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Volumn 9, Issue 1, 2016, Pages

Targeting cell survival proteins for cancer cell death

Author keywords

Apoptosis; Bcl 2 family; Chemotherapeutics; Nutraceuticals; Survival proteins; Surviving

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; ALVESPIMYCIN; ANTISENSE OLIGONUCLEOTIDE; BH3 PROTEIN; CELL PROTEIN; CELL SURVIVAL PROTEIN; CHELERYTHRINE; CURCUMIN; GAMBOGIC ACID; GANETESPIB; GELDANAMYCIN; GOSSYPOL; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 90 INHIBITOR; INHIBITOR OF APOPTOSIS PROTEIN; NAVITOCLAX; NOVOBIOCIN; NUTRACEUTICAL; OBATOCLAX; OBLIMERSEN; POLYPHENON E; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; RESORCINOL; ROSMARINIC ACID; TANESPIMYCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VENETOCLAX; X LINKED INHIBITOR OF APOPTOSIS;

EID: 84959375244     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph9010011     Document Type: Review
Times cited : (36)

References (223)
  • 1
    • 0021821903 scopus 로고
    • Involvement of the bcl-2 gene in human follicular lymphoma
    • [CrossRef] [PubMed]
    • Tsujimoto, Y.; Cossman, J.; Jaffe, E.; Croce, C.M. Involvement of the bcl-2 gene in human follicular lymphoma. Science 1985, 228, 1440-1443. [CrossRef] [PubMed]
    • (1985) Science , vol.228 , pp. 1440-1443
    • Tsujimoto, Y.1    Cossman, J.2    Jaffe, E.3    Croce, C.M.4
  • 2
    • 22144460556 scopus 로고    scopus 로고
    • Apoptosis-based therapies for hematologic malignancies
    • [CrossRef] [PubMed]
    • Reed, J.C.; Pellecchia, M. Apoptosis-based therapies for hematologic malignancies. Blood 2005, 106, 408-418. [CrossRef] [PubMed]
    • (2005) Blood , vol.106 , pp. 408-418
    • Reed, J.C.1    Pellecchia, M.2
  • 3
    • 16444375702 scopus 로고    scopus 로고
    • Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia
    • [CrossRef] [PubMed]
    • Packham, G.; Stevenson, F.K. Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia. Immunology 2005, 114, 441-449. [CrossRef] [PubMed]
    • (2005) Immunology , vol.114 , pp. 441-449
    • Packham, G.1    Stevenson, F.K.2
  • 4
    • 63149129655 scopus 로고    scopus 로고
    • Bcl-2 inhibitors: Targeting mitochondrial apoptotic pathways in cancer therapy
    • [CrossRef] [PubMed]
    • Kang, M.H.; Reynolds, C.P. Bcl-2 inhibitors: Targeting mitochondrial apoptotic pathways in cancer therapy. Clin. Cancer Res. 2009, 15, 1126-1132. [CrossRef] [PubMed]
    • (2009) Clin. Cancer Res , vol.15 , pp. 1126-1132
    • Kang, M.H.1    Reynolds, C.P.2
  • 5
    • 0036463649 scopus 로고    scopus 로고
    • Apoptosis-based therapies
    • CrossRef] [PubMed]
    • Reed, J.C. Apoptosis-based therapies. Nat. Rev. Drug Discov. 2002, 1, 111-121. CrossRef] [PubMed]
    • (2002) Nat. Rev. Drug Discov , vol.1 , pp. 111-121
    • Reed, J.C.1
  • 7
    • 43549112759 scopus 로고    scopus 로고
    • Bcl-2-family proteins and hematologic malignancies: History and future prospects
    • [CrossRef] [PubMed]
    • Reed, J.C. Bcl-2-family proteins and hematologic malignancies: History and future prospects. Blood 2008, 111, 3322-3330. [CrossRef] [PubMed]
    • (2008) Blood , vol.111 , pp. 3322-3330
    • Reed, J.C.1
  • 8
    • 0028865264 scopus 로고
    • Prognostic value of bcl-2 oncoprotein expression in stage II colon carcinoma
    • [PubMed]
    • Sinicrope, F.A.; Hart, J.; Michelassi, F.; Lee, J.J. Prognostic value of bcl-2 oncoprotein expression in stage II colon carcinoma. Clin. Cancer Res. 1995, 1, 1103-1110. [PubMed]
    • (1995) Clin. Cancer Res , vol.1 , pp. 1103-1110
    • Sinicrope, F.A.1    Hart, J.2    Michelassi, F.3    Lee, J.J.4
  • 9
    • 0028857747 scopus 로고
    • Expression of bcl-2 oncogene protein is prevalent in small cell lung carcinomas
    • [CrossRef] [PubMed]
    • Jiang, S.X.; Sato, Y.; Kuwao, S.; Kameya, T. Expression of bcl-2 oncogene protein is prevalent in small cell lung carcinomas. J. Pathol. 1995, 177, 135-138. [CrossRef] [PubMed]
    • (1995) J. Pathol , vol.177 , pp. 135-138
    • Jiang, S.X.1    Sato, Y.2    Kuwao, S.3    Kameya, T.4
  • 10
    • 0027093255 scopus 로고
    • Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer
    • [PubMed]
    • McDonnell, T.J.; Troncoso, P.; Brisbay, S.M.; Logothetis, C.; Chung, L.W.; Hsieh, J.T.; Tu, S.M.; Campbell, M.L. Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer. Cancer Res. 1992, 52, 6940-6944. [PubMed]
    • (1992) Cancer Res , vol.52 , pp. 6940-6944
    • McDonnell, T.J.1    Troncoso, P.2    Brisbay, S.M.3    Logothetis, C.4    Chung, L.W.5    Hsieh, J.T.6    Tu, S.M.7    Campbell, M.L.8
  • 11
    • 0027944957 scopus 로고
    • Bcl-2 protein expression and long-term survival in breast cancer
    • [PubMed]
    • Joensuu, H.; Pylkkanen, L.; Toikkanen, S. Bcl-2 protein expression and long-term survival in breast cancer. Am. J. Pathol. 1994, 145, 1191-1198. [PubMed]
    • (1994) Am. J. Pathol , vol.145 , pp. 1191-1198
    • Joensuu, H.1    Pylkkanen, L.2    Toikkanen, S.3
  • 12
    • 0027164144 scopus 로고
    • High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy
    • [PubMed]
    • Campos, L.; Rouault, J.P.; Sabido, O.; Oriol, P.; Roubi, N.; Vasselon, C.; Archimbaud, E.; Magaud, J.P.; Guyotat, D. High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy. Blood 1993, 81, 3091-3096. [PubMed]
    • (1993) Blood , vol.81 , pp. 3091-3096
    • Campos, L.1    Rouault, J.P.2    Sabido, O.3    Oriol, P.4    Roubi, N.5    Vasselon, C.6    Archimbaud, E.7    Magaud, J.P.8    Guyotat, D.9
  • 13
    • 0030029443 scopus 로고    scopus 로고
    • Prognostic significance of bcl-2 protein expression in aggressive non-hodgkin’s lymphoma. Groupe d’etude des lymphomes de l’adulte (gela)
    • [PubMed]
    • Hermine, O.; Haioun, C.; Lepage, E.; d’Agay, M.F.; Briere, J.; Lavignac, C.; Fillet, G.; Salles, G.; Marolleau, J.P.; Diebold, J.; et al. Prognostic significance of bcl-2 protein expression in aggressive non-hodgkin’s lymphoma. Groupe d’etude des lymphomes de l’adulte (gela). Blood 1996, 87, 265-272. [PubMed]
    • (1996) Blood , vol.87 , pp. 265-272
    • Hermine, O.1    Haioun, C.2    Lepage, E.3    D’Agay, M.F.4    Briere, J.5    Lavignac, C.6    Fillet, G.7    Salles, G.8    Marolleau, J.P.9    Diebold, J.10
  • 14
    • 0029748608 scopus 로고    scopus 로고
    • Bcl-2 expression in malignant melanoma and its prognostic significance
    • [CrossRef]
    • Grover, R.; Wilson, G.D. Bcl-2 expression in malignant melanoma and its prognostic significance. Eur. J. Surg. Oncol. 1996, 22, 347-349. [CrossRef]
    • (1996) Eur. J. Surg. Oncol , vol.22 , pp. 347-349
    • Grover, R.1    Wilson, G.D.2
  • 15
    • 0029010631 scopus 로고
    • Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation
    • [CrossRef] [PubMed]
    • Weller, M.; Malipiero, U.; Aguzzi, A.; Reed, J.C.; Fontana, A. Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation. J. Clin. Investig. 1995, 95, 2633-2643. [CrossRef] [PubMed]
    • (1995) J. Clin. Investig , vol.95 , pp. 2633-2643
    • Weller, M.1    Malipiero, U.2    Aguzzi, A.3    Reed, J.C.4    Fontana, A.5
  • 17
    • 84861220123 scopus 로고    scopus 로고
    • Downregulation of bcl2 by mirnas augments drug-induced apoptosis—a combined computational and experimental approach
    • [CrossRef] [PubMed]
    • Singh, R.; Saini, N. Downregulation of bcl2 by mirnas augments drug-induced apoptosis—a combined computational and experimental approach. J. Cell Sci. 2012, 125, 1568-1578. [CrossRef] [PubMed]
    • (2012) J. Cell Sci. , vol.125 , pp. 1568-1578
    • Singh, R.1    Saini, N.2
  • 19
    • 0027239823 scopus 로고
    • Bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia
    • [PubMed]
    • Hanada, M.; Delia, D.; Aiello, A.; Stadtmauer, E.; Reed, J.C. Bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood 1993, 82, 1820-1828. [PubMed]
    • (1993) Blood , vol.82 , pp. 1820-1828
    • Hanada, M.1    Delia, D.2    Aiello, A.3    Stadtmauer, E.4    Reed, J.C.5
  • 20
    • 0026627872 scopus 로고
    • Myc rearrangements in histologically progressed follicular lymphomas
    • [PubMed]
    • Yano, T.; Jaffe, E.S.; Longo, D.L.; Raffeld, M. Myc rearrangements in histologically progressed follicular lymphomas. Blood 1992, 80, 758-767. [PubMed]
    • (1992) Blood , vol.80 , pp. 758-767
    • Yano, T.1    Jaffe, E.S.2    Longo, D.L.3    Raffeld, M.4
  • 21
    • 0025251664 scopus 로고
    • Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
    • [CrossRef] [PubMed]
    • Strasser, A.; Harris, A.W.; Bath, M.L.; Cory, S. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 1990, 348, 331-333. [CrossRef] [PubMed]
    • (1990) Nature , vol.348 , pp. 331-333
    • Strasser, A.1    Harris, A.W.2    Bath, M.L.3    Cory, S.4
  • 22
    • 0029739901 scopus 로고    scopus 로고
    • Progenitor tumours from Emu-bcl-2-myc transgenic mice have lymphomyeloid differentiation potential and reveal developmental differences in cell survival
    • [PubMed]
    • Strasser, A.; Elefanty, A.G.; Harris, A.W.; Cory, S. Progenitor tumours from Emu-bcl-2-myc transgenic mice have lymphomyeloid differentiation potential and reveal developmental differences in cell survival. EMBO J. 1996, 15, 3823-3834. [PubMed]
    • (1996) EMBO J , vol.15 , pp. 3823-3834
    • Strasser, A.1    Elefanty, A.G.2    Harris, A.W.3    Cory, S.4
  • 23
    • 0030669560 scopus 로고    scopus 로고
    • Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice
    • [CrossRef] [PubMed]
    • Jager, R.; Herzer, U.; Schenkel, J.; Weiher, H. Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice. Oncogene 1997, 15, 1787-1795. [CrossRef] [PubMed]
    • (1997) Oncogene , vol.15 , pp. 1787-1795
    • Jager, R.1    Herzer, U.2    Schenkel, J.3    Weiher, H.4
  • 24
    • 0029833679 scopus 로고    scopus 로고
    • The rise and fall of apoptosis during multistage tumorigenesis: Down-modulation contributes to tumor progression from angiogenic progenitors
    • [CrossRef] [PubMed]
    • Naik, P.; Karrim, J.; Hanahan, D. The rise and fall of apoptosis during multistage tumorigenesis: Down-modulation contributes to tumor progression from angiogenic progenitors. Genes Dev. 1996, 10, 2105-2116. [CrossRef] [PubMed]
    • (1996) Genes Dev , vol.10 , pp. 2105-2116
    • Naik, P.1    Karrim, J.2    Hanahan, D.3
  • 26
    • 0031920608 scopus 로고    scopus 로고
    • Expression of bcl-2 and bcl-x in bladder cancer
    • [CrossRef]
    • Kirsh, E.J.; Baunoch, D.A.; Stadler, W.M. Expression of bcl-2 and bcl-x in bladder cancer. J. Urol. 1998, 159, 1348-1353. [CrossRef]
    • (1998) J. Urol , vol.159 , pp. 1348-1353
    • Kirsh, E.J.1    Baunoch, D.A.2    Stadler, W.M.3
  • 27
    • 33748754286 scopus 로고    scopus 로고
    • Bcl-xl is overexpressed in hormone-resistant prostate cancer and promotes survival of lncap cells via interaction with proapoptotic bak
    • [CrossRef] [PubMed]
    • Castilla, C.; Congregado, B.; Chinchon, D.; Torrubia, F.J.; Japon, M.A.; Saez, C. Bcl-xl is overexpressed in hormone-resistant prostate cancer and promotes survival of lncap cells via interaction with proapoptotic bak. Endocrinology 2006, 147, 4960-4967. [CrossRef] [PubMed]
    • (2006) Endocrinology , vol.147 , pp. 4960-4967
    • Castilla, C.1    Congregado, B.2    Chinchon, D.3    Torrubia, F.J.4    Japon, M.A.5    Saez, C.6
  • 28
    • 0027480450 scopus 로고
    • Mcl1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to bcl2
    • [CrossRef] [PubMed]
    • Kozopas, K.M.; Yang, T.; Buchan, H.L.; Zhou, P.; Craig, R.W. Mcl1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to bcl2. Proc. Natl. Acad. Sci. USA 1993, 90, 3516-3520. [CrossRef] [PubMed]
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 3516-3520
    • Kozopas, K.M.1    Yang, T.2    Buchan, H.L.3    Zhou, P.4    Craig, R.W.5
  • 29
    • 45849104776 scopus 로고    scopus 로고
    • Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with mcl-1
    • [CrossRef] [PubMed]
    • Day, C.L.; Smits, C.; Fan, F.C.; Lee, E.F.; Fairlie, W.D.; Hinds, M.G. Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with mcl-1. J. Mol. Biol. 2008, 380, 958-971. [CrossRef] [PubMed]
    • (2008) J. Mol. Biol. , vol.380 , pp. 958-971
    • Day, C.L.1    Smits, C.2    Fan, F.C.3    Lee, E.F.4    Fairlie, W.D.5    Hinds, M.G.6
  • 30
    • 0033954132 scopus 로고    scopus 로고
    • Mcl-1 deficiency results in peri-implantation embryonic lethality
    • [PubMed]
    • Rinkenberger, J.L.; Horning, S.; Klocke, B.; Roth, K.; Korsmeyer, S.J. Mcl-1 deficiency results in peri-implantation embryonic lethality. Genes Dev. 2000, 14, 23-27. [PubMed]
    • (2000) Genes Dev , vol.14 , pp. 23-27
    • Rinkenberger, J.L.1    Horning, S.2    Klocke, B.3    Roth, K.4    Korsmeyer, S.J.5
  • 31
    • 13844319184 scopus 로고    scopus 로고
    • Obligate role of anti-apoptotic mcl-1 in the survival of hematopoietic stem cells
    • [CrossRef] [PubMed]
    • Opferman, J.T.; Iwasaki, H.; Ong, C.C.; Suh, H.; Mizuno, S.; Akashi, K.; Korsmeyer, S.J. Obligate role of anti-apoptotic mcl-1 in the survival of hematopoietic stem cells. Science 2005, 307, 1101-1104. [CrossRef] [PubMed]
    • (2005) Science , vol.307 , pp. 1101-1104
    • Opferman, J.T.1    Iwasaki, H.2    Ong, C.C.3    Suh, H.4    Mizuno, S.5    Akashi, K.6    Korsmeyer, S.J.7
  • 32
    • 0348148880 scopus 로고    scopus 로고
    • Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
    • [CrossRef] [PubMed]
    • Opferman, J.T.; Letai, A.; Beard, C.; Sorcinelli, M.D.; Ong, C.C.; Korsmeyer, S.J. Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature 2003, 426, 671-676. [CrossRef] [PubMed]
    • (2003) Nature , vol.426 , pp. 671-676
    • Opferman, J.T.1    Letai, A.2    Beard, C.3    Sorcinelli, M.D.4    Ong, C.C.5    Korsmeyer, S.J.6
  • 34
    • 84871623647 scopus 로고    scopus 로고
    • Delving deeper: Mcl-1’s contributions to normal and cancer biology
    • [CrossRef] [PubMed]
    • Perciavalle, R.M.; Opferman, J.T. Delving deeper: Mcl-1’s contributions to normal and cancer biology. Trends Cell Biol. 2013, 23, 22-29. [CrossRef] [PubMed]
    • (2013) Trends Cell Biol , vol.23 , pp. 22-29
    • Perciavalle, R.M.1    Opferman, J.T.2
  • 37
    • 0035855625 scopus 로고    scopus 로고
    • The anti-apoptotic role of interleukin-6 in human cervical cancer is mediated by up-regulation of mcl-1 through a pi 3-k/akt pathway
    • [CrossRef] [PubMed]
    • Wei, L.H.; Kuo, M.L.; Chen, C.A.; Chou, C.H.; Cheng, W.F.; Chang, M.C.; Su, J.L.; Hsieh, C.Y. The anti-apoptotic role of interleukin-6 in human cervical cancer is mediated by up-regulation of mcl-1 through a pi 3-k/akt pathway. Oncogene 2001, 20, 5799-5809. [CrossRef] [PubMed]
    • (2001) Oncogene , vol.20 , pp. 5799-5809
    • Wei, L.H.1    Kuo, M.L.2    Chen, C.A.3    Chou, C.H.4    Cheng, W.F.5    Chang, M.C.6    Su, J.L.7    Hsieh, C.Y.8
  • 38
    • 0036313642 scopus 로고    scopus 로고
    • Increased mcl-1 expression is associated with poor prognosis in ovarian carcinomas
    • [CrossRef] [PubMed]
    • Shigemasa, K.; Katoh, O.; Shiroyama, Y.; Mihara, S.; Mukai, K.; Nagai, N.; Ohama, K. Increased mcl-1 expression is associated with poor prognosis in ovarian carcinomas. Jpn. J. Cancer Res. 2002, 93, 542-550. [CrossRef] [PubMed]
    • (2002) Jpn. J. Cancer Res , vol.93 , pp. 542-550
    • Shigemasa, K.1    Katoh, O.2    Shiroyama, Y.3    Mihara, S.4    Mukai, K.5    Nagai, N.6    Ohama, K.7
  • 40
    • 21244472965 scopus 로고    scopus 로고
    • Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of mcl-1 and regulates apoptosis
    • [CrossRef] [PubMed]
    • Zhong, Q.; Gao, W.; Du, F.; Wang, X. Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of mcl-1 and regulates apoptosis. Cell 2005, 121, 1085-1095. [CrossRef] [PubMed]
    • (2005) Cell , vol.121 , pp. 1085-1095
    • Zhong, Q.1    Gao, W.2    Du, F.3    Wang, X.4
  • 42
    • 79952261405 scopus 로고    scopus 로고
    • SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
    • [CrossRef] [PubMed]
    • Inuzuka, H.; Shaik, S.; Onoyama, I.; Gao, D.; Tseng, A.; Maser, R.S.; Zhai, B.; Wan, L.; Gutierrez, A.; Lau, A.W.; et al. SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature 2011, 471, 104-109. [CrossRef] [PubMed]
    • (2011) Nature , vol.471 , pp. 104-109
    • Inuzuka, H.1    Shaik, S.2    Onoyama, I.3    Gao, D.4    Tseng, A.5    Maser, R.S.6    Zhai, B.7    Wan, L.8    Gutierrez, A.9    Lau, A.W.10
  • 43
    • 0031018674 scopus 로고    scopus 로고
    • Somatic frameshift mutations in the bax gene in colon cancers of the microsatellite mutator phenotype
    • [CrossRef] [PubMed]
    • Rampino, N.; Yamamoto, H.; Ionov, Y.; Li, Y.; Sawai, H.; Reed, J.C.; Perucho, M. Somatic frameshift mutations in the bax gene in colon cancers of the microsatellite mutator phenotype. Science 1997, 275, 967-969. [CrossRef] [PubMed]
    • (1997) Science , vol.275 , pp. 967-969
    • Rampino, N.1    Yamamoto, H.2    Ionov, Y.3    Li, Y.4    Sawai, H.5    Reed, J.C.6    Perucho, M.7
  • 44
    • 0028880633 scopus 로고
    • New type of t(14;18) in a non-Hodgkin’s lymphoma provides insight in molecular events in early B-cell differentiation
    • [CrossRef] [PubMed]
    • Meijerink, J.P.; Raemaekers, J.M.; Mensink, E.J. New type of t(14;18) in a non-Hodgkin’s lymphoma provides insight in molecular events in early B-cell differentiation. Br. J. Haematol. 1995, 91, 630-639. [CrossRef] [PubMed]
    • (1995) Br. J. Haematol , vol.91 , pp. 630-639
    • Meijerink, J.P.1    Raemaekers, J.M.2    Mensink, E.J.3
  • 46
    • 0035265686 scopus 로고    scopus 로고
    • Puma, a novel proapoptotic gene, is induced by p53. Mol
    • [CrossRef]
    • Nakano, K.; Vousden, K.H. Puma, a novel proapoptotic gene, is induced by p53. Mol. Cell 2001, 7, 683-694.[CrossRef]
    • (2001) Cell , vol.7 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 47
    • 84856495152 scopus 로고    scopus 로고
    • Proteins for therapeutic intervention in cancer. Nat
    • [CrossRef] [PubMed]
    • Fulda, S.; Vucic, D. Targeting IAP proteins for therapeutic intervention in cancer. Nat. Rev. Drug Discov. 2012, 11, 109-124. [CrossRef] [PubMed]
    • (2012) Rev. Drug Discov , vol.11 , pp. 109-124
    • Fulda, S.1    Vucic, D.2    Targeting, I.3
  • 48
    • 0028274132 scopus 로고
    • An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with cys/his sequence motifs
    • [PubMed]
    • Birnbaum, M.J.; Clem, R.J.; Miller, L.K. An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with cys/his sequence motifs. J. Virol. 1994, 68, 2521-2528. [PubMed]
    • (1994) J. Virol , vol.68 , pp. 2521-2528
    • Birnbaum, M.J.1    Clem, R.J.2    Miller, L.K.3
  • 49
    • 0027537461 scopus 로고
    • An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif
    • [PubMed]
    • Crook, N.E.; Clem, R.J.; Miller, L.K. An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif. J. Virol. 1993, 67, 2168-2174. [PubMed]
    • (1993) J. Virol , vol.67 , pp. 2168-2174
    • Crook, N.E.1    Clem, R.J.2    Miller, L.K.3
  • 50
    • 0036088471 scopus 로고    scopus 로고
    • IAP proteins: Blocking the road to death’s door
    • [CrossRef] [PubMed]
    • Salvesen, G.S.; Duckett, C.S. IAP proteins: Blocking the road to death’s door. Nat. Rev. Mol. Cell Biol. 2002, 3, 401-410. [CrossRef] [PubMed]
    • (2002) Nat. Rev. Mol. Cell Biol , vol.3 , pp. 401-410
    • Salvesen, G.S.1    Duckett, C.S.2
  • 51
    • 0036178047 scopus 로고    scopus 로고
    • IAP suppression of apoptosis involves distinct mechanisms: The TAK1/JNK1 signaling cascade and caspase inhibition
    • [CrossRef] [PubMed]
    • Sanna, M.G.; da Silva Correia, J.; Ducrey, O.; Lee, J.; Nomoto, K.; Schrantz, N.; Deveraux, Q.L.; Ulevitch, R.J. IAP suppression of apoptosis involves distinct mechanisms: The TAK1/JNK1 signaling cascade and caspase inhibition. Mol. Cell. Biol. 2002, 22, 1754-1766. [CrossRef] [PubMed]
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 1754-1766
    • Sanna, M.G.1    Da Silva Correia, J.2    Ducrey, O.3    Lee, J.4    Nomoto, K.5    Schrantz, N.6    Deveraux, Q.L.7    Ulevitch, R.J.8
  • 52
    • 0034698053 scopus 로고    scopus 로고
    • Activation of NF-κb by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1
    • [CrossRef] [PubMed]
    • Hofer-Warbinek, R.; Schmid, J.A.; Stehlik, C.; Binder, B.R.; Lipp, J.; de Martin, R. Activation of NF-κb by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1. J. Biol. Chem. 2000, 275, 22064-22068. [CrossRef] [PubMed]
    • (2000) J. Biol. Chem , vol.275 , pp. 22064-22068
    • Hofer-Warbinek, R.1    Schmid, J.A.2    Stehlik, C.3    Binder, B.R.4    Lipp, J.5    De Martin, R.6
  • 53
    • 0035895597 scopus 로고    scopus 로고
    • XIAP induces cell-cycle arrest and activates nuclear factor-κb: New survival pathways disabled by caspase-mediated cleavage during apoptosis of human endothelial cells
    • [CrossRef] [PubMed]
    • Levkau, B.; Garton, K.J.; Ferri, N.; Kloke, K.; Nofer, J.R.; Baba, H.A.; Raines, E.W.; Breithardt, G. XIAP induces cell-cycle arrest and activates nuclear factor-κb: New survival pathways disabled by caspase-mediated cleavage during apoptosis of human endothelial cells. Circ. Res. 2001, 88, 282-290. [CrossRef] [PubMed]
    • (2001) Circ. Res , vol.88 , pp. 282-290
    • Levkau, B.1    Garton, K.J.2    Ferri, N.3    Kloke, K.4    Nofer, J.R.5    Baba, H.A.6    Raines, E.W.7    Breithardt, G.8
  • 54
    • 45849120966 scopus 로고    scopus 로고
    • (Un)expected roles of c-IAPs in apoptotic and nfkappab signaling pathways
    • [CrossRef] [PubMed]
    • Varfolomeev, E.; Vucic, D. (Un)expected roles of c-IAPs in apoptotic and nfkappab signaling pathways. Cell Cycle 2008, 7, 1511-1521. [CrossRef] [PubMed]
    • (2008) Cell Cycle , vol.7 , pp. 1511-1521
    • Varfolomeev, E.1    Vucic, D.2
  • 55
    • 17144377113 scopus 로고    scopus 로고
    • Iaps, rings and ubiquitylation
    • [CrossRef] [PubMed]
    • Vaux, D.L.; Silke, J. Iaps, rings and ubiquitylation. Nat. Rev. Mol. Cell. Biol. 2005, 6, 287-297. [CrossRef] [PubMed]
    • (2005) Nat. Rev. Mol. Cell. Biol , vol.6 , pp. 287-297
    • Vaux, D.L.1    Silke, J.2
  • 56
    • 5644259587 scopus 로고    scopus 로고
    • Inhibitor of apoptosis proteins: Translating basic knowledge into clinical practice
    • [CrossRef] [PubMed]
    • Schimmer, A.D. Inhibitor of apoptosis proteins: Translating basic knowledge into clinical practice. Cancer Res. 2004, 64, 7183-7190. [CrossRef] [PubMed]
    • (2004) Cancer Res , vol.64 , pp. 7183-7190
    • Schimmer, A.D.1
  • 58
    • 0033215040 scopus 로고    scopus 로고
    • Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases
    • [CrossRef] [PubMed]
    • Deveraux, Q.L.; Leo, E.; Stennicke, H.R.; Welsh, K.; Salvesen, G.S.; Reed, J.C. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J. 1999, 18, 5242-5251. [CrossRef] [PubMed]
    • (1999) EMBO J , vol.18 , pp. 5242-5251
    • Deveraux, Q.L.1    Leo, E.2    Stennicke, H.R.3    Welsh, K.4    Salvesen, G.S.5    Reed, J.C.6
  • 60
    • 0034597630 scopus 로고    scopus 로고
    • Ml-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas
    • [CrossRef]
    • Vucic, D.; Stennicke, H.R.; Pisabarro, M.T.; Salvesen, G.S.; Dixit, V.M. Ml-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas. Curr. Biol. 2000, 10, 1359-1366. [CrossRef]
    • (2000) Curr. Biol , vol.10 , pp. 1359-1366
    • Vucic, D.1    Stennicke, H.R.2    Pisabarro, M.T.3    Salvesen, G.S.4    Dixit, V.M.5
  • 62
  • 64
    • 0033980409 scopus 로고    scopus 로고
    • Expression of survivin and its relationship to loss of apoptosis in breast carcinomas
    • [PubMed]
    • Tanaka, K.; Iwamoto, S.; Gon, G.; Nohara, T.; Iwamoto, M.; Tanigawa, N. Expression of survivin and its relationship to loss of apoptosis in breast carcinomas. Clin. Cancer Res. 2000, 6, 127-134. [PubMed]
    • (2000) Clin. Cancer Res. , vol.6 , pp. 127-134
    • Tanaka, K.1    Iwamoto, S.2    Gon, G.3    Nohara, T.4    Iwamoto, M.5    Tanigawa, N.6
  • 65
    • 0035126561 scopus 로고    scopus 로고
    • Expression of survivin in normal, hyperplastic, and neoplastic colonic mucosa. Hum
    • [CrossRef] [PubMed]
    • Gianani, R.; Jarboe, E.; Orlicky, D.; Frost, M.; Bobak, J.; Lehner, R.; Shroyer, K.R. Expression of survivin in normal, hyperplastic, and neoplastic colonic mucosa. Hum. Pathol. 2001, 32, 119-125. [CrossRef] [PubMed]
    • (2001) Pathol , vol.32 , pp. 119-125
    • Gianani, R.1    Jarboe, E.2    Orlicky, D.3    Frost, M.4    Bobak, J.5    Lehner, R.6    Shroyer, K.R.7
  • 66
    • 0034021068 scopus 로고    scopus 로고
    • Expression of the antiapoptosis gene, survivin, predicts death from recurrent colorectal carcinoma
    • [CrossRef] [PubMed]
    • Sarela, A.I.; Macadam, R.C.; Farmery, S.M.; Markham, A.F.; Guillou, P.J. Expression of the antiapoptosis gene, survivin, predicts death from recurrent colorectal carcinoma. Gut 2000, 46, 645-650. [CrossRef] [PubMed]
    • (2000) Gut , vol.46 , pp. 645-650
    • Sarela, A.I.1    Macadam, R.C.2    Farmery, S.M.3    Markham, A.F.4    Guillou, P.J.5
  • 68
    • 0030746636 scopus 로고    scopus 로고
    • A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
    • [CrossRef] [PubMed]
    • Ambrosini, G.; Adida, C.; Altieri, D.C. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat. Med. 1997, 3, 917-921. [CrossRef] [PubMed]
    • (1997) Nat. Med , vol.3 , pp. 917-921
    • Ambrosini, G.1    Adida, C.2    Altieri, D.C.3
  • 69
    • 34447507818 scopus 로고    scopus 로고
    • Inhibitors of the heat shock response: Biology and pharmacology
    • [CrossRef] [PubMed]
    • Powers, M.V.; Workman, P. Inhibitors of the heat shock response: Biology and pharmacology. FEBS Lett. 2007, 581, 3758-3769. [CrossRef] [PubMed]
    • (2007) FEBS Lett. , vol.581 , pp. 3758-3769
    • Powers, M.V.1    Workman, P.2
  • 70
    • 5044239107 scopus 로고    scopus 로고
    • Pathways of chaperone-mediated protein folding in the cytosol
    • [PubMed]
    • Young, J.C.; Agashe, V.R.; Siegers, K.; Hartl, F.U. Pathways of chaperone-mediated protein folding in the cytosol. Nat. Rev. Mol. Cell Biol. 2004, 5, 781-791. [CrossRef] [PubMed]
    • (2004) Nat. Rev. Mol. Cell Biol , vol.5 , pp. 781-791
    • Young, J.C.1    Agashe, V.R.2    Siegers, K.3    Hartl, F.U.4
  • 71
    • 84865794941 scopus 로고    scopus 로고
    • Molecular pathways: Targeting hsp90-who benefits and who does not
    • [CrossRef] [PubMed]
    • Scaltriti, M.; Dawood, S.; Cortes, J. Molecular pathways: Targeting hsp90-who benefits and who does not. Clin. Cancer Res. 2012, 18, 4508-4513. [CrossRef] [PubMed]
    • (2012) Clin. Cancer Res , vol.18 , pp. 4508-4513
    • Scaltriti, M.1    Dawood, S.2    Cortes, J.3
  • 72
    • 58849160500 scopus 로고    scopus 로고
    • Heat shock protein 90 as a drug target: Some like it hot
    • [CrossRef] [PubMed]
    • Banerji U. Heat shock protein 90 as a drug target: Some like it hot. Clin. Cancer Res. 2009, 15, 9-14. [CrossRef] [PubMed]
    • (2009) Clin. Cancer Res , vol.15 , pp. 9-14
    • Banerji, U.1
  • 73
    • 25844519550 scopus 로고    scopus 로고
    • Hsp90 and the chaperoning of cancer
    • [CrossRef] [PubMed]
    • Whitesell, L.; Lindquist, S.L. Hsp90 and the chaperoning of cancer. Nat. Rev. Cancer 2005, 5, 761-772.[CrossRef] [PubMed]
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 761-772
    • Whitesell, L.1    Lindquist, S.L.2
  • 74
    • 34248195608 scopus 로고    scopus 로고
    • High hsp90 expression is associated with decreased survival in breast cancer
    • [CrossRef] [PubMed]
    • Pick, E.; Kluger, Y.; Giltnane, J.M.; Moeder, C.; Camp, R.L.; Rimm, D.L.; Kluger, H.M. High hsp90 expression is associated with decreased survival in breast cancer. Cancer Res. 2007, 67, 2932-2937. [CrossRef] [PubMed]
    • (2007) Cancer Res , vol.67 , pp. 2932-2937
    • Pick, E.1    Kluger, Y.2    Giltnane, J.M.3    Moeder, C.4    Camp, R.L.5    Rimm, D.L.6    Kluger, H.M.7
  • 75
    • 0029775839 scopus 로고    scopus 로고
    • Do heat shock proteins have a role in breast cancer
    • [CrossRef] [PubMed]
    • Conroy, S.E.; Latchman, D.S. Do heat shock proteins have a role in breast cancer? Br. J. Cancer 1996, 74, 717-721. [CrossRef] [PubMed]
    • (1996) Br. J. Cancer , vol.74 , pp. 717-721
    • Conroy, S.E.1    Latchman, D.S.2
  • 76
    • 77953916528 scopus 로고    scopus 로고
    • Hsp90 at the hub of protein homeostasis: Emerging mechanistic insights
    • [CrossRef] [PubMed]
    • Taipale, M.; Jarosz, D.F.; Lindquist, S. Hsp90 at the hub of protein homeostasis: Emerging mechanistic insights. Nat. Rev. Mol. Cell Biol. 2010, 11, 515-528. [CrossRef] [PubMed]
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 515-528
    • Taipale, M.1    Jarosz, D.F.2    Lindquist, S.3
  • 78
    • 84855457952 scopus 로고    scopus 로고
    • Hsp90 molecular chaperone inhibitors: Are we there yet? Clin
    • [CrossRef] [PubMed]
    • Neckers, L.; Workman, P. Hsp90 molecular chaperone inhibitors: Are we there yet? Clin. Cancer Res. 2012, 18, 64-76. [CrossRef] [PubMed]
    • (2012) Cancer Res , vol.18 , pp. 64-76
    • Neckers, L.1    Workman, P.2
  • 80
    • 22244464818 scopus 로고    scopus 로고
    • Proapoptotic bak is sequestered by mcl-1 and bcl-xl, but not bcl-2, until displaced by BH3-only proteins
    • [CrossRef] [PubMed]
    • Willis, S.N.; Chen, L.; Dewson, G.; Wei, A.; Naik, E.; Fletcher, J.I.; Adams, J.M.; Huang, D.C. Proapoptotic bak is sequestered by mcl-1 and bcl-xl, but not bcl-2, until displaced by BH3-only proteins. Genes Dev. 2005, 19, 1294-1305. [CrossRef] [PubMed]
    • (2005) Genes Dev , vol.19 , pp. 1294-1305
    • Willis, S.N.1    Chen, L.2    Dewson, G.3    Wei, A.4    Naik, E.5    Fletcher, J.I.6    Adams, J.M.7    Huang, D.C.8
  • 81
    • 52949131927 scopus 로고    scopus 로고
    • A short nur77-derived peptide converts bcl-2 from a protector to a killer
    • [CrossRef] [PubMed]
    • Kolluri, S.K.; Zhu, X.; Zhou, X.; Lin, B.; Chen, Y.; Sun, K.; Tian, X.; Town, J.; Cao, X.; Lin, F.; et al. A short nur77-derived peptide converts bcl-2 from a protector to a killer. Cancer Cell 2008, 14, 285-298. [CrossRef] [PubMed]
    • (2008) Cancer Cell , vol.14 , pp. 285-298
    • Kolluri, S.K.1    Zhu, X.2    Zhou, X.3    Lin, B.4    Chen, Y.5    Sun, K.6    Tian, X.7    Town, J.8    Cao, X.9    Lin, F.10
  • 84
    • 0035059838 scopus 로고    scopus 로고
    • Targeting tumor cell resistance to apoptosis induction with antisense oligonucleotides
    • [CrossRef] [PubMed]
    • Olie, R.A.; Zangemeister-Wittke, U. Targeting tumor cell resistance to apoptosis induction with antisense oligonucleotides: Progress and therapeutic potential. Drug Resist. Updates 2001, 4, 9-15. [CrossRef] [PubMed]
    • (2001) Progress and Therapeutic Potential. Drug Resist. Updates , vol.4 , pp. 9-15
    • Olie, R.A.1    Zangemeister-Wittke, U.2
  • 85
    • 70449723145 scopus 로고    scopus 로고
    • 5-year survival in patients with relapsed or refractory chronic lymphocytic leukemia in a randomized, phase III trial of fludarabine plus cyclophosphamide with or without oblimersen
    • [CrossRef] [PubMed]
    • O’Brien, S.; Moore, J.O.; Boyd, T.E.; Larratt, L.M.; Skotnicki, A.B.; Koziner, B.; Chanan-Khan, A.A.; Seymour, J.F.; Gribben, J.; Itri, L.M.; et al. 5-year survival in patients with relapsed or refractory chronic lymphocytic leukemia in a randomized, phase III trial of fludarabine plus cyclophosphamide with or without oblimersen. J. Clin. Oncol. 2009, 27, 5208-5212. [CrossRef] [PubMed]
    • (2009) J. Clin. Oncol. , vol.27 , pp. 5208-5212
    • O’Brien, S.1    Moore, J.O.2    Boyd, T.E.3    Larratt, L.M.4    Skotnicki, A.B.5    Koziner, B.6    Chanan-Khan, A.A.7    Seymour, J.F.8    Gribben, J.9    Itri, L.M.10
  • 86
    • 33750600634 scopus 로고    scopus 로고
    • Bcl-2 antisense (Oblimersen sodium) plus dacarbazine in patients with advanced melanoma: The oblimersen melanoma study group
    • [CrossRef] [PubMed]
    • Bedikian, A.Y.; Millward, M.; Pehamberger, H.; Conry, R.; Gore, M.; Trefzer, U.; Pavlick, A.C.; DeConti, R.; Hersh, E.M.; Hersey, P.; et al. Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: The oblimersen melanoma study group. J. Clin. Oncol. 2006, 24, 4738-4745. [CrossRef] [PubMed]
    • (2006) J. Clin. Oncol. , vol.24 , pp. 4738-4745
    • Bedikian, A.Y.1    Millward, M.2    Pehamberger, H.3    Conry, R.4    Gore, M.5    Trefzer, U.6    Pavlick, A.C.7    Deconti, R.8    Hersh, E.M.9    Hersey, P.10
  • 89
    • 1642430704 scopus 로고    scopus 로고
    • Antisense oligonucleotide-based therapeutics for cancer
    • [CrossRef] [PubMed]
    • Dean, N.M.; Bennett, C.F. Antisense oligonucleotide-based therapeutics for cancer. Oncogene 2003, 22, 9087-9096. [CrossRef] [PubMed]
    • (2003) Oncogene , vol.22 , pp. 9087-9096
    • Dean, N.M.1    Bennett, C.F.2
  • 90
    • 84858957737 scopus 로고    scopus 로고
    • Discovery of marinopyrrole A (Maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation
    • [CrossRef]
    • Doi, K.; Li, R.; Sung, S.S.; Wu, H.; Liu, Y.; Manieri, W.; Krishnegowda, G.; Awwad, A.; Dewey, A.; Liu, X.; et al. Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation. J. Biol. Chem. 2012, 287, 10224-10235. [CrossRef]
    • (2012) J. Biol. Chem. , vol.287 , pp. 10224-10235
    • Doi, K.1    Li, R.2    Sung, S.S.3    Wu, H.4    Liu, Y.5    Manieri, W.6    Krishnegowda, G.7    Awwad, A.8    Dewey, A.9    Liu, X.10
  • 91
    • 84892615179 scopus 로고    scopus 로고
    • Proteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cells
    • [CrossRef]
    • Pandey, M.K.; Gowda, K.; Doi, K.; Sharma, A.K.; Wang, H.G.; Amin, S. Proteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cells. PLoS ONE 2013, 8. [CrossRef]
    • (2013) Plos ONE , pp. 8
    • Pandey, M.K.1    Gowda, K.2    Doi, K.3    Sharma, A.K.4    Wang, H.G.5    Amin, S.6
  • 93
    • 0141569444 scopus 로고    scopus 로고
    • Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins
    • [CrossRef] [PubMed]
    • Kitada, S.; Leone, M.; Sareth, S.; Zhai, D.; Reed, J.C.; Pellecchia, M. Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J. Med. Chem. 2003, 46, 4259-4264. [CrossRef] [PubMed]
    • (2003) J. Med. Chem , vol.46 , pp. 4259-4264
    • Kitada, S.1    Leone, M.2    Sareth, S.3    Zhai, D.4    Reed, J.C.5    Pellecchia, M.6
  • 95
    • 77957954881 scopus 로고    scopus 로고
    • The bcl-xl inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib
    • [CrossRef] [PubMed]
    • Hikita, H.; Takehara, T.; Shimizu, S.; Kodama, T.; Shigekawa, M.; Iwase, K.; Hosui, A.; Miyagi, T.; Tatsumi, T.; Ishida, H.; et al. The bcl-xl inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib. Hepatology 2010, 52, 1310-1321. [CrossRef] [PubMed]
    • (2010) Hepatology , vol.52 , pp. 1310-1321
    • Hikita, H.1    Takehara, T.2    Shimizu, S.3    Kodama, T.4    Shigekawa, M.5    Iwase, K.6    Hosui, A.7    Miyagi, T.8    Tatsumi, T.9    Ishida, H.10
  • 98
    • 84863116430 scopus 로고    scopus 로고
    • Substantial susceptibility of chronic lymphocytic leukemia to bcl2 inhibition: Results of a phase I study of navitoclax in patients with relapsed or refractory disease
    • [CrossRef] [PubMed]
    • Roberts, A.W.; Seymour, J.F.; Brown, J.R.; Wierda, W.G.; Kipps, T.J.; Khaw, S.L.; Carney, D.A.; He, S.Z.; Huang, D.C.; Xiong, H.; et al. Substantial susceptibility of chronic lymphocytic leukemia to bcl2 inhibition: Results of a phase I study of navitoclax in patients with relapsed or refractory disease. J. Clin. Oncol. 2012, 30, 488-496. [CrossRef] [PubMed]
    • (2012) J. Clin. Oncol. , vol.30 , pp. 488-496
    • Roberts, A.W.1    Seymour, J.F.2    Brown, J.R.3    Wierda, W.G.4    Kipps, T.J.5    Khaw, S.L.6    Carney, D.A.7    He, S.Z.8    Huang, D.C.9    Xiong, H.10
  • 99
    • 78649630259 scopus 로고    scopus 로고
    • Navitoclax, a targeted high-affinity inhibitor of bcl-2, in lymphoid malignancies: A phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity
    • [CrossRef]
    • Wilson, W.H.; O’Connor, O.A.; Czuczman, M.S.; LaCasce, A.S.; Gerecitano, J.F.; Leonard, J.P.; Tulpule, A.; Dunleavy, K.; Xiong, H.; Chiu, Y.L.; et al. Navitoclax, a targeted high-affinity inhibitor of bcl-2, in lymphoid malignancies: A phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity. Lancet Oncol. 2010, 11, 1149-1159. [CrossRef]
    • (2010) Lancet Oncol , vol.11 , pp. 1149-1159
    • Wilson, W.H.1    O’Connor, O.A.2    Czuczman, M.S.3    Lacasce, A.S.4    Gerecitano, J.F.5    Leonard, J.P.6    Tulpule, A.7    Dunleavy, K.8    Xiong, H.9    Chiu, Y.L.10
  • 100
    • 84884520490 scopus 로고    scopus 로고
    • BH3 mimetics: Status of the field and new developments
    • [CrossRef] [PubMed]
    • Billard, C. BH3 mimetics: Status of the field and new developments. Mol. Cancer Ther. 2013, 12, 1691-1700. [CrossRef] [PubMed]
    • (2013) Mol. Cancer Ther , vol.12 , pp. 1691-1700
    • Billard, C.1
  • 101
    • 77951442337 scopus 로고    scopus 로고
    • Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1
    • [CrossRef] [PubMed]
    • Yecies, D.; Carlson, N.E.; Deng, J.; Letai, A. Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1. Blood 2010, 115, 3304-3313. [CrossRef] [PubMed]
    • (2010) Blood , vol.115 , pp. 3304-3313
    • Yecies, D.1    Carlson, N.E.2    Deng, J.3    Letai, A.4
  • 102
    • 33750834023 scopus 로고    scopus 로고
    • The BH3 mimetic ABT-737 targets selective bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if mcl-1 is neutralized
    • [CrossRef]
    • Van Delft, M.F.; Wei, A.H.; Mason, K.D.; Vandenberg, C.J.; Chen, L.; Czabotar, P.E.; Willis, S.N.; Scott, C.L.; Day, C.L.; Cory, S.; et al. The BH3 mimetic ABT-737 targets selective bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if mcl-1 is neutralized. Cancer Cell 2006, 10, 389-399. [CrossRef]
    • (2006) Cancer Cell , vol.10 , pp. 389-399
    • Van Delft, M.F.1    Wei, A.H.2    Mason, K.D.3    Vandenberg, C.J.4    Chen, L.5    Czabotar, P.E.6    Willis, S.N.7    Scott, C.L.8    Day, C.L.9    Cory, S.10
  • 104
    • 77950231711 scopus 로고    scopus 로고
    • A Bax-mediated mechanism for obatoclax-induced apoptosis of cholangiocarcinoma cells
    • [CrossRef] [PubMed]
    • Smoot, R.L.; Blechacz, B.R.; Werneburg, N.W.; Bronk, S.F.; Sinicrope, F.A.; Sirica, A.E.; Gores, G.J. A Bax-mediated mechanism for obatoclax-induced apoptosis of cholangiocarcinoma cells. Cancer Res. 2010, 70, 1960-1969. [CrossRef] [PubMed]
    • (2010) Cancer Res , vol.70 , pp. 1960-1969
    • Smoot, R.L.1    Blechacz, B.R.2    Werneburg, N.W.3    Bronk, S.F.4    Sinicrope, F.A.5    Sirica, A.E.6    Gores, G.J.7
  • 106
    • 77952525706 scopus 로고    scopus 로고
    • The BH3-mimetic GX15-070 induces autophagy, potentiates the cytotoxicity of carboplatin and 5-fluorouracil in esophageal carcinoma cells
    • [CrossRef]
    • Pan, J.; Cheng, C.; Verstovsek, S.; Chen, Q.; Jin, Y.; Cao, Q. The BH3-mimetic GX15-070 induces autophagy, potentiates the cytotoxicity of carboplatin and 5-fluorouracil in esophageal carcinoma cells. Cancer Lett. 2010, 293, 167-174. [CrossRef]
    • (2010) Cancer Lett , vol.293 , pp. 167-174
    • Pan, J.1    Cheng, C.2    Verstovsek, S.3    Chen, Q.4    Jin, Y.5    Cao, Q.6
  • 107
    • 84856813420 scopus 로고    scopus 로고
    • Obatoclax mesylate: Pharmacology and potential for therapy of hematological neoplasms
    • [CrossRef] [PubMed
    • Joudeh, J.; Claxton, D. Obatoclax mesylate: Pharmacology and potential for therapy of hematological neoplasms. Expert Opin. Investig. Drugs 2012, 21, 363-373. [CrossRef] [PubMed]
    • (2012) Expert Opin. Investig. Drugs , vol.21 , pp. 363-373
    • Joudeh, J.1    Claxton, D.2
  • 108
    • 77955102504 scopus 로고    scopus 로고
    • Dose finding studies of obatoclax (GX15-070), a small molecule pan-bcl-2 family antagonist, in patients with advanced solid tumors or lymphoma
    • [CrossRef] [PubMed]
    • Hwang, J.J.; Kuruvilla, J.; Mendelson, D.; Pishvaian, M.J.; Deeken, J.F.; Siu, L.L.; Berger, M.S.; Viallet, J.; Marshall, J.L. Phase I dose finding studies of obatoclax (GX15-070), a small molecule pan-bcl-2 family antagonist, in patients with advanced solid tumors or lymphoma. Clin. Cancer Res. 2010, 16, 4038-4045. [CrossRef] [PubMed]
    • (2010) Clin. Cancer Res , vol.16 , pp. 4038-4045
    • Hwang, J.J.1    Kuruvilla, J.2    Mendelson, D.3    Pishvaian, M.J.4    Deeken, J.F.5    Siu, L.L.6    Berger, M.S.7    Viallet, J.8    Marshall, J.L.9    Phase, I.10
  • 109
    • 39749179651 scopus 로고    scopus 로고
    • The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp
    • [CrossRef] [PubMed]
    • Hughes, C.C.; Prieto-Davo, A.; Jensen, P.R.; Fenical, W. The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp. Org. Lett. 2008, 10, 629-631. [CrossRef] [PubMed]
    • (2008) Org. Lett , vol.10 , pp. 629-631
    • Hughes, C.C.1    Prieto-Davo, A.2    Jensen, P.R.3    Fenical, W.4
  • 110
    • 84905439095 scopus 로고    scopus 로고
    • Maritoclax induces apoptosis in acute myeloid leukemia cells with elevated mcl-1 expression
    • [CrossRef] [PubMed]
    • Doi, K.; Liu, Q.; Gowda, K.; Barth, B.M.; Claxton, D.; Amin, S.; Loughran, T.P., Jr.; Wang, H.G. Maritoclax induces apoptosis in acute myeloid leukemia cells with elevated mcl-1 expression. Cancer Biol. Ther. 2014, 15. [CrossRef] [PubMed]
    • (2014) Cancer Biol. Ther , pp. 15
    • Doi, K.1    Liu, Q.2    Gowda, K.3    Barth, B.M.4    Claxton, D.5    Amin, S.6    Loughran, T.P.7    Wang, H.G.8
  • 111
    • 78649503621 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins
    • [CrossRef] [PubMed]
    • Wei, J.; Kitada, S.; Stebbins, J.L.; Placzek, W.; Zhai, D.; Wu, B.; Rega, M.F.; Zhang, Z.; Cellitti, J.; Yang, L.; et al. Synthesis and biological evaluation of apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (bcl-2) family proteins. J. Med. Chem. 2010, 53, 8000-8011. [CrossRef] [PubMed]
    • (2010) J. Med. Chem. , vol.53 , pp. 8000-8011
    • Wei, J.1    Kitada, S.2    Stebbins, J.L.3    Placzek, W.4    Zhai, D.5    Wu, B.6    Rega, M.F.7    Zhang, Z.8    Cellitti, J.9    Yang, L.10
  • 114
    • 34247529341 scopus 로고    scopus 로고
    • Preclinical studies of TW-37, a new nonpeptidic small-molecule inhibitor of bcl-2, in diffuse large cell lymphoma xenograft model reveal drug action on both bcl-2 and mcl-1
    • [CrossRef] [PubMed]
    • Mohammad, R.M.; Goustin, A.S.; Aboukameel, A.; Chen, B.; Banerjee, S.; Wang, G.; Nikolovska-Coleska, Z.; Wang, S.; Al-Katib, A. Preclinical studies of TW-37, a new nonpeptidic small-molecule inhibitor of bcl-2, in diffuse large cell lymphoma xenograft model reveal drug action on both bcl-2 and mcl-1. Clin. Cancer Res. 2007, 13, 2226-2235. [CrossRef] [PubMed]
    • (2007) Clin. Cancer Res , vol.13 , pp. 2226-2235
    • Mohammad, R.M.1    Goustin, A.S.2    Aboukameel, A.3    Chen, B.4    Banerjee, S.5    Wang, G.6    Nikolovska-Coleska, Z.7    Wang, S.8    Al-Katib, A.9
  • 116
    • 68249160072 scopus 로고    scopus 로고
    • Apogossypolone inhibits cell growth by inducing cell cycle arrest in u937 cells
    • [PubMed]
    • Sun, J.; Li, Z.M.; Hu, Z.Y.; Zeng, Z.L.; Yang, D.J.; Jiang, W.Q. Apogossypolone inhibits cell growth by inducing cell cycle arrest in u937 cells. Oncol. Rep. 2009, 22, 193-198. [PubMed]
    • (2009) Oncol. Rep , vol.22 , pp. 193-198
    • Sun, J.1    Li, Z.M.2    Hu, Z.Y.3    Zeng, Z.L.4    Yang, D.J.5    Jiang, W.Q.6
  • 117
    • 45949094910 scopus 로고    scopus 로고
    • Targeting bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of b-cell lymphoma
    • [CrossRef] [PubMed]
    • Paoluzzi, L.; Gonen, M.; Gardner, J.R.; Mastrella, J.; Yang, D.; Holmlund, J.; Sorensen, M.; Leopold, L.; Manova, K.; Marcucci, G.; et al. Targeting bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of b-cell lymphoma. Blood 2008, 111, 5350-5358. [CrossRef] [PubMed]
    • (2008) Blood , vol.111 , pp. 5350-5358
    • Paoluzzi, L.1    Gonen, M.2    Gardner, J.R.3    Mastrella, J.4    Yang, D.5    Holmlund, J.6    Sorensen, M.7    Leopold, L.8    Manova, K.9    Marcucci, G.10
  • 118
    • 77952719306 scopus 로고    scopus 로고
    • BI-97C1, an optically pure apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins
    • [CrossRef] [PubMed]
    • Wei, J.; Stebbins, J.L.; Kitada, S.; Dash, R.; Placzek, W.; Rega, M.F.; Wu, B.; Cellitti, J.; Zhai, D.; Yang, L.; et al. BI-97C1, an optically pure apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (bcl-2) family proteins. J. Med. Chem. 2010, 53, 4166-4176. [CrossRef] [PubMed]
    • (2010) J. Med. Chem. , vol.53 , pp. 4166-4176
    • Wei, J.1    Stebbins, J.L.2    Kitada, S.3    Dash, R.4    Placzek, W.5    Rega, M.F.6    Wu, B.7    Cellitti, J.8    Zhai, D.9    Yang, L.10
  • 119
    • 79957689156 scopus 로고    scopus 로고
    • Apogossypol derivative BI-97C1 (Sabutoclax) targeting mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity
    • [CrossRef] [PubMed]
    • Dash, R.; Azab, B.; Quinn, B.A.; Shen, X.; Wang, X.Y.; Das, S.K.; Rahmani, M.; Wei, J.; Hedvat, M.; Dent, P.; et al. Apogossypol derivative BI-97C1 (Sabutoclax) targeting mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity. Proc. Natl. Acad. Sci. USA 2011, 108, 8785-8790. [CrossRef] [PubMed]
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 8785-8790
    • Dash, R.1    Azab, B.2    Quinn, B.A.3    Shen, X.4    Wang, X.Y.5    Das, S.K.6    Rahmani, M.7    Wei, J.8    Hedvat, M.9    Dent, P.10
  • 120
    • 79953222918 scopus 로고    scopus 로고
    • The BH3 α-helical mimic BH3-m6 disrupts bcl-x(L), bcl-2, and mcl-1 protein-protein interactions with bax, bak, bad, or bim and induces apoptosis in a bax- and bimdependent manner
    • [CrossRef] [PubMed]
    • Kazi, A.; Sun, J.; Doi, K.; Sung, S.S.; Takahashi, Y.; Yin, H.; Rodriguez, J.M.; Becerril, J.; Berndt, N.; Hamilton, A.D.; et al. The BH3 α-helical mimic BH3-m6 disrupts bcl-x(l), bcl-2, and mcl-1 protein-protein interactions with bax, bak, bad, or bim and induces apoptosis in a bax- and bimdependent manner. J. Biol. Chem. 2011, 286, 9382-9392. [CrossRef] [PubMed]
    • (2011) J. Biol. Chem. , vol.286 , pp. 9382-9392
    • Kazi, A.1    Sun, J.2    Doi, K.3    Sung, S.S.4    Takahashi, Y.5    Yin, H.6    Rodriguez, J.M.7    Becerril, J.8    Berndt, N.9    Hamilton, A.D.10
  • 123
    • 67650787318 scopus 로고    scopus 로고
    • Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists
    • [CrossRef] [PubMed]
    • Ndubaku, C.; Varfolomeev, E.; Wang, L.; Zobel, K.; Lau, K.; Elliott, L.O.; Maurer, B.; Fedorova, A.V.; Dynek, J.N.; Koehler, M.; et al. Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists. ACS Chem. Biol. 2009, 4, 557-566. [CrossRef] [PubMed]
    • (2009) ACS Chem. Biol , vol.4 , pp. 557-566
    • Ndubaku, C.1    Varfolomeev, E.2    Wang, L.3    Zobel, K.4    Lau, K.5    Elliott, L.O.6    Maurer, B.7    Fedorova, A.V.8    Dynek, J.N.9    Koehler, M.10
  • 124
    • 30844457537 scopus 로고    scopus 로고
    • Targeting XIAP for the treatment of malignancy
    • [CrossRef] [PubMed]
    • Schimmer, A.D.; Dalili, S.; Batey, R.A.; Riedl, S.J. Targeting XIAP for the treatment of malignancy. Cell Death Differ. 2006, 13, 179-188. [CrossRef] [PubMed]
    • (2006) Cell Death Differ , vol.13 , pp. 179-188
    • Schimmer, A.D.1    Dalili, S.2    Batey, R.A.3    Riedl, S.J.4
  • 125
    • 4444243683 scopus 로고    scopus 로고
    • A small molecule smac mimic potentiates trail- and TNFα-mediated cell death
    • [CrossRef] [PubMed]
    • Li, L.; Thomas, R.M.; Suzuki, H.; De Brabander, J.K.; Wang, X.; Harran, P.G. A small molecule smac mimic potentiates trail- and TNFα-mediated cell death. Science 2004, 305, 1471-1474. [CrossRef] [PubMed]
    • (2004) Science , vol.305 , pp. 1471-1474
    • Li, L.1    Thomas, R.M.2    Suzuki, H.3    De Brabander, J.K.4    Wang, X.5    Harran, P.G.6
  • 126
    • 77949485585 scopus 로고    scopus 로고
    • Targeting inhibitor of apoptosis proteins for therapeutic intervention
    • [CrossRef] [PubMed]
    • Ndubaku, C.; Cohen, F.; Varfolomeev, E.; Vucic, D. Targeting inhibitor of apoptosis proteins for therapeutic intervention. Future Med. Chem. 2009, 1, 1509-1525. [CrossRef] [PubMed]
    • (2009) Future Med. Chem , vol.1 , pp. 1509-1525
    • Ndubaku, C.1    Cohen, F.2    Varfolomeev, E.3    Vucic, D.4
  • 127
    • 37049019494 scopus 로고    scopus 로고
    • Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP
    • [CrossRef] [PubMed]
    • Sun, H.; Nikolovska-Coleska, Z.; Lu, J.; Meagher, J.L.; Yang, C.Y.; Qiu, S.; Tomita, Y.; Ueda, Y.; Jiang, S.; Krajewski, K.; et al. Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP. J. Am. Chem. Soc. 2007, 129, 15279-15294. [CrossRef] [PubMed]
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 15279-15294
    • Sun, H.1    Nikolovska-Coleska, Z.2    Lu, J.3    Meagher, J.L.4    Yang, C.Y.5    Qiu, S.6    Tomita, Y.7    Ueda, Y.8    Jiang, S.9    Krajewski, K.10
  • 128
    • 35948994157 scopus 로고    scopus 로고
    • Autocrine TNFα signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis
    • [CrossRef] [PubMed]
    • Petersen, S.L.; Wang, L.; Yalcin-Chin, A.; Li, L.; Peyton, M.; Minna, J.; Harran, P.; Wang, X. Autocrine TNFα signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell 2007, 12, 445-456. [CrossRef] [PubMed]
    • (2007) Cancer Cell , vol.12 , pp. 445-456
    • Petersen, S.L.1    Wang, L.2    Yalcin-Chin, A.3    Li, L.4    Peyton, M.5    Minna, J.6    Harran, P.7    Wang, X.8
  • 129
    • 0034710649 scopus 로고    scopus 로고
    • Structural and biochemical basis of apoptotic activation by Smac/DIABLO
    • [PubMed]
    • Chai, J.; Du, C.; Wu, J.W.; Kyin, S.; Wang, X.; Shi, Y. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature 2000, 406, 855-862. [PubMed]
    • (2000) Nature , vol.406 , pp. 855-862
    • Chai, J.1    Du, C.2    Wu, J.W.3    Kyin, S.4    Wang, X.5    Shi, Y.6
  • 130
    • 0034616942 scopus 로고    scopus 로고
    • Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
    • [CrossRef]
    • Verhagen, A.M.; Ekert, P.G.; Pakusch, M.; Silke, J.; Connolly, L.M.; Reid, G.E.; Moritz, R.L.; Simpson, R.J.; Vaux, D.L. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 2000, 102, 43-53. [CrossRef]
    • (2000) Cell , vol.102 , pp. 43-53
    • Verhagen, A.M.1    Ekert, P.G.2    Pakusch, M.3    Silke, J.4    Connolly, L.M.5    Reid, G.E.6    Moritz, R.L.7    Simpson, R.J.8    Vaux, D.L.9
  • 131
    • 0034700491 scopus 로고    scopus 로고
    • Structural basis of IAP recognition by Smac/DIABLO
    • [PubMed]
    • Wu, G.; Chai, J.; Suber, T.L.; Wu, J.W.; Du, C.; Wang, X.; Shi, Y. Structural basis of IAP recognition by Smac/DIABLO. Nature 2000, 408, 1008-1012. [PubMed]
    • (2000) Nature , vol.408 , pp. 1008-1012
    • Wu, G.1    Chai, J.2    Suber, T.L.3    Wu, J.W.4    Du, C.5    Wang, X.6    Shi, Y.7
  • 133
    • 0037023712 scopus 로고    scopus 로고
    • Smac negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)
    • [CrossRef] [PubMed]
    • Vucic, D.; Deshayes, K.; Ackerly, H.; Pisabarro, M.T.; Kadkhodayan, S.; Fairbrother, W.J.; Dixit, V.M. Smac negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP). J. Biol. Chem. 2002, 277, 12275-12279. [CrossRef] [PubMed]
    • (2002) J. Biol. Chem , vol.277 , pp. 12275-12279
    • Vucic, D.1    Deshayes, K.2    Ackerly, H.3    Pisabarro, M.T.4    Kadkhodayan, S.5    Fairbrother, W.J.6    Dixit, V.M.7
  • 134
    • 0036341291 scopus 로고    scopus 로고
    • Smac agonists sensitize for APO2L/trail- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo
    • [CrossRef] [PubMed]
    • Fulda, S.; Wick, W.; Weller, M.; Debatin, K.M. Smac agonists sensitize for APO2L/trail- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Nat. Med. 2002, 8, 808-815. [CrossRef] [PubMed]
    • (2002) Nat. Med , vol.8 , pp. 808-815
    • Fulda, S.1    Wick, W.2    Weller, M.3    Debatin, K.M.4
  • 135
    • 0031875042 scopus 로고    scopus 로고
    • The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to hsp90 and shares important biologic activities with geldanamycin
    • [CrossRef] [PubMed]
    • Schulte, T.W.; Neckers, L.M. The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to hsp90 and shares important biologic activities with geldanamycin. Cancer Chemother. Pharmacol. 1998, 42, 273-279. [CrossRef] [PubMed]
    • (1998) Cancer Chemother. Pharmacol , vol.42 , pp. 273-279
    • Schulte, T.W.1    Neckers, L.M.2
  • 137
    • 33751258297 scopus 로고    scopus 로고
    • Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against hsp90
    • [CrossRef] [PubMed]
    • Sydor, J.R.; Normant, E.; Pien, C.S.; Porter, J.R.; Ge, J.; Grenier, L.; Pak, R.H.; Ali, J.A.; Dembski, M.S.; Hudak, J.; et al. Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against hsp90. Proc. Natl. Acad. Sci. USA 2006, 103, 17408-17413. [CrossRef] [PubMed]
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 17408-17413
    • Sydor, J.R.1    Normant, E.2    Pien, C.S.3    Porter, J.R.4    Ge, J.5    Grenier, L.6    Pak, R.H.7    Ali, J.A.8    Dembski, M.S.9    Hudak, J.10
  • 138
    • 33746662241 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of hsp90
    • [CrossRef] [PubMed]
    • Ge, J.; Normant, E.; Porter, J.R.; Ali, J.A.; Dembski, M.S.; Gao, Y.; Georges, A.T.; Grenier, L.; Pak, R.H.; Patterson, J.; et al. Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of hsp90. J. Med. Chem. 2006, 49, 4606-4615. [CrossRef] [PubMed]
    • (2006) J. Med. Chem. , vol.49 , pp. 4606-4615
    • Ge, J.1    Normant, E.2    Porter, J.R.3    Ali, J.A.4    Dembski, M.S.5    Gao, Y.6    Georges, A.T.7    Grenier, L.8    Pak, R.H.9    Patterson, J.10
  • 139
    • 3042685847 scopus 로고    scopus 로고
    • New efficient synthesis of resorcinylic macrolides via ynolides: Establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on hsp90 as the target
    • [CrossRef] [PubMed]
    • Yang, Z.Q.; Geng, X.; Solit, D.; Pratilas, C.A.; Rosen, N.; Danishefsky, S.J. New efficient synthesis of resorcinylic macrolides via ynolides: Establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on hsp90 as the target. J. Am. Chem. Soc. 2004, 126, 7881-7889. [CrossRef] [PubMed]
    • (2004) J. Am. Chem. Soc , vol.126 , pp. 7881-7889
    • Yang, Z.Q.1    Geng, X.2    Solit, D.3    Pratilas, C.A.4    Rosen, N.5    Danishefsky, S.J.6
  • 140
    • 84857039457 scopus 로고    scopus 로고
    • Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers
    • [CrossRef] [PubMed]
    • Jhaveri, K.; Taldone, T.; Modi, S.; Chiosis, G. Advances in the clinical development of heat shock protein 90 (hsp90) inhibitors in cancers. Biochim. Biophys. Acta 2012, 1823, 742-755. [CrossRef] [PubMed]
    • (2012) Biochim. Biophys. Acta , vol.1823 , pp. 742-755
    • Jhaveri, K.1    Taldone, T.2    Modi, S.3    Chiosis, G.4
  • 141
    • 0035071607 scopus 로고    scopus 로고
    • Small molecule designed to bind to the adenine nucleotide pocket of hsp90 causes her2 degradation and the growth arrest and differentiation of breast cancer cells
    • [CrossRef]
    • Chiosis, G.; Timaul, M.N.; Lucas, B.; Munster, P.N.; Zheng, F.F.; Sepp-Lorenzino, L.; Rosen, N. A small molecule designed to bind to the adenine nucleotide pocket of hsp90 causes her2 degradation and the growth arrest and differentiation of breast cancer cells. Chem. Biol. 2001, 8, 289-299. [CrossRef]
    • (2001) Chem. Biol , vol.8 , pp. 289-299
    • Chiosis, G.1    Timaul, M.N.2    Lucas, B.3    Munster, P.N.4    Zheng, F.F.5    Sepp-Lorenzino, L.6    Rosen, N.A.7
  • 144
    • 67449138839 scopus 로고    scopus 로고
    • CUDC-305, a novel synthetic HSP90 inhibitor with unique pharmacologic properties for cancer therapy
    • [CrossRef] [PubMed]
    • Bao, R.; Lai, C.J.; Qu, H.; Wang, D.; Yin, L.; Zifcak, B.; Atoyan, R.; Wang, J.; Samson, M.; Forrester, J.; et al. CUDC-305, a novel synthetic HSP90 inhibitor with unique pharmacologic properties for cancer therapy. Clin. Cancer Res. 2009, 15, 4046-4057. [CrossRef] [PubMed]
    • (2009) Clin. Cancer Res , vol.15 , pp. 4046-4057
    • Bao, R.1    Lai, C.J.2    Qu, H.3    Wang, D.4    Yin, L.5    Zifcak, B.6    Atoyan, R.7    Wang, J.8    Samson, M.9    Forrester, J.10
  • 146
    • 68149145788 scopus 로고    scopus 로고
    • Molecular targets of nutraceuticals derived from dietary spices: Potential role in suppression of inflammation and tumorigenesis
    • [CrossRef] [PubMed]
    • Aggarwal, B.B.; Van Kuiken, M.E.; Iyer, L.H.; Harikumar, K.B.; Sung, B. Molecular targets of nutraceuticals derived from dietary spices: Potential role in suppression of inflammation and tumorigenesis. Exp. Biol. Med. 2009, 234, 825-849. [CrossRef] [PubMed]
    • (2009) Exp. Biol. Med , vol.234 , pp. 825-849
    • Aggarwal, B.B.1    Van Kuiken, M.E.2    Iyer, L.H.3    Harikumar, K.B.4    Sung, B.5
  • 148
    • 84859423230 scopus 로고    scopus 로고
    • Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer
    • [CrossRef] [PubMed]
    • Sonpavde, G.; Matveev, V.; Burke, J.M.; Caton, J.R.; Fleming, M.T.; Hutson, T.E.; Galsky, M.D.; Berry, W.R.; Karlov, P.; Holmlund, J.T.; et al. Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer. Ann. Oncol. 2012, 23, 1803-1808. [CrossRef] [PubMed]
    • (2012) Ann. Oncol , vol.23 , pp. 1803-1808
    • Sonpavde, G.1    Matveev, V.2    Burke, J.M.3    Caton, J.R.4    Fleming, M.T.5    Hutson, T.E.6    Galsky, M.D.7    Berry, W.R.8    Karlov, P.9    Holmlund, J.T.10
  • 149
    • 45349087492 scopus 로고    scopus 로고
    • Effect of curcumin on expression of survivin, bcl-2 and bax in human multiple myeloma cell line
    • [PubMed]
    • Liu, B.; Bai, Q.X.; Chen, X.Q.; Gao, G.X.; Gu, H.T. Effect of curcumin on expression of survivin, bcl-2 and bax in human multiple myeloma cell line. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2007, 15, 762-766. [PubMed]
    • (2007) Zhongguo Shi Yan Xue Ye Xue Za Zhi , vol.15 , pp. 762-766
    • Liu, B.1    Bai, Q.X.2    Chen, X.Q.3    Gao, G.X.4    Gu, H.T.5
  • 150
    • 33646124027 scopus 로고    scopus 로고
    • Rosmarinic acid failed to suppress hydrogen peroxide-mediated apoptosis but induced apoptosis of jurkat cells which was suppressed by bcl-2
    • [CrossRef] [PubMed]
    • Kolettas, E.; Thomas, C.; Leneti, E.; Skoufos, I.; Mbatsi, C.; Sisoula, C.; Manos, G.; Evangelou, A. Rosmarinic acid failed to suppress hydrogen peroxide-mediated apoptosis but induced apoptosis of jurkat cells which was suppressed by bcl-2. Mol. Cell. Biochem. 2006, 285, 111-120. [CrossRef] [PubMed]
    • (2006) Mol. Cell. Biochem , vol.285 , pp. 111-120
    • Kolettas, E.1    Thomas, C.2    Leneti, E.3    Skoufos, I.4    Mbatsi, C.5    Sisoula, C.6    Manos, G.7    Evangelou, A.8
  • 151
    • 0035570174 scopus 로고    scopus 로고
    • Ajoene, a garlic-derived natural compound, enhances chemotherapy-induced apoptosis in human myeloid leukaemia CD34-positive resistant cells
    • [PubMed]
    • Ahmed, N.; Laverick, L.; Sammons, J.; Zhang, H.; Maslin, D.J.; Hassan, H.T. Ajoene, a garlic-derived natural compound, enhances chemotherapy-induced apoptosis in human myeloid leukaemia CD34-positive resistant cells. Anticancer Res. 2001, 21, 3519-3523. [PubMed]
    • (2001) Anticancer Res , vol.21 , pp. 3519-3523
    • Ahmed, N.1    Laverick, L.2    Sammons, J.3    Zhang, H.4    Maslin, D.J.5    Hassan, H.T.6
  • 152
    • 84910036348 scopus 로고    scopus 로고
    • Phase I/II study of the pan bcl-2 inhibitor obatoclax mesylate plus bortezomib for relapsed or refractory mantle cell lymphoma
    • [CrossRef] [PubMed]
    • Goy, A.; Hernandez-Ilzaliturri, F.J.; Kahl, B.; Ford, P.; Protomastro, E.; Berger, M. A phase I/II study of the pan bcl-2 inhibitor obatoclax mesylate plus bortezomib for relapsed or refractory mantle cell lymphoma. Leuk. Lymphoma 2014, 55, 2761-2768. [CrossRef] [PubMed]
    • (2014) Leuk. Lymphoma , vol.55 , pp. 2761-2768
    • Goy, A.1    Hernandez-Ilzaliturri, F.J.2    Kahl, B.3    Ford, P.4    Protomastro, E.5    Berger, M.A.6
  • 153
    • 84895060456 scopus 로고    scopus 로고
    • A randomised phase 2 study combining ly2181308 sodium (Survivin antisense oligonucleotide) with first-line docetaxel/prednisone in patients with castration-resistant prostate cancer
    • [CrossRef] [PubMed]
    • Wiechno, P.; Somer, B.G.; Mellado, B.; Chlosta, P.L.; Cervera Grau, J.M.; Castellano, D.; Reuter, C.; Stockle, M.; Kamradt, J.; Pikiel, J.; et al. A randomised phase 2 study combining ly2181308 sodium (survivin antisense oligonucleotide) with first-line docetaxel/prednisone in patients with castration-resistant prostate cancer. Eur. Urol. 2014, 65, 516-520. [CrossRef] [PubMed]
    • (2014) Eur. Urol , vol.65 , pp. 516-520
    • Wiechno, P.1    Somer, B.G.2    Mellado, B.3    Chlosta, P.L.4    Cervera Grau, J.M.5    Castellano, D.6    Reuter, C.7    Stockle, M.8    Kamradt, J.9    Pikiel, J.10
  • 154
    • 11144230279 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by bcl-2 but restored by the small molecule bcl-2 inhibitor, HA 14-1, in human colon cancer cells. Clin
    • [CrossRef] [PubMed]
    • Sinicrope, F.A.; Penington, R.C.; Tang, X.M. Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by bcl-2 but restored by the small molecule bcl-2 inhibitor, HA 14-1, in human colon cancer cells. Clin. Cancer Res. 2004, 10, 8284-8292. [CrossRef] [PubMed]
    • (2004) Cancer Res , vol.10 , pp. 8284-8292
    • Sinicrope, F.A.1    Penington, R.C.2    Tang, X.M.3
  • 155
    • 0034789355 scopus 로고    scopus 로고
    • Cancer gene therapy using a survivin mutant adenovirus
    • [CrossRef] [PubMed]
    • Mesri, M.; Wall, N.R.; Li, J.; Kim, R.W.; Altieri, D.C. Cancer gene therapy using a survivin mutant adenovirus. J. Clin. Investig. 2001, 108, 981-990. [CrossRef] [PubMed]
    • (2001) J. Clin. Investig , vol.108 , pp. 981-990
    • Mesri, M.1    Wall, N.R.2    Li, J.3    Kim, R.W.4    Altieri, D.C.5
  • 156
    • 74849090776 scopus 로고    scopus 로고
    • Small inhibitor of bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating bcl-2 family members in MDA-MB-231 breast cancer cells
    • [CrossRef] [PubMed]
    • Arisan, E.D.; Kutuk, O.; Tezil, T.; Bodur, C.; Telci, D.; Basaga, H. Small inhibitor of bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating bcl-2 family members in MDA-MB-231 breast cancer cells. Breast Cancer Res. Treat. 2010, 119, 271-281. [CrossRef] [PubMed]
    • (2010) Breast Cancer Res. Treat , vol.119 , pp. 271-281
    • Arisan, E.D.1    Kutuk, O.2    Tezil, T.3    Bodur, C.4    Telci, D.5    Basaga, H.6
  • 157
    • 84959434445 scopus 로고    scopus 로고
    • A phase I study of EZN-3042, a novel survivin messenger ribonucleic acid (MRNA) antagonist, administered in combination with chemotherapy in children with relapsed acute lymphoblastic leukemia (ALL): A report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium
    • [CrossRef]
    • Raetz, E.A.; Morrison, D.; Romanos-Sirakis, E.; Gaynon, P.; Sposto, R.; Bhojwani, D.; Bostrom, B.C.; Brown, P.; Eckroth, E.; Cassar, J.; et al. A phase I study of EZN-3042, a novel survivin messenger ribonucleic acid (mRNA) antagonist, administered in combination with chemotherapy in children with relapsed acute lymphoblastic leukemia (ALL): A report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium. J. Pediatr. Hematol. Oncol. 2013. [CrossRef]
    • (2013) J. Pediatr. Hematol. Oncol
    • Raetz, E.A.1    Morrison, D.2    Romanos-Sirakis, E.3    Gaynon, P.4    Sposto, R.5    Bhojwani, D.6    Bostrom, B.C.7    Brown, P.8    Eckroth, E.9    Cassar, J.10
  • 160
    • 84885046193 scopus 로고    scopus 로고
    • Interaction studies to evaluate 2-carboxyphenolate analogues as inhibitor of anti-apoptotic protein bcl-2
    • [CrossRef] [PubMed]
    • Al-Karaawi, M.A. Interaction studies to evaluate 2-carboxyphenolate analogues as inhibitor of anti-apoptotic protein bcl-2. Bioinformation 2013, 9, 477-480. [CrossRef] [PubMed]
    • (2013) Bioinformation , vol.9 , pp. 477-480
    • Al-Karaawi, M.A.1
  • 161
    • 84884717482 scopus 로고    scopus 로고
    • A phase I/II study of sepantronium bromide (YM155, survivin suppressor) with paclitaxel and carboplatin in patients with advanced non-small-cell lung cancer
    • [CrossRef] [PubMed]
    • Kelly, R.J.; Thomas, A.; Rajan, A.; Chun, G.; Lopez-Chavez, A.; Szabo, E.; Spencer, S.; Carter, C.A.; Guha, U.; Khozin, S.; et al. A phase I/II study of sepantronium bromide (YM155, survivin suppressor) with paclitaxel and carboplatin in patients with advanced non-small-cell lung cancer. Ann. Oncol. 2013, 24, 2601-2606. [CrossRef] [PubMed]
    • (2013) Ann. Oncol , vol.24 , pp. 2601-2606
    • Kelly, R.J.1    Thomas, A.2    Rajan, A.3    Chun, G.4    Lopez-Chavez, A.5    Szabo, E.6    Spencer, S.7    Carter, C.A.8    Guha, U.9    Khozin, S.10
  • 162
    • 84890515602 scopus 로고    scopus 로고
    • SF002-96-1, a new drimane sesquiterpene lactone from an aspergillus species, inhibits survivin expression. Beilstein
    • [CrossRef] [PubMed]
    • Felix, S.; Sandjo, L.P.; Opatz, T.; Erkel, G. SF002-96-1, a new drimane sesquiterpene lactone from an aspergillus species, inhibits survivin expression. Beilstein J. Org. Chem. 2013, 9, 2866-2876. [CrossRef] [PubMed]
    • (2013) J. Org. Chem , vol.9 , pp. 2866-2876
    • Felix, S.1    Sandjo, L.P.2    Opatz, T.3    Erkel, G.4
  • 163
    • 84872058507 scopus 로고    scopus 로고
    • Phase 2 trial of daily, oral polyphenon e in patients with asymptomatic, RAI stage 0 to II chronic lymphocytic leukemia
    • [CrossRef] [PubMed]
    • Shanafelt, T.D.; Call, T.G.; Zent, C.S.; Leis, J.F.; LaPlant, B.; Bowen, D.A.; Roos, M.; Laumann, K.; Ghosh, A.K.; Lesnick, C.; et al. Phase 2 trial of daily, oral polyphenon e in patients with asymptomatic, RAI stage 0 to II chronic lymphocytic leukemia. Cancer 2013, 119, 363-370. [CrossRef] [PubMed]
    • (2013) Cancer , vol.119 , pp. 363-370
    • Shanafelt, T.D.1    Call, T.G.2    Zent, C.S.3    Leis, J.F.4    Laplant, B.5    Bowen, D.A.6    Roos, M.7    Laumann, K.8    Ghosh, A.K.9    Lesnick, C.10
  • 164
    • 84885834652 scopus 로고    scopus 로고
    • Withanone as an inhibitor of survivin: A potential drug candidate for cancer therapy
    • [CrossRef] [PubMed]
    • Wadegaonkar, V.P.; Wadegaonkar, P.A. Withanone as an inhibitor of survivin: A potential drug candidate for cancer therapy. J. Biotechnol. 2013, 168, 229-233. [CrossRef] [PubMed]
    • (2013) J. Biotechnol , vol.168 , pp. 229-233
    • Wadegaonkar, V.P.1    Wadegaonkar, P.A.2
  • 165
    • 84903464142 scopus 로고    scopus 로고
    • Photoreactive stapled peptides to identify and characterize bcl-2 family interaction sites by mass spectrometry
    • [PubMed]
    • Lee, S.; Braun, C.R.; Bird, G.H.; Walensky, L.D. Photoreactive stapled peptides to identify and characterize bcl-2 family interaction sites by mass spectrometry. Methods Enzymol. 2014, 544, 25-48. [PubMed]
    • (2014) Methods Enzymol , vol.544 , pp. 25-48
    • Lee, S.1    Braun, C.R.2    Bird, G.H.3    Walensky, L.D.4
  • 166
    • 77953712587 scopus 로고    scopus 로고
    • GDP366, a novel small molecule dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells
    • [CrossRef] [PubMed]
    • Shi, X.; Wang, D.; Ding, K.; Lu, Z.; Jin, Y.; Zhang, J.; Pan, J. GDP366, a novel small molecule dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. Cancer Biol. Ther. 2010, 9, 640-650. [CrossRef] [PubMed]
    • (2010) Cancer Biol. Ther , vol.9 , pp. 640-650
    • Shi, X.1    Wang, D.2    Ding, K.3    Lu, Z.4    Jin, Y.5    Zhang, J.6    Pan, J.7
  • 167
    • 7444241537 scopus 로고    scopus 로고
    • Breast cancer cells can evade apoptosis-mediated selective killing by a novel small molecule inhibitor of bcl-2
    • [CrossRef] [PubMed]
    • Real, P.J.; Cao, Y.; Wang, R.; Nikolovska-Coleska, Z.; Sanz-Ortiz, J.; Wang, S.; Fernandez-Luna, J.L. Breast cancer cells can evade apoptosis-mediated selective killing by a novel small molecule inhibitor of bcl-2. Cancer Res. 2004, 64, 7947-7953. [CrossRef] [PubMed]
    • (2004) Cancer Res , vol.64 , pp. 7947-7953
    • Real, P.J.1    Cao, Y.2    Wang, R.3    Nikolovska-Coleska, Z.4    Sanz-Ortiz, J.5    Wang, S.6    Fernandez-Luna, J.L.7
  • 168
    • 0035832097 scopus 로고    scopus 로고
    • Synthesis of tetrocarcin derivatives with specific inhibitory activity towards bcl-2 functions
    • [CrossRef]
    • Kaneko, M.; Nakashima, T.; Uosaki, Y.; Hara, M.; Ikeda, S.; Kanda, Y. Synthesis of tetrocarcin derivatives with specific inhibitory activity towards bcl-2 functions. Bioorg. Med. Chem. Lett. 2001, 11, 887-890. [CrossRef]
    • (2001) Bioorg. Med. Chem. Lett , vol.11 , pp. 887-890
    • Kaneko, M.1    Nakashima, T.2    Uosaki, Y.3    Hara, M.4    Ikeda, S.5    Kanda, Y.6
  • 172
    • 22944468183 scopus 로고    scopus 로고
    • Differential effect of anti-apoptotic genes bcl-xl and c-flip on sensitivity of mcf-7 breast cancer cells to paclitaxel and docetaxel
    • [PubMed]
    • Wang, Z.; Goulet, R., 3rd; Stanton, K.J.; Sadaria, M.; Nakshatri, H. Differential effect of anti-apoptotic genes bcl-xl and c-flip on sensitivity of mcf-7 breast cancer cells to paclitaxel and docetaxel. Anticancer Res. 2005, 25, 2367-2379. [PubMed]
    • (2005) Anticancer Res , vol.25 , pp. 2367-2379
    • Wang, Z.1    Goulet, R.2    Stanton, K.J.3    Sadaria, M.4    Nakshatri, H.5
  • 173
    • 0041913978 scopus 로고    scopus 로고
    • Development and characterization of nonpeptidic small molecule inhibitors of the xiap/caspase-3 interaction
    • [CrossRef]
    • Wu, T.Y.; Wagner, K.W.; Bursulaya, B.; Schultz, P.G.; Deveraux, Q.L. Development and characterization of nonpeptidic small molecule inhibitors of the xiap/caspase-3 interaction. Chem. Biol. 2003, 10, 759-767. [CrossRef]
    • (2003) Chem. Biol , vol.10 , pp. 759-767
    • Wu, T.Y.1    Wagner, K.W.2    Bursulaya, B.3    Schultz, P.G.4    Deveraux, Q.L.5
  • 174
    • 84902477584 scopus 로고    scopus 로고
    • BM-1197: A novel and specific bcl-2/bcl-xl inhibitor inducing complete and long-lasting tumor regression in vivo
    • [CrossRef] [PubMed]
    • Bai, L.; Chen, J.; McEachern, D.; Liu, L.; Zhou, H.; Aguilar, A.; Wang, S. BM-1197: A novel and specific bcl-2/bcl-xl inhibitor inducing complete and long-lasting tumor regression in vivo. PLoS ONE 2014, 9. [CrossRef] [PubMed]
    • (2014) Plos ONE , pp. 9
    • Bai, L.1    Chen, J.2    McEachern, D.3    Liu, L.4    Zhou, H.5    Aguilar, A.6    Wang, S.7
  • 176
    • 84866534987 scopus 로고    scopus 로고
    • Novel small molecule FL118 that selectively inhibits survivin, mcl-1, XIAP and cIAP2 in a p53-independent manner, shows superior antitumor activity
    • [CrossRef] [PubMed]
    • Ling, X.; Cao, S.; Cheng, Q.; Keefe, J.T.; Rustum, Y.M.; Li, F. A novel small molecule FL118 that selectively inhibits survivin, mcl-1, XIAP and cIAP2 in a p53-independent manner, shows superior antitumor activity. PLoS ONE 2012, 7. [CrossRef] [PubMed]
    • (2012) Plos ONE , pp. 7
    • Ling, X.1    Cao, S.2    Cheng, Q.3    Keefe, J.T.4    Rustum, Y.M.5    Li, F.A.6
  • 178
    • 65249099649 scopus 로고    scopus 로고
    • A novel bcl-xl inhibitor z36 that induces autophagic cell death in hela cells
    • [CrossRef] [PubMed]
    • Lin, J.; Zheng, Z.; Li, Y.; Yu, W.; Zhong, W.; Tian, S.; Zhao, F.; Ren, X.; Xiao, J.; Wang, N.; et al. A novel bcl-xl inhibitor z36 that induces autophagic cell death in hela cells. Autophagy 2009, 5, 314-320. [CrossRef] [PubMed]
    • (2009) Autophagy , vol.5 , pp. 314-320
    • Lin, J.1    Zheng, Z.2    Li, Y.3    Yu, W.4    Zhong, W.5    Tian, S.6    Zhao, F.7    Ren, X.8    Xiao, J.9    Wang, N.10
  • 180
    • 54049131208 scopus 로고    scopus 로고
    • A novel Bim-BH3-derived bcl-XL inhibitor: Biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity
    • [CrossRef] [PubMed]
    • Ponassi, R.; Biasotti, B.; Tomati, V.; Bruno, S.; Poggi, A.; Malacarne, D.; Cimoli, G.; Salis, A.; Pozzi, S.; Miglino, M.; et al. A novel Bim-BH3-derived bcl-XL inhibitor: Biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity. Cell Cycle 2008, 7, 3211-3224. [CrossRef] [PubMed]
    • (2008) Cell Cycle , vol.7 , pp. 3211-3224
    • Ponassi, R.1    Biasotti, B.2    Tomati, V.3    Bruno, S.4    Poggi, A.5    Malacarne, D.6    Cimoli, G.7    Salis, A.8    Pozzi, S.9    Miglino, M.10
  • 181
    • 33845306864 scopus 로고    scopus 로고
    • Novobiocin: Redesigning a DNA gyrase inhibitor for selective inhibition of hsp90
    • [CrossRef] [PubMed]
    • Burlison, J.A.; Neckers, L.; Smith, A.B.; Maxwell, A.; Blagg, B.S. Novobiocin: Redesigning a DNA gyrase inhibitor for selective inhibition of hsp90. J. Am. Chem. Soc. 2006, 128, 15529-15536. [CrossRef] [PubMed]
    • (2006) J. Am. Chem. Soc , vol.128 , pp. 15529-15536
    • Burlison, J.A.1    Neckers, L.2    Smith, A.B.3    Maxwell, A.4    Blagg, B.S.5
  • 183
    • 84904364428 scopus 로고    scopus 로고
    • Anticancer effects of the hsp90 inhibitor 17-demethoxy-reblastatin in human breast cancer MDA-MB-231 cells
    • [PubMed]
    • Zhao, Q.; Wu, C.Z.; Lee, J.K.; Zhao, S.R.; Li, H.M.; Huo, Q.; Ma, T.; Zhang, J.; Hong, Y.S.; Liu, H. Anticancer effects of the hsp90 inhibitor 17-demethoxy-reblastatin in human breast cancer MDA-MB-231 cells. J. Microbiol. Biotechnol. 2014, 24, 914-920. [PubMed]
    • (2014) J. Microbiol. Biotechnol , vol.24 , pp. 914-920
    • Zhao, Q.1    Wu, C.Z.2    Lee, J.K.3    Zhao, S.R.4    Li, H.M.5    Huo, Q.6    Ma, T.7    Zhang, J.8    Hong, Y.S.9    Liu, H.10
  • 184
    • 0036138556 scopus 로고    scopus 로고
    • Inhibition of bcl-xl expression sensitizes t-cell acute lymphoblastic leukemia cells to chemotherapeutic drugs
    • [CrossRef]
    • Broome, H.E.; Yu, A.L.; Diccianni, M.; Camitta, B.M.; Monia, B.P.; Dean, N.M. Inhibition of bcl-xl expression sensitizes t-cell acute lymphoblastic leukemia cells to chemotherapeutic drugs. Leuk. Res. 2002, 26, 311-316. [CrossRef]
    • (2002) Leuk. Res , vol.26 , pp. 311-316
    • Broome, H.E.1    Yu, A.L.2    Diccianni, M.3    Camitta, B.M.4    Monia, B.P.5    Dean, N.M.6
  • 185
    • 84907998268 scopus 로고    scopus 로고
    • DEBIO 0932, a new oral hsp90 inhibitor, alleviates psoriasis in a xenograft transplantation model
    • [CrossRef] [PubMed]
    • Stenderup, K.; Rosada, C.; Gavillet, B.; Vuagniaux, G.; Dam, T.N. DEBIO 0932, a new oral hsp90 inhibitor, alleviates psoriasis in a xenograft transplantation model. Acta Derm. Venereol. 2014, 94, 672-676. [CrossRef] [PubMed]
    • (2014) Acta Derm. Venereol , vol.94 , pp. 672-676
    • Stenderup, K.1    Rosada, C.2    Gavillet, B.3    Vuagniaux, G.4    Dam, T.N.5
  • 187
    • 40749103835 scopus 로고    scopus 로고
    • SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against her kinase-dependent cancers
    • [CrossRef] [PubMed]
    • Chandarlapaty, S.; Sawai, A.; Ye, Q.; Scott, A.; Silinski, M.; Huang, K.; Fadden, P.; Partdrige, J.; Hall, S.; Steed, P.; et al. SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against her kinase-dependent cancers. Clin. Cancer Res. 2008, 14, 240-248. [CrossRef] [PubMed]
    • (2008) Clin. Cancer Res , vol.14 , pp. 240-248
    • Chandarlapaty, S.1    Sawai, A.2    Ye, Q.3    Scott, A.4    Silinski, M.5    Huang, K.6    Fadden, P.7    Partdrige, J.8    Hall, S.9    Steed, P.10
  • 189
    • 78049498581 scopus 로고    scopus 로고
    • Biomimetic total synthesis of meiogynin a, an inhibitor of bcl-xl and bak interaction
    • [CrossRef] [PubMed]
    • Fotsop, D.F.; Roussi, F.; Leverrier, A.; Breteche, A.; Gueritte, F. Biomimetic total synthesis of meiogynin a, an inhibitor of bcl-xl and bak interaction. J. Org. Chem. 2010, 75, 7412-7415. [CrossRef] [PubMed]
    • (2010) J. Org. Chem. , vol.75 , pp. 7412-7415
    • Fotsop, D.F.1    Roussi, F.2    Leverrier, A.3    Breteche, A.4    Gueritte, F.5
  • 190
    • 77955873344 scopus 로고    scopus 로고
    • Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydrois oindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone hsp90 by fragment based drug design
    • [CrossRef] [PubMed]
    • Woodhead, A.J.; Angove, H.; Carr, M.G.; Chessari, G.; Congreve, M.; Coyle, J.E.; Cosme, J.; Graham, B.; Day, P.J.; Downham, R.; et al. Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydrois oindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone hsp90 by fragment based drug design. J. Med. Chem. 2010, 53, 5956-5969. [CrossRef] [PubMed]
    • (2010) J. Med. Chem. , vol.53 , pp. 5956-5969
    • Woodhead, A.J.1    Angove, H.2    Carr, M.G.3    Chessari, G.4    Congreve, M.5    Coyle, J.E.6    Cosme, J.7    Graham, B.8    Day, P.J.9    Downham, R.10
  • 191
    • 84879857354 scopus 로고    scopus 로고
    • NMS-E973, a novel synthetic inhibitor of hsp90 with activity against multiple models of drug resistance to targeted agents, including intracranial metastases
    • [CrossRef] [PubMed]
    • Fogliatto, G.; Gianellini, L.; Brasca, M.G.; Casale, E.; Ballinari, D.; Ciomei, M.; Degrassi, A.; De Ponti, A.; Germani, M.; Guanci, M.; et al. NMS-E973, a novel synthetic inhibitor of hsp90 with activity against multiple models of drug resistance to targeted agents, including intracranial metastases. Clin. Cancer Res. 2013, 19, 3520-3532. [CrossRef] [PubMed]
    • (2013) Clin. Cancer Res , vol.19 , pp. 3520-3532
    • Fogliatto, G.1    Gianellini, L.2    Brasca, M.G.3    Casale, E.4    Ballinari, D.5    Ciomei, M.6    Degrassi, A.7    De Ponti, A.8    Germani, M.9    Guanci, M.10
  • 193
    • 84921687193 scopus 로고    scopus 로고
    • Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors
    • [CrossRef] [PubMed]
    • Bhat, R.; Tummalapalli, S.R.; Rotella, D.P. Progress in the discovery and development of heat shock protein 90 (hsp90) inhibitors. J. Med. Chem. 2014, 57, 8718-8728. [CrossRef] [PubMed]
    • (2014) J. Med. Chem. , vol.57 , pp. 8718-8728
    • Bhat, R.1    Tummalapalli, S.R.2    Rotella, D.P.3
  • 195
    • 84884173540 scopus 로고    scopus 로고
    • Identification of the plant compound geraniin as a novel hsp90 inhibitor
    • [CrossRef]
    • Vassallo, A.; Vaccaro, M.C.; De Tommasi, N.; Dal Piaz, F.; Leone, A. Identification of the plant compound geraniin as a novel hsp90 inhibitor. PLoS ONE 2013, 8. [CrossRef]
    • (2013) Plos ONE , pp. 8
    • Vassallo, A.1    Vaccaro, M.C.2    De Tommasi, N.3    Dal Piaz, F.4    Leone, A.5
  • 196
    • 84856471585 scopus 로고    scopus 로고
    • Preclinical antitumor activity of the novel heat shock protein 90 inhibitor CH5164840 against human epidermal growth factor receptor 2 (HER2)-overexpressing cancers
    • [CrossRef] [PubMed]
    • Ono, N.; Yamazaki, T.; Nakanishi, Y.; Fujii, T.; Sakata, K.; Tachibana, Y.; Suda, A.; Hada, K.; Miura, T.; Sato, S.; et al. Preclinical antitumor activity of the novel heat shock protein 90 inhibitor CH5164840 against human epidermal growth factor receptor 2 (HER2)-overexpressing cancers. Cancer Sci. 2012, 103, 342-349. [CrossRef] [PubMed]
    • (2012) Cancer Sci , vol.103 , pp. 342-349
    • Ono, N.1    Yamazaki, T.2    Nakanishi, Y.3    Fujii, T.4    Sakata, K.5    Tachibana, Y.6    Suda, A.7    Hada, K.8    Miura, T.9    Sato, S.10
  • 197
    • 84867341788 scopus 로고    scopus 로고
    • Structure-based discovery of BM-957 as a potent small-molecule inhibitor of bcl-2 and bcl-xl capable of achieving complete tumor regression
    • [CrossRef] [PubMed]
    • Chen, J.; Zhou, H.; Aguilar, A.; Liu, L.; Bai, L.; McEachern, D.; Yang, C.Y.; Meagher, J.L.; Stuckey, J.A.; Wang, S. Structure-based discovery of BM-957 as a potent small-molecule inhibitor of bcl-2 and bcl-xl capable of achieving complete tumor regression. J. Med. Chem. 2012, 55, 8502-8514. [CrossRef] [PubMed]
    • (2012) J. Med. Chem. , vol.55 , pp. 8502-8514
    • Chen, J.1    Zhou, H.2    Aguilar, A.3    Liu, L.4    Bai, L.5    McEachern, D.6    Yang, C.Y.7    Meagher, J.L.8    Stuckey, J.A.9    Wang, S.10
  • 198
    • 84882391806 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationships of EGCG analogues, a recently identified hsp90 inhibitor
    • [CrossRef] [PubMed]
    • Khandelwal, A.; Hall, J.A.; Blagg, B.S. Synthesis and structure-activity relationships of EGCG analogues, a recently identified hsp90 inhibitor. J. Org. Chem. 2013, 78, 7859-7884. [CrossRef] [PubMed]
    • (2013) J. Org. Chem , vol.78 , pp. 7859-7884
    • Khandelwal, A.1    Hall, J.A.2    Blagg, B.S.3
  • 202
    • 77957374909 scopus 로고    scopus 로고
    • The novel hsp-90 inhibitor SNX7081 is significantly more potent than 17-AAG against primary cll cells and a range of haematological cell lines, irrespective of lesions in the tp53 pathway
    • [CrossRef] [PubMed]
    • Best, O.G.; Singh, N.; Forsyth, C.; Mulligan, S.P. The novel hsp-90 inhibitor SNX7081 is significantly more potent than 17-AAG against primary cll cells and a range of haematological cell lines, irrespective of lesions in the tp53 pathway. Br. J. Haematol. 2010, 151, 185-188. [CrossRef] [PubMed]
    • (2010) Br. J. Haematol , vol.151 , pp. 185-188
    • Best, O.G.1    Singh, N.2    Forsyth, C.3    Mulligan, S.P.4
  • 203
  • 204
    • 84879606038 scopus 로고    scopus 로고
    • Radicicol, a heat shock protein 90 inhibitor, inhibits differentiation and adipogenesis in 3T3-L1 preadipocytes
    • [CrossRef] [PubMed]
    • He, Y.; Li, Y.; Zhang, S.; Perry, B.; Zhao, T.; Wang, Y.; Sun, C. Radicicol, a heat shock protein 90 inhibitor, inhibits differentiation and adipogenesis in 3T3-L1 preadipocytes. Biochem. Biophys. Res. Commun. 2013, 436, 169-174. [CrossRef] [PubMed]
    • (2013) Biochem. Biophys. Res. Commun , vol.436 , pp. 169-174
    • He, Y.1    Li, Y.2    Zhang, S.3    Perry, B.4    Zhao, T.5    Wang, Y.6    Sun, C.7
  • 209
    • 77952383375 scopus 로고    scopus 로고
    • New molecular and biological mechanism of antitumor activities of KW-2478, a novel nonansamycin heat shock protein 90 inhibitor, in multiple myeloma cells
    • [CrossRef] [PubMed]
    • Nakashima, T.; Ishii, T.; Tagaya, H.; Seike, T.; Nakagawa, H.; Kanda, Y.; Akinaga, S.; Soga, S.; Shiotsu, Y. New molecular and biological mechanism of antitumor activities of KW-2478, a novel nonansamycin heat shock protein 90 inhibitor, in multiple myeloma cells. Clin. Cancer Res. 2010, 16, 2792-2802. [CrossRef] [PubMed]
    • (2010) Clin. Cancer Res , vol.16 , pp. 2792-2802
    • Nakashima, T.1    Ishii, T.2    Tagaya, H.3    Seike, T.4    Nakagawa, H.5    Kanda, Y.6    Akinaga, S.7    Soga, S.8    Shiotsu, Y.9
  • 210
    • 84866342651 scopus 로고    scopus 로고
    • Discovery of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl) sulfanyl]-9h-purin-9-yl}et hyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a purine-based hsp90 inhibitor
    • [CrossRef] [PubMed]
    • Kim, S.H.; Bajji, A.; Tangallapally, R.; Markovitz, B.; Trovato, R.; Shenderovich, M.; Baichwal, V.; Bartel, P.; Cimbora, D.; McKinnon, R.; et al. Discovery of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl) sulfanyl]-9h-purin-9-yl}et hyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a purine-based hsp90 inhibitor. J. Med. Chem. 2012, 55, 7480-7501. [CrossRef] [PubMed]
    • (2012) J. Med. Chem. , vol.55 , pp. 7480-7501
    • Kim, S.H.1    Bajji, A.2    Tangallapally, R.3    Markovitz, B.4    Trovato, R.5    Shenderovich, M.6    Baichwal, V.7    Bartel, P.8    Cimbora, D.9    McKinnon, R.10
  • 211
    • 84922946712 scopus 로고    scopus 로고
    • Randomized phase II study of the X-linked inhibitor of apoptosis (XIAP) antisense AEG35156 in combination with sorafenib in patients with advanced hepatocellular carcinoma (HCC)
    • [CrossRef] [PubMed]
    • Lee, F.A.; Zee, B.C.; Cheung, F.Y.; Kwong, P.; Chiang, C.L.; Leung, K.C.; Siu, S.W.; Lee, C.; Lai, M.; Kwok, C.; et al. Randomized phase II study of the X-linked inhibitor of apoptosis (XIAP) antisense AEG35156 in combination with sorafenib in patients with advanced hepatocellular carcinoma (HCC). Am. J. Clin. Oncol. 2014. [CrossRef] [PubMed]
    • (2014) Am. J. Clin. Oncol
    • Lee, F.A.1    Zee, B.C.2    Cheung, F.Y.3    Kwong, P.4    Chiang, C.L.5    Leung, K.C.6    Siu, S.W.7    Lee, C.8    Lai, M.9    Kwok, C.10
  • 212
  • 213
    • 2342448582 scopus 로고    scopus 로고
    • Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database
    • [CrossRef] [PubMed]
    • Nikolovska-Coleska, Z.; Xu, L.; Hu, Z.; Tomita, Y.; Li, P.; Roller, P.P.; Wang, R.; Fang, X.; Guo, R.; Zhang, M.; et al. Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J. Med. Chem. 2004, 47, 2430-2440. [CrossRef] [PubMed]
    • (2004) J. Med. Chem. , vol.47 , pp. 2430-2440
    • Nikolovska-Coleska, Z.1    Xu, L.2    Hu, Z.3    Tomita, Y.4    Li, P.5    Roller, P.P.6    Wang, R.7    Fang, X.8    Guo, R.9    Zhang, M.10
  • 214
    • 79952734485 scopus 로고    scopus 로고
    • A phase I study of the heat shock protein 90 inhibitor alvespimycin (17-DMAG) given intravenously to patients with advanced solid tumors
    • [CrossRef] [PubMed]
    • Pacey, S.; Wilson, R.H.; Walton, M.; Eatock, M.M.; Hardcastle, A.; Zetterlund, A.; Arkenau, H.T.; Moreno-Farre, J.; Banerji, U.; Roels, B.; et al. A phase I study of the heat shock protein 90 inhibitor alvespimycin (17-DMAG) given intravenously to patients with advanced solid tumors. Clin. Cancer Res. 2011, 17, 1561-1570. [CrossRef] [PubMed]
    • (2011) Clin. Cancer Res , vol.17 , pp. 1561-1570
    • Pacey, S.1    Wilson, R.H.2    Walton, M.3    Eatock, M.M.4    Hardcastle, A.5    Zetterlund, A.6    Arkenau, H.T.7    Moreno-Farre, J.8    Banerji, U.9    Roels, B.10
  • 215
    • 84880739009 scopus 로고    scopus 로고
    • Trial of the hsp90 inhibitor PF-04929113 (SNX5422) in adult patients with recurrent, refractory hematologic malignancies. Clin
    • [CrossRef] [PubMed]
    • Reddy, N.; Voorhees, P.M.; Houk, B.E.; Brega, N.; Hinson, J.M., Jr.; Jillela, A. Phase I trial of the hsp90 inhibitor PF-04929113 (SNX5422) in adult patients with recurrent, refractory hematologic malignancies. Clin. Lymphoma Myeloma Leuk. 2013, 13, 385-391. [CrossRef] [PubMed]
    • (2013) Lymphoma Myeloma Leuk , vol.13 , pp. 385-391
    • Reddy, N.1    Voorhees, P.M.2    Houk, B.E.3    Brega, N.4    Hinson, J.M.5    Jillela, A.6    Phase, I.7
  • 216
    • 84861034546 scopus 로고    scopus 로고
    • Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152)
    • [CrossRef] [PubMed]
    • Flygare, J.A.; Beresini, M.; Budha, N.; Chan, H.; Chan, I.T.; Cheeti, S.; Cohen, F.; Deshayes, K.; Doerner, K.; Eckhardt, S.G.; et al. Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). J. Med. Chem. 2012, 55, 4101-4113. [CrossRef] [PubMed]
    • (2012) J. Med. Chem. , vol.55 , pp. 4101-4113
    • Flygare, J.A.1    Beresini, M.2    Budha, N.3    Chan, H.4    Chan, I.T.5    Cheeti, S.6    Cohen, F.7    Deshayes, K.8    Doerner, K.9    Eckhardt, S.G.10
  • 218
    • 84856554767 scopus 로고    scopus 로고
    • A phase II trial of 17-allylamino, 17-demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma. Investig
    • [CrossRef] [PubMed]
    • Pacey, S.; Gore, M.; Chao, D.; Banerji, U.; Larkin, J.; Sarker, S.; Owen, K.; Asad, Y.; Raynaud, F.; Walton, M.; et al. A phase II trial of 17-allylamino, 17-demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma. Investig. New Drugs 2012, 30, 341-349. [CrossRef] [PubMed]
    • (2012) New Drugs , vol.30 , pp. 341-349
    • Pacey, S.1    Gore, M.2    Chao, D.3    Banerji, U.4    Larkin, J.5    Sarker, S.6    Owen, K.7    Asad, Y.8    Raynaud, F.9    Walton, M.10
  • 219
    • 84880315330 scopus 로고    scopus 로고
    • Time-dependent inhibition and induction of human cytochrome P4503A4/5 by an oral iap antagonist, LCL161, in vitro and in vivo in healthy subjects
    • [CrossRef] [PubMed]
    • Dhuria, S.; Einolf, H.; Mangold, J.; Sen, S.; Gu, H.; Wang, L.; Cameron, S. Time-dependent inhibition and induction of human cytochrome P4503A4/5 by an oral iap antagonist, LCL161, in vitro and in vivo in healthy subjects. J. Clin. Pharmacol. 2013, 53, 642-653. [CrossRef] [PubMed]
    • (2013) J. Clin. Pharmacol , vol.53 , pp. 642-653
    • Dhuria, S.1    Einolf, H.2    Mangold, J.3    Sen, S.4    Gu, H.5    Wang, L.6    Cameron, S.7
  • 221
    • 84882861205 scopus 로고    scopus 로고
    • Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists
    • [CrossRef] [PubMed]
    • Asano, M.; Hashimoto, K.; Saito, B.; Shiokawa, Z.; Sumi, H.; Yabuki, M.; Yoshimatsu, M.; Aoyama, K.; Hamada, T.; Morishita, N.; et al. Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists. Bioorg. Med. Chem. 2013, 21, 5725-5737. [CrossRef] [PubMed]
    • (2013) Bioorg. Med. Chem. , vol.21 , pp. 5725-5737
    • Asano, M.1    Hashimoto, K.2    Saito, B.3    Shiokawa, Z.4    Sumi, H.5    Yabuki, M.6    Yoshimatsu, M.7    Aoyama, K.8    Hamada, T.9    Morishita, N.10
  • 222
    • 80052330412 scopus 로고    scopus 로고
    • Multicenter phase II trial of the heat shock protein 90 inhibitor, retaspimycin hydrochloride (IPI-504), in patients with castration-resistant prostate cancer
    • [CrossRef] [PubMed]
    • Oh, W.K.; Galsky, M.D.; Stadler, W.M.; Srinivas, S.; Chu, F.; Bubley, G.; Goddard, J.; Dunbar, J.; Ross, R.W. Multicenter phase II trial of the heat shock protein 90 inhibitor, retaspimycin hydrochloride (IPI-504), in patients with castration-resistant prostate cancer. Urology 2011, 78, 626-630. [CrossRef] [PubMed]
    • (2011) Urology , vol.78 , pp. 626-630
    • Oh, W.K.1    Galsky, M.D.2    Stadler, W.M.3    Srinivas, S.4    Chu, F.5    Bubley, G.6    Goddard, J.7    Dunbar, J.8    Ross, R.W.9
  • 223
    • 67650456926 scopus 로고    scopus 로고
    • The inhibitor of apoptosis protein livin (ML-IAP) plays a dual role in tumorigenicity
    • [CrossRef] [PubMed]
    • Abd-Elrahman, I.; Hershko, K.; Neuman, T.; Nachmias, B.; Perlman, R.; Ben-Yehuda, D. The inhibitor of apoptosis protein livin (ML-IAP) plays a dual role in tumorigenicity. Cancer Res. 2009, 69, 5475-5480. [CrossRef] [PubMed]
    • (2009) Cancer Res , vol.69 , pp. 5475-5480
    • Abd-Elrahman, I.1    Hershko, K.2    Neuman, T.3    Nachmias, B.4    Perlman, R.5    Ben-Yehuda, D.6


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