Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template

Nucleic Acids Research

Volumn 39, Issue 3, 2011, Pages 926-935

  Metzger, Michael J ^a,b   McConnell Smith, Audrey ^a,b   Stoddard, Barry L ^a   Miller, A Dusty ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; ENDONUCLEASE; LENTIVIRUS VECTOR; PARVOVIRUS VECTOR; PLASMID VECTOR; SINGLE STRANDED DNA;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; EMBRYO; GENE MUTATION; GENE TARGETING; GENETIC ENGINEERING; GENETIC TRANSFECTION; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SINGLE STRANDED DNA BREAK;

CELL LINE; DEPENDOVIRUS; DNA BREAKS, DOUBLE-STRANDED; ENDODEOXYRIBONUCLEASES; GENETIC VECTORS; HUMANS; MUTATION; RECOMBINATION, GENETIC; TEMPLATES, GENETIC;

ADENO-ASSOCIATED VIRUS;

EID: 79951565665     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkq826     Document Type: Article

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