BRCA2 is required for homology-directed repair of chromosomal breaks

Molecular Cell

Volumn 7, Issue 2, 2001, Pages 263-272

  Moynahan, Mary Ellen ^a   Pierce, Andrew J ^a   Jasin, Maria ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; ENDONUCLEASE;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL LINE; CHROMOSOME BREAKAGE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; GENE LOCUS; GENE MUTATION; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; SEQUENCE HOMOLOGY;

ANIMALIA;

EID: 0035099044     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00174-5     Document Type: Article

References (68)

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3. Mice heterozygous for a Brca1 or Brca2 mutation display distinct mammary gland and ovarian phenotypes in response to diethylstilbestrol
4. Nuclear location and cell cycle regulation of the BRCA2 protein
5. The breast cancer-susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA crosslinking agent cisplatin
6. Xrcc3 is required for assembly of Rad51 complexes in vivo
7. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
8. The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment
9. Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control
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13. The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells
14. BRCA2 controls the RAD51 DNA repair protein
15. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation
16. Mouse RAD54 affects DNA double-strand break repair and sister chromatid exchange
17. Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination
18. Homologous and non-homologous recombination differentially affect DNA damage repair in mice
19. γ-rays-induced death of human cells carrying mutations of BRCA1 or BRCA2
20. Thymic lymphomas in mice with a truncating mutation in Brca2
21. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination
22. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development
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25. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse
26. DNA breakage and repair
27. Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells
28. Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination
29. The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts
30. Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2
31. Small-scale preparation of nuclear extracts from mammalian cells
32. Homology-directed repair is a major double-strand break repair pathway in mammalian cells
33. A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53
34. Inactivation of the mouse BRCA1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development
35. Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos
36. The BRCA2 gene product functionally interacts with p53 and RAD51
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38. Cells deleted for Brca2 COOH terminus exhibit hypersensitivity to γ-radiation and premature senescence
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40. Brca1 controls homology-directed repair
41. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
42. Involvement of Brca2 in DNA repair
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44. The genetics of breast cancer susceptibility
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47. Double-strand break repair by interchromosomal recombination: Suppression of chromosomal translocations
48. Association of BRCA1 with Rad51 in mitotic and meiotic cells
49. Murine Brca2: Sequence, map position, and expression pattern
50. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
51. A targeted disruption of the murine Brca1 gene causes γ-irradiation hypersensitivity and genetic instability
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53. Characterization of BRCA2: Temperature sensitivity of detection and cell-cycle regulated expression
54. Brca2 is required for embryonic cellular proliferation in the mouse
55. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
56. Antisense inhibition of the RAD51 enhances radiosensitivity
57. Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51 foci formation
58. S phase specific formation of the human Rad51 protein nuclear foci in lymphocytes
59. Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells
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61. Targeted disruption of the Rad51 gene leads to lethality in embryonic mice
62. Cell cycle control of BRCA2
63. Insights into the functions of BRCA1 and BRCA2
64. RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2
65. Cell cycle-dependent expression of the mouse Rad51 gene in proliferating cells
66. Nuclear localization signals of the BRCA2 protein
67. Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation
68. BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo