Preclinical antitumor activity of the novel heat shock protein 90 inhibitor CH5164840 against human epidermal growth factor receptor 2 (HER2)-overexpressing cancers

Cancer Science

Volumn 103, Issue 2, 2012, Pages 342-349

  Ono, Naomi ^a   Yamazaki, Toshikazu ^a   Nakanishi, Yoshito ^a   Fujii, Toshihiko ^a   Sakata, Kiyoaki ^a   Tachibana, Yukako ^a   Suda, Atsushi ^a   Hada, Kihito ^a   Miura, Takaaki ^a   Sato, Shigeo ^a   Saitoh, Ryoichi ^a   Nakano, Kohnosuke ^a   Tsukuda, Takuo ^a   Mio, Toshiyuki ^a   Ishii, Nobuya ^a   Kondoh, Osamu ^a   Aoki, Yuko ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CH 5164840; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HEAT SHOCK PROTEIN 90 INHIBITOR; LAPATINIB; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER REGRESSION; CANCER TISSUE; CELL ASSAY; CELL PROLIFERATION; CONTROLLED STUDY; DRUG BINDING; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG TOLERABILITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER; SURFACE PLASMON RESONANCE; TUMOR XENOGRAFT; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BENZOQUINONES; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASMS; ONCOGENE PROTEIN V-AKT; QUINAZOLINES; RECEPTOR, ERBB-2; STOMACH NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84856471585     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2011.02144.x     Document Type: Article

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