DNA helicases Sgs1 and BLM promote DNA double-strand break resection

Genes and Development

Volumn 22, Issue 20, 2008, Pages 2767-2772

  Gravel, Serge ^a   Chapman, J Ross ^a   Magill, Christine ^a   Jackson, Stephen P ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

ATR; DNA damage checkpoint; DNA repair; DNA resection; Exonuclease 1; RecQ helicases

Indexed keywords

BLOOM SYNDROME HELICASE; HELICASE; PROTEIN SGS 1; RECQ HELICASE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CONTROLLED STUDY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; EUKARYOTE; GENE DELETION; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; IONIZING RADIATION; ORTHOLOGY; PHENOTYPE; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

BLOOM SYNDROME; BONE NEOPLASMS; DNA BREAKS, DOUBLE-STRANDED; DNA HELICASES; DNA REPAIR; EXODEOXYRIBONUCLEASES; HUMANS; MICROSCOPY, FLUORESCENCE; MUTATION; OSTEOSARCOMA; PLASMIDS; RECOMBINATION, GENETIC; RECQ HELICASES; RNA, SMALL INTERFERING; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED;

MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 53649090109     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.503108     Document Type: Article

References (33)

1. Anantha, R.W., Vassin, V.M., and Borowiec, J.A. 2007. Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair. J. Biol. Chem. 282: 35910-35923.
2. Bachrati, C.Z. and Hickson, I.D. 2003. RecQ helicases: Suppressors of tumorigenesis and premature aging. Biochem. J. 374: 577-606.
3. Bermejo, R., Doksani, Y., Capra, T., Katou, Y.M., Tanaka, H., Shirahige, K., and Foiani, M. 2007. Top1- and Top2-mediated topological transitions at replication forks ensure fork progression and stability and prevent DNA damage checkpoint activation. Genes & Dev. 21: 1921-1936.
4. Clerici, M., Mantiero, D., Lucchini, G., and Longhese, M.P. 2006. The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling. EMBO Rep. 7: 212-218.
5. Cobb, J.A., Bjergbaek, L., and Gasser, S.M. 2002. RecQ helicases: At the heart of genetic stability. FEBS Lett. 529: 43-48.
6. Cotta-Ramusino, C., Fachinetti, D., Lucca, C., Doksani, Y., Lopes, M., Sogo, J., and Foiani, M. 2005. Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells. Mol. Cell 17: 153-159.
7. Ira, G., Pellicioli, A., Balijja, A., Wang, X., Fiorani, S., Carotenuto, W., Liberi, G., Bressan, D., Wan, L., Hollingsworth, N.M., et al. 2004. DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 431: 1011-1017.
8. Jazayeri, A., Falck, J., Lukas, C., Bartek, J., Smith, G.C., Lukas, J., and Jackson, S.P. 2006. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat. Cell Biol. 8: 37-45.
9. Kastan, M.B. and Bartek, J. 2004. Cell-cycle checkpoints and cancer. Nature 432: 316-323.
10. Khanna, K.K. and Jackson, S.P. 2001. DNA double-strand breaks: Signaling, repair and the cancer connection. Nat. Genet. 27: 247-254.
11. Lee, S.E., Moore, J.K., Holmes, A., Umezu, K., Kolodner, R.D., and Haber, J.E. 1998. Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage. Cell 94: 399-409.
12. Lisby, M. and Rothstein, R. 2004. DNA damage checkpoint and repair centers. Curr. Opin. Cell Biol. 16: 328-334.
13. Lohman, T.M., Tomko, E.J., and Wu, C.G. 2008. Non-hexameric DNA helicases and translocases: Mechanisms and regulation. Nat. Rev. Mol. Cell Biol. 9: 391-401.
14. Lu, J., Mullen, J.R., Brill, S.J., Kleff, S., Romeo, A.M., and Sternglanz, R. 1996. Human homologues of yeast helicase. Nature 383: 678-679.
15. Maringele, L. and Lydall, D. 2002. EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Δ mutants. Genes & Dev. 16: 1919-1933.
16. Moreau, S., Morgan, E.A., and Symington, L.S. 2001. Overlapping functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 nucleases in DNA metabolism. Genetics 159: 1423-1433.
17. Myung, K., Datta, A., Chen, C., and Kolodner, R.D. 2001. SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination. Nat. Genet. 27: 113-116.
18. Nakada, D., Hirano, Y., and Sugimoto, K. 2004. Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway. Mol. Cell. Biol. 24: 10016-10025.
19. Pommier, Y., Redon, C., Rao, V.A., Seiler, J.A., Sordet, O., Takemura, H., Antony, S., Meng, L., Liao, Z., Kohlhagen, G., et al. 2003. Repair of and checkpoint response to topoisomerase I-mediated DNA damage. Mutat. Res. 532: 173-203.
20. Rogakou, E.P., Boon, C., Redon, C., and Bonner, W.M. 1999. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J. Cell Biol. 146: 905-916.
21. Rouse, J. and Jackson, S.P. 2002. Interfaces between the detection, signaling, and repair of DNA damage. Science 297: 547-551.
22. San Filippo, J., Sung, P., and Klein, H. 2008. Mechanism of eukaryotic homologous recombination. Annu. Rev. Biochem. 77: 229-257.
23. Sartori, A.A., Lukas, C., Coates, J., Mistrik, M., Fu, S., Bartek, J., Baer, R., Lukas, J., and Jackson, S.P. 2007. Human CtIP promotes DNA end resection. Nature 450: 509-514.
24. Schaetzlein, S., Kodandaramireddy, N.R., Ju, Z., Lechel, A., Stepczynska, A., Lilli, D.R., Clark, A.B., Rudolph, C., Kuhnel, F., Wei, K., et al. 2007. Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice. Cell 130: 863-877.
25. Shao, R.G., Cao, C.X., Zhang, H., Kohn, K.W., Wold, M.S., and Pommier, Y. 1999. Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. EMBO J. 18: 1397-1406.
26. Singleton, M.R., Dillingham, M.S., and Wigley, D.B. 2007. Structure and mechanism of helicases and nucleic acid translocases. Annu. Rev. Biochem. 76: 23-50.
27. Smith, S., Gupta, A., Kolodner, R.D., and Myung, K. 2005. Suppression of gross chromosomal rearrangements by the multiple functions of the Mre11-Rad50-Xrs2 complex in Saccharomyces cerevisiae. DNA Repair (Amst.) 4: 606-617.
28. Tran, P.T., Erdeniz, N., Dudley, S., and Liskay, R.M. 2002. Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae. DNA Repair (Amst.) 1: 895-912.
29. Tran, P.T., Erdeniz, N., Symington, L.S., and Liskay, R.M. 2004. EXO1-A multi-tasking eukaryotic nuclease. DNA Repair (Amst.) 3: 1549-1559.
30. Wyman, C. and Kanaar, R. 2006. DNA double-strand break repair: All's well that ends well. Annu. Rev. Genet. 40: 363-383.
31. Yu, X. and Baer, R. 2000. Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. J. Biol. Chem. 275: 18541-18549.
32. Zhou, B.B. and Elledge, S.J. 2000. The DNA damage response: Putting checkpoints in perspective. Nature 408: 433-439.
33. Zou, L. and Elledge, S.J. 2003. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300: 1542-1548.