Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/caspase-3 interaction

Chemistry and Biology

Volumn 10, Issue 8, 2003, Pages 759-767

  Wu, Tom Y H ^a   Wagner, Klaus W ^b   Bursulaya, Badry ^b   Schultz, Peter G ^a,b   Deveraux, Quinn L ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTRACISTERNAL A-PARTICLES; MAMMALIA; VERTEBRATA;

EID: 0041913978     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(03)00157-1     Document Type: Article

References (23)

1. Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell. 100:2000;57-70.
2. Huang Z. The chemical biology of apoptosis. exploring protein-protein interactions and the life and death of cells with small molecules Chem. Biol. 9:2002;1059-1072.
3. Salvesen G.S., Duckett C.S. IAP proteins. blocking the road to death's door Nat. Rev. Mol. Cell Biol. 3:2002;401-410.
4. Holcik M., Korneluk R.G. XIAP, the guardian angel. Nat. Rev. Mol. Cell Biol. 2:2001;550-556.
5. Morris M.J., Tong W.P., Cordon-Cardo C., Drobnjak M., Kelly W.K., Slovin S.F., Terry K.L., Siedlecki K., Swanson P., Rafi M.et al. Phase I trial of BCL-2 antisense oligonucleotide (G3139) administered by continuous intravenous infusion in patients with advanced cancer. Clin. Cancer Res. 8:2002;679-683.
6. Deveraux Q.L., Takahashi R., Salvesen G.S., Reed J.C. X-linked IAP is a direct inhibitor of cell-death proteases. Nature. 388:1997;300-304.
7. Chai J., Shiozaki E., Srinivasula S.M., Wu Q., Dataa P., Alnemri E.S., Shi Y. Structural basis of caspase-7 inhibition by XIAP. Cell. 104:2001;769-780.
8. Huang Y., Park Y.C., Rich R.L., Segal D., Myszka D.G., Wu H. Structural basis of caspase inhibition by XIAP. differential roles of the linker versus the BIR domain Cell. 104:2001;781-790.
9. Riedl S.J., Renatus M., Schwarzenbacher R., Zhou Q., Sun C., Fesik S.W., Liddington R.C., Salvesen G.S. Structural basis for the inhibition of caspase-3 by XIAP. Cell. 104:2001;791-800.
10. Deveraux Q.L., Leo E., Stennicke H.R., Welsh K., Salvesen G.S., Reed J.C. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J. 18:1999;5242-5251.
11. Du C., Fang M., Li Y., Li L., Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell. 102:2000;33-42.
12. Liu Z., Sun C., Olejniczak E.T., Meadows R.P., Betz S.F., Oost T., Herrmann J., Wu J.C., Fesik S.W. Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain. Nature. 408:2001;1004-1008.
13. Wu G., Chai J., Suber T.L., Wu J.-W., Du C., Wang X., Shi Y. Structural basis of IAP recognition by Smac/DIABLO. Nature. 408:2001;1008-1012.
14. Shiozaki E.N., Chai J., Rigotti D.J., Riedl S.J., Li P., Srinivasula S.M., Alnemri E.S., Fairman R., Shi Y. Mechanism of XIAP-mediated inhibition of caspase-9. Mol. Cell. 11:2003;519-527.
15. Kipp R.A., Case M.A., Wist A.D., Cresson C.M., Carrell M., Griner E., Wiita A., Albiniak P.A., Chai J., Shi Y.et al. Molecular targeting of inhibitor of apoptosis proteins based on small molecule mimics of natural binding partners. Biochemistry. 41:2002;7344-7349.
16. Chia J., Du C., Wu J.-W., Kyin S., Wang X., Shi Y. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature. 406:2000;855-862.
17. Deveraux Q.L., Welsh K., Reed J.C. Purification and use of recombinant inhibitor of apoptosis proteins as caspase inhibitors. Methods Enzymol. 322:2000;154-161.
18. 2A antagonist Bioorg. Med. Chem. Lett. 10:2000;2693-2696.
19. Wolfe J.P., Tomori H., Sadighi J.P., Yin J., Buchwald S.L. Simple, efficient catalyst system for the palladium-catalyzed amination of aryl chlorides, bromides, and triflates. J. Org. Chem. 65:2000;1144-1157.
20. Wajant H., Pfizenmaier K., Scheurich P. TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy. Apoptosis. 7:2002;449-459.
21. Deng Y., Lin Y., Wu X. TRIAL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO. Genes Dev. 16:2002;33-45.
22. LeBlanc H., Lawrence D., Varfolomeev E., Totpal K., Morlan J., Schow P., Fong S., Schwall R., Sinicropi D., Ashkenazi A. Tumor-cell resistance to death receptor-induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog bax. Nat. Med. 8:2002;274-281.
23. Stenicke H.R., Salvesen G.S. Caspase assays. Methods Enzymol. 332:2000;91-100.