Radicicol, a heat shock protein 90 inhibitor, inhibits differentiation and adipogenesis in 3T3-L1 preadipocytes

Biochemical and Biophysical Research Communications

Volumn 436, Issue 2, 2013, Pages 169-174

  He, Yonghan ^a,b,e   Li, Ying ^a   Zhang, Shuocheng ^b   Perry, Ben ^b,d   Zhao, Tiantian ^b,c   Wang, Yanwen ^b,d   Sun, Changhao ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF PRINCE EDWARD ISLAND   (Canada)

^e KUNMING INSTITUTE OF ZOOLOGY   (China)

Author keywords

Adipocytes; Differentiation; Heat shock protein; Radicicol

Indexed keywords

BETA CATENIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; FATTY ACID BINDING PROTEIN 4; FATTY ACID SYNTHASE; HEAT SHOCK PROTEIN 90 INHIBITOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; RADICICOL;

ADIPOGENESIS; ARTICLE; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL STRAIN 3T3; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; LIPID STORAGE; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; BLOTTING, WESTERN; CCAAT-ENHANCER-BINDING PROTEINS; CELL DIFFERENTIATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FATS; FATTY ACID SYNTHETASE COMPLEX; FATTY ACID-BINDING PROTEINS; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINTS; HSP90 HEAT-SHOCK PROTEINS; MACROLIDES; MICE; PHOSPHORYLATION; PPAR GAMMA; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84879606038     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.05.068     Document Type: Article

References (33)

1. Despres J.P., Lemieux I. Abdominal obesity and metabolic syndrome. Nature 2006, 444:881-887.
2. Kopelman P.G. Obesity as a medical problem. Nature 2000, 404:635-643.
3. Hausman D.B., DiGirolamo M., Bartness T.J., Hausman G.J., Martin R.J. The biology of white adipocyte proliferation. Obes. Rev. 2001, 2:239-254.
4. Avram M.M., Avram A.S., James W.D. Subcutaneous fat in normal and diseased states 3. Adipogenesis: from stem cell to fat cell. J. Am. Acad. Dermatol. 2007, 56:472-492.
5. Gregoire F.M., Smas C.M., Sul H.S. Understanding adipocyte differentiation. Physiol. Rev. 1998, 78:783-809.
6. Hartl F.U. Molecular chaperones in cellular protein folding. Nature 1996, 381:571-579.
7. Helmbrecht K., Zeise E., Rensing L. Chaperones in cell cycle regulation and mitogenic signal transduction: a review. Cell Prolif. 2000, 33:341-365.
8. Lanneau D., de Thonel A., Maurel S., Didelot C., Garrido C. Apoptosis versus cell differentiation: role of heat shock proteins HSP90, HSP70 and HSP27. Prion 2007, 1:53-60.
9. Yun B.G., Matts R.L. Differential effects of Hsp90 inhibition on protein kinases regulating signal transduction pathways required for myoblast differentiation. Exp. Cell Res. 2005, 307:212-223.
10. Didelot C., Lanneau D., Brunet M., Bouchot A., Cartier J., Jacquel A., Ducoroy P., Cathelin S., Decologne N., Chiosis G., Dubrez-Daloz L., Solary E., Garrido C. Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation. Cell Death Differ. 2008, 15:859-866.
11. Yu W., Rao Q., Wang M., Tian Z., Lin D., Liu X., Wang J. The Hsp90 inhibitor 17-allylamide-17-demethoxygeldanamycin induces apoptosis and differentiation of Kasumi-1 harboring the Asn822Lys KIT mutation and down-regulates KIT protein level. Leuk. Res. 2006, 30:575-582.
12. Jakob U., Buchner J. Assisting spontaneity: the role of Hsp90 and small Hsps as molecular chaperones. Trends Biochem. Sci. 1994, 19:205-211.
13. Chiosis G., Timaul M.N., Lucas B., Munster P.N., Zheng F.F., Sepp-Lorenzino L., Rosen N. A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells. Chem. Biol. 2001, 8:289-299.
14. Kohda T., Kondo K., Oishi M. Cellular HSP90 (HSP86) mRNA level and in vitro differentiation of mouse embryonal carcinoma (F9) cells. FEBS Lett. 1991, 290:107-110.
15. Munster P.N., Srethapakdi M., Moasser M.M., Rosen N. Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells. Cancer Res. 2001, 61:2945-2952.
16. Gruppi C.M., Zakeri Z.F., Wolgemuth D.J. Stage and lineage-regulated expression of two hsp90 transcripts during mouse germ cell differentiation and embryogenesis. Mol. Reprod. Dev. 1991, 28:209-217.
17. Quinta H.R., Maschi D., Gomez-Sanchez C., Piwien-Pilipuk G., Galigniana M.D. Subcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth. J. Neurochem. 2010, 115:716-734.
18. Wagatsuma A., Shiozuka M., Kotake N., Takayuki K., Yusuke H., Mabuchi K., Matsuda R., Yamada S. Pharmacological inhibition of HSP90 activity negatively modulates myogenic differentiation and cell survival in C2C12 cells. Mol. Cell. Biochem. 2011, 358:265-280.
19. Yun B.G., Matts R.L. Hsp90 functions to balance the phosphorylation state of Akt during C2C12 myoblast differentiation. Cell Signal. 2005, 17:1477-1485.
20. Schulte T.W., Akinaga S., Soga S., Sullivan W., Stensgard B., Toft D., Neckers L.M. Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin. Cell Stress Chaperones 1998, 3:100-108.
21. Farmer S.R. Regulation of PPARgamma activity during adipogenesis. Int. J. Obes. (Lond). 2005, 29(Suppl. 1):S13-S16.
22. Hertzel A.V., Bernlohr D.A. The mammalian fatty acid-binding protein multigene family: molecular and genetic insights into function. Trends Endocrinol. Metab. 2000, 11:175-180.
23. Paulauskis J.D., Sul H.S. Cloning and expression of mouse fatty acid synthase and other specific mRNAs. Developmental and hormonal regulation in 3T3-L1 cells. J. Biol. Chem. 1988, 263:7049-7054.
24. Cristancho A.G., Lazar M.A. Forming functional fat: a growing understanding of adipocyte differentiation. Nat. Rev. Mol. Cell Biol. 2011, 12:722-734.
25. Kim G.S., Park H.J., Woo J.H., Kim M.K., Koh P.O., Min W., Ko Y.G., Kim C.H., Won C.K., Cho J.H. Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells. BMC Complement. Altern. Med. 2012, 12:31.
26. Jo J., Gavrilova O., Pack S., Jou W., Mullen S., Sumner A.E., Cushman S.W., Periwal V. Hypertrophy and/or hyperplasia: dynamics of adipose tissue growth. PLoS Comput. Biol. 2009, 5:e1000324.
27. Zhang J.W., Tang Q.Q., Vinson C., Lane M.D. Dominant-negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes. Proc. Natl. Acad. Sci. USA 2004, 101:43-47.
28. Sakaue H., Ogawa W., Matsumoto M., Kuroda S., Takata M., Sugimoto T., Spiegelman B.M., Kasuga M. Posttranscriptional control of adipocyte differentiation through activation of phosphoinositide 3-kinase. J. Biol. Chem. 1998, 273:28945-28952.
29. Bennett C.N., Ross S.E., Longo K.A., Bajnok L., Hemati N., Johnson K.W., Harrison S.D., MacDougald O.A. Regulation of Wnt signaling during adipogenesis. J. Biol. Chem. 2002, 277:30998-31004.
30. Ross S.E., Hemati N., Longo K.A., Bennett C.N., Lucas P.C., Erickson R.L., MacDougald O.A. Inhibition of adipogenesis by Wnt signaling. Science 2000, 289:950-953.
31. Leonardini A., Laviola L., Perrini S., Natalicchio A., Giorgino F. Cross-talk between PPARgamma and insulin signaling and modulation of insulin sensitivity. PPAR Res. 2009, 2009:818945.
32. Gelman L., Feige J.N., Desvergne B. Molecular basis of selective PPARgamma modulation for the treatment of type 2 diabetes. Biochim. Biophys. Acta 2007, 1771:1094-1107.
33. Waki H., Yamauchi T., Kadowaki T. PPARgamma antagonist as a potential drug for the treatment of obesity and diabetes. Nihon Rinsho 2010, 68:350-355.