Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP

Journal of the American Chemical Society

Volumn 129, Issue 49, 2007, Pages 15279-15294

  Sun, Haiying ^a   Nikolovska Coleska, Zaneta ^a   Lu, Jianfeng ^a   Meagher, Jennifer L ^a   Yang, Chao Yie ^a   Qiu, Su ^a   Tomita, York ^c   Ueda, Yumi ^c   Jiang, Sheng ^d   Krajewski, Krzysztof ^d   Roller, Peter P ^d   Stuckey, Jeanne A ^a,b   Wang, Shaomeng ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEUKEMIA CELL LINE; SMAC PROTEIN; XIAP;

BIOASSAY; CELL DEATH; CHARACTERIZATION; ENZYME INHIBITION; INITIATORS (CHEMICAL); SYNTHESIS (CHEMICAL);

PROTEINS;

INHIBITOR OF APOPTOSIS PROTEIN; N,N' [1,1' [4,4' (1,4 PHENYLENE)BIS(BUTANE 4,1 DIYL)BIS(1H 1,2,3, TRIAZOLE 4,1 DIYL)]BIS(PHENYLMETHYLENE)]BIS[6 2 (METHYLAMINO)PROPANAMIDO) 5 OXODECAHYDROYRROL[1,2 A]AZOCINE 3 CARBOXAMIDE]; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SM 164; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CELL ASSAY; CELL GROWTH; CELL PERMEABILIZATION; CELL STRAIN HL 60; CONTROLLED STUDY; HUMAN; HUMAN CELL; IC 50; MOLECULAR MODEL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING, COMPETITIVE; BIOMIMETIC MATERIALS; CASPASES; DRUG DESIGN; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; MITOCHONDRIAL PROTEINS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, TERTIARY; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 37049019494     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja074725f     Document Type: Article

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