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Volumn 3, Issue 6, 2002, Pages 401-410

IAP proteins: Blocking the road to death's door

Author keywords

[No Author keywords available]

Indexed keywords

INHIBITOR OF APOPTOSIS PROTEIN;

EID: 0036088471     PISSN: 14710072     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrm830     Document Type: Review
Times cited : (1610)

References (154)
  • 3
    • 0028943734 scopus 로고
    • Apoptosis in the pathogenesis and treatment of disease
    • (1995) Science , vol.267 , pp. 1456-1462
    • Thompson, C.B.1
  • 8
    • 15844425961 scopus 로고    scopus 로고
    • A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors
    • (1996) EMBO J. , vol.15 , pp. 2685-2694
    • Duckett, C.S.1
  • 9
    • 13344278692 scopus 로고    scopus 로고
    • Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes
    • (1996) Nature , vol.379 , pp. 349-353
    • Liston, P.1
  • 10
    • 0028896092 scopus 로고
    • The gene for neuronal apoptosis inhibitory protein is partaily deleted in individuals with spinal muscular atrophy
    • (1995) Cell , vol.80 , pp. 167-178
    • Roy, N.1
  • 18
    • 0033592470 scopus 로고    scopus 로고
    • NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP
    • (1999) Nature , vol.401 , pp. 818-822
    • Sun, C.1
  • 24
    • 0032522738 scopus 로고    scopus 로고
    • IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
    • (1998) EMBO J. , vol.17 , pp. 2215-2223
    • Deveraux, Q.L.1
  • 25
    • 0034967005 scopus 로고    scopus 로고
    • Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein (IAP) family
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 4292-4301
    • Richter, B.W.M.1
  • 30
    • 0028883850 scopus 로고
    • Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
    • (1995) EMBO J. , vol.14 , pp. 5579-5588
    • Kischkel, F.C.1
  • 31
    • 0030925774 scopus 로고    scopus 로고
    • FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
    • (1997) EMBO J. , vol.16 , pp. 2794-2804
    • Medema, J.P.1
  • 35
    • 0036187036 scopus 로고    scopus 로고
    • Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation
    • (2002) Mol. Cell , vol.9 , pp. 423-432
    • Acehan, D.1
  • 38
    • 0034105784 scopus 로고    scopus 로고
    • Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes
    • (2000) J. Biol. Chem. , vol.275 , pp. 6067-6070
    • Cain, K.1
  • 39
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    • (1998) Cell , vol.94 , pp. 491-501
    • Li, H.1    Zhu, H.2    Xu, C.J.3    Yuan, J.4
  • 40
    • 0034786019 scopus 로고    scopus 로고
    • L sequester BH3 domainonly molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
    • (2001) Mol. Cell , vol.8 , pp. 705-711
    • Cheng, E.H.1
  • 41
    • 0032568954 scopus 로고    scopus 로고
    • Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c
    • (1998) J. Biol. Chem. , vol.273 , pp. 16589-16594
    • Kuwana, T.1
  • 43
    • 0033215040 scopus 로고    scopus 로고
    • Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases
    • (1999) EMBO J. , vol.18 , pp. 5242-5251
    • Deveraux, Q.L.1
  • 44
    • 0035282570 scopus 로고    scopus 로고
    • A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
    • (2001) Nature , vol.410 , pp. 112-116
    • Srinivasula, S.M.1
  • 45
    • 0034721940 scopus 로고    scopus 로고
    • NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP
    • (2000) J. Biol. Chem. , vol.275 , pp. 33777-33781
    • Sun, C.1
  • 47
    • 0035831022 scopus 로고    scopus 로고
    • Structural basis of caspase inhibition by XIAP. Differential roles of the linker versus the BIR domain
    • (2001) Cell , vol.104 , pp. 781-790
    • Huang, Y.1
  • 48
    • 0035831019 scopus 로고    scopus 로고
    • Structural basis for the inhibition of caspase-3 by XIAP
    • (2001) Cell , vol.104 , pp. 791-800
    • Riedl, S.J.1
  • 50
    • 0035831021 scopus 로고    scopus 로고
    • Structural basis of caspase-7 inhibition by XIAP
    • (2001) Cell , vol.104 , pp. 769-780
    • Chai, J.1
  • 52
    • 0036205587 scopus 로고    scopus 로고
    • Mechanisms of caspase activation and inhibition during apoptosis
    • (2002) Mol. Cell , vol.9 , pp. 459-470
    • Shi, Y.1
  • 55
    • 0032506524 scopus 로고    scopus 로고
    • Control of apoptosis and mitotic spindle checkpoint by survivin
    • (1998) Nature , vol.396 , pp. 580-584
    • Li, F.1
  • 56
    • 0034597594 scopus 로고    scopus 로고
    • Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype
    • (2000) Curr. Biol. , vol.10 , pp. 1319-1328
    • Uren, A.G.1
  • 57
    • 0030885421 scopus 로고    scopus 로고
    • Suppression of tumor necrosis factor induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10057-10062
    • Chu, Z.-L.1
  • 58
    • 0032490670 scopus 로고    scopus 로고
    • Nuclear factor (NF)-κB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor-α-induced apoptosis
    • (1998) J. Exp. Med. , vol.188 , pp. 211-216
    • Stehlik, C.1
  • 59
    • 0035891320 scopus 로고    scopus 로고
    • Inhibition of JNK activation through NF-κB target genes
    • (2001) Nature , vol.414 , pp. 313-317
    • Tang, G.1
  • 64
    • 0035504081 scopus 로고    scopus 로고
    • Transcriptional regulation of Bcl-2 by nuclear factor κB and its significance in prostate cancer
    • (2001) Oncogene , vol.20 , pp. 7342-7351
    • Catz, S.D.1    Johnson, J.L.2
  • 69
    • 0030800070 scopus 로고    scopus 로고
    • Inhibition of death receptor signals by cellular FLIP
    • (1997) Nature , vol.388 , pp. 190-195
    • Irmler, M.1
  • 70
    • 7344220967 scopus 로고    scopus 로고
    • Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex
    • (1998) Cell Death Differ. , vol.5 , pp. 271-288
    • Rasper, D.M.1
  • 72
    • 0030810981 scopus 로고    scopus 로고
    • FLAME-1, a novel FADD-like antiapoptotic molecule that regulates Fas/TNFR1-induced apoptosis
    • (1997) J. Biol. Chem. , vol.272 , pp. 18542-18545
    • Srinivasula, S.M.1
  • 85
    • 0034282432 scopus 로고    scopus 로고
    • The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7
    • (2000) J. Biol. Chem. , vol.275 , pp. 26661-26664
    • Huang, H.-K.1
  • 87
    • 0034616945 scopus 로고    scopus 로고
    • Smac, a mitochondrial protein that promotes cytochrome cdependent caspase activation by eliminating IAP inhibition
    • (2000) Cell , vol.102 , pp. 33-42
    • Du, C.1    Fang, M.2    Li, Y.3    Li, L.4    Wang, X.5
  • 88
    • 0034616942 scopus 로고    scopus 로고
    • Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
    • (2000) Cell , vol.102 , pp. 43-53
    • Verhagen, A.M.1
  • 89
    • 0034710649 scopus 로고    scopus 로고
    • Structural and biochemical basis of apoptotic activation by Smac/DIABLO
    • (2000) Nature , vol.406 , pp. 855-862
    • Chai, J.1
  • 90
    • 0034700495 scopus 로고    scopus 로고
    • Structural basis for binding of Smac/DIABLO to the XIAP BIR 3 domain
    • (2000) Nature , vol.408 , pp. 1004-1008
    • Liu, Z.1
  • 91
    • 0034680876 scopus 로고    scopus 로고
    • Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway
    • (2000) J. Biol. Chem. , vol.275 , pp. 36152-36157
    • Srinivasula, S.M.1
  • 92
    • 0034700491 scopus 로고    scopus 로고
    • Structural basis of IAP recognition by Smac/DIABLO
    • (2000) Nature , vol.408 , pp. 1008-1012
    • Wu, G.1
  • 93
    • 0037154009 scopus 로고    scopus 로고
    • Drosophila sickle is a novel grim-reaper cell death activator
    • (2002) Curr. Biol. , vol.12 , pp. 131-135
    • Wing, J.P.1
  • 94
    • 0037154010 scopus 로고    scopus 로고
    • Sickle, a novel Drosophilla death gene in the reaper-hid-grim region, encodes an IAP-inhibitory protein
    • (2002) Curr. Biol. , vol.12 , pp. 125-130
    • Srinivasula, S.M.1
  • 95
    • 0037154014 scopus 로고    scopus 로고
    • The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid
    • (2002) Curr. Biol. , vol.12 , pp. 137-140
    • Christich, A.1
  • 96
    • 0037169556 scopus 로고    scopus 로고
    • Sequence requirements for hid binding and apoptosis regulation in the anti-apoptotic baculovirus protein Op-IAP: Hid binds Op-IAP in a manner similar to Smac binding of XIAP
    • (2001) J. Biol. Chem. , vol.277 , pp. 2454-2462
    • Wright, C.W.1    Clem, R.J.2
  • 101
    • 0034029577 scopus 로고    scopus 로고
    • Biochemical and genetic interactions between Drosophila caspases and the proapoptotic genes rpr, hid, and grim
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 2907-2914
    • Song, Z.1
  • 104
    • 0036141029 scopus 로고    scopus 로고
    • TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO
    • (2002) Genes Dev. , vol.16 , pp. 33-45
    • Deng, Y.1    Un, Y.2    Wu, X.3
  • 107
    • 0036131142 scopus 로고    scopus 로고
    • Tumor-cell resistance to death receptor induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax
    • (2002) Nature Med. , vol.8 , pp. 274-281
    • LeBlanc, H.1
  • 108
    • 0034785591 scopus 로고    scopus 로고
    • A serine protease, HtrA2, is released from the mitochondria end interacts with XIAP, inducing cell death
    • (2001) Mol. Cell , vol.8 , pp. 613-621
    • Suzuki, Y.1
  • 109
    • 18544386724 scopus 로고    scopus 로고
    • Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts IAP caspase interaction
    • (2001) J. Biol. Chem. , vol.277 , pp. 432-438
    • Hegde, R.1
  • 110
    • 18244386261 scopus 로고    scopus 로고
    • The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity
    • (2002) Cell Death Differ. , vol.9 , pp. 20-26
    • Van Loo, G.1
  • 111
    • 0037016686 scopus 로고    scopus 로고
    • HtrA 2 promotes cell death through its serine protease activity and its ability to antagonise inhibitor of apoptosis proteins
    • (2001) J. Biol. Chem. , vol.277 , pp. 445-454
    • Verhagen, A.M.1
  • 112
    • 0037016707 scopus 로고    scopus 로고
    • The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a Reaper-like motif
    • (2001) J. Biol. Chem. , vol.277 , pp. 439-444
    • Martins, L.M.1
  • 113
    • 0036263973 scopus 로고    scopus 로고
    • Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi
    • 22 April (DOI 10, 1038/nsb 795)
    • (2002) Nature Struct. Biol.
    • Li, W.1
  • 116
    • 0036300215 scopus 로고    scopus 로고
    • Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis
    • (2002) Nature Cell Biol. , vol.4 , pp. 451-456
    • Wing, J.P.1
  • 117
    • 0036300082 scopus 로고    scopus 로고
    • Hid, Rpr and Grim negatively regulate DIAP 1 levels through distinct mechanisms
    • (2002) Nature Cell Biol. , vol.4 , pp. 416-424
    • Yoo, S.J.1
  • 119
    • 0035156848 scopus 로고    scopus 로고
    • Identification of XAF1 as an antagonist of XIAP anti-caspase activity
    • (2001) Nature Cell Biol. , vol.3 , pp. 128-133
    • Uston, P.1
  • 120
    • 0034672506 scopus 로고    scopus 로고
    • Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines
    • (2000) Genomics , vol.70 , pp. 113-122
    • Fong, W.G.1
  • 121
    • 0035955631 scopus 로고    scopus 로고
    • Neurotrophin receptor-interacting mage homologue is an inducible inhibitor of apoptosis protein interacting protein that augments cell death
    • (2001) J. Biol. Chem. , vol.276 , pp. 39985-39989
    • Jordan, B.W.1
  • 123
    • 0034088845 scopus 로고    scopus 로고
    • The hippocampal neurons of neuronal apoptosis inhibitory protein 1 (NAIP1)-deleted mica display increased vulnerability to kainic acid-induced injury
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 2286-2290
    • Holcik, M.1
  • 128
    • 0034993758 scopus 로고    scopus 로고
    • Two kinds of BIR-containing protein - Inhibitors of apoptosis, or required for mitosis
    • (2001) J. Cell Sci. , vol.114 , pp. 1821-1827
    • Silke, J.1    Vaux, D.L.2
  • 129
    • 0036189157 scopus 로고    scopus 로고
    • Schizosaccharomyces pombe Bir1p, a nuclear protein that localizes to kinetochores and the spindle midzone, is essential for chromosome condensation and spindle elongation during mitosis
    • (2002) Genetics , vol.160 , pp. 445-456
    • Rajagopalan, S.1    Balasubramanian, M.K.2
  • 131
    • 0033258543 scopus 로고    scopus 로고
    • Pleiotropic cell-division defects and apoptosis induced by interference with survivin function
    • (1999) Nature Cell Biol. , vol.1 , pp. 461-466
    • Li, F.1
  • 133
    • 0035831533 scopus 로고    scopus 로고
    • C-IAP1 is cleaved by caspases to produce a pro-apoptotic C-terminal fragment
    • (2001) J. Biol. Chem. , vol.276 , pp. 7602-7608
    • Clem, R.J.1
  • 134
    • 0035895597 scopus 로고    scopus 로고
    • XIAP induces cell-cycle arrest and activates nuclear factor-κB: New survival pathways disabled by caspase-mediated cleavage during apoptosis of human endothelial calls
    • (2001) Circ. Res. , vol.88 , pp. 282-290
    • Levkau, B.1
  • 135
    • 0035876176 scopus 로고    scopus 로고
    • Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP
    • (2001) EMBO J. , vol.20 , pp. 3114-3123
    • Silke, J.1
  • 136
    • 0036544535 scopus 로고    scopus 로고
    • The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites
    • (2002) J. Cell Biol. , vol.157 , pp. 115-124
    • Silke, J.1
  • 137
    • 0036300214 scopus 로고    scopus 로고
    • The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis
    • (2002) Nature Cell Biol. , vol.4 , pp. 445-450
    • Wilson, R.1
  • 138
    • 0033521529 scopus 로고    scopus 로고
    • XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK 1 in the BMP signaling pathway
    • (1999) EMBO J. , vol.18 , pp. 179-187
    • Yamaguchi, K.1
  • 140
    • 0029551805 scopus 로고
    • Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction
    • (1995) Science , vol.270 , pp. 2008-2011
    • Yamaguchi, K.1
  • 141
    • 0029940355 scopus 로고    scopus 로고
    • TAB1: An activator of the TAK1 MAPKKK in TGF-β signal transduction
    • (1996) Science , vol.272 , pp. 1179-1182
    • Shibuya, H.1
  • 142
    • 0036178047 scopus 로고    scopus 로고
    • IAP suppression of apoptosis involves distinct mechanisms: The TAK1/JNK 1 signaling cascade and caspase inhibition
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 1754-1766
    • Sanna, M.G.1
  • 145
    • 0037023712 scopus 로고    scopus 로고
    • SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)
    • (2002) J. Biol. Chem. , vol.277 , pp. 12275-12279
    • Vucic, D.1
  • 146
    • 0028797783 scopus 로고
    • Identification and characterization of a spinal muscular atrophy-determining gene
    • (1995) Cell , vol.80 , pp. 155-165
    • Lefebvre, S.1
  • 147
    • 0031710558 scopus 로고    scopus 로고
    • Identification of a candidate modifying gene for spinal muscular atrophy by comparative genomics
    • (1998) Nature Genet. , vol.20 , pp. 83-86
    • Scharf, J.M.1
  • 148
    • 0033151510 scopus 로고    scopus 로고
    • The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas
    • (1999) Blood , vol.93 , pp. 3601-3669
    • Dierlamm, J.1
  • 149
    • 0033638182 scopus 로고    scopus 로고
    • Identification of paracaspases and metacaspases: Two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma
    • (2000) Mol. Cell , vol.6 , pp. 961-967
    • Uren, A.G.1
  • 151
    • 0034266807 scopus 로고    scopus 로고
    • BIRinging chromosomes through cell division - And survivin' the experience
    • (2000) Cell , vol.102 , pp. 545-548
    • Reed, J.C.1    Bischoff, J.R.2
  • 152
    • 0035884398 scopus 로고    scopus 로고
    • Identification of cIAP1 as a candidate target gene within an amplicon at 11q22 in esophageal squamous cell carcinomas
    • (2001) Cancer Res. , vol.61 , pp. 6629-6634
    • Imoto, I.1
  • 153
    • 17144438370 scopus 로고    scopus 로고
    • Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias
    • (2000) Clin. Cancer Res. , vol.6 , pp. 1796-1803
    • Tamm, I.1
  • 154
    • 0037088904 scopus 로고    scopus 로고
    • The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7
    • (2002) J. Neurosci. , vol.22 , pp. 2035-2043
    • Maier, J.K.1


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