메뉴 건너뛰기




Volumn 22, Issue 1, 2009, Pages 193-198

Apogossypolone inhibits cell growth by inducing cell cycle arrest in U937 cells

Author keywords

ApoG2; Cell cycle arrest; Cyclin; Cyclin dependent kinases; U937

Indexed keywords

ANTINEOPLASTIC AGENT; APOGOSSYPOLONE; CASPASE 3; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN E; CYCLINE; CYTOCHROME C; GOSSYPOL DERIVATIVE; MYC PROTEIN; UNCLASSIFIED DRUG;

EID: 68249160072     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000424     Document Type: Article
Times cited : (20)

References (29)
  • 1
    • 0035902115 scopus 로고    scopus 로고
    • Proliferation, cell cycle and apoptosis in cancer
    • Evan GI and Vousden KH: Proliferation, cell cycle and apoptosis in cancer. Nature 411: 342-348, 2001.
    • (2001) Nature , vol.411 , pp. 342-348
    • Evan, G.I.1    Vousden, K.H.2
  • 2
    • 0034654326 scopus 로고    scopus 로고
    • Activation of apoptosis pathways by anticancer treatment
    • Debatin K: Activation of apoptosis pathways by anticancer treatment. Toxicol Lett 112-113: 41-48, 2000.
    • (2000) Toxicol Lett , vol.112-113 , pp. 41-48
    • Debatin, K.1
  • 4
    • 0036180120 scopus 로고    scopus 로고
    • Molecular aspects of the mammalian cell cycle and cancer
    • Sandal T: Molecular aspects of the mammalian cell cycle and cancer. Oncologist 7: 73-81, 2002.
    • (2002) Oncologist , vol.7 , pp. 73-81
    • Sandal, T.1
  • 5
    • 0038013875 scopus 로고    scopus 로고
    • Senescence, apoptosis and therapy - cutting the lifelines of cancer
    • Schmitt CA: Senescence, apoptosis and therapy - cutting the lifelines of cancer. Nat Rev Cancer 3: 286-295, 2003.
    • (2003) Nat Rev Cancer , vol.3 , pp. 286-295
    • Schmitt, C.A.1
  • 6
    • 0029317904 scopus 로고
    • Cyclin-dependent protein kinases: Key regulators of the eukaryotic cell cycle
    • Nigg EA: Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. Bioessays 17: 471-480, 1995.
    • (1995) Bioessays , vol.17 , pp. 471-480
    • Nigg, E.A.1
  • 7
    • 0034820022 scopus 로고    scopus 로고
    • Cell cycle regulation in the G1 phase: A promising target for the development of new chemotherapeutic anticancer agents
    • Owa T, Yoshino H, Yoshimatsu K, et al: Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents. Curr Med Chem 8 1487-1503, 2001.
    • (2001) Curr Med Chem , vol.8 , pp. 1487-1503
    • Owa, T.1    Yoshino, H.2    Yoshimatsu, K.3
  • 8
    • 0032955675 scopus 로고    scopus 로고
    • Modulating apoptosis: Current applications and prospects for future drug development
    • Deigner HP and Kinscherf R: Modulating apoptosis: current applications and prospects for future drug development. Curr Med Chem 6: 399-414, 1999.
    • (1999) Curr Med Chem , vol.6 , pp. 399-414
    • Deigner, H.P.1    Kinscherf, R.2
  • 9
    • 0034692871 scopus 로고    scopus 로고
    • Cytotoxic effect of gossypol on colon carcinoma cells
    • Wang X, Wang J, Wong SC, et al: Cytotoxic effect of gossypol on colon carcinoma cells. Life Sci 67: 2663-2671, 2000.
    • (2000) Life Sci , vol.67 , pp. 2663-2671
    • Wang, X.1    Wang, J.2    Wong, S.C.3
  • 10
    • 9344226187 scopus 로고    scopus 로고
    • In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells
    • Oliver CL, Bauer JA, Wolter KG, et al: In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res 10: 7757-7763, 2004.
    • (2004) Clin Cancer Res , vol.10 , pp. 7757-7763
    • Oliver, C.L.1    Bauer, J.A.2    Wolter, K.G.3
  • 11
    • 13944252626 scopus 로고    scopus 로고
    • Preclinical studies of a non-peptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(-)-gossypol] against diffuse large cell lymphoma
    • Mohammad RM, Wang S, Aboukameel A, et al: Preclinical studies of a non-peptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(-)-gossypol] against diffuse large cell lymphoma. Mol Cancer Ther 4: 13-21, 2005.
    • (2005) Mol Cancer Ther , vol.4 , pp. 13-21
    • Mohammad, R.M.1    Wang, S.2    Aboukameel, A.3
  • 12
    • 20044368078 scopus 로고    scopus 로고
    • Xu L, Yang D, Wang S, et al: (-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer. Mol Cancer Ther 4: 197-205, 2005.
    • Xu L, Yang D, Wang S, et al: (-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer. Mol Cancer Ther 4: 197-205, 2005.
  • 13
    • 52149098982 scopus 로고    scopus 로고
    • Apogossypolone, a non-peptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo
    • Sun Y, Wu J, Aboukameel A, et al: Apogossypolone, a non-peptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. Cancer Biol Ther 7: 1418-146, 2008.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1418-2146
    • Sun, Y.1    Wu, J.2    Aboukameel, A.3
  • 14
    • 53449100203 scopus 로고    scopus 로고
    • ApoG2, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces apoptosis and suppresses tumor growth in nasopharyngeal carcinoma xenografts
    • Hu ZY, Zhu XF, Zhong ZD, et al: ApoG2, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces apoptosis and suppresses tumor growth in nasopharyngeal carcinoma xenografts. Int J Cancer 123: 2418-2429, 2008.
    • (2008) Int J Cancer , vol.123 , pp. 2418-2429
    • Hu, Z.Y.1    Zhu, X.F.2    Zhong, Z.D.3
  • 15
    • 40549146581 scopus 로고    scopus 로고
    • Preclinical studies of Apogossypolone: A new non-peptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model
    • Arnold AA, Aboukameel A, Chen J, et al: Preclinical studies of Apogossypolone: a new non-peptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model. Mol Cancer 7: 20, 2008.
    • (2008) Mol Cancer , vol.7 , pp. 20
    • Arnold, A.A.1    Aboukameel, A.2    Chen, J.3
  • 16
    • 54249116969 scopus 로고    scopus 로고
    • ApoG2 inhibits antiapoptotic Bcl-2 family proteins and induces mitochondria-dependent apoptosis in human lymphoma U937 cells
    • Sun J, Li ZM, Hu ZY, et al: ApoG2 inhibits antiapoptotic Bcl-2 family proteins and induces mitochondria-dependent apoptosis in human lymphoma U937 cells. Anticancer Drugs 19: 967-974, 2008.
    • (2008) Anticancer Drugs , vol.19 , pp. 967-974
    • Sun, J.1    Li, Z.M.2    Hu, Z.Y.3
  • 17
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    • Zou H, Henzel WJ, Liu X, et al: Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90: 405-413, 1997.
    • (1997) Cell , vol.90 , pp. 405-413
    • Zou, H.1    Henzel, W.J.2    Liu, X.3
  • 18
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • Li P, Nijhawan D, Budihardjo I, et al: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479-489, 1997.
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3
  • 19
    • 0035525733 scopus 로고    scopus 로고
    • Cellular stress response and apoptosis in cancer therapy
    • Herr I and Debatin KM: Cellular stress response and apoptosis in cancer therapy. Blood 98: 2603-2614, 2001.
    • (2001) Blood , vol.98 , pp. 2603-2614
    • Herr, I.1    Debatin, K.M.2
  • 20
    • 0034630167 scopus 로고    scopus 로고
    • Induction of apoptosis by cancer chemotherapy
    • Kaufmann SH and Earnshaw WC: Induction of apoptosis by cancer chemotherapy. Exp Cell Res 256: 42-49, 2000.
    • (2000) Exp Cell Res , vol.256 , pp. 42-49
    • Kaufmann, S.H.1    Earnshaw, W.C.2
  • 21
    • 0028988585 scopus 로고
    • Inhibitors of mammalian G1 cyclin-dependent kinases
    • Sherr CJ and Roberts JM: Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9: 1149-1163, 1995.
    • (1995) Genes Dev , vol.9 , pp. 1149-1163
    • Sherr, C.J.1    Roberts, J.M.2
  • 22
    • 0037187453 scopus 로고    scopus 로고
    • Convergence of mitogenic and DNA damage signaling in the G1 phase of the cell cycle
    • Agami R and Bernards R: Convergence of mitogenic and DNA damage signaling in the G1 phase of the cell cycle. Cancer Lett 177: 111-118, 2002.
    • (2002) Cancer Lett , vol.177 , pp. 111-118
    • Agami, R.1    Bernards, R.2
  • 23
    • 0027154638 scopus 로고
    • Cyclin D1 is a nuclear protein required for cell cycle progression in G1
    • Baldin V, Lukas J, Marcote MJ, et al: Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev 7: 812-821, 1993.
    • (1993) Genes Dev , vol.7 , pp. 812-821
    • Baldin, V.1    Lukas, J.2    Marcote, M.J.3
  • 24
    • 0027298902 scopus 로고
    • The cdk2 kinase is required for the G1-to-S transition in mammalian cells
    • Tsai LH, Lees E, Faha B, et al: The cdk2 kinase is required for the G1-to-S transition in mammalian cells. Oncogene 8: 1593-1602, 1993.
    • (1993) Oncogene , vol.8 , pp. 1593-1602
    • Tsai, L.H.1    Lees, E.2    Faha, B.3
  • 25
    • 0742281300 scopus 로고    scopus 로고
    • E2F1 and c-Myc in cell growth and death
    • Matsumura I, Tanaka H and Kanakura Y: E2F1 and c-Myc in cell growth and death. Cell Cycle 2: 333-338, 2003.
    • (2003) Cell Cycle , vol.2 , pp. 333-338
    • Matsumura, I.1    Tanaka, H.2    Kanakura, Y.3
  • 27
    • 0038481271 scopus 로고    scopus 로고
    • Mitochondrial regulation of apoptosis
    • Mayer B and Oberbauer R: Mitochondrial regulation of apoptosis. News Physiol Sci 18: 89-94, 2003.
    • (2003) News Physiol Sci , vol.18 , pp. 89-94
    • Mayer, B.1    Oberbauer, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.