Discovery of Embelin as a Cell-Permeable, Small-Molecular Weight Inhibitor of XIAP through Structure-Based Computational Screening of a Traditional Herbal Medicine Three-Dimensional Structure Database

Journal of Medicinal Chemistry

Volumn 47, Issue 10, 2004, Pages 2430-2440

  Nikolovska Coleska, Zaneta ^a   Xu, Liang ^a   Hu, Zengjian ^a   Tomita, York ^b   Li, Peng ^c   Roller, Peter P ^c   Wang, Renxiao ^a   Fang, Xueliang ^a   Guo, Ribo ^a   Zhang, Manchao ^a   Lippman, Marc E ^a   Yang, Dajun ^a   Wang, Shaomeng ^a  

^a UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 9; EMBELIN; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER RESISTANCE; CELL GROWTH; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; HERBAL MEDICINE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; ARDISIA; BENZOQUINONES; CASPASE 9; CASPASES; CELL DIVISION; CELL LINE, TUMOR; COMPUTER SIMULATION; DATABASES, FACTUAL; DRUG SCREENING ASSAYS, ANTITUMOR; DRUGS, CHINESE HERBAL; ENZYME ACTIVATION; FLUORESCENCE POLARIZATION; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PLANT PREPARATIONS; PROTEINS; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 2342448582     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030420+     Document Type: Article

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