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Volumn 15, Issue 1, 2009, Pages 9-14

Heat shock protein 90 as a drug target: Some like it hot

Author keywords

[No Author keywords available]

Indexed keywords

17 DEMETHOXY 17 (2 DIMETHYLAMINOETHYLAMINO)GELDANAMYCIN; ALVESPIMYCIN; AUY 922A; B RAF KINASE; BCR ABL PROTEIN; BII 021; BIIB 021; BORTEZOMIB; CISPLATIN; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FLUORODEOXYGLUCOSE F 18; GELDANAMYCIN; GEMCITABINE; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; IMATINIB; IRINOTECAN; KF 58333; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; RADICICOL; RAF PROTEIN; RAS PROTEIN; SNX 2112; SORAFENIB; TANESPIMYCIN; TANESPIMYCIN HYDROQUINONE; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 58849160500     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-08-0132     Document Type: Article
Times cited : (220)

References (87)
  • 1
    • 0020491477 scopus 로고
    • Purification of the major mammalian heat shock proteins
    • Welch WJ, Feramisco JR. Purification of the major mammalian heat shock proteins. J Biol Chem 1982;257:14949-59.
    • (1982) J Biol Chem , vol.257 , pp. 14949-14959
    • Welch, W.J.1    Feramisco, J.R.2
  • 2
    • 1542718628 scopus 로고    scopus 로고
    • Heat shock proteins in the regulation of apoptosis: New strategies in tumor therapy
    • Sreedhar AS, Csermely P. Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy. Pharmacol Ther 2004;101:227-57.
    • (2004) Pharmacol Ther , vol.101 , pp. 227-257
    • Sreedhar, A.S.1    Csermely, P.2
  • 3
    • 0037040975 scopus 로고    scopus 로고
    • The role of Hsp90N, a new member of the Hsp90 family, in signal transduction and neoplastic transformation
    • Grammatikakis N, Vultur A, Ramana CV, et al. The role of Hsp90N, a new member of the Hsp90 family, in signal transduction and neoplastic transformation. J Biol Chem 2002;277:8312-20.
    • (2002) J Biol Chem , vol.277 , pp. 8312-8320
    • Grammatikakis, N.1    Vultur, A.2    Ramana, C.V.3
  • 4
    • 38349132541 scopus 로고    scopus 로고
    • A critical role for HSP90 in cancer cell invasion involves interaction with the extracellular domain of HER-2
    • Sidera K, Gaitanou M, Stellas D, Matsas R, Patsavoudi E. A critical role for HSP90 in cancer cell invasion involves interaction with the extracellular domain of HER-2. J Biol Chem 2008;283:2031-41.
    • (2008) J Biol Chem , vol.283 , pp. 2031-2041
    • Sidera, K.1    Gaitanou, M.2    Stellas, D.3    Matsas, R.4    Patsavoudi, E.5
  • 5
    • 0141596939 scopus 로고    scopus 로고
    • Structure and functional relationships of Hsp90
    • Prodromou C, Pearl LH. Structure and functional relationships of Hsp90. Curr Cancer Drug Targets 2003;3:301-23.
    • (2003) Curr Cancer Drug Targets , vol.3 , pp. 301-323
    • Prodromou, C.1    Pearl, L.H.2
  • 6
    • 0031444238 scopus 로고    scopus 로고
    • Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
    • Prodromou C, Roe SM, O'Brien R, Ladbury JE, Piper PW, Pearl LH. Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone. Cell 1997;90:65-75.
    • (1997) Cell , vol.90 , pp. 65-75
    • Prodromou, C.1    Roe, S.M.2    O'Brien, R.3    Ladbury, J.E.4    Piper, P.W.5    Pearl, L.H.6
  • 7
    • 41149111451 scopus 로고    scopus 로고
    • The Hsp90 molecular chaperone: An open and shut case for treatment
    • Pearl LH, Prodromou C, Workman P. The Hsp90 molecular chaperone: an open and shut case for treatment. Biochem J 2008;410:439-53.
    • (2008) Biochem J , vol.410 , pp. 439-453
    • Pearl, L.H.1    Prodromou, C.2    Workman, P.3
  • 8
    • 34447507818 scopus 로고    scopus 로고
    • Inhibitors of the heat shock response: Biology and pharmacology
    • Powers MV, Workman P. Inhibitors of the heat shock response: biology and pharmacology. FEBS Lett 2007;581:3758-69.
    • (2007) FEBS Lett , vol.581 , pp. 3758-3769
    • Powers, M.V.1    Workman, P.2
  • 9
    • 0035146685 scopus 로고    scopus 로고
    • The co-chaper-one CHIP regulates protein triage decisions mediated by heat-shock proteins
    • Connell P, Ballinger CA, Jiang J, et al. The co-chaper-one CHIP regulates protein triage decisions mediated by heat-shock proteins. Nat Cell Biol 2001;3:93-6.
    • (2001) Nat Cell Biol , vol.3 , pp. 93-96
    • Connell, P.1    Ballinger, C.A.2    Jiang, J.3
  • 10
    • 33846861747 scopus 로고    scopus 로고
    • Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors
    • Powers MV, Workman P. Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors. Endocr Relat Cancer 2006;13 Suppl 1:S125-35.
    • (2006) Endocr Relat Cancer , vol.13 , Issue.SUPPL. 1
    • Powers, M.V.1    Workman, P.2
  • 11
    • 35348890981 scopus 로고    scopus 로고
    • Drugging the cancer chaperone HSP90: Combinatorial therapeutic exploitation of oncogene addiction and tumor stress
    • Workman P, Burrows F, Neckers L, Rosen N. Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress. Ann N Y Acad Sci 2007;1113:202-16.
    • (2007) Ann N Y Acad Sci , vol.1113 , pp. 202-216
    • Workman, P.1    Burrows, F.2    Neckers, L.3    Rosen, N.4
  • 12
    • 44849093562 scopus 로고    scopus 로고
    • Oncogene addiction
    • discussion 80
    • Weinstein IB, Joe A. Oncogene addiction. Cancer Res 2008;68:3077-80; discussion 80.
    • (2008) Cancer Res , vol.68 , pp. 3077-3080
    • Weinstein, I.B.1    Joe, A.2
  • 13
    • 28244444919 scopus 로고    scopus 로고
    • Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin
    • da Rocha Dias S, Friedlos F, Light Y, Springer C, Workman P, Marais R. Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin. Cancer Res 2005;65:10686-91.
    • (2005) Cancer Res , vol.65 , pp. 10686-10691
    • da Rocha Dias, S.1    Friedlos, F.2    Light, Y.3    Springer, C.4    Workman, P.5    Marais, R.6
  • 14
    • 22244485706 scopus 로고    scopus 로고
    • Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins
    • Shimamura T, Lowell AM, Engelman JA, Shapiro Gl. Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins. Cancer Res 2005;65:6401-8.
    • (2005) Cancer Res , vol.65 , pp. 6401-6408
    • Shimamura, T.1    Lowell, A.M.2    Engelman, J.A.3    Shapiro, G.4
  • 15
    • 0141819958 scopus 로고    scopus 로고
    • The stress response: Implications for the clinical development of hsp90 inhibitors
    • Whitesell L, Bagatell R, Falsey R. The stress response: implications for the clinical development of hsp90 inhibitors. Curr Cancer Drug Targets 2003;3:349-58.
    • (2003) Curr Cancer Drug Targets , vol.3 , pp. 349-358
    • Whitesell, L.1    Bagatell, R.2    Falsey, R.3
  • 16
    • 0141484615 scopus 로고    scopus 로고
    • A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
    • Kamal A, Thao L, Sensintaffar J, et al. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature 2003;425:407-10.
    • (2003) Nature , vol.425 , pp. 407-410
    • Kamal, A.1    Thao, L.2    Sensintaffar, J.3
  • 17
    • 0028064940 scopus 로고
    • Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation
    • Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci U S A 1994;91:8324-8.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 8324-8328
    • Whitesell, L.1    Mimnaugh, E.G.2    De Costa, B.3    Myers, C.E.4    Neckers, L.M.5
  • 19
    • 33751258297 scopus 로고    scopus 로고
    • Development of 17-allylamino-17- demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90
    • Sydor JR, Normant E, Pien CS, et al. Development of 17-allylamino-17- demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90. Proc Natl Acad Sci U S A 2006;103:17408-13.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 17408-17413
    • Sydor, J.R.1    Normant, E.2    Pien, C.S.3
  • 20
    • 0035676830 scopus 로고    scopus 로고
    • A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1α and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts
    • Kurebayashi J, Otsuki T, Kurosumi M, Soga S, Akinaga S, Sonoo H. A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1α and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts. Jpn J Cancer Res 2001;92:1342-51.
    • (2001) Jpn J Cancer Res , vol.92 , pp. 1342-1351
    • Kurebayashi, J.1    Otsuki, T.2    Kurosumi, M.3    Soga, S.4    Akinaga, S.5    Sonoo, H.6
  • 21
    • 42349084306 scopus 로고    scopus 로고
    • NVP-AUY922: A novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis. and metastasis
    • Eccles SA, Massey A, Raynaud Fl, et al. NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis. and metastasis. Cancer Res 2008;68:2850-60.
    • (2008) Cancer Res , vol.68 , pp. 2850-2860
    • Eccles, S.A.1    Massey, A.2    Raynaud, F.3
  • 22
    • 55249118494 scopus 로고    scopus 로고
    • BIIB021, an oral synthetic non ansamycin Hsp90 inhibitor: Phase I experience
    • Elfiky A, Saif W, Beeram M, et al. BIIB021, an oral synthetic non ansamycin Hsp90 inhibitor: phase I experience. Proc Am Soc Clin Oncol 2008;26:2503.
    • (2008) Proc Am Soc Clin Oncol , vol.26 , pp. 2503
    • Elfiky, A.1    Saif, W.2    Beeram, M.3
  • 23
    • 40749103835 scopus 로고    scopus 로고
    • SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers
    • Chandarlapaty S, Sawai A, Ye Q, et al. SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers. Clin Cancer Res 2008;14:240-8.
    • (2008) Clin Cancer Res , vol.14 , pp. 240-248
    • Chandarlapaty, S.1    Sawai, A.2    Ye, Q.3
  • 24
    • 41349108858 scopus 로고    scopus 로고
    • Synthesis and biological activity of simplified denoviose-cou-marins related to novobiocin as potent inhibitors of heat-shock protein 90 (hsp90)
    • Radanyi C, Le Bras G, Messaoudi S, et al. Synthesis and biological activity of simplified denoviose-cou-marins related to novobiocin as potent inhibitors of heat-shock protein 90 (hsp90). Bioorg Med Chem Lett 2008;18:2495-8.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 2495-2498
    • Radanyi, C.1    Le Bras, G.2    Messaoudi, S.3
  • 25
    • 40449089789 scopus 로고    scopus 로고
    • Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin
    • Holmes JL, Sharp SY, Hobbs S, Workman P. Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin. Cancer Res 2008;68:1188-97.
    • (2008) Cancer Res , vol.68 , pp. 1188-1197
    • Holmes, J.L.1    Sharp, S.Y.2    Hobbs, S.3    Workman, P.4
  • 26
    • 38349153572 scopus 로고    scopus 로고
    • A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells
    • Zhang T, Hamza A, Cao X, et al. A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells. Mol Cancer Ther 2008;7:162-70.
    • (2008) Mol Cancer Ther , vol.7 , pp. 162-170
    • Zhang, T.1    Hamza, A.2    Cao, X.3
  • 27
    • 34548131162 scopus 로고    scopus 로고
    • Expressed as the sole Hsp90 of yeast, the α and β isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90β generates sensitivity to the Hsp90 inhibitor radicicol
    • Millson SH, Truman AW, Racz A, et al. Expressed as the sole Hsp90 of yeast, the α and β isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90β generates sensitivity to the Hsp90 inhibitor radicicol. FEBS J 2007;274:4453-63.
    • (2007) FEBS J , vol.274 , pp. 4453-4463
    • Millson, S.H.1    Truman, A.W.2    Racz, A.3
  • 28
    • 39149109163 scopus 로고    scopus 로고
    • Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects
    • Chan CT, Paulmurugan R, Gheysens OS, Kim J, Chiosis G, Gambhir SS. Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects. Cancer Res 2008;68:216-26.
    • (2008) Cancer Res , vol.68 , pp. 216-226
    • Chan, C.T.1    Paulmurugan, R.2    Gheysens, O.S.3    Kim, J.4    Chiosis, G.5    Gambhir, S.S.6
  • 29
    • 0034890377 scopus 로고    scopus 로고
    • Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner
    • Munster PN, Basso A, Solit D, Norton L, Rosen N. Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. Clin Cancer Res 2001;7:2228-36.
    • (2001) Clin Cancer Res , vol.7 , pp. 2228-2236
    • Munster, P.N.1    Basso, A.2    Solit, D.3    Norton, L.4    Rosen, N.5
  • 30
    • 0034777916 scopus 로고    scopus 로고
    • Destabilization of steroid receptors by heat shock protein 90-binding drugs: A ligand-independent approach to hormonal therapy of breast cancer
    • Bagatell R, Khan O, Paine-Murrieta G, Taylor CW, Akinaga S, Whitesell L. Destabilization of steroid receptors by heat shock protein 90-binding drugs: a ligand-independent approach to hormonal therapy of breast cancer. Clin Cancer Res 2001;7:2076-84.
    • (2001) Clin Cancer Res , vol.7 , pp. 2076-2084
    • Bagatell, R.1    Khan, O.2    Paine-Murrieta, G.3    Taylor, C.W.4    Akinaga, S.5    Whitesell, L.6
  • 31
    • 38849091289 scopus 로고    scopus 로고
    • Activation of fibronectin/PI-3K/Akt2 leads to chemoresistance to docetaxel by regulating survivin protein expression in ovarian and breast cancer cells
    • Xing H, Weng D, Chen G, et al. Activation of fibronectin/PI-3K/Akt2 leads to chemoresistance to docetaxel by regulating survivin protein expression in ovarian and breast cancer cells. Cancer Lett 2008;261:108-19.
    • (2008) Cancer Lett , vol.261 , pp. 108-119
    • Xing, H.1    Weng, D.2    Chen, G.3
  • 32
    • 34248195608 scopus 로고    scopus 로고
    • High HSP90 expression is associated with decreased survival in breast cancer
    • Pick E, Kluger Y, Giltnane JM, et al. High HSP90 expression is associated with decreased survival in breast cancer. Cancer Res 2007;67:2932-7.
    • (2007) Cancer Res , vol.67 , pp. 2932-2937
    • Pick, E.1    Kluger, Y.2    Giltnane, J.M.3
  • 33
    • 36849055007 scopus 로고    scopus 로고
    • Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: A phase I dose-escalation study
    • Modi S, Stopeck AT, Gordon MS, et al. Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study. J Clin Oncol 2007;25:5410-7.
    • (2007) J Clin Oncol , vol.25 , pp. 5410-5417
    • Modi, S.1    Stopeck, A.T.2    Gordon, M.S.3
  • 35
    • 34047241332 scopus 로고    scopus 로고
    • The Hsp90 inhibitor, 17-AAG, prevents the ligand-independent nuclear localization of androgen receptor in refractory prostate cancer cells
    • Saporita AJ, Ai J, Wang Z. The Hsp90 inhibitor, 17-AAG, prevents the ligand-independent nuclear localization of androgen receptor in refractory prostate cancer cells. Prostate 2007;67:509-20.
    • (2007) Prostate , vol.67 , pp. 509-520
    • Saporita, A.J.1    Ai, J.2    Wang, Z.3
  • 36
    • 0036091221 scopus 로고    scopus 로고
    • 17-Allylamino-17- demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts
    • Solit DB, Zheng FF, Drobnjak M, et al. 17-Allylamino-17- demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts. Clin Cancer Res 2002;8:986-93.
    • (2002) Clin Cancer Res , vol.8 , pp. 986-993
    • Solit, D.B.1    Zheng, F.F.2    Drobnjak, M.3
  • 37
    • 33750683926 scopus 로고    scopus 로고
    • IL-6, IL-10 and HSP-90 expression in tissue microarrays from human prostate cancer assessed by computer-assisted image analysis
    • Cardillo MR, Ippoliti F. IL-6, IL-10 and HSP-90 expression in tissue microarrays from human prostate cancer assessed by computer-assisted image analysis. Anticancer Res 2006;26:3409-16.
    • (2006) Anticancer Res , vol.26 , pp. 3409-3416
    • Cardillo, M.R.1    Ippoliti, F.2
  • 38
    • 18744390800 scopus 로고    scopus 로고
    • Heat shock protein 90 (Hsp90) chaperone complex inhibitor, radicicol, potentiated radiation-induced cell killing in a hormone-sensitive prostate cancer cell line through degradation of the androgen receptor
    • Harashima K, Akimoto T, Nonaka T, Tsuzuki K, Mitsuhashi N, NakanoT. Heat shock protein 90 (Hsp90) chaperone complex inhibitor, radicicol, potentiated radiation-induced cell killing in a hormone-sensitive prostate cancer cell line through degradation of the androgen receptor. Int J Radiat Biol 2005;81:63-76.
    • (2005) Int J Radiat Biol , vol.81 , pp. 63-76
    • Harashima, K.1    Akimoto, T.2    Nonaka, T.3    Tsuzuki, K.4    Mitsuhashi, N.5    NakanoT6
  • 39
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature 2002;417:949-54.
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 40
    • 40149102363 scopus 로고    scopus 로고
    • HSP90 as a marker of progression in melanoma
    • McCarthy MM, Pick E, Kluger Y, et al. HSP90 as a marker of progression in melanoma. Ann Oncol 2008;19:590-4.
    • (2008) Ann Oncol , vol.19 , pp. 590-594
    • McCarthy, M.M.1    Pick, E.2    Kluger, Y.3
  • 41
    • 38949105894 scopus 로고    scopus 로고
    • Immune expression and inhibition of heat shock protein 90 in uveal melanoma
    • Faingold D, Marshall JC, Antecka E, et al. Immune expression and inhibition of heat shock protein 90 in uveal melanoma. Clin Cancer Res 2008;14:847-55.
    • (2008) Clin Cancer Res , vol.14 , pp. 847-855
    • Faingold, D.1    Marshall, J.C.2    Antecka, E.3
  • 42
    • 23044441106 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies
    • Banerji U, O'Donnell A, Scurr M, et al. Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies. J Clin Oncol 2005;23:4152-61.
    • (2005) J Clin Oncol , vol.23 , pp. 4152-4161
    • Banerji, U.1    O'Donnell, A.2    Scurr, M.3
  • 43
    • 45849105629 scopus 로고    scopus 로고
    • Gallegos Ruiz Ml, Floor K, Roepman P, et al. Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target. PLoS ONE 2008;3:e000l722.
    • Gallegos Ruiz Ml, Floor K, Roepman P, et al. Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target. PLoS ONE 2008;3:e000l722.
  • 44
    • 34447498813 scopus 로고    scopus 로고
    • Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer
    • Rodina A, Vilenchik M, Moulick K, et al. Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. Nat Chem Biol 2007;3:498-507.
    • (2007) Nat Chem Biol , vol.3 , pp. 498-507
    • Rodina, A.1    Vilenchik, M.2    Moulick, K.3
  • 46
    • 42649125571 scopus 로고    scopus 로고
    • Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
    • Haigis KM, Kendall KR, Wang Y, et al. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet 2008;40:600-8.
    • (2008) Nat Genet , vol.40 , pp. 600-608
    • Haigis, K.M.1    Kendall, K.R.2    Wang, Y.3
  • 47
    • 40949135397 scopus 로고    scopus 로고
    • PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab
    • Jhawer M, Goel S, Wilson AJ, et al. PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab. Cancer Res 2008;68:1953-61.
    • (2008) Cancer Res , vol.68 , pp. 1953-1961
    • Jhawer, M.1    Goel, S.2    Wilson, A.J.3
  • 48
    • 0033579175 scopus 로고    scopus 로고
    • DT-diaphorase expression and tumor cell sensitivity to 17-allylamino, 17- demethoxygeldanamycin, an inhibitor of heat shock protein 90
    • Kelland LR, Sharp SY, Rogers PM, Myers TG, Workman P. DT-diaphorase expression and tumor cell sensitivity to 17-allylamino, 17- demethoxygeldanamycin, an inhibitor of heat shock protein 90. J Natl Cancer Inst 1999;91:1940-9.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1940-1949
    • Kelland, L.R.1    Sharp, S.Y.2    Rogers, P.M.3    Myers, T.G.4    Workman, P.5
  • 49
    • 28244490997 scopus 로고    scopus 로고
    • High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma
    • Oda K, Stokoe D, Taketani Y, McCormick F. High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. Cancer Res 2005;65:10669-73.
    • (2005) Cancer Res , vol.65 , pp. 10669-10673
    • Oda, K.1    Stokoe, D.2    Taketani, Y.3    McCormick, F.4
  • 50
    • 0034976644 scopus 로고    scopus 로고
    • Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas
    • Kurose K, Zhou XP, Araki T, Cannistra SA, Maher ER, Eng C. Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas. Am J Pathol 2001;158:2097-106.
    • (2001) Am J Pathol , vol.158 , pp. 2097-2106
    • Kurose, K.1    Zhou, X.P.2    Araki, T.3    Cannistra, S.A.4    Maher, E.R.5    Eng, C.6
  • 51
    • 0037119415 scopus 로고    scopus 로고
    • Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 α-degradative pathway
    • Isaacs JS, Jung YJ, Mirnnaugh EG, Martinez A, Cuttitta F, Neckers LM. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 α-degradative pathway. J Biol Chem 2002;277:29936-44.
    • (2002) J Biol Chem , vol.277 , pp. 29936-29944
    • Isaacs, J.S.1    Jung, Y.J.2    Mirnnaugh, E.G.3    Martinez, A.4    Cuttitta, F.5    Neckers, L.M.6
  • 52
    • 33645470397 scopus 로고    scopus 로고
    • Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis
    • Sanderson S, Valenti M, Gowan S, et al. Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis. Mol Cancer Ther 2006;5:522-32.
    • (2006) Mol Cancer Ther , vol.5 , pp. 522-532
    • Sanderson, S.1    Valenti, M.2    Gowan, S.3
  • 53
    • 33747691089 scopus 로고    scopus 로고
    • A phase II trial of 17-(allylamino)-17-demethoxygeldanamycin in patients with papillary and clear cell renal cell carcinoma
    • Ronnen EA, Kondagunta GV, Ishill N, et al. A phase II trial of 17-(allylamino)-17-demethoxygeldanamycin in patients with papillary and clear cell renal cell carcinoma. Invest New Drugs 2006;24:543-6.
    • (2006) Invest New Drugs , vol.24 , pp. 543-546
    • Ronnen, E.A.1    Kondagunta, G.V.2    Ishill, N.3
  • 54
    • 58849149317 scopus 로고    scopus 로고
    • Phase I trial of intravenous 17-allylarninogeldanamycin (A) and oral sorafenib (B) in pretreated advanced malignancy: Plasma Hsp90α induction correlates with clinical benefit [abstract 3531]
    • Vaishampayan U, Sausville E, Horiba M, et al. Phase I trial of intravenous 17-allylarninogeldanamycin (A) and oral sorafenib (B) in pretreated advanced malignancy: plasma Hsp90α induction correlates with clinical benefit [abstract 3531]. Proc Annu Meet Am Soc Clin Oncol 2007;25:145.
    • (2007) Proc Annu Meet Am Soc Clin Oncol , vol.25 , pp. 145
    • Vaishampayan, U.1    Sausville, E.2    Horiba, M.3
  • 55
    • 33749461709 scopus 로고    scopus 로고
    • Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor
    • Bauer S, Yu LX, Demetri GD, Fletcher JA. Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor. Cancer Res 2006;66:9153-61.
    • (2006) Cancer Res , vol.66 , pp. 9153-9161
    • Bauer, S.1    Yu, L.X.2    Demetri, G.D.3    Fletcher, J.A.4
  • 56
    • 33846813443 scopus 로고    scopus 로고
    • Targeting EGF-receptor-signalling in squamous cell carcinomas of the head and neck
    • Reuter CW, Morgan MA, Eckardt A. Targeting EGF-receptor-signalling in squamous cell carcinomas of the head and neck. Br J Cancer 2007;96:408-16.
    • (2007) Br J Cancer , vol.96 , pp. 408-416
    • Reuter, C.W.1    Morgan, M.A.2    Eckardt, A.3
  • 57
    • 30344435264 scopus 로고    scopus 로고
    • Heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin potentiates the radiation response of tumor cells grown as monolayer cultures and spheroids by inducing apoptosis
    • Machida H, Nakajima S, Shikano N, et al. Heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin potentiates the radiation response of tumor cells grown as monolayer cultures and spheroids by inducing apoptosis. Cancer Sci 2005;96:911-7.
    • (2005) Cancer Sci , vol.96 , pp. 911-917
    • Machida, H.1    Nakajima, S.2    Shikano, N.3
  • 58
    • 0036233939 scopus 로고    scopus 로고
    • Heat shock protein 90-antagonist destabilizes Bcr-Abl/HSP90 chaperone complex
    • Shiotsu Y, Soga S, Akinaga S. Heat shock protein 90-antagonist destabilizes Bcr-Abl/HSP90 chaperone complex. Leuk Lymphoma 2002;43:961-8.
    • (2002) Leuk Lymphoma , vol.43 , pp. 961-968
    • Shiotsu, Y.1    Soga, S.2    Akinaga, S.3
  • 59
    • 35148813851 scopus 로고    scopus 로고
    • Heat shock protein 90: A potential therapeutic target in leukemic progenitor and stem cells harboring mutant BCR-ABL resistant to kinase inhibitors
    • Peng C, Li D, Li S. Heat shock protein 90: a potential therapeutic target in leukemic progenitor and stem cells harboring mutant BCR-ABL resistant to kinase inhibitors. Cell Cycle 2007;6:2227-31.
    • (2007) Cell Cycle , vol.6 , pp. 2227-2231
    • Peng, C.1    Li, D.2    Li, S.3
  • 60
    • 33846208233 scopus 로고    scopus 로고
    • STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90α and β in multiple myeloma cells, which critically contribute to tumor-cell survival
    • Chatterjee M, Jain S, Stuhmer T, et al. STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90α and β in multiple myeloma cells, which critically contribute to tumor-cell survival. Blood 2007;109:720-8.
    • (2007) Blood , vol.109 , pp. 720-728
    • Chatterjee, M.1    Jain, S.2    Stuhmer, T.3
  • 61
    • 31544436323 scopus 로고    scopus 로고
    • Antimyeloma activity of heat shock protein-90 inhibition
    • Mitsiades CS, Mitsiades NS, McMullan CJ, et al. Antimyeloma activity of heat shock protein-90 inhibition. Blood 2006;107:1092-100.
    • (2006) Blood , vol.107 , pp. 1092-1100
    • Mitsiades, C.S.1    Mitsiades, N.S.2    McMullan, C.J.3
  • 62
    • 34948890040 scopus 로고    scopus 로고
    • Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells
    • Davenport EL, Moore HE, Dunlop AS, et al. Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells. Blood 2007;110:2641-9.
    • (2007) Blood , vol.110 , pp. 2641-2649
    • Davenport, E.L.1    Moore, H.E.2    Dunlop, A.S.3
  • 63
    • 27144551963 scopus 로고    scopus 로고
    • ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: Inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia
    • Castro JE, Prada CE, Loria O, et al. ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia. Blood 2005;106:2506-12.
    • (2005) Blood , vol.106 , pp. 2506-2512
    • Castro, J.E.1    Prada, C.E.2    Loria, O.3
  • 64
    • 42249109027 scopus 로고    scopus 로고
    • Heat shock protein 90 inhibition is cytotoxic to primary AML cells expressing mutant FLT3 and results in altered downstream signalling
    • Al Shaer L, Walsby E, Gilkes A, et al. Heat shock protein 90 inhibition is cytotoxic to primary AML cells expressing mutant FLT3 and results in altered downstream signalling. Br J Haematol 2008;141:483-93.
    • (2008) Br J Haematol , vol.141 , pp. 483-493
    • Al Shaer, L.1    Walsby, E.2    Gilkes, A.3
  • 65
    • 58849090397 scopus 로고    scopus 로고
    • The novel HSP90 inhibitor IPI-504 synergizes with bortezomib in mantel cell lymphoma cells by targeting both NF-κB signalling and unfolded protein response and leading to increased mitochondrial apoptosis
    • Roue G, Perez-Galan P, Lopez-Guerra M, Villamor N, Campo E, Colomer D. The novel HSP90 inhibitor IPI-504 synergizes with bortezomib in mantel cell lymphoma cells by targeting both NF-κB signalling and unfolded protein response and leading to increased mitochondrial apoptosis. Proc Annu Meet Am Assoc Cancer Res 2008;49:4010.
    • (2008) Proc Annu Meet Am Assoc Cancer Res , vol.49 , pp. 4010
    • Roue, G.1    Perez-Galan, P.2    Lopez-Guerra, M.3    Villamor, N.4    Campo, E.5    Colomer, D.6
  • 66
    • 58849087470 scopus 로고    scopus 로고
    • Synergistic interactions of the Hsp90 inhibitor 17AAG and PI3K inhibitor LY294002 in non-small cell lung cancer (NSCLC) cell lines involve disruption of Akt and c-raf signalling
    • Angelaki S, Lnu S, Brown E, Ayers G, Papadimitrakopoulou V. Synergistic interactions of the Hsp90 inhibitor 17AAG and PI3K inhibitor LY294002 in non-small cell lung cancer (NSCLC) cell lines involve disruption of Akt and c-raf signalling. Proc Annu Meet Am Assoc Cancer Res 2005;46:4200.
    • (2005) Proc Annu Meet Am Assoc Cancer Res , vol.46 , pp. 4200
    • Angelaki, S.1    Lnu, S.2    Brown, E.3    Ayers, G.4    Papadimitrakopoulou, V.5
  • 67
    • 49849084850 scopus 로고    scopus 로고
    • An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models
    • Banerji U, Sain N, Sharp SY, et al. An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models. Cancer Chemother Pharmacol 2008;62:769-78.
    • (2008) Cancer Chemother Pharmacol , vol.62 , pp. 769-778
    • Banerji, U.1    Sain, N.2    Sharp, S.Y.3
  • 68
    • 0034886833 scopus 로고    scopus 로고
    • Combining cytotoxics and 17-allylamino, 17- demethoxygeldanamycin: Sequence and tumor biology matters
    • Sausville E. Combining cytotoxics and 17-allylamino, 17- demethoxygeldanamycin: sequence and tumor biology matters. Clin Cancer Res 2001;7:2155-8.
    • (2001) Clin Cancer Res , vol.7 , pp. 2155-2158
    • Sausville, E.1
  • 69
    • 21744462772 scopus 로고    scopus 로고
    • Synergistic activity of imatinib and 17-AAG in imatinib-resistant CML cells overexpressing BCR-ABL-inhibition of Pglycoprotein function by 17-AAG
    • Radujkovic A, Schad M, Topaly J, et al. Synergistic activity of imatinib and 17-AAG in imatinib-resistant CML cells overexpressing BCR-ABL-inhibition of Pglycoprotein function by 17-AAG. Leukemia 2005;19:1198-206.
    • (2005) Leukemia , vol.19 , pp. 1198-1206
    • Radujkovic, A.1    Schad, M.2    Topaly, J.3
  • 70
    • 33749469341 scopus 로고    scopus 로고
    • Inhibition of hsp90 compromises the DNA damage response to radiation
    • Dote H, Burgan WE, Camphausen K, Tofilon PJ. Inhibition of hsp90 compromises the DNA damage response to radiation. Cancer Res 2006;66:9211-20.
    • (2006) Cancer Res , vol.66 , pp. 9211-9220
    • Dote, H.1    Burgan, W.E.2    Camphausen, K.3    Tofilon, P.J.4
  • 71
    • 23044480581 scopus 로고    scopus 로고
    • ErbB3 expression predicts tumor cell radiosensitization induced by Hsp90 inhibition
    • Dote H, Cerna D, Burgan WE, Camphausen K, Tofilon PJ. ErbB3 expression predicts tumor cell radiosensitization induced by Hsp90 inhibition. Cancer Res 2005;65:6967-75.
    • (2005) Cancer Res , vol.65 , pp. 6967-6975
    • Dote, H.1    Cerna, D.2    Burgan, W.E.3    Camphausen, K.4    Tofilon, P.J.5
  • 72
    • 44449168998 scopus 로고    scopus 로고
    • Radiosensitization of human vascular endothelial cells through Hsp90 inhibition with 17-N-allilamino-17- demethoxygeldanamycin
    • Kabakov AE, Makarova YM, Malyutina YV. Radiosensitization of human vascular endothelial cells through Hsp90 inhibition with 17-N-allilamino-17- demethoxygeldanamycin. Int J Radiat Oncol Biol Phys 2008;71:858-65.
    • (2008) Int J Radiat Oncol Biol Phys , vol.71 , pp. 858-865
    • Kabakov, A.E.1    Makarova, Y.M.2    Malyutina, Y.V.3
  • 73
    • 51449118446 scopus 로고    scopus 로고
    • Inhibition of heat shock protein 90 (Hsp90) with a novel agent IPI-504 in metastatic GIST following failure of tyrosine kinase inhibitors (TKIs) or other sarcomas: Clinical results from a phase I trial [abstract 10503]
    • Wagner A, Morgan J, Chugh R, et al. Inhibition of heat shock protein 90 (Hsp90) with a novel agent IPI-504 in metastatic GIST following failure of tyrosine kinase inhibitors (TKIs) or other sarcomas: clinical results from a phase I trial [abstract 10503]. Proc Annu Meet Am Soc Clin Oncol 2008;26:55.
    • (2008) Proc Annu Meet Am Soc Clin Oncol , vol.26 , pp. 55
    • Wagner, A.1    Morgan, J.2    Chugh, R.3
  • 74
    • 42249096283 scopus 로고    scopus 로고
    • BRAF and NRAS mutations in melanoma: Potential relationships to clinical response to HSP90 inhibitors
    • Banerji U, Affolter A, Judson I, Marais R, Workman P. BRAF and NRAS mutations in melanoma: potential relationships to clinical response to HSP90 inhibitors. Mol Cancer Ther 2008;7:737-9.
    • (2008) Mol Cancer Ther , vol.7 , pp. 737-739
    • Banerji, U.1    Affolter, A.2    Judson, I.3    Marais, R.4    Workman, P.5
  • 75
    • 58849152682 scopus 로고    scopus 로고
    • A phase I of the heat shock protein 90 (HSP90) inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG, alvespimycin) administered weekly [abstract 3568]
    • Pacey S, Wilson R, Walton M, et al. A phase I of the heat shock protein 90 (HSP90) inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG, alvespimycin) administered weekly [abstract 3568]. Proc Annu Meet Am Soc Clin Oncol 2007;25:154.
    • (2007) Proc Annu Meet Am Soc Clin Oncol , vol.25 , pp. 154
    • Pacey, S.1    Wilson, R.2    Walton, M.3
  • 76
    • 20944444881 scopus 로고    scopus 로고
    • Phase I pharmacokinetic- pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin (17AAG, NSC 330507), a novel inhibitor of heat shock protein 90, in patients with refractory advanced cancers
    • Ramanathan RK, Trump DL, Eiseman JL, et al. Phase I pharmacokinetic- pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin (17AAG, NSC 330507), a novel inhibitor of heat shock protein 90, in patients with refractory advanced cancers. Clin Cancer Res 2005;11:3385-91.
    • (2005) Clin Cancer Res , vol.11 , pp. 3385-3391
    • Ramanathan, R.K.1    Trump, D.L.2    Eiseman, J.L.3
  • 77
    • 34250197902 scopus 로고    scopus 로고
    • Phase I trial of 17-allylamino-17- demethoxygeldanamycin in patients with advanced cancer
    • Solit DB, Ivy SP, Kopil C, et al. Phase I trial of 17-allylamino-17- demethoxygeldanamycin in patients with advanced cancer. Clin Cancer Res 2007;13:1775-82.
    • (2007) Clin Cancer Res , vol.13 , pp. 1775-1782
    • Solit, D.B.1    Ivy, S.P.2    Kopil, C.3
  • 78
    • 34250160933 scopus 로고    scopus 로고
    • Phase I and pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with refractory advanced cancers
    • Ramanathan RK, Egorin MJ, Eiseman JL, et al. Phase I and pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with refractory advanced cancers. Clin Cancer Res 2007;13:1769-74.
    • (2007) Clin Cancer Res , vol.13 , pp. 1769-1774
    • Ramanathan, R.K.1    Egorin, M.J.2    Eiseman, J.L.3
  • 79
    • 20144375312 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of 17- (allylamino) -17-demethoxygeldanamycin in adult patients with solid tumors
    • Grem JL, Morrison G, Guo XD, et al. Phase I and pharmacologic study of 17- (allylamino) -17-demethoxygeldanamycin in adult patients with solid tumors. J Clin Oncol 2005;23:1885-93.
    • (2005) J Clin Oncol , vol.23 , pp. 1885-1893
    • Grem, J.L.1    Morrison, G.2    Guo, X.D.3
  • 80
    • 51449115938 scopus 로고    scopus 로고
    • A phase 1 dose-escalation study of the safety and pharmacokinetics (PK) of the oral Hsp90 inhibitor SNX-5422 [abstract 14613]
    • Bryson J, Infante J, Ramanathan RK, Jones S, Von Hoff D, Burris H. A phase 1 dose-escalation study of the safety and pharmacokinetics (PK) of the oral Hsp90 inhibitor SNX-5422 [abstract 14613]. Proc Annu Meet Am Soc Clin Oncol 2008;26:636.
    • (2008) Proc Annu Meet Am Soc Clin Oncol , vol.26 , pp. 636
    • Bryson, J.1    Infante, J.2    Ramanathan, R.K.3    Jones, S.4    Von Hoff, D.5    Burris, H.6
  • 81
    • 49849088582 scopus 로고    scopus 로고
    • A phase I trial of gemcitabine (Gem), 17-allylaminogeldanamcyin (17-AAG) and cisplatin (CDDP) in solid tumor patients [abstract 3058]
    • Haluska P, Toft D, Steinmetz S, et al. A phase I trial of gemcitabine (Gem), 17-allylaminogeldanamcyin (17-AAG) and cisplatin (CDDP) in solid tumor patients [abstract 3058]. Proc Annu Meet Am Soc Clin Oncol 2004;23:209.
    • (2004) Proc Annu Meet Am Soc Clin Oncol , vol.23 , pp. 209
    • Haluska, P.1    Toft, D.2    Steinmetz, S.3
  • 82
    • 41949133119 scopus 로고    scopus 로고
    • Phase II trial of tanespimycin (KOS-953), a heat shock protein 90 (Hsp90) inhibitor in patients with metastatic melanoma [abstract 8558]
    • Kefford R, Millward M, Hersey P, et al. Phase II trial of tanespimycin (KOS-953), a heat shock protein 90 (Hsp90) inhibitor in patients with metastatic melanoma [abstract 8558]. Proc Annu Meet Am Soc Clin Oncol 2007;25:486.
    • (2007) Proc Annu Meet Am Soc Clin Oncol , vol.25 , pp. 486
    • Kefford, R.1    Millward, M.2    Hersey, P.3
  • 83
    • 34247534251 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic trial of docetaxel and 17AAG (17-allylamino-17- demethoxygeldanamycin) [abstract 3051]
    • Solit D, B, Egorin MJ, Kopil C, et al. Phase I pharmacokinetic and pharmacodynamic trial of docetaxel and 17AAG (17-allylamino-17- demethoxygeldanamycin) [abstract 3051]. Proc Annu Meet Am Soc Clin Oncol 2005;23:204.
    • (2005) Proc Annu Meet Am Soc Clin Oncol , vol.23 , pp. 204
    • Solit, D.B.1    Egorin, M.J.2    Kopil, C.3
  • 84
    • 26944439006 scopus 로고    scopus 로고
    • A phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancer
    • Heath El, Gaskins M, Pitot HC, et al. A phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancer. Clin Prostate Cancer 2005;4:138-41.
    • (2005) Clin Prostate Cancer , vol.4 , pp. 138-141
    • Heath, E.1    Gaskins, M.2    Pitot, H.C.3
  • 85
    • 58849123076 scopus 로고    scopus 로고
    • Phase 1 dose escalation study of 17-allylamino-17-demethoxygeldanamycin (17AAG) in combination with irinotecan in patients with solid tumours [abstract 3533]
    • Tse A, Carvajal R, Shah M, et al. Phase 1 dose escalation study of 17-allylamino-17-demethoxygeldanamycin (17AAG) in combination with irinotecan in patients with solid tumours [abstract 3533]. Proc Annu Meet Am Soc Clin Oncol 2007;25:146.
    • (2007) Proc Annu Meet Am Soc Clin Oncol , vol.25 , pp. 146
    • Tse, A.1    Carvajal, R.2    Shah, M.3
  • 86
    • 33748912183 scopus 로고    scopus 로고
    • Phase 1 trial of KOS-953 + bortezomib (BZ) in relapsed refractory multiple myeloma [abstract 3066]
    • Chanan-Khan A, Richardson P, Alsina M. et al. Phase 1 trial of KOS-953 + bortezomib (BZ) in relapsed refractory multiple myeloma [abstract 3066]. Proc Annu Meet Am Soc Clin Oncol 2006;24:137.
    • (2006) Proc Annu Meet Am Soc Clin Oncol , vol.24 , pp. 137
    • Chanan-Khan, A.1    Richardson, P.2    Alsina, M.3
  • 87
    • 58849127295 scopus 로고    scopus 로고
    • Alvespimycin (KOS-1022) and trastuzumab (T): Activity in HER2+ metastatic breast cancer (MBC) [abstract 115]
    • Modi S, Miller K, Rosen L, et al. Alvespimycin (KOS-1022) and trastuzumab (T): activity in HER2+ metastatic breast cancer (MBC) [abstract 115]. Proc Annu Meet Am Soc Clin Oncol 2007;25:60.
    • (2007) Proc Annu Meet Am Soc Clin Oncol , vol.25 , pp. 60
    • Modi, S.1    Miller, K.2    Rosen, L.3


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