Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype

Science

Volumn 275, Issue 5302, 1997, Pages 967-969

  Rampino, Nicholas ^a   Yamamoto, Hiroyuki ^a   Ionov, Yurij ^a   Li, Yan ^a   Sawai, Hisako ^a   Reed, John C ^a   Perucho, Manuel ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYGUANOSINE; MICROSATELLITE DNA; PROTEIN BAX;

ARTICLE; COLON CANCER; COLON CARCINOGENESIS; DNA SEQUENCE; FRAMESHIFT MUTATION; GENE DELETION; GENE FREQUENCY; GENE REPRESSION; GENETIC STABILITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PHENOTYPE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SOMATIC MUTATION; TUMOR CELL LINE;

ADENOCARCINOMA; ALLELES; APOPTOSIS; BASE SEQUENCE; BCL-2-ASSOCIATED X PROTEIN; COLONIC NEOPLASMS; FRAMESHIFT MUTATION; GENE EXPRESSION; GENES, TUMOR SUPPRESSOR; HUMANS; MICROSATELLITE REPEATS; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SEQUENCE DELETION; TUMOR CELLS, CULTURED;

EID: 0031018674     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.275.5302.967     Document Type: Article

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39. We thank D. Casacuberta for comments on the manuscript and G. Wahl for his gift of the CAL51 cell line. Supported by NIH grants CA63585 and CA38579. H.Y. is a postdoctoral fellow from the Japan Society for the Promotion of Science.