Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer

Journal of Medicinal Chemistry

Volumn 47, Issue 18, 2004, Pages 4417-4426

  Oost, Thorsten K ^a,e   Sun, Chaohong ^a   Armstrong, Robert C ^b   Al Assaad, Ali Samer ^b   Betz, Stephen F ^c   Deckwerth, Thomas L ^b   Ding, Hong ^a   Elmore, Steven W ^a   Meadows, Robert P ^d   Olejniczak, Edward T ^a   Oleksijew, Andrew ^a   Oltersdorf, Tilman ^b   Rosenberg, Saul H ^a   Shoemaker, Alexander R ^a   Tomaselli, Kevin J ^b   Zou, Hua ^b   Fesik, Stephen W ^a,f  

^a ABBOTT LABORATORIES   (United States)

^b PFIZER INC   (United States)

^c NEUROCRINE BIOSCIENCES INC   (United States)

^d Ferring Pharmaceuticals AS   (Denmark)

^e ABBOTT GMBH AND CO KG   (Germany)

^f Bldg AP10 LL ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; N METHYLALANYL TERT LEUCYL 4 PHENOXYPROLYL TETRAHYDRONAPHTH 1 YLAMIDE; N METHYLALANYL TERT LEUCYLPROLYL FLUOREN 9 YLAMIDE; N METHYLALANYL TERT LEUCYLPROLYL INDAN 1 YLAMIDE; N METHYLALANYL TERT LEUCYLPROLYL NAPHTH 1 YLAMIDE; N METHYLALANYL TERT LEUCYLPROLYL NAPHTH 2 YLAMIDE; N METHYLALANYL TERT LEUCYLPROLYL PHENETHYLAMIDE; N METHYLALANYL TERT LEUCYLPROLYL TETRAHYDRONAPHTH 1 YLAMIDE; N METHYLALANYLCYCLOHEXYLGLYCINE 4 PHENOXYPROLYL TETRAHYDRONAPHTH 1 YLAMIDE; N METHYLALANYLCYCLOHEXYLGLYCYLPROLYL TETRAHYDRONAPHTH 1 YLAMIDE; N,N DIMETHYLALANYL TERT LEUCYLPROLYL TETRAHYDRONAPHTH 1 YLAMIDE; N,N DIMETHYLALANYLCYCLOHEXYLGLYCYLPROLYL TETRAHYDRONAPHTH 1 YLAMIDE; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BACULOVIRUS; BINDING AFFINITY; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL DEATH; CONTROLLED STUDY; DRUG ACTIVITY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PATHOGENESIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; STRUCTURE ANALYSIS; TUMOR GROWTH; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING SITES; BREAST NEOPLASMS; CARRIER PROTEINS; CASPASES; CELL DIVISION; CELL LINE, TUMOR; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MICE; MITOCHONDRIAL PROTEINS; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 4143099131     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040037k     Document Type: Article

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