Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3

Nature Cell Biology

Volumn 3, Issue 2, 2001, Pages 183-191

  Tzung, Shie Pon ^a   Kim, Kristine M ^b   Basãez, Gorka ^c   Giedt, Chris D ^b   Simon, Julian ^b   Zimmerberg, Joshua ^c   Zhang, Kam Y J ^b   Hockenbery, David M ^b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMYCIN A1; PROTEIN BCL 2; TUMOR NECROSIS FACTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL DEATH; CELL RESPIRATION; CELL SURVIVAL; COMPETITIVE INHIBITION; ELECTRON TRANSPORT; GENE DELETION; MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; SEQUENCE HOMOLOGY;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMYCIN A; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-X PROTEIN; CELL LINE; FLOW CYTOMETRY; HEPATOCYTES; IMMUNOBLOTTING; LIPOSOMES; MEMBRANE PROTEINS; MICE; MITOCHONDRIA; MITOCHONDRIAL SWELLING; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT PROTEINS; TRANSFECTION;

ANIMALIA;

EID: 0035147650     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/35055095     Document Type: Article

References (48)

1. Bcl-2-family proteins: The role of the BH3 domain in apoptosis
2. A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions
3. Structure of Bcl-xL-Bak peptide complex: Recognition between regulators of apoptosis
4. Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases
5. Regulation of apoptosis by BH3 domains in a cell-free system
6. Mitochondrial control of apoptosis
7. Mitochondria and apoptosis
8. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo
9. Mitochondrial control of nuclear apoptosis
10. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
11. Molecular characterization of mitochondrial apoptosis-inducing factor
12. Apoptosis in cancer therapy: Crossing the threshold
13. Expression of Bcl-xL can confer a multidrug resistance phenotype
14. Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents
15. JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess ΔΨ changes in intact cells: Implications for studies on mitochondrial functionality during apoptosis
16. A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethy lbenzimidazolcarbocyanine iodide (JC-1)
17. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1
18. Mitochondrial proliferation and paradoxical membrane depolarization during terminal differentiation and apoptosis in a human colon carcinoma cell line
19. BAX-induced cell death may not require interleukin-1-converting enzyme-like proteases
20. The mitochondrial permeability transition
21. Participation of inorganic phosphate in the chemiosmotic mechanism of mitochondrial energy transduction
22. Structure-based strategies for drug design and discovery
23. The allosteric binding of antimycin to cytochrome b in the mitochondrial membrane
24. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria
25. A model of antimycin A binding based on structure-activity studies of synthetic antimycin A analogues
26. Structural factors of antimycin A molecule required for inhibitory action
27. The isolation and properties of antimycin A
28. 1 complex from bovine heart mitochondria
29. Expression of BCL-2 protein enhances the survival of mouse fibrosarcoid cells in tumor necrosis factor-mediated cytotoxicity
30. Bax interacts with the permeability transition pore to induce permeability, transition and cytochrome c release in isolated mitochondria
31. Solution structure of the proapoptotic molecule BID: A structural basis for apoptotic agonists and antagonists
32. Bcl-x(L) forms an ion channel in synthetic lipid membranes
33. Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange
34. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
35. The thiol crosslinking agent diamide overcomes the apoptosis-inhibitory effect of Bcl-2 by enforcing mitochondrial permeability transition
36. Conversion of Bcl-2 to a Bax-like death effector by caspases
37. Modulation of cell death by Bcl-XL through caspase interaction
38. Inhibition of virus-induced neuronal apoptosis by Bax
39. Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors
40. Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak
41. The effect of antimycin A on mouse liver inner mitochondrial membrane channel activity
42. Autonomous growth in serumfree medium and production of hepatocellular carcinomas by differentiated hepatocyte lines that overexpress transforming growth factor alpha 1
43. Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha
44. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
45. Vesicles of variable sizes produced by a rapid extrusion procedure
46. Colorimetric determination of phospholipids with ammonium ferrothiocyanate
47. The chemistry of antimycin A X: Structure of the antimycins