A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors

EMBO Journal

Volumn 15, Issue 11, 1996, Pages 2685-2694

  Colin, S Duckett ^a   Nava, Victor E ^c   Gedrich, Richard W ^a,b   Clem, Rollie J ^c   Van Dongen, Jennifer L ^a,b   Gilfillan, Molly C ^a   Shiels, Helena ^a   Hardwick, J Marie ^c   Thompson, Craig B ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; iap; Molecular cloning; Programmed cell death; Viruses

Indexed keywords

CYTOPLASM PROTEIN; PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BACULOVIRUS; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CELL STRAIN BHK; CONTROLLED STUDY; DATA BASE; GENE SEQUENCE; HUMAN CELL; MAMMAL CELL; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; VIRUS GENE;

EID: 15844425961     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00629.x     Document Type: Article

References (57)

1. Beidler,D.R., Tewari,M., Friesen,P.D., Poirier,G. and Dixit,V.M. (1995) The haculovirus p35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis. J. Biol. Chem., 270, 16526-16528.
2. Birnbaum,M.J., Clem,R.J. and Miller,L.K. (1994) An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs. J. Virol., 68, 2521-2528.
3. Bishop,J.M. (1991) Molecular themes in oncogenesis. Cell, 64, 235-248.
4. Blake,T.J., Shapiro,M., Morse,H.C.,III and Langdon,W.Y. (1991) The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif. Oncogene, 6, 653-657.
5. Boise,L.H., González-García,M., Postema,C.E., Ding,L., Lindsten,T., Turka,L. A., Mao,X., Nuñez,G. and Thompson,C.B. (1993) bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell, 74, 597-608.
6. Borden,K.L., Boddy,M.N., Lally,J., O'Reilly,N.J., Martin,S., Howe,K., Solomon,E. and Freemont,P.S. (1995) The solution structure of the RING finger domain from the acute promyelocytic leukaemia protooncoprotein PML. EMBO J., 14, 1532-1541.
7. Bump,N.J. et al. (1995) Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35. Science, 269, 1885-1888.
8. Cavener,D.R. and Ray,S.C. (1991) Eukaryotic start and stop translation sites. Nucleic Acids Res., 19, 3185-3192.
9. Cheng,G., Cleary,A.M., Ye,Z.-s., Hong,D.I., Lederman,S. and Baltimore,D. (1995) Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science, 267, 1494-1498.
10. Chiou,S.K., Tseng,C.C., Rao,L. and White,E. (1994) Functional complementation of the adenovirus E1B 10-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells. J. Virol., 68, 6553-6566.
11. Clem,R.J. and Miller,L.K. (1993) Apoptosis reduces both the in vitro replication and the in vivo infectivity of a baculovirus. J. Virol., 67, 3730-3738.
12. Clem,R.J. and Miller,L.K. (1994a) Induction and inhibition of apoptosis by insect viruses. In Tomei,L.D. and Cope,F.O. (eds), Apoptosis II: The Molecular Basis of Apoptosis in Disease. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 89-110.
13. Clem,R.J. and Miller,L.K. (1994b) Control of programmed cell death by the baculovirus genes p35 and iap. Mol. Cell. Biol., 14, 5212-5222.
14. Clem,R.J., Fechheimer,M. and Miller,L.K. (1991) Prevention of apoptosis by a baculovirus gene during infection of insect cells. Science, 254, 1388-1390.
15. Crook,N.E., Clem,R.J. and Miller,L.K. (1993) An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif. J. Virol., 67, 2168-2174.
16. de The,H., Lavau,C., Marchio,A., Chomienne,C., Degos,L. and Dejean,A. (1991) The PML-RAR alpha fusion mRNA generated by the t(15:17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell, 66, 675-684.
17. Debbas,M. and White,E. (1993) Wild-type p53 mediates apoptosis by E1A, which is inhibited by EIB. Genes Dev., 7, 546-554.
18. Duckett,C.S., Perkins,N.D., Kowalik,T.F., Schmid,R.M., Huang,E.S., Baldwin,A.S., Jr and Nabel,G.J. (1993) Dimerization of NF-κB2 with RelA(p65) regulates DNA binding, transcriptional activation and inhibition by an I kappa B-alpha (MAD-3). Mol Cell. Biol., 13, 1315-1322.
19. Farrow,S.N., White,J.H., Martinou,I., Raven,T., Pun,K.T., Grinham,C.J., Martinou,J.C. and Brown,R. (1995) Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K. Nature, 374, 731-733.
20. Fernandes-Alnemri,T., Litwack,G. and Alnemri,E.S. (1995) Mch2, a new member of the apoptotic Ced-3/ICE cysteine protease gene family. Cancer Res., 55, 2737-2742.
21. Friesen,P.D. and Miller,L.K. (1987) Divergent transcription of early 35 and 94-kilodalton protein genes encoded by the HindIII K genome fragment of the baculovirus Autographa californica nuclear polyhedrosis virus. J. Virol., 61, 2264-2272.
22. Gagliardini,V., Fernandez,P.A., Lee,R.K., Drexler,H.C., Rotello,R.J., Fishman,M.C. and Yuan,J. (1994) Prevention of vertebrate neuronal death by the crmA gene. Science, 263, 826-828.
23. Gorman,C.M., Moffat,L.F. and Howard,B.H. (1982) Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Bio., 2, 1044-1051.
24. Henderson,S., Huen,D., Rowe,M., Dawson,C., Johnson,G. and Rickinson,A. (1993) Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death. Proc. Natl Acad. Sci. USA, 90, 8479-8483.
25. Hershberger,P.A., Dickson,J.A. and Friesen,P.D. (1992) Site-specific mutagenesis of the 35-kilodalton protein gene encoded by Autographa californica nuclear polyhedrosis virus: cell line-specific effects on virus replication. J. Virol., 66, 5525-5533.
26. Hershberger,P.A., LaCount,D.J. and Friesen,P.D. (1994) The apoptotic suppressor p35 is required early during baculovirus replication and is targeted to the cytosol of infected cells. J. Virol., 68, 3467-3477.
27. Hertz,J.M. and Huang,H.V. (1992) Utilization of heterologous alphavirus junction sequences as promoters by Sindbis virus. J. Virol., 66, 857-864.
28. Hsiao,K.-c. (1991) A fast and simple procedure for sequencing double stranded DNA with Sequenase. Nucleic Acids Res., 19, 2787.
29. Hu,H.M., O'Rourke,K., Boguski,M.S. and Dixit,V.M. (1994) A novel RING finger protein interacts with the cytoplasmic domain of CD40. J. Biol. Chem., 269, 30069-30072.
30. June,C.H., Ledbetter,J.A., Gillespie,M.M., Lindsten,T. and Thompson, C.B. (1987) T-cell proliferation involving the CD28 pathway is associated with cyclosporin-resistant interleukin 2 gene expression. Mol. Cell. Biol., 7, 4472-4481.
31. Kamita,S.G., Majima,K. and Maeda,S. (1993) Identification and characterization of the p35 gene of Bombyx mori nuclear polyhedrosis virus that prevents virus-induced apoptosis. J. Virol., 67, 455-463.
32. Komiyama,T., Ray,C.A., Pickup,D.J., Howard,A.D., Thornberry,N.A., Peterson,E.P. and Salvesen,G. (1994) Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition. J. Biol. Chem., 269, 19331-19337.
33. Kumar,S., Kinoshita,M., Noda,M., Copeland,N.G. and Jenkins,N.A. (1994) Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1β-converting enzyme. Genes Dev., 8, 1613-1626.
34. Levine,B., Huang,Q., Isaacs,J.T., Reed,J.C., Griffin,D.E. and Hardwick, J.M. (1993) Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene. Nature, 361, 739-742.
35. Los,M. et al. (1995) Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis. Nature, 375, 81-83.
36. Lovering,R. et al. (1993) Identification and preliminary characterization of a protein motif related to the zinc finger. Proc. Natl Acad. Sci. USA, 90, 2112-2116.
37. Lustig,S., Jackson,A.C., Hahn,C.S., Griffin,D.E., Strauss,E.G. and Strauss,J.H. (1988) Molecular basis of Sindbis virus neurovirulence in mice. J. Virol., 62, 2329-2336.
38. Miura,M., Zhu,H., Rotello,R., Hartwieg,E.A. and Yuan,J. (1993) Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C.elegans cell death gene ced-3. Cell, 75, 653-660.
39. Oltvai,Z.N. and Korsmeyer,S.J. (1994) Checkpoints of dueling dimers foil death wishes. Cell, 79, 189-192.
40. Perkins,N.D., Agranoff,A.B., Duckett,C.S. and Nabel,G.J. (1994) Transcription factor AP-2 regulates human immunodeficiency virus type 1 gene expression. J. Virol., 68, 6820-6823.
41. Rabizadeh,S., LaCount,D.J., Friesen,P.D. and Bredesen,D.E. (1993) Expression of the baculovirus p35 gene inhibits mammalian neural cell death. J. Neurochem., 61, 2318-2321.
42. Ross,J.L., Davis,M.B., MacIntyre,R.J. and McKechnie,S.W. (1994) A model of the Drosophila melanogaster glycerol-3-phosphate oxidase-encoding gene. Gene, 139, 219-221.
43. Rothe,M., Wong,S.C., Henzel,W.J. and Goeddel,D.V. (1994) A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell, 78, 681-692.
44. Roy,N. et al. (1995) The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Cell, 80, 167-178.
45. Sabbatini,P., Chiou,S.K., Rao,L. and White,E. (1995) Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein. Mol. Cell. Biol., 15, 1060-1070.
46. Sato,T., Irie,S. and Reed,J.C. (1995) A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. FEBS Lett., 358, 113-118.
47. Song,H.Y. and Donner,D.B. (1995) Association of a RING finger protein with the cytoplasmic domain of the human type 2 TNF receptor. Biochem. J., 309, 825-829.
48. Tewari,M. and Dixit,V.M. (1995) Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J. Biol. Chem., 270, 3255-3260.
49. Tewari,M., Quan,L.T., O'Rourke,K., Desnoyers,S., Zeng,Z., Beidler, D.R., Poirier,G.G., Salvesen,G.S. and Dixit,V.M. (1995) Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell, 81, 801-809.
50. Thornberry,N.A. et al. (1992) A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature, 356, 768-774.
51. Vaux,D.L., Haecker,G. and Strasser,A. (1994) An evolutionary perspective on apoptosis. Cell, 76, 777-779.
52. Wang,L., Miura,M., Bergeron,L., Zhu,H. and Yuan,J. (1994) Ich-1 and Icelced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell, 78, 739-750.
53. White,E. (1993) Death-defying acts: a meeting review on apoptosis. Genes Dev., 7, 2277-2284.
54. White,E. and Gooding,L.R. (1994) Regulation of apoptosis by human adenoviruses. In Tomei,L.D. and Cope,F.O. (eds), Apoptosis II: The Molecular Basis of Apoptosis in Disease. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 111-141.
55. White,K., Grether,M.E., Abrams,J.M., Young,L., Farrell,K. and Steller,H. (1994) Genetic control of programmed cell death in Drosophila. Science, 264, 677-683.
56. Xue,D. and Horvitz,H.R. (1995) Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein. Nature, 377, 248-251.
57. Yuan,J., Shaham,S., Ledoux,S., Ellis,H.M. and Horvitz,H.R. (1993) The C.elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell, 75, 641-652.