Repair of double-strand breaks by homologous recombination in mismatch repair-defective mammalian cells

Molecular and Cellular Biology

Volumn 21, Issue 8, 2001, Pages 2671-2682

  Elliott, B ^a   Jasin, M ^a  

^a Weill Cornell Graduate School of Biomedical Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE;

ANIMAL CELL; ARTICLE; BASE MISPAIRING; CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; EMBRYO; GENE CONVERSION; GENE TARGETING; GENETIC RECOMBINATION; MAMMAL CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL;

ANIMALS; BASE PAIR MISMATCH; BASE SEQUENCE; CELL LINE; CHROMOSOMES; DNA DAMAGE; DNA PRIMERS; DNA REPAIR; DNA-BINDING PROTEINS; GENE CONVERSION; GENE TARGETING; MICE; MODELS, GENETIC; MUTS HOMOLOG 2 PROTEIN; PROTO-ONCOGENE PROTEINS; RECOMBINATION, GENETIC;

ANIMALIA; MAMMALIA; MURINAE;

EID: 0035081417     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.8.2671-2682.2001     Document Type: Article

References (59)

1. Genetic analysis of mouse embryonic stem cells bearing Msh3 and Msh2 single and compound mutations
2. hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6
3. One-sided invasion events in homologous recombination at double-strand breaks
4. Genomic instability in colorectal carcinomas: Comparison of different evaluation methods and their biological significance
5. Hereditary nonpolyposis colorectal cancer
6. Mammalian DNA mismatch repair
7. Mismatch repair proteins regulate heteroduplex formation during mitotic recombination in yeast
8. The role of the mismatch repair machinery in regulating mitotic and meiotic recombination between diverged sequences in yeast
9. The nature and mechanisms of human gene mutation
10. Mitotic crossovers between diverged sequences are regulated by mismatch repair proteins in Saccharomyces cerevisiae
11. Dual roles for DNA sequence identity, and the mismatch repair system in the regulation of mitotic crossing-over in yeast
12. Molecular mechanism of nucleotide excision repair
13. Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer
14. HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions
15. Analysis of gene targeting and intrachromosomal homologous recombination stimulated by genomic double-strand breaks in mouse embryonic stem cells
16. Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells
17. Gene conversion tracts from double-strand break repair in mammalian cells
18. Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53
19. Recombinational repair of gaps in DNA is asymmetric in Ustilago maydis and can be explained by a migrating D-loop model
20. Causes and consequences of microsatellite instability in endometrial carcinoma
21. DNA repair. Gatekeepers of recombination
22. Rapid kinetics of mismatch repair of heteroduplex DNA that is formed during recombination in yeast
23. The hallmarks of cancer
24. Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells
25. Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stability
26. Molecular analysis of the pac gene encoding a puromycin N-acetyl transferase from Streptomyces alboniger
27. Genetic instabilities in human cancers
28. Genetic instability in colorectal cancers
29. Gene targeting by linear duplex DNA frequently occurs by assimilation of a single strand that is subject to preferential mismatch correction
30. Use of a small palindrome genetic marker to investigate mechanisms of double-strand-break repair in mammalian cells
31. The mechanism of mammalian gene replacement is consistent with the formation of long regions of heteroduplex DNA associated with two crossing-over events
32. Homologydirected repair is a major double-strand break repair pathway in mammalian cells
33. Chromosomal double-strand break repair in Ku80-deficient cells
34. Mutator phenotype may be required for multistage carcinogenesis
35. Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair
36. Coconversion of flanking sequences with homothallic switching
37. Mismatch repair in replication fidelity, genetic recombination, and cancer biology
38. Efficient copying of nonhomologous sequences from ectopic sites via P-elementinduced gap repair
39. Influence of DNA sequence identity on efficiency of targeted gene replacement
40. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
41. Two pathways for removal of nonhomologous DNA ends during double-strand break repair in Saccharomyces cerevisiae
42. Recombination in yeast
43. Control of large chromosomal duplications in Escherichia coli by the mismatch repair system
44. Heteroduplex formation and mismatch repair of the "stuck" mutation during mating-type switching in Saccharomyces cerevisiae
45. The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants
46. Double-strand break repair by interchromosomal recombination: Suppression of chromosomal translocations
47. Embryo-derived stem cell lines
48. Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease
49. Requirement of mismatch repair genes MSH2 and MSH3 in the RAD1-RAD10 pathway of mitotic recombination in Saccharomyces cerevisiae
50. Repair of sitespecific double-strand breaks in a mammalian chromosome by homologous and illegitimate recombination
51. Alu: Structure, origin, evolution, significance and function of one-tenth of human DNA
52. Mismatch correction acts as a barrier to homeologous recombination in Saccharomyces cerevisiae
53. Double-strand breaks at the target locus stimulate gene targeting in embryonic stem cells
54. The partial tandem duplication of ALL1 (MLL) is consistently generated by Alu-mediated homologous recombination in acute myeloid leukemia
55. Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination
56. Chromosomal double-strand breaks induce gene conversion at high frequency in mammalian cells
57. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
58. Evidence for independent mismatch repair processing on opposite sides of a double-strand break in Saccharomyces cerevisiae
59. Mismatch repair proteins MutS and MutL inhibit RecA-catalyzed strand transfer between diverged DNAs