Mcl-1 deficiency results in peri-implantation embryonic lethality

Genes and Development

Volumn 14, Issue 1, 2000, Pages 23-27

  Rinkenberger, Julie L ^a   Horning, Susan ^a   Klocke, Barbara ^a   Roth, Kevin ^a   Korsmeyer, Stanley J ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Bcl 2 family; Blastocyst; Embryo; Implantation; Mcl 1

Indexed keywords

ONCOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLASTOCYST; CONTROLLED STUDY; EMBRYO DEATH; GENE DISRUPTION; MOUSE; NIDATION; NONHUMAN; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL; STEM CELL;

ANIMALS; APOPTOSIS; CROSSES, GENETIC; EMBRYO IMPLANTATION; FEMALE; FETAL DEATH; HUMANS; IN SITU HYBRIDIZATION; IN SITU NICK-END LABELING; NEOPLASM PROTEINS; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-BCL-2;

ANIMALIA; MAMMALIA; MURINAE;

EID: 0033954132     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Behrendtsen, O. and Z. Werb. 1997. Metalloproteinases regulate parietal endoderm differentiating and migrating in cultured mouse embryos. Dev. Dyn. 208: 255-265.
2. Bodrug, S.E., C. Aime-Sempe, T. Sato, S. Krajewski, M. Hanada, and J.C. Reed. 1995. Biochemical and functional comparisons of Mcl-1 and Bcl-2 proteins: Evidence for a novel mechanism of regulating Bcl-2 family protein function. Cell Death Differ. 2: 173-182.
3. Deckwerth, T.L., J.L. Elliott, C.M. Knudson, E.M. Johnson, Jr., W.D. Snider, and S.J. Korsmeyer. 1996. BAX is required for neuronal death after trophic factor deprivation and during development. Neuron 17:401-411.
4. El-Shershaby, A.M. and J.R. Hinchliffe. 1974. Cell redundancy in the zona-intact preimplantation mouse blastocyst: A light and electron microscope study of dead cells and their fate. J. Embryol. Exp. Morphol. 31: 643-654.
5. Fassler, R. and M. Meyer. 1995. Consequences of lack of β 1 integrin gene expression in mice. Genes & Dev. 9: 1896-1908.
6. Guillemot, F., A. Nagy, A. Auerbach, J. Rossant, and A.L. Joyner. 1994. Essential role of Mash-2 in extraembryonic development. Nature 371: 333-336.
7. Hakem, R., J.L. de la Pompa, C. Sirard, R. Mo, M. Woo, A. Hakem, A. Wakeham, J. Potter, A. Reitmair, F. Billia et al. 1996. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell 85: 1009-1023.
8. Handyside, A.H. and S. Hunter. 1986. Cell division and death in the mouse blastocyst before implantation. Wilhelm Roux's Arch. Dev. Biol. 195: 519-526.
9. Jones, S.N., A.E. Roe, L.A. Donehower, and A. Bradley. 1995. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378: 206-208.
10. Knudson, C.M., K.S. Tung, W.G. Tourtellotte, G.A. Brown, and S.J. Korsmeyer. 1995. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270:96-99.
11. Kozopas, K.M., T. Yang, H.L. Buchan, P. Zhou, and R.W. Craig. 1993. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc. Natl. Acad. Sci. 90: 3516-3520.
12. Krajewski, S., S. Bodrug, R. Gascoyne, K. Berean, M. Krajewska, and J.C. Reed. 1994. Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes. Am. J. Pathol. 145: 515-525.
13. Krajewski, S., S. Bodrug, M. Krajewska, A. Shabaik, R. Gascoyne, K. Berean, and J.C. Reed. 1995. Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo. Am. J. Pathol. 146: 1309-1319.
14. Larue, L., M. Ohsugi, J. Hirchenhain, and R. Kemler. 1994. E-cadherin null mutant embryos fail to form a trophectoderm epithelium. Proc. Natl. Acad. Sci. 91: 8263-8267.
15. Lim, D.S. and P. Hasty. 1996. A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol. Cell. Biol. 16: 7133-7143.
16. Liu, C.Y., A. Flesken-Nikitin, S. Li, Y. Zeng, and W.H. Lee. 1996. Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes & Dev. 10: 1835-1843.
17. Matsui, M., M. Oshima, H. Oshima, K. Takaku, T. Maruyama, J. Yodoi, and M.M. Taketo. 1996. Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene. Dev. Biol. 178: 179-185.
18. Montes de Oca Luna, R., D.S. Wagner, and G. Lozano. 1995. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378: 203-206.
19. Motoyama, N., F. Wang, K.A. Roth, H. Sawa, K. Nakayama, I. Negishi, S. Senju, Q. Zhang, S. Fujii and D.Y. Loh. 1995. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267: 1506-1510.
20. Print, C.G., K.L. Loveland, L. Gibson, T. Meehan, A. Stylianou, N. Wreford, D. de Kretser, D. Metcalf, F. Kontgen, J.M. Adams, and S. Cory. 1998. Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant. Proc. Natl. Acad. Sci. 95: 12424-12431.
21. Ratts, V.S., J.A. Flaws, R. Kolp, C.M. Sorenson, and J.L. Tilly. 1995. Ablation of bcl-2 gene expression decreases the numbers of oocytes and primordial follicles established in the post-natal female mouse gonad. Endocrinology 136: 3665-3668.
22. Reynolds, J.E., T. Yang, L. Qian, J.D. Jenkinson, P. Zhou, A. Eastman, and R.W. Craig. 1994. Mcl-1, a member of the Bcl-2 family, delays apoptosis induced by c-Myc overexpression in Chinese hamster ovary cells. Cancer Res. 54: 6348-6352.
23. Reynolds, J.E., J. Li, R.W. Craig, and A. Eastman. 1996. BCL-2 and MCL-1 expression in Chinese hamster ovary cells inhibits intracellular acidification and apoptosis induced by staurosporine. Exp. Cell. Res. 225: 430-436.
24. Riethmacher, D., V. Brinkmann, and C. Birchmeier. 1995. A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development. Proc. Natl. Acad. Sci. 92: 855-859.
25. Rinkenberger, J.L., J.C. Cross, and Z. Werb. 1997. Molecular genetics of implantation in the mouse. Dev. Genet. 21: 6-20.
26. Ross, A.J., K.G. Waymire, J.E. Moss, A.F. Parlow, M.K. Skinner, L.D. Russell, and G.R. MacGregor. 1998. Testicular degeneration in Bclw-deficient mice. Nat. Genet. 18: 251-256.
27. Stephens, L.E., A.E. Sutherland, I.V. Klimanskaya, A. Andrieux, J. Meneses, R.A. Pedersen, and C.H. Damsky. 1995. Deletion of β 1 integrins in mice results in inner cell mass failure and peri-implantation lethality. Genes & Dev. 9: 1883-1895.
28. Torres, M., A. Stoykova, O. Huber, K. Chowdhury, P. Bonaldo, A. Mansouri, S. Butz, R. Kemler, and P. Gruss. 1997. An alpha-E-catenin gene trap mutation defines its function in preimplantation development. Proc. Natl. Acad. Sci. 94: 901-906.
29. Veis, D.J., C.M. Sorenson, J.R. Shutter, and S.J. Korsmeyer. 1993. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75: 229-240.
30. Welsh, A.O. 1993. Uterine cell death during implantation and early placentation. Microsc. Res. Tech. 25:223-245.
31. Wilcox, A.J., C.R. Weinberg, J.F. O'Connor, D.D. Baird, J.P. Schlatterer, R.E. Canfield, E.G. Armstrong, and B.C. Nisula. 1988. Incidence of early loss of pregnancy. N. Engl. J. Med. 319: 189-194.
32. Wilkinson, D.G. and M.A. Nieto. 1993. Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. Methods Enzymol. 225: 361-373.
33. Xanthoudakis, S., R.J. Smeyne, J.D. Wallace, and T. Curran. 1996. The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. Proc. Natl. Acad. Sci. 93: 8919-8923.
34. Yang, T., K.M. Kozopas, and R.W. Craig. 1995. The intracellular distribution and pattern of expression of Mcl-1 overlap with, hut are not identical to, those of Bcl-2. J. Cell. Biol 128: 1173-1184.
35. Yang, T., H.L. Buchan, K.J. Townsend, and R.W. Craig. 1996. MCL-1, a member of the BLC-2 family, is induced rapidly in response to signals for cell differentiation or death, but not to signals for cell proliferation. J. Cell. Physiol. 166: 523-536.
36. Zha, J., H. Harada, E. Yang, J. Jockel, and S.J. Korsmeyer. 1996. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 87: 619-628.
37. Zhou, P., L. Qian, K.M. Kozopas, and R.W. Craig. 1997. Mcl-1, a Bcl-2 family member, delays the death of hematopoietic cells under a variety of apoptosis-inducing conditions. Blood 89: 630-643.
38. Zhou, P., L. Qian, C.K. Bieszczad, R. Noelle, M. Binder, N.B. Levy, and R.W. Craig. 1998. Mcl-1 in transgenic mice promotes survival in a spectrum of hematopoietic cell types and immortalization in the myeloid lineage. Blood 92: 3226-3639.