-
1
-
-
0043288724
-
Heat shock protein 90 as a molecular target for cancer therapeutics
-
Isaacs JS, Xu W, Neckers L. Heat shock protein 90 as a molecular target for cancer therapeutics. Cancer Cell 2003;3:213-7.
-
(2003)
Cancer Cell
, vol.3
, pp. 213-217
-
-
Isaacs, J.S.1
Xu, W.2
Neckers, L.3
-
2
-
-
77953916528
-
HSP90 at the hub of protein homeostasis: Emerging mechanistic insights
-
Taipale M, Jarosz DF, Lindquist S. HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol 2010;11:515-28.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 515-528
-
-
Taipale, M.1
Jarosz, D.F.2
Lindquist, S.3
-
3
-
-
58849160500
-
Heat shock protein 90 as a drug target: Some like it hot
-
Banerji U. Heat shock protein 90 as a drug target: some like it hot. Clin Cancer Res 2009;15:9-14.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 9-14
-
-
Banerji, U.1
-
4
-
-
34248187981
-
Heat shock protein 90: The cancer chaperone
-
Neckers L. Heat shock protein 90: the cancer chaperone. J Biosci 2007;32:517-30.
-
(2007)
J Biosci
, vol.32
, pp. 517-530
-
-
Neckers, L.1
-
5
-
-
0029775839
-
Do heat shock proteins have a role in breast cancer?
-
Conroy SE, Latchman DS. Do heat shock proteins have a role in breast cancer? Br J Cancer 1996;74:717-21.
-
(1996)
Br J Cancer
, vol.74
, pp. 717-721
-
-
Conroy, S.E.1
Latchman, D.S.2
-
6
-
-
0026544498
-
Clinical and biological significance of HSP89 alpha in human breast cancer
-
Jameel A, Skilton RA, Campbell TA, Chander SK, Coombes RC, Luqmani YA. Clinical and biological significance of HSP89 alpha in human breast cancer. Int J Cancer 1992;50:409-15.
-
(1992)
Int J Cancer
, vol.50
, pp. 409-415
-
-
Jameel, A.1
Skilton, R.A.2
Campbell, T.A.3
Chander, S.K.4
Coombes, R.C.5
Luqmani, Y.A.6
-
7
-
-
59449087254
-
Heat shock protein 90 overexpression independently predicts inferior disease-free survival with differential expression of the alpha and beta isoforms in gastrointestinal stromal tumors
-
Li CF, Huang WW, Wu JM, Yu SC, Hu TH, Uen YH, et al. Heat shock protein 90 overexpression independently predicts inferior disease-free survival with differential expression of the alpha and beta isoforms in gastrointestinal stromal tumors. Clin Cancer Res 2008;14:7822-31.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7822-7831
-
-
Li, C.F.1
Huang, W.W.2
Wu, J.M.3
Yu, S.C.4
Hu, T.H.5
Uen, Y.H.6
-
8
-
-
34248195608
-
High HSP90 expression is associated with decreased survival in breast cancer
-
Pick E, Kluger Y, Giltnane JM, Moeder C, Camp RL, Rimm DL, et al. High HSP90 expression is associated with decreased survival in breast cancer. Cancer Res 2007;67:2932-7.
-
(2007)
Cancer Res
, vol.67
, pp. 2932-2937
-
-
Pick, E.1
Kluger, Y.2
Giltnane, J.M.3
Moeder, C.4
Camp, R.L.5
Rimm, D.L.6
-
9
-
-
0141484615
-
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
-
Kamal A, Thao L, Sensintaffar J, Zhang L, Boehm MF, Fritz LC, et al. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature 2003;425:407-10.
-
(2003)
Nature
, vol.425
, pp. 407-410
-
-
Kamal, A.1
Thao, L.2
Sensintaffar, J.3
Zhang, L.4
Boehm, M.F.5
Fritz, L.C.6
-
10
-
-
33746417580
-
Hsp90: A novel target for cancer therapy
-
Solit DB, Rosen N. Hsp90: a novel target for cancer therapy. Curr Top Med Chem 2006;6:1205-14.
-
(2006)
Curr Top Med Chem
, vol.6
, pp. 1205-1214
-
-
Solit, D.B.1
Rosen, N.2
-
11
-
-
0035146685
-
The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins
-
Connell P, Ballinger CA, Jiang J, Wu Y, Thompson LJ, Hohfeld J, et al. The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. Nat Cell Biol 2001;3:93-6.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 93-96
-
-
Connell, P.1
Ballinger, C.A.2
Jiang, J.3
Wu, Y.4
Thompson, L.J.5
Hohfeld, J.6
-
12
-
-
0037023732
-
HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor
-
Hernandez MP, Chadli A, Toft DO. HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor. J Biol Chem 2002;277:11873-81.
-
(2002)
J Biol Chem
, vol.277
, pp. 11873-11881
-
-
Hernandez, M.P.1
Chadli, A.2
Toft, D.O.3
-
14
-
-
27744551993
-
Exposure of protein kinase motifs that trigger binding of Hsp90 and Cdc37
-
Prince T, Matts RL. Exposure of protein kinase motifs that trigger binding of Hsp90 and Cdc37. Biochem Biophys Res Commun 2005; 338:1447-54.
-
(2005)
Biochem Biophys Res Commun
, vol.338
, pp. 1447-1454
-
-
Prince, T.1
Matts, R.L.2
-
15
-
-
33646269303
-
Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases
-
Terasawa K, Yoshimatsu K, Iemura S, Natsume T, Tanaka K, Minami Y. Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases. Mol Cell Biol 2006;26:3378-89.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 3378-3389
-
-
Terasawa, K.1
Yoshimatsu, K.2
Iemura, S.3
Natsume, T.4
Tanaka, K.5
Minami, Y.6
-
16
-
-
0033524442
-
Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90
-
Xu Y, Singer MA, Lindquist S. Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90. Proc Natl Acad Sci U S A 1999;96:109-14.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 109-114
-
-
Xu, Y.1
Singer, M.A.2
Lindquist, S.3
-
17
-
-
33748747967
-
Defining the requirements for Hsp40 and Hsp70 in the Hsp90 chaperone pathway
-
Cintron NS, Toft D. Defining the requirements for Hsp40 and Hsp70 in the Hsp90 chaperone pathway. J Biol Chem 2006;281:26235-44.
-
(2006)
J Biol Chem
, vol.281
, pp. 26235-26244
-
-
Cintron, N.S.1
Toft, D.2
-
18
-
-
0037064023
-
The assembly and intermolecular properties of the hsp70-Hop-hsp90 molecular chaperone complex
-
Hernandez MP, Sullivan WP, Toft DO. The assembly and intermolecular properties of the hsp70-Hop-hsp90 molecular chaperone complex. J Biol Chem 2002;277:38294-304.
-
(2002)
J Biol Chem
, vol.277
, pp. 38294-38304
-
-
Hernandez, M.P.1
Sullivan, W.P.2
Toft, D.O.3
-
19
-
-
0027439595
-
Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70
-
Smith DF, Sullivan WP, Marion TN, Zaitsu K, Madden B, McCormick DJ, et al. Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70. Mol Cell Biol 1993;13:869-76.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 869-876
-
-
Smith, D.F.1
Sullivan, W.P.2
Marion, T.N.3
Zaitsu, K.4
Madden, B.5
McCormick, D.J.6
-
20
-
-
36849083947
-
Dimerization of Hsp90 is required for in vivo function. Design and analysis of monomers and dimers
-
Wayne N, Bolon DN. Dimerization of Hsp90 is required for in vivo function. Design and analysis of monomers and dimers. J Biol Chem 2007;282:35386-95.
-
(2007)
J Biol Chem
, vol.282
, pp. 35386-35395
-
-
Wayne, N.1
Bolon, D.N.2
-
21
-
-
31344453190
-
Substrate transfer from the chaperone Hsp70 to Hsp90
-
Wegele H, Wandinger SK, Schmid AB, Reinstein J, Buchner J. Substrate transfer from the chaperone Hsp70 to Hsp90. J Mol Biol 2006;356:802-11.
-
(2006)
J Mol Biol
, vol.356
, pp. 802-811
-
-
Wegele, H.1
Wandinger, S.K.2
Schmid, A.B.3
Reinstein, J.4
Buchner, J.5
-
22
-
-
0027526899
-
ATP induces a conformational change of the 90-kDa heat shock protein (hsp90)
-
Csermely P, Kajtar J, Hollosi M, Jalsovszky G, Holly S, Kahn CR, et al. ATP induces a conformational change of the 90-kDa heat shock protein (hsp90). J Biol Chem 1993;268:1901-7.
-
(1993)
J Biol Chem
, vol.268
, pp. 1901-1907
-
-
Csermely, P.1
Kajtar, J.2
Hollosi, M.3
Jalsovszky, G.4
Holly, S.5
Kahn, C.R.6
-
23
-
-
31344474558
-
The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins
-
McLaughlin SH, Sobott F, Yao ZP, Zhang W, Nielsen PR, Grossmann JG, et al. The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins. J Mol Biol 2006;356:746-58.
-
(2006)
J Mol Biol
, vol.356
, pp. 746-758
-
-
McLaughlin, S.H.1
Sobott, F.2
Yao, Z.P.3
Zhang, W.4
Nielsen, P.R.5
Grossmann, J.G.6
-
24
-
-
0030938717
-
Nucleotides and two functional states of hsp90
-
Sullivan W, Stensgard B, Caucutt G, Bartha B, McMahon N, Alnemri ES, et al. Nucleotides and two functional states of hsp90. J Biol Chem 1997;272:8007-12.
-
(1997)
J Biol Chem
, vol.272
, pp. 8007-8012
-
-
Sullivan, W.1
Stensgard, B.2
Caucutt, G.3
Bartha, B.4
McMahon, N.5
Alnemri, E.S.6
-
25
-
-
0037195951
-
The influence of ATP and p23 on the conformation of hsp90
-
Sullivan WP, Owen BA, Toft DO. The influence of ATP and p23 on the conformation of hsp90. J Biol Chem 2002;277:45942-8.
-
(2002)
J Biol Chem
, vol.277
, pp. 45942-45948
-
-
Sullivan, W.P.1
Owen, B.A.2
Toft, D.O.3
-
26
-
-
0032538995
-
In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis
-
Obermann WM, Sondermann H, Russo AA, Pavletich NP, Hartl FU. In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. J Cell Biol 1998;143:901-10.
-
(1998)
J Cell Biol
, vol.143
, pp. 901-910
-
-
Obermann, W.M.1
Sondermann, H.2
Russo, A.A.3
Pavletich, N.P.4
Hartl, F.U.5
-
27
-
-
0032541344
-
ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo
-
Panaretou B, Prodromou C, Roe SM, O'Brien R, Ladbury JE, Piper PW, et al. ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo. EMBO J 1998;17:4829-36.
-
(1998)
EMBO J
, vol.17
, pp. 4829-4836
-
-
Panaretou, B.1
Prodromou, C.2
Roe, S.M.3
O'Brien, R.4
Ladbury, J.E.5
Piper, P.W.6
-
28
-
-
0028064940
-
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation
-
Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci U S A 1994;91:8324-8.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 8324-8328
-
-
Whitesell, L.1
Mimnaugh, E.G.2
De Costa, B.3
Myers, C.E.4
Neckers, L.M.5
-
30
-
-
0031875042
-
The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin
-
Schulte TW, Neckers LM. The benzoquinone ansamycin 17-allylamino-17- demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin. Cancer Chemother Pharmacol 1998;42:273-9.
-
(1998)
Cancer Chemother Pharmacol
, vol.42
, pp. 273-279
-
-
Schulte, T.W.1
Neckers, L.M.2
-
31
-
-
74249085361
-
Update on Hsp90 inhibitors in clinical trial
-
Kim YS, Alarcon SV, Lee S, Lee MJ, Giaccone G, Neckers L, et al. Update on Hsp90 inhibitors in clinical trial. Curr Top Med Chem 2009;9:1479-92.
-
(2009)
Curr Top Med Chem
, vol.9
, pp. 1479-1492
-
-
Kim, Y.S.1
Alarcon, S.V.2
Lee, S.3
Lee, M.J.4
Giaccone, G.5
Neckers, L.6
-
32
-
-
33746662241
-
Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90
-
Ge J, Normant E, Porter JR, Ali JA, Dembski MS, Gao Y, et al. Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90. J Med Chem 2006;49:4606-15.
-
(2006)
J Med Chem
, vol.49
, pp. 4606-4615
-
-
Ge, J.1
Normant, E.2
Porter, J.R.3
Ali, J.A.4
Dembski, M.S.5
Gao, Y.6
-
33
-
-
33751258297
-
Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90
-
Sydor JR, Normant E, Pien CS, Porter JR, Ge J, Grenier L, et al. Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90. Proc Natl Acad Sci U S A 2006;103:17408-13.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 17408-17413
-
-
Sydor, J.R.1
Normant, E.2
Pien, C.S.3
Porter, J.R.4
Ge, J.5
Grenier, L.6
-
34
-
-
0035071607
-
A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells
-
Chiosis G, Timaul MN, Lucas B, Munster PN, Zheng FF, Sepp-Lorenzino L, et al. A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells. Chem Biol 2001;8:289-99.
-
(2001)
Chem Biol
, vol.8
, pp. 289-299
-
-
Chiosis, G.1
Timaul, M.N.2
Lucas, B.3
Munster, P.N.4
Zheng, F.F.5
Sepp-Lorenzino, L.6
-
35
-
-
66249138886
-
Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models
-
Caldas-Lopes E, Cerchietti L, Ahn JH, Clement CC, Robles AI, Rodina A, et al. Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proc Natl Acad Sci U S A 2009;106:8368-73.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 8368-8373
-
-
Caldas-Lopes, E.1
Cerchietti, L.2
Ahn, J.H.3
Clement, C.C.4
Robles, A.I.5
Rodina, A.6
-
36
-
-
34250877881
-
Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity
-
Kasibhatla SR, Hong K, Biamonte MA, Busch DJ, Karjian PL, Sensintaffar JL, et al. Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity. J Med Chem 2007;50:2767-78.
-
(2007)
J Med Chem
, vol.50
, pp. 2767-2778
-
-
Kasibhatla, S.R.1
Hong, K.2
Biamonte, M.A.3
Busch, D.J.4
Karjian, P.L.5
Sensintaffar, J.L.6
-
37
-
-
66449094961
-
BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90
-
Lundgren K, Zhang H, Brekken J, Huser N, Powell RE, Timple N, et al. BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Mol Cancer Ther 2009;8:921-9.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 921-929
-
-
Lundgren, K.1
Zhang, H.2
Brekken, J.3
Huser, N.4
Powell, R.E.5
Timple, N.6
-
38
-
-
67449138839
-
CUDC-305, a novel synthetic HSP90 inhibitor with unique pharmacologic properties for cancer therapy
-
Bao R, Lai CJ, Qu H, Wang D, Yin L, Zifcak B, et al. CUDC-305, a novel synthetic HSP90 inhibitor with unique pharmacologic properties for cancer therapy. Clin Cancer Res 2009;15:4046-57.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4046-4057
-
-
Bao, R.1
Lai, C.J.2
Qu, H.3
Wang, D.4
Yin, L.5
Zifcak, B.6
-
39
-
-
68549115383
-
Combining hit identification strategies: Fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone
-
Brough PA, Barril X, Borgognoni J, Chene P, Davies NG, Davis B, et al. Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone. J Med Chem 2009;52:4794-809.
-
(2009)
J Med Chem
, vol.52
, pp. 4794-4809
-
-
Brough, P.A.1
Barril, X.2
Borgognoni, J.3
Chene, P.4
Davies, N.G.5
Davis, B.6
-
40
-
-
3042685847
-
New efficient synthesis of resorcinylic macrolides via ynolides: Establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on Hsp90 as the target
-
Yang ZQ, Geng X, Solit D, Pratilas CA, Rosen N, Danishefsky SJ. New efficient synthesis of resorcinylic macrolides via ynolides: establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on Hsp90 as the target. J Am Chem Soc 2004;126:7881-9.
-
(2004)
J Am Chem Soc
, vol.126
, pp. 7881-7889
-
-
Yang, Z.Q.1
Geng, X.2
Solit, D.3
Pratilas, C.A.4
Rosen, N.5
Danishefsky, S.J.6
-
41
-
-
84857039457
-
Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers
-
Jhaveri K, Taldone T, Modi S, Chiosis G. Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers. Biochimica Biophys Acta 2012;1823:742-55.
-
(2012)
Biochimica Biophys Acta
, vol.1823
, pp. 742-755
-
-
Jhaveri, K.1
Taldone, T.2
Modi, S.3
Chiosis, G.4
-
42
-
-
75149123144
-
Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth
-
Chandarlapaty S, Scaltriti M, Angelini P, Ye Q, Guzman M, Hudis CA, et al. Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth. Oncogene 2010;29:325-34.
-
(2010)
Oncogene
, vol.29
, pp. 325-334
-
-
Chandarlapaty, S.1
Scaltriti, M.2
Angelini, P.3
Ye, Q.4
Guzman, M.5
Hudis, C.A.6
-
43
-
-
79956001501
-
Antitumor activity of the Hsp90 inhibitor IPI-504 in HER2-positive trastuzumab-resistant breast cancer
-
Scaltriti M, Serra V, Normant E, Guzman M, Rodriguez O, Lim AR, et al. Antitumor activity of the Hsp90 inhibitor IPI-504 in HER2-positive trastuzumab-resistant breast cancer. Mol Cancer Ther 2011;10:817-24.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 817-824
-
-
Scaltriti, M.1
Serra, V.2
Normant, E.3
Guzman, M.4
Rodriguez, O.5
Lim, A.R.6
-
44
-
-
51449087794
-
Targeting the androgen receptor pathway in prostate cancer
-
Chen Y, Sawyers CL, Scher HI. Targeting the androgen receptor pathway in prostate cancer. Curr Opin Pharmacol 2008;8:440-8.
-
(2008)
Curr Opin Pharmacol
, vol.8
, pp. 440-448
-
-
Chen, Y.1
Sawyers, C.L.2
Scher, H.I.3
-
46
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011;364:2507-16.
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
Haanen, J.B.4
Ascierto, P.5
Larkin, J.6
-
47
-
-
28244444919
-
Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin
-
da Rocha Dias S, Friedlos F, Light Y, Springer C, Workman P, Marais R. Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin. Cancer Res 2005;65:10686-91.
-
(2005)
Cancer Res
, vol.65
, pp. 10686-10691
-
-
Da Rocha Dias, S.1
Friedlos, F.2
Light, Y.3
Springer, C.4
Workman, P.5
Marais, R.6
-
48
-
-
42649125571
-
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
-
Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, et al. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet 2008;40:600-8.
-
(2008)
Nat Genet
, vol.40
, pp. 600-608
-
-
Haigis, K.M.1
Kendall, K.R.2
Wang, Y.3
Cheung, A.4
Haigis, M.C.5
Glickman, J.N.6
-
49
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, et al. Mutations of the BRAF gene in human cancer. Nature 2002;417:949-54.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
-
50
-
-
22244485706
-
Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins
-
Shimamura T, Lowell AM, Engelman JA, Shapiro GI. Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins. Cancer Res 2005;65:6401-8.
-
(2005)
Cancer Res
, vol.65
, pp. 6401-6408
-
-
Shimamura, T.1
Lowell, A.M.2
Engelman, J.A.3
Shapiro, G.I.4
-
51
-
-
0036233939
-
Heat shock protein 90-antagonist destabilizes Bcr-Abl/HSP90 chaperone complex
-
Shiotsu Y, Soga S, Akinaga S. Heat shock protein 90-antagonist destabilizes Bcr-Abl/HSP90 chaperone complex. Leuk Lymphoma 2002;43:961-8.
-
(2002)
Leuk Lymphoma
, vol.43
, pp. 961-968
-
-
Shiotsu, Y.1
Soga, S.2
Akinaga, S.3
-
52
-
-
27144551963
-
ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: Inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia
-
Castro JE, Prada CE, Loria O, Kamal A, Chen L, Burrows FJ, et al. ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia. Blood 2005;106:2506-12.
-
(2005)
Blood
, vol.106
, pp. 2506-2512
-
-
Castro, J.E.1
Prada, C.E.2
Loria, O.3
Kamal, A.4
Chen, L.5
Burrows, F.J.6
-
53
-
-
33749461709
-
Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor
-
Bauer S, Yu LK, Demetri GD, Fletcher JA. Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor. Cancer Res 2006;66:9153-61.
-
(2006)
Cancer Res
, vol.66
, pp. 9153-9161
-
-
Bauer, S.1
Yu, L.K.2
Demetri, G.D.3
Fletcher, J.A.4
-
54
-
-
33846208233
-
STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90alpha and beta in multiple myeloma cells, which critically contribute to tumor-cell survival
-
Chatterjee M, Jain S, Stuhmer T, Andrulis M, Ungethum U, Kuban RJ, et al. STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90alpha and beta in multiple myeloma cells, which critically contribute to tumor-cell survival. Blood 2007;109:720-8.
-
(2007)
Blood
, vol.109
, pp. 720-728
-
-
Chatterjee, M.1
Jain, S.2
Stuhmer, T.3
Andrulis, M.4
Ungethum, U.5
Kuban, R.J.6
-
55
-
-
31544436323
-
Antimyeloma activity of heat shock protein-90 inhibition
-
Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Kung AL, Davies FE, et al. Antimyeloma activity of heat shock protein-90 inhibition. Blood 2006;107:1092-100.
-
(2006)
Blood
, vol.107
, pp. 1092-1100
-
-
Mitsiades, C.S.1
Mitsiades, N.S.2
McMullan, C.J.3
Poulaki, V.4
Kung, A.L.5
Davies, F.E.6
-
56
-
-
23044441106
-
Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies
-
Banerji U, O'Donnell A, Scurr M, Pacey S, Stapleton S, Asad Y, et al. Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies. J Clin Oncol 2005;23:4152-61.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4152-4161
-
-
Banerji, U.1
O'Donnell, A.2
Scurr, M.3
Pacey, S.4
Stapleton, S.5
Asad, Y.6
-
57
-
-
34250197902
-
Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer
-
Solit DB, Ivy SP, Kopil C, Sikorski R, Morris MJ, Slovin SF, et al. Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer. Clin Cancer Res 2007;13:1775-82.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1775-1782
-
-
Solit, D.B.1
Ivy, S.P.2
Kopil, C.3
Sikorski, R.4
Morris, M.J.5
Slovin, S.F.6
-
58
-
-
77955141041
-
Tanespimycin monotherapy in relapsed multiple myeloma: Results of a phase 1 dose-escalation study
-
Richardson PG, Chanan-Khan AA, Alsina M, Albitar M, Berman D, Messina M, et al. Tanespimycin monotherapy in relapsed multiple myeloma: results of a phase 1 dose-escalation study. Br J Haematol 2010;150:438-45.
-
(2010)
Br J Haematol
, vol.150
, pp. 438-445
-
-
Richardson, P.G.1
Chanan-Khan, A.A.2
Alsina, M.3
Albitar, M.4
Berman, D.5
Messina, M.6
-
59
-
-
79952734485
-
A phase I study of the heat shock protein 90 inhibitor alvespimycin (17-DMAG) given intravenously to patients with advanced solid tumors
-
Pacey S, Wilson RH, Walton M, Eatock MM, Hardcastle A, Zetterlund A, et al. A phase I study of the heat shock protein 90 inhibitor alvespimycin (17-DMAG) given intravenously to patients with advanced solid tumors. Clin Cancer Res 2011;17:1561-70.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1561-1570
-
-
Pacey, S.1
Wilson, R.H.2
Walton, M.3
Eatock, M.M.4
Hardcastle, A.5
Zetterlund, A.6
-
60
-
-
79960985354
-
HSP90 inhibition is effective in breast cancer: A phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab
-
Modi S, Stopeck A, Linden H, Solit D, Chandarlapaty S, Rosen N, et al. HSP90 inhibition is effective in breast cancer: a phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab. Clin Cancer Res 2011;17:5132-9.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 5132-5139
-
-
Modi, S.1
Stopeck, A.2
Linden, H.3
Solit, D.4
Chandarlapaty, S.5
Rosen, N.6
-
61
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
-
Kwak EL, Bang YJ, Camidge DR, Shaw AT, Solomon B, Maki RG, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010;363:1693-703.
-
(2010)
N Engl J Med
, vol.363
, pp. 1693-1703
-
-
Kwak, E.L.1
Bang, Y.J.2
Camidge, D.R.3
Shaw, A.T.4
Solomon, B.5
Maki, R.G.6
-
62
-
-
79956318797
-
Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK
-
Katayama R, Khan TM, Benes C, Lifshits E, Ebi H, Rivera VM, et al. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A 2011;108:7535-40.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 7535-7540
-
-
Katayama, R.1
Khan, T.M.2
Benes, C.3
Lifshits, E.4
Ebi, H.5
Rivera, V.M.6
-
63
-
-
79951885125
-
Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer
-
Sequist LV, Gettinger S, Senzer NN, Martins RG, Janne PA, Lilenbaum R, et al. Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer. J Clin Oncol 2010;28:4953-60.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4953-4960
-
-
Sequist, L.V.1
Gettinger, S.2
Senzer, N.N.3
Martins, R.G.4
Janne, P.A.5
Lilenbaum, R.6
-
64
-
-
80053948169
-
Targeting HSP 90 induces apoptosis and inhibits critical survival and proliferation pathways in multiple myeloma
-
Khong T, Spencer A. Targeting HSP 90 induces apoptosis and inhibits critical survival and proliferation pathways in multiple myeloma. Mol Cancer Ther 2011;10:1909-17.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 1909-1917
-
-
Khong, T.1
Spencer, A.2
-
65
-
-
78851472038
-
Inhibition of heat shock protein 90 (HSP90) as a therapeutic strategy for the treatment of myeloma and other cancers
-
Richardson PG, Mitsiades CS, Laubach JP, Lonial S, Chanan-Khan AA, Anderson KC. Inhibition of heat shock protein 90 (HSP90) as a therapeutic strategy for the treatment of myeloma and other cancers. Br J Haematol 2011;152:367-79.
-
(2011)
Br J Haematol
, vol.152
, pp. 367-379
-
-
Richardson, P.G.1
Mitsiades, C.S.2
Laubach, J.P.3
Lonial, S.4
Chanan-Khan, A.A.5
Anderson, K.C.6
-
66
-
-
79957539428
-
Tanespimycin and bortezomib combination treatment in patients with relapsed or relapsed and refractory multiple myeloma: Results of a phase 1/2 study
-
Richardson PG, Chanan-Khan AA, Lonial S, Krishnan AY, Carroll MP, Alsina M, et al. Tanespimycin and bortezomib combination treatment in patients with relapsed or relapsed and refractory multiple myeloma: results of a phase 1/2 study. Br J Haematol 2011;153:729-40.
-
(2011)
Br J Haematol
, vol.153
, pp. 729-740
-
-
Richardson, P.G.1
Chanan-Khan, A.A.2
Lonial, S.3
Krishnan, A.Y.4
Carroll, M.P.5
Alsina, M.6
-
67
-
-
49849084850
-
An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models
-
Banerji U, Sain N, Sharp SY, Valenti M, Asad Y, Ruddle R, et al. An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models. Cancer Chemother Pharmacol 2008;62:769-78.
-
(2008)
Cancer Chemother Pharmacol
, vol.62
, pp. 769-778
-
-
Banerji, U.1
Sain, N.2
Sharp, S.Y.3
Valenti, M.4
Asad, Y.5
Ruddle, R.6
-
68
-
-
0034890377
-
Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner
-
See: E. A. Sausville, Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin: sequence and tumor biology matters, Clin. Cancer Res., 7: 2155-2158, 2001
-
Munster PN, Basso A, Solit D, Norton L, Rosen N. Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. See: E. A. Sausville, Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin: sequence and tumor biology matters, Clin. Cancer Res., 7: 2155-2158, 2001. Clin Cancer Res 2001;7:2228-36.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 2228-2236
-
-
Munster, P.N.1
Basso, A.2
Solit, D.3
Norton, L.4
Rosen, N.5
-
69
-
-
79955603500
-
Phase I study of 17-allylamino-17 demethoxygeldanamycin, gemcitabine and/or cisplatin in patients with refractory solid tumors
-
Hubbard J, Erlichman C, Toft DO, Qin R, Stensgard BA, Felten S, et al. Phase I study of 17-allylamino-17 demethoxygeldanamycin, gemcitabine and/or cisplatin in patients with refractory solid tumors. Invest New Drugs 2011;29:473-80.
-
(2011)
Invest New Drugs
, vol.29
, pp. 473-480
-
-
Hubbard, J.1
Erlichman, C.2
Toft, D.O.3
Qin, R.4
Stensgard, B.A.5
Felten, S.6
-
70
-
-
84859794081
-
A phase I trial of docetaxel and pulse-dose 17-allylamino-17- demethoxygeldanamycin in adult patients with solid tumors
-
Iyer G, Morris MJ, Rathkopf D, Slovin SF, Steers M, Larson SM, et al. A phase I trial of docetaxel and pulse-dose 17-allylamino-17-demethoxygeldanamycin in adult patients with solid tumors. Cancer Chemother Pharmacol 2012;69:1089-97.
-
(2012)
Cancer Chemother Pharmacol
, vol.69
, pp. 1089-1097
-
-
Iyer, G.1
Morris, M.J.2
Rathkopf, D.3
Slovin, S.F.4
Steers, M.5
Larson, S.M.6
-
71
-
-
58149180924
-
A phase 1 dose-escalation study of irinotecan in combination with 17-allylamino-17-demethoxygeldanamycin in patients with solid tumors
-
Tse AN, Klimstra DS, Gonen M, Shah M, Sheikh T, Sikorski R, et al. A phase 1 dose-escalation study of irinotecan in combination with 17-allylamino-17-demethoxygeldanamycin in patients with solid tumors. Clin Cancer Res 2008;14:6704-11.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6704-6711
-
-
Tse, A.N.1
Klimstra, D.S.2
Gonen, M.3
Shah, M.4
Sheikh, T.5
Sikorski, R.6
-
72
-
-
44449168998
-
Radiosensitization of human vascular endothelial cells through Hsp90 inhibition with 17-N-allilamino-17-demethoxygeldanamycin
-
Kabakov AE, Makarova YM, Malyutina YV. Radiosensitization of human vascular endothelial cells through Hsp90 inhibition with 17-N-allilamino-17- demethoxygeldanamycin. Int J Radiat Oncol Biol Phys 2008;71:858-65.
-
(2008)
Int J Radiat Oncol Biol Phys
, vol.71
, pp. 858-865
-
-
Kabakov, A.E.1
Makarova, Y.M.2
Malyutina, Y.V.3
-
73
-
-
33749469341
-
Inhibition of hsp90 compromises the DNA damage response to radiation
-
Dote H, Burgan WE, Camphausen K, Tofilon PJ. Inhibition of hsp90 compromises the DNA damage response to radiation. Cancer Res 2006;66:9211-20.
-
(2006)
Cancer Res
, vol.66
, pp. 9211-9220
-
-
Dote, H.1
Burgan, W.E.2
Camphausen, K.3
Tofilon, P.J.4
-
74
-
-
23044480581
-
ErbB3 expression predicts tumor cell radiosensitization induced by Hsp90 inhibition
-
Dote H, Cerna D, Burgan WE, Camphausen K, Tofilon PJ. ErbB3 expression predicts tumor cell radiosensitization induced by Hsp90 inhibition. Cancer Res 2005;65:6967-75.
-
(2005)
Cancer Res
, vol.65
, pp. 6967-6975
-
-
Dote, H.1
Cerna, D.2
Burgan, W.E.3
Camphausen, K.4
Tofilon, P.J.5
-
75
-
-
77958019101
-
Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma
-
Davenport EL, Zeisig A, Aronson LI, Moore HE, Hockley S, Gonzalez D, et al. Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma. Leukemia 2010;24:1804-7.
-
(2010)
Leukemia
, vol.24
, pp. 1804-1807
-
-
Davenport, E.L.1
Zeisig, A.2
Aronson, L.I.3
Moore, H.E.4
Hockley, S.5
Gonzalez, D.6
-
76
-
-
77953734857
-
Heat shock protein 70 (hsp70) as an emerging drug target
-
Evans CG, Chang L, Gestwicki JE. Heat shock protein 70 (hsp70) as an emerging drug target. J Med Chem 2010;53:4585-602.
-
(2010)
J Med Chem
, vol.53
, pp. 4585-4602
-
-
Evans, C.G.1
Chang, L.2
Gestwicki, J.E.3
-
77
-
-
68249119157
-
Heat shock protein 27 as a new therapeutic target for radiation sensitization of head and neck squamous cell carcinoma
-
Hadchity E, Aloy MT, Paulin C, Armandy E, Watkin E, Rousson R, et al. Heat shock protein 27 as a new therapeutic target for radiation sensitization of head and neck squamous cell carcinoma. Mol Ther 2009;17:1387-94.
-
(2009)
Mol Ther
, vol.17
, pp. 1387-1394
-
-
Hadchity, E.1
Aloy, M.T.2
Paulin, C.3
Armandy, E.4
Watkin, E.5
Rousson, R.6
-
78
-
-
77953576838
-
Targeting HSP70: The second potentially druggable heat shock protein and molecular chaperone?
-
Powers MV, Jones K, Barillari C, Westwood I, van Montfort RL, Workman P. Targeting HSP70: the second potentially druggable heat shock protein and molecular chaperone? Cell Cycle 2010;9:1542-50.
-
(2010)
Cell Cycle
, vol.9
, pp. 1542-1550
-
-
Powers, M.V.1
Jones, K.2
Barillari, C.3
Westwood, I.4
Van Montfort, R.L.5
Workman, P.6
-
79
-
-
34447507818
-
Inhibitors of the heat shock response: Biology and pharmacology
-
Powers MV, Workman P. Inhibitors of the heat shock response: biology and pharmacology. FEBS Lett 2007;581:3758-69.
-
(2007)
FEBS Lett
, vol.581
, pp. 3758-3769
-
-
Powers, M.V.1
Workman, P.2
-
80
-
-
79952264098
-
New strategies in HER2-overexpressing breast cancer: Many combinations of targeted drugs available
-
Abramson V, Arteaga CL. New strategies in HER2-overexpressing breast cancer: many combinations of targeted drugs available. Clin Cancer Res 2011;17:952-8.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 952-958
-
-
Abramson, V.1
Arteaga, C.L.2
-
81
-
-
79960983010
-
Why is this effective HSP90 inhibitor not being developed in HER2+ breast cancer?
-
Arteaga CL. Why is this effective HSP90 inhibitor not being developed in HER2+ breast cancer? Clin Cancer Res 2011;17:4919-21.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 4919-4921
-
-
Arteaga, C.L.1
-
82
-
-
84864012288
-
Negative feedback and adaptive resistance to the targeted therapy of cancer
-
Chandarlapaty S. Negative feedback and adaptive resistance to the targeted therapy of cancer. Cancer Discov 2012;2:311-9.
-
(2012)
Cancer Discov
, vol.2
, pp. 311-319
-
-
Chandarlapaty, S.1
|