, pp. 153-160
-
-
Storb, U.1
-
8
-
-
0031891768
-
Ig heavy chain class switching in Rag-deficient mice
-
Lansford, R., Manis, J. P., Sonoda, E., Rajewsky, K. & Alt, F. W. Ig heavy chain class switching in Rag-deficient mice. Int. Immunol. 10, 325-332 (1998).
-
(1998)
Int. Immunol.
, vol.10
, pp. 325-332
-
-
Lansford, R.1
Manis, J.P.2
Sonoda, E.3
Rajewsky, K.4
Alt, F.W.5
-
9
-
-
0027190015
-
DNA sequences at immunoglobulin switch region recombination sites
-
Dunnick, W., Hertz, G. Z., Scappino, L. & Gritzmacher, C. DNA sequences at immunoglobulin switch region recombination sites, Nucleic Acids Res. 21, 365-372 (1993).
-
(1993)
Nucleic Acids Res.
, vol.21
, pp. 365-372
-
-
Dunnick, W.1
Hertz, G.Z.2
Scappino, L.3
Gritzmacher, C.4
-
10
-
-
0038664358
-
The influence of transcriptional orientation on endogenous switch region function
-
Shinkura, R. et al. The influence of transcriptional orientation on endogenous switch region function. Nature Immunol. 4, 435-441 (2003). Provides the first evidence in vivo that the transcriptional orientation of S regions is important in CSR. In addition, the authors show that a synthetic G-rich sequence that lacks S-region motifs can replace an endogenous S region during CSR in vivo.
-
(2003)
Nature Immunol.
, vol.4
, pp. 435-441
-
-
Shinkura, R.1
-
11
-
-
0037452080
-
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
-
Chaudhuri, J. et al. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature 422, 726-730 (2003). Demonstrates biochemically that AID is a ssDNA deaminase. The authors also show a direct link between transcription and DNA deamination.
-
(2003)
Nature
, vol.422
, pp. 726-730
-
-
Chaudhuri, J.1
-
12
-
-
0038713344
-
Immunity through DNA deamination
-
Neuberger, M. S., Harris, R. S., Di Noia, J. & Petersen-Mahrt, S. K. Immunity through DNA deamination. Trends Biochem. Sci. 28, 305-312 (2003).
-
(2003)
Trends Biochem. Sci.
, vol.28
, pp. 305-312
-
-
Neuberger, M.S.1
Harris, R.S.2
Di Noia, J.3
Petersen-Mahrt, S.K.4
-
13
-
-
0029931447
-
Immunoglobulin class switching
-
Stavnezer, J. Immunoglobulin class switching. Curr. Opin. Immunol. 8, 199-205 (1996).
-
(1996)
Curr. Opin. Immunol.
, vol.8
, pp. 199-205
-
-
Stavnezer, J.1
-
14
-
-
0035862327
-
The μ switch region tandem repeats are important, but not required, for antibody class switch recombination
-
Luby, T. M., Schrader, C. E., Stavnezer, J. & Selsing, E. The μ switch region tandem repeats are important, but not required, for antibody class switch recombination. J. Exp. Med. 193, 159-168 (2001).
-
(2001)
J. Exp. Med.
, vol.193
, pp. 159-168
-
-
Luby, T.M.1
Schrader, C.E.2
Stavnezer, J.3
Selsing, E.4
-
15
-
-
0030022218
-
Antibody class switching
-
Stavnezer, J. Antibody class switching. Adv. Immunol. 61, 79-146 (1996).
-
(1996)
Adv. Immunol.
, vol.61
, pp. 79-146
-
-
Stavnezer, J.1
-
16
-
-
0032858194
-
Molecular processes that regulate class switching
-
Stavnezer, J. Molecular processes that regulate class switching. Curr. Top. Microbiol. Immunol. 245, 127-168 (2000).
-
(2000)
Curr. Top. Microbiol. Immunol.
, vol.245
, pp. 127-168
-
-
Stavnezer, J.1
-
17
-
-
0023020765
-
H replacement by a LINE-1 sequence and directed class switching
-
H replacement by a LINE-1 sequence and directed class switching. EMBO J. 5, 3259-3266 (1986).
-
(1986)
EMBO J.
, vol.5
, pp. 3259-3266
-
-
Yancopoulos, G.D.1
-
18
-
-
0022599997
-
Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching
-
Stavnezer-Nordgren, J. & Sirlin, S. Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching. EMBO J. 5, 95-102 (1986).
-
(1986)
EMBO J.
, vol.5
, pp. 95-102
-
-
Stavnezer-Nordgren, J.1
Sirlin, S.2
-
19
-
-
0025225502
-
Induction of RNA-stabilized DNA conformers by transcription of an immunoglobulin switch region
-
Reaban, M. E. & Griffin, J. A. Induction of RNA-stabilized DNA conformers by transcription of an immunoglobulin switch region. Nature 348, 342-344 (1990).
-
(1990)
Nature
, vol.348
, pp. 342-344
-
-
Reaban, M.E.1
Griffin, J.A.2
-
20
-
-
0028106344
-
Transcription induces the formation of a stable RNA. DNA hybrid in the immunoglobulin α switch region
-
Reaban, M. E., Lebowitz, J. & Griffin, J. A. Transcription induces the formation of a stable RNA. DNA hybrid in the immunoglobulin α switch region. J. Biol. Chem. 269, 21850-21857 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 21850-21857
-
-
Reaban, M.E.1
Lebowitz, J.2
Griffin, J.A.3
-
21
-
-
0029046127
-
Strand specificity in the transcriptional targeting of recombination at immunoglobulin switch sequences
-
Daniels, G. A. & Lieber, M. R. Strand specificity in the transcriptional targeting of recombination at immunoglobulin switch sequences. Proc. Natl Acad. Sci. USA 92, 5625-5629 (1995).
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 5625-5629
-
-
Daniels, G.A.1
Lieber, M.R.2
-
22
-
-
0034604622
-
Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro
-
Tian, M. & Alt, F. W. Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro. J. Biol. Chem. 275, 24163-24172 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 24163-24172
-
-
Tian, M.1
Alt, F.W.2
-
23
-
-
0029598833
-
RNA:DNA complex formation upon transcription of immunoglobulin switch regions: Implications for the mechanism and regulation of class switch recombination
-
Daniels, G. A. & Lieber, M. R. RNA:DNA complex formation upon transcription of immunoglobulin switch regions: implications for the mechanism and regulation of class switch recombination. Nucleic Acids Res. 23, 5006-5011 (1995).
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 5006-5011
-
-
Daniels, G.A.1
Lieber, M.R.2
-
24
-
-
0013277286
-
Molecular visualization of immunoglobulin switch region RNA/DNA complex by atomic force microscope
-
Mizuta, R. et al. Molecular visualization of immunoglobulin switch region RNA/DNA complex by atomic force microscope. J. Biol. Chem. 278, 4431-4434 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 4431-4434
-
-
Mizuta, R.1
-
25
-
-
0037650190
-
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
-
Yu, K., Chedin, F., Hsieh, C. L., Wilson, T. E. & Lieber, M. R. R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nature Immunol. 4, 442-451 (2003). Uses chemical probes to demonstrate that S regions form R loops in vivo in B cells undergoing CSR.
-
(2003)
Nature Immunol.
, vol.4
, pp. 442-451
-
-
Yu, K.1
Chedin, F.2
Hsieh, C.L.3
Wilson, T.E.4
Lieber, M.R.5
-
26
-
-
0035067615
-
Palindromic but not G-rich sequences are targets of class switch recombination
-
Tashiro, J., Kinoshita, K. & Honjo, T. Palindromic but not G-rich sequences are targets of class switch recombination. Int. Immunol. 13, 495-505 (2001).
-
(2001)
Int. Immunol.
, vol.13
, pp. 495-505
-
-
Tashiro, J.1
Kinoshita, K.2
Honjo, T.3
-
27
-
-
0023788886
-
Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis
-
Sen, D. & Gilbert, W. Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis. Nature 334, 364-366 (1988).
-
(1988)
Nature
, vol.334
, pp. 364-366
-
-
Sen, D.1
Gilbert, W.2
-
28
-
-
0033534467
-
G4 DNA binding by LR1 and its subunits, nucleolin and hnRNP D, a role for G-G pairing in immunoglobulin switch recombination
-
Dempsey, L. A., Sun, H., Hanakahi, L. A. & Maizels, N. G4 DNA binding by LR1 and its subunits, nucleolin and hnRNP D, a role for G-G pairing in immunoglobulin switch recombination. J. Biol. Chem. 274, 1066-1071 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 1066-1071
-
-
Dempsey, L.A.1
Sun, H.2
Hanakahi, L.A.3
Maizels, N.4
-
29
-
-
0028318228
-
Sequence specific thermodynamic and structural properties for DNA.RNA duplexes
-
Ratmeyer, L., Vinayak, R., Zhong, Y. Y., Zon, G. & Wilson, W. D. Sequence specific thermodynamic and structural properties for DNA.RNA duplexes. Biochemistry 33, 5298-5304 (1994).
-
(1994)
Biochemistry
, vol.33
, pp. 5298-5304
-
-
Ratmeyer, L.1
Vinayak, R.2
Zhong, Y.Y.3
Zon, G.4
Wilson, W.D.5
-
30
-
-
0032428658
-
Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions
-
Kinoshita, K., Tashiro, J., Tomita, S., Lee, C. G. & Honjo, T. Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions. Immunity 9, 849-858 (1998).
-
(1998)
Immunity
, vol.9
, pp. 849-858
-
-
Kinoshita, K.1
Tashiro, J.2
Tomita, S.3
Lee, C.G.4
Honjo, T.5
-
31
-
-
1842298136
-
Microsites for immunoglobulin switch recombination breakpoints from Xenopus to mammals
-
Mussmann, R., Courtet, M., Schwager, J. & Du Pasquier, L. Microsites for immunoglobulin switch recombination breakpoints from Xenopus to mammals. Eur. J. Immunol. 27, 2610-2619 (1997).
-
(1997)
Eur. J. Immunol.
, vol.27
, pp. 2610-2619
-
-
Mussmann, R.1
Courtet, M.2
Schwager, J.3
Du Pasquier, L.4
-
32
-
-
0038293484
-
Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
-
Ramiro, A. R., Stavropoulos, P., Jankovic, M. & Nussenzweig, M. C. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nature Immunol. 4, 452-456 (2003). Shows that AID targets the non-template strand of DNA when transcription is carried out in bacteria.
-
(2003)
Nature Immunol.
, vol.4
, pp. 452-456
-
-
Ramiro, A.R.1
Stavropoulos, P.2
Jankovic, M.3
Nussenzweig, M.C.4
-
33
-
-
0037901850
-
Human activation-induced cytidine deaminase causes transcription- dependent, strand-biased C to U deaminations
-
Sohail, A., Klapacz, J., Samaranayake, M., Ullah, A. & Bhagwat, A. S. Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations. Nucleic Acids Res. 31, 2990-2994 (2003).
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 2990-2994
-
-
Sohail, A.1
Klapacz, J.2
Samaranayake, M.3
Ullah, A.4
Bhagwat, A.S.5
-
34
-
-
0037926476
-
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
-
Pham, P., Bransteitter, R., Petruska, J. & Goodman, M. F. Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature 424, 103-107 (2003). Shows that AID preferably deaminates cytidine residues within SHM motifs in an ordered fashion.
-
(2003)
Nature
, vol.424
, pp. 103-107
-
-
Pham, P.1
Bransteitter, R.2
Petruska, J.3
Goodman, M.F.4
-
35
-
-
0033603340
-
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
-
Muramatsu, M. et al. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J. Biol. Chem. 274, 18470-18476 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 18470-18476
-
-
Muramatsu, M.1
-
36
-
-
0034268780
-
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
-
Muramatsu, M. et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102, 553-563 (2000).
-
(2000)
Cell
, vol.102
, pp. 553-563
-
-
Muramatsu, M.1
-
37
-
-
0034264851
-
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
-
Revy P. et al. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell 102, 565-575 (2000).
-
(2000)
Cell
, vol.102
, pp. 565-575
-
-
Revy, P.1
-
38
-
-
0037076967
-
AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts
-
Yoshikawa, K. et al. AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts. Science 296, 2033-2036 (2002).
-
(2002)
Science
, vol.296
, pp. 2033-2036
-
-
Yoshikawa, K.1
-
39
-
-
0037126038
-
Somatic hypermutation of the AID transgene in B and non-B cells
-
Martin, A. & Scharff, M. D. Somatic hypermutation of the AID transgene in B and non-B cells. Proc. Natl Acad. Sci. USA 99, 12304-12308 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 12304-12308
-
-
Martin, A.1
Scharff, M.D.2
-
40
-
-
0037149473
-
The AID enzyme induces class switch recombination in fibroblasts
-
Okazaki, I. M., Kinoshita, K., Muramatsu, M., Yoshikawa, K. & Honjo, T. The AID enzyme induces class switch recombination in fibroblasts. Nature 416, 340-345 (2002). References 38 to 40 provide evidence that AID is probably the only activated B-cell factor required for SHM and CSR.
-
(2002)
Nature
, vol.416
, pp. 340-345
-
-
Okazaki, I.M.1
Kinoshita, K.2
Muramatsu, M.3
Yoshikawa, K.4
Honjo, T.5
-
41
-
-
0037418279
-
De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination
-
Doi, T., Kinoshita, K., Ikegawa, M., Muramatsu, M. & Honjo, T. De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination. Proc. Natl Acad. Sci. USA 100, 2634-2638 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 2634-2638
-
-
Doi, T.1
Kinoshita, K.2
Ikegawa, M.3
Muramatsu, M.4
Honjo, T.5
-
42
-
-
0036863733
-
RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators
-
Harris, R. S., Petersen-Mahrt, S. K. & Neuberger, M. S. RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators. Mol. Cell 10, 1247-1253 (2002). Shows that other APOBEC1-family members have DNA-deamination activity, indicating that the RNA-editing enzyme APOBEC1 is probably an outlier in this family of proteins.
-
(2002)
Mol. Cell
, vol.10
, pp. 1247-1253
-
-
Harris, R.S.1
Petersen-Mahrt, S.K.2
Neuberger, M.S.3
-
43
-
-
0037019315
-
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
-
Petersen-Mahrt, S. K., Harris, R. S. & Neuberger, M. S. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 418, 99-103 (2002). The first paper to present the DNA-deamination model for CSR and SHM. In addition, it provides evidence that the target of AID is not RNA but DNA.
-
(2002)
Nature
, vol.418
, pp. 99-103
-
-
Petersen-Mahrt, S.K.1
Harris, R.S.2
Neuberger, M.S.3
-
44
-
-
0037388165
-
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
-
Bransteitter, R., Pham, P., Scharff, M. D. & Goodman, M. F. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc. Natl Acad. Sci. USA 100, 4102-4107 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 4102-4107
-
-
Bransteitter, R.1
Pham, P.2
Scharff, M.D.3
Goodman, M.F.4
-
45
-
-
0037561998
-
AID mediates hypermutation by deaminating single stranded DNA
-
Dickerson, S. K., Market, E., Besmer, E. & Papavasiliou, F. N. AID mediates hypermutation by deaminating single stranded DNA. J. Exp. Med. 197, 1291-1296 (2003).
-
(2003)
J. Exp. Med.
, vol.197
, pp. 1291-1296
-
-
Dickerson, S.K.1
Market, E.2
Besmer, E.3
Papavasiliou, F.N.4
-
46
-
-
0346362489
-
Transcription-coupled events associating with immunoglobulin switch region chromatin
-
Nambu, Y. et al. Transcription-coupled events associating with immunoglobulin switch region chromatin. Science 302, 2137-2140 (2003). Shows that AID binds to chromatin that is associated with transcribed S regions, thereby providing further evidence that AID acts directly on DNA.
-
(2003)
Science
, vol.302
, pp. 2137-2140
-
-
Nambu, Y.1
-
47
-
-
0031278299
-
Ig Sγ3 DNA-specific double strand breaks are induced in mitogen-activated B cells and are implicated in switch recombination
-
Wuerffel, R. A., Du, J., Thompson, R. J. & Kenter, A. L. Ig Sγ3 DNA-specific double strand breaks are induced in mitogen-activated B cells and are implicated in switch recombination. J. Immunol. 159, 4139-4144 (1997).
-
(1997)
J. Immunol.
, vol.159
, pp. 4139-4144
-
-
Wuerffel, R.A.1
Du, J.2
Thompson, R.J.3
Kenter, A.L.4
-
48
-
-
0042931069
-
The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch μ region
-
Catalan, N. et al. The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch μ region. J. Immunol. 171, 2504-2509 (2003).
-
(2003)
J. Immunol.
, vol.171
, pp. 2504-2509
-
-
Catalan, N.1
-
49
-
-
0032489520
-
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
-
Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S. & Bonner, W. M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273, 5858-5868 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5858-5868
-
-
Rogakou, E.P.1
Pilch, D.R.2
Orr, A.H.3
Ivanova, V.S.4
Bonner, W.M.5
-
50
-
-
0035818990
-
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
-
Petersen, S. et al. AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching. Nature 414, 660-665 (2001). Shows that H2AX has a role in CSR and that the role of AID in CSR is probably upstream of S-region breaks.
-
(2001)
Nature
, vol.414
, pp. 660-665
-
-
Petersen, S.1
-
51
-
-
0042991379
-
Histone H2AX: A dosage-dependent suppressor of oncogenic translocations and tumors
-
Bassing, C. H. et al. Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell 114, 359-370 (2003). Reports that haploinsufficiency of H2AX can lead to transclocations that involve S regions.
-
(2003)
Cell
, vol.114
, pp. 359-370
-
-
Bassing, C.H.1
-
52
-
-
2442707746
-
53BP1 links DNA damage response to immunoglobulin class switch recombination
-
Manis, J. P. et al. 53BP1 links DNA damage response to immunoglobulin class switch recombination. Nature Immunol. 5, 481-487 (2004). Describes the effect of 53BP1 mutation in CSR and SHM.
-
(2004)
Nature Immunol.
, vol.5
, pp. 481-487
-
-
Manis, J.P.1
-
53
-
-
0032522564
-
Ku80 is required for immunoglobulin isotype switching
-
Casellas, R. et al. Ku80 is required for immunoglobulin isotype switching. EMBO J. 17, 2404-2411 (1998).
-
(1998)
EMBO J.
, vol.17
, pp. 2404-2411
-
-
Casellas, R.1
-
54
-
-
0032526290
-
Ku70 is required for late B cell development and immunoglobulin heavy chain class switching
-
Manis, J. P. et al. Ku70 is required for late B cell development and immunoglobulin heavy chain class switching. J. Exp. Med. 187, 2081-2089 (1998).
-
(1998)
J. Exp. Med.
, vol.187
, pp. 2081-2089
-
-
Manis, J.P.1
-
55
-
-
0036224604
-
IgH class switch recombination to IgG1 in DNA-PKcs-deficient B Cells
-
Manis, J. P., Dudley, D., Kaylor, L. & Alt, F. W. IgH class switch recombination to IgG1 in DNA-PKcs-deficient B Cells. Immunity 16, 607-617 (2002). Together with references 93 and 94, this paper indicates that the role of DNA-PKcs in CSR might extend beyond the role it has in NHEJ.
-
(2002)
Immunity
, vol.16
, pp. 607-617
-
-
Manis, J.P.1
Dudley, D.2
Kaylor, L.3
Alt, F.W.4
-
56
-
-
0037029663
-
DNA double-strand breaks: Prior to but not sufficient in targeting hypermutation
-
Bross, L., Muramatsu, M., Kinoshita, K., Honjo, T. & Jacobs, H. DNA double-strand breaks: prior to but not sufficient in targeting hypermutation. J. Exp. Med. 195, 1187-1192 (2002).
-
(2002)
J. Exp. Med.
, vol.195
, pp. 1187-1192
-
-
Bross, L.1
Muramatsu, M.2
Kinoshita, K.3
Honjo, T.4
Jacobs, H.5
-
57
-
-
0030803748
-
V(D)J recombination in mature B cells: A mechanism for altering antibody responses
-
Papavasiliou, E et al. V(D)J recombination in mature B cells: a mechanism for altering antibody responses. Science 278, 298-301 (1997).
-
(1997)
Science
, vol.278
, pp. 298-301
-
-
Papavasiliou, E.1
-
58
-
-
0036732772
-
AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line
-
Faili, A. et al. AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line. Nature Immunol. 3, 815-821 (2002).
-
(2002)
Nature Immunol.
, vol.3
, pp. 815-821
-
-
Faili, A.1
-
59
-
-
0142188274
-
Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin
-
Woo, C. J., Martin, A. & Scharff, M. D. Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin. Immunity 19, 479-489 (2003).
-
(2003)
Immunity
, vol.19
, pp. 479-489
-
-
Woo, C.J.1
Martin, A.2
Scharff, M.D.3
-
60
-
-
0037108463
-
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
-
Rada, C. et al. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr. Biol. 12, 1748-1755 (2002).
-
(2002)
Curr. Biol.
, vol.12
, pp. 1748-1755
-
-
Rada, C.1
-
61
-
-
0142092610
-
Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination
-
Imai, K. et al. Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination. Nature Immunol. 4, 1023-1028 (2003). References 60 and 61 show that UNG has a crucial role in CSR and thereby provide evidence for a DNA-deamination step in CSR.
-
(2003)
Nature Immunol.
, vol.4
, pp. 1023-1028
-
-
Imai, K.1
-
62
-
-
0033081331
-
Severe attenuation of the B cell immune response in Msh2-deficient mice
-
Vora, K. A. et al. Severe attenuation of the B cell immune response in Msh2-deficient mice. J. Exp. Med. 189, 471-482 (1999).
-
(1999)
J. Exp. Med.
, vol.189
, pp. 471-482
-
-
Vora, K.A.1
-
63
-
-
0033564878
-
Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: Parallels with somatic hypermutation
-
Ehrenstein, M. R. & Neuberger, M. S. Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation. EMBO J. 18, 3484-3490 (1999).
-
(1999)
EMBO J.
, vol.18
, pp. 3484-3490
-
-
Ehrenstein, M.R.1
Neuberger, M.S.2
-
64
-
-
0033517129
-
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes
-
Schrader, C. E., Edelmann, W., Kucherlapati, R. & Stavnezer, J. Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes. J. Exp. Med. 190, 323-330 (1999).
-
(1999)
J. Exp. Med.
, vol.190
, pp. 323-330
-
-
Schrader, C.E.1
Edelmann, W.2
Kucherlapati, R.3
Stavnezer, J.4
-
65
-
-
0242268033
-
Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism
-
Yu, K. & Lieber, M. R. Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism. DNA Repair (Amst.) 2, 1163-1174 (2003).
-
(2003)
DNA Repair (Amst.)
, vol.2
, pp. 1163-1174
-
-
Yu, K.1
Lieber, M.R.2
-
66
-
-
1842865725
-
Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to Sμ in immunoglobulin class switch recombination
-
Rush, J. S., Fugmann, S. D. & Schatz, D. G. Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to Sμ in immunoglobulin class switch recombination. Int. Immunol. 16, 549-557 (2004).
-
(2004)
Int. Immunol.
, vol.16
, pp. 549-557
-
-
Rush, J.S.1
Fugmann, S.D.2
Schatz, D.G.3
-
67
-
-
1642499721
-
DNA Polymerase η is involved in hypermutation occurring during immunoglobulin class switch recombination
-
Faili, A. et al. DNA Polymerase η is involved in hypermutation occurring during immunoglobulin class switch recombination. J. Exp. Med. 199, 265-270 (2004).
-
(2004)
J. Exp. Med.
, vol.199
, pp. 265-270
-
-
Faili, A.1
-
68
-
-
0037017390
-
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions
-
Schrader, C. E., Vardo, J. & Stavnezer, J. Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions. J. Exp. Med. 195, 367-373 (2002).
-
(2002)
J. Exp. Med.
, vol.195
, pp. 367-373
-
-
Schrader, C.E.1
Vardo, J.2
Stavnezer, J.3
-
69
-
-
0142250490
-
The Sμ tandem repeat region is critical for Ig isotype switching in the absence of Msh2
-
Min, I. M. et al. The Sμ tandem repeat region is critical for Ig isotype switching in the absence of Msh2. Immunity 19, 515-524 (2003).
-
(2003)
Immunity
, vol.19
, pp. 515-524
-
-
Min, I.M.1
-
70
-
-
0038799991
-
Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
-
Paques, F. & Haber, J. E. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 63, 349-404 (1999).
-
(1999)
Microbiol. Mol. Biol. Rev.
, vol.63
, pp. 349-404
-
-
Paques, F.1
Haber, J.E.2
-
71
-
-
1542284083
-
Deficiency in nuclease activity of xeroderma pigmentosum G in mice leads to hypersensitivity to UV radiation
-
Tian, M., Jones, A. M., Smith, M., Shinkura, R. & Alt, F. W. Deficiency in nuclease activity of xeroderma pigmentosum G in mice leads to hypersensitivity to UV radiation. Mol. Cell. Biol. 24, 2237-2242 (2004).
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 2237-2242
-
-
Tian, M.1
Jones, A.M.2
Smith, M.3
Shinkura, R.4
Alt, F.W.5
-
72
-
-
1542309071
-
Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF
-
Tian, M., Shinkura, R., Shinkura, N. & Alt, F. W. Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF. Mol. Cell. Biol. 24, 1200-1205 (2004).
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 1200-1205
-
-
Tian, M.1
Shinkura, R.2
Shinkura, N.3
Alt, F.W.4
-
73
-
-
0030037519
-
B cell differentiation and isotype switching is related to division cycle number
-
Hodgkin, P. D., Lee, J. H. & Lyons, A. B. B cell differentiation and isotype switching is related to division cycle number. J. Exp. Med. 184, 277-281 (1996).
-
(1996)
J. Exp. Med.
, vol.184
, pp. 277-281
-
-
Hodgkin, P.D.1
Lee, J.H.2
Lyons, A.B.3
-
74
-
-
0035902585
-
Single-strand interruptions in replicating chromosomes cause double-strand breaks
-
Kuzminov, A. Single-strand interruptions in replicating chromosomes cause double-strand breaks. Proc. Natl Acad. Sci. USA 98, 8241-8246 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 8241-8246
-
-
Kuzminov, A.1
-
75
-
-
0037162518
-
Internal IgH class switch region deletions are position-independent and enhanced by AID expression
-
Dudley, D. D. et al. Internal IgH class switch region deletions are position-independent and enhanced by AID expression. Proc. Natl Acad. Sci. USA 99, 9984-9989 (2002). Shows that S-region internal deletions are AID dependent and provides evidence that synapsis between two S regions is not required for targeting AID.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 9984-9989
-
-
Dudley, D.D.1
-
76
-
-
0020038653
-
Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line
-
Alt, F. W., Rosenberg, N., Casanova, R. J., Thomas, E. & Baltimore, D. Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line. Nature 296, 325-331 (1982).
-
(1982)
Nature
, vol.296
, pp. 325-331
-
-
Alt, F.W.1
Rosenberg, N.2
Casanova, R.J.3
Thomas, E.4
Baltimore, D.5
-
77
-
-
0027280936
-
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
-
Gu, H., Zou, Y. R. & Rajewsky, K. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 73, 1155-1164 (1993).
-
(1993)
Cell
, vol.73
, pp. 1155-1164
-
-
Gu, H.1
Zou, Y.R.2
Rajewsky, K.3
-
78
-
-
0242473148
-
Mutations occur in the Ig Sμ region but rarely in Sγ regions prior to class switch recombination
-
Schrader, C. E. et al. Mutations occur in the Ig Sμ region but rarely in Sγ regions prior to class switch recombination. EMBO J. 22, 5893-5903 (2003).
-
(2003)
EMBO J.
, vol.22
, pp. 5893-5903
-
-
Schrader, C.E.1
-
79
-
-
0037866984
-
H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation
-
Reina-San-Martin, B. et al. H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. J. Exp. Med. 197, 1767-1778 (2003). Indicates that H2AX might have a role in the synapsis of two S regions during CSR.
-
(2003)
J. Exp. Med.
, vol.197
, pp. 1767-1778
-
-
Reina-San-Martin, B.1
-
80
-
-
2442706035
-
H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity
-
Bassing, C. H. & Alt, F. W. H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity. Cell Cycle 3, 149-153 (2004).
-
(2004)
Cell Cycle
, vol.3
, pp. 149-153
-
-
Bassing, C.H.1
Alt, F.W.2
-
81
-
-
0031466618
-
Ataxia-telangiectasia and the Nijmegen breakage syndrome: Related disorders but genes apart
-
Shiloh, Y. Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart. Annu. Rev. Genet. 31, 635-662 (1997).
-
(1997)
Annu. Rev. Genet.
, vol.31
, pp. 635-662
-
-
Shiloh, Y.1
-
82
-
-
0036105322
-
Alternative end joining during switch recombination in patients with ataxia-telangiectasia
-
Pan, Q. et al. Alternative end joining during switch recombination in patients with ataxia-telangiectasia. Eur. J. Immunol. 32, 1300-1308 (2002).
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 1300-1308
-
-
Pan, Q.1
-
83
-
-
0037377943
-
H, but is involved in the introduction of mutations in the switch μ region
-
H, but is involved in the introduction of mutations in the switch μ region. J. Immunol. 170, 3707-3716 (2003).
-
(2003)
J. Immunol.
, vol.170
, pp. 3707-3716
-
-
Pan-Hammarstrom, Q.1
-
84
-
-
0035834693
-
ATM phosphorylates histone H2AX in response to DNA double-strand breaks
-
Burma, S., Chen, B. P., Murphy, M., Kurimasa, A. & Chen, D. J. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J. Biol. Chem. 276, 42462-42467 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 42462-42467
-
-
Burma, S.1
Chen, B.P.2
Murphy, M.3
Kurimasa, A.4
Chen, D.J.5
-
85
-
-
1942538492
-
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
-
Stiff, T. et al. ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res. 64, 2390-2396 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 2390-2396
-
-
Stiff, T.1
-
86
-
-
0035930537
-
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
-
Ward, I. M. & Chen, J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J. Biol. Chem. 276, 47759-47762 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47759-47762
-
-
Ward, I.M.1
Chen, J.2
-
87
-
-
0029844048
-
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
-
Xu, Y. et al. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev. 10, 2411-2422 (1996).
-
(1996)
Genes Dev.
, vol.10
, pp. 2411-2422
-
-
Xu, Y.1
-
88
-
-
0037124373
-
Synapsis of DNA ends by DNA-dependent protein kinase
-
DeFazio, L. G., Stansel, R. M., Griffith, J. D. & Chu, G. Synapsis of DNA ends by DNA-dependent protein kinase. EMBO J. 21, 3192-3200 (2002).
-
(2002)
EMBO J.
, vol.21
, pp. 3192-3200
-
-
DeFazio, L.G.1
Stansel, R.M.2
Griffith, J.D.3
Chu, G.4
-
89
-
-
0035807955
-
Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination
-
Ehrenstein, M. R., Rada, C., Jones, A. M., Milstein, C. & Neuberger, M. S. Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination. Proc. Natl Acad. Sci. USA 98, 14553-14558 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 14553-14558
-
-
Ehrenstein, M.R.1
Rada, C.2
Jones, A.M.3
Milstein, C.4
Neuberger, M.S.5
-
90
-
-
0035965136
-
High affinity cooperative DNA binding by the yeast Mlh1-Pms1 heterodimer
-
Hall, M. C., Wang, H., Erie, D. A. & Kunkel, T. A. High affinity cooperative DNA binding by the yeast Mlh1-Pms1 heterodimer. J. Mol. Biol. 312, 637-647 (2001).
-
(2001)
J. Mol. Biol.
, vol.312
, pp. 637-647
-
-
Hall, M.C.1
Wang, H.2
Erie, D.A.3
Kunkel, T.A.4
-
91
-
-
0038190805
-
Mlh1 can function in antibody class switch recombination independently of Msh2
-
Schrader, C. E., Vardo, J. & Stavnezer, J. Mlh1 can function in antibody class switch recombination independently of Msh2. J. Exp. Med. 197, 1377-1383 (2003).
-
(2003)
J. Exp. Med.
, vol.197
, pp. 1377-1383
-
-
Schrader, C.E.1
Vardo, J.2
Stavnezer, J.3
-
92
-
-
0037226473
-
The mismatch repair system is required for S-phase checkpoint activation
-
Brown, K. D. et al. The mismatch repair system is required for S-phase checkpoint activation. Nature Genet. 33, 80-84 (2003).
-
(2003)
Nature Genet.
, vol.33
, pp. 80-84
-
-
Brown, K.D.1
-
93
-
-
0037011116
-
DNA-dependent protein kinase activity is not required for immunoglobulin class switching
-
Bosma, G. C. et al. DNA-dependent protein kinase activity is not required for immunoglobulin class switching. J. Exp. Med. 196, 1483-1495 (2002).
-
(2002)
J. Exp. Med.
, vol.196
, pp. 1483-1495
-
-
Bosma, G.C.1
-
94
-
-
0345735841
-
Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions
-
Cook, A. J. et al. Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions. J. Immunol. 171, 6556-6564 (2003).
-
(2003)
J. Immunol.
, vol.171
, pp. 6556-6564
-
-
Cook, A.J.1
-
95
-
-
0037155703
-
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
-
Ma, Y., Pannicke, U., Schwarz, K. & Ueber, M. R. Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell 108, 781-794 (2002).
-
(2002)
Cell
, vol.108
, pp. 781-794
-
-
Ma, Y.1
Pannicke, U.2
Schwarz, K.3
Ueber, M.R.4
-
96
-
-
0035853127
-
Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development
-
Sekiguchi, J. et al. Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development. Proc. Natl Acad. Sci. USA 98, 3243-3248 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 3243-3248
-
-
Sekiguchi, J.1
-
97
-
-
0041381361
-
AID mutant analyses indicate requirement for class-switch-specific cofactors
-
Ta, V. T. et al. AID mutant analyses indicate requirement for class-switch-specific cofactors. Nature Immunol. 4, 843-848 (2003).
-
(2003)
Nature Immunol.
, vol.4
, pp. 843-848
-
-
Ta, V.T.1
-
98
-
-
0141992113
-
C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion
-
Barreto, V., Reina-San-Martin, B., Ramiro, A. R., McBride, K. M. & Nussenzweig, M. C. C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. Mol. Cell 12, 501-508 (2003). References 97 and 98 provide evidence that the carboxyl terminus of AID could have specific roles in CSR that might be downstream of DNA deamination.
-
(2003)
Mol. Cell
, vol.12
, pp. 501-508
-
-
Barreto, V.1
Reina-San-Martin, B.2
Ramiro, A.R.3
McBride, K.M.4
Nussenzweig, M.C.5
-
99
-
-
0034694086
-
Somatic Hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) or recombination-activating gene (RAG) 1 activity
-
Bemark, M. et al. Somatic Hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) or recombination-activating gene (RAG) 1 activity. J. Exp. Med. 192, 1509-1514 (2000).
-
(2000)
J. Exp. Med.
, vol.192
, pp. 1509-1514
-
-
Bemark, M.1
-
100
-
-
85047693702
-
Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination
-
Imai, K. et al. Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination. J. Clin. Invest. 112, 136-142 (2003). Reports on a newly characterized human immunodeficiency, in which the defect in CSR is probably downstream of AID-mediated DNA deamination.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 136-142
-
-
Imai, K.1
-
101
-
-
0034678391
-
Evidence for class-specific factors in immunoglobulin isotype switching
-
Shanmugam, A., Shi, M. J., Yauch, L., Stavnezer, J. & Kenter, A. L. Evidence for class-specific factors in immunoglobulin isotype switching. J. Exp. Med. 191, 1365-1380 (2000).
-
(2000)
J. Exp. Med.
, vol.191
, pp. 1365-1380
-
-
Shanmugam, A.1
Shi, M.J.2
Yauch, L.3
Stavnezer, J.4
Kenter, A.L.5
-
102
-
-
0037087306
-
Two new isotype-specific switching activities detected for Ig class switching
-
Ma, L., Wortis, H. H. & Kenter, A. L. Two new isotype-specific switching activities detected for Ig class switching. J. Immunol. 168, 2835-2846 (2002).
-
(2002)
J. Immunol.
, vol.168
, pp. 2835-2846
-
-
Ma, L.1
Wortis, H.H.2
Kenter, A.L.3
-
103
-
-
1242341972
-
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1
-
Ito, S. et al. Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1. Proc. Natl Acad. Sci. USA 101, 1975-1980 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 1975-1980
-
-
Ito, S.1
-
104
-
-
0142250270
-
Msh2 ATPase activity is essential for somatic hypermutation at A-T basepairs and for efficient class switch recombination
-
Martin, A. et al. Msh2 ATPase activity is essential for somatic hypermutation at A-T basepairs and for efficient class switch recombination. J. Exp. Med. 198, 1171-1178 (2003).
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1171-1178
-
-
Martin, A.1
-
105
-
-
1142299546
-
Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice
-
Bardwell, P. D. et al. Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice. Nature Immunol. 5, 224-229 (2004).
-
(2004)
Nature Immunol.
, vol.5
, pp. 224-229
-
-
Bardwell, P.D.1
|