Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 18, 2013, Pages 5725-5737

  Asano, Moriteru ^a   Hashimoto, Kentaro ^a   Saito, Bunnai ^a   Shiokawa, Zenyu ^a   Sumi, Hiroyuki ^a   Yabuki, Masato ^a   Yoshimatsu, Mie ^a   Aoyama, Kazunobu ^a   Hamada, Teruki ^a   Morishita, Nao ^a   Dougan, Douglas R ^b   Mol, Clifford D ^b   Yoshida, Sei ^a   Ishikawa, Tomoyasu ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b Takeda San Diego Inc   (United States)

Author keywords

Inhibitor of apoptosis proteins (IAP); Octahydro 1H cyclopropa 4,5 pyrrolo 1,2 a pyrazine; Simmons Smith cyclopropanation

Indexed keywords

5 [2 CYCLOHEXYL 2 [(N METHYL ALANYL)AMINO]ACETYL] N [3,4 DIHYDRO 2H CHROMEN 4 YL]OCTAHYDRO 1H CYCLOPROPA[4,5]PYRROLO[1,2 A]PYRAZINE 4 CARBOXAMIDE DIHYDROCHLORIDE; ANTINEOPLASTIC AGENT; INHIBITOR OF APOPTOSIS PROTEIN; OCTAHYDROPYRROLO[1,2 A]PYRAZINE; PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CANCER INHIBITION; CONTROLLED STUDY; CYCLOPROPANATION; DOSE RESPONSE; DRUG BINDING; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PREDICTION;

INHIBITOR OF APOPTOSIS PROTEINS (IAP); OCTAHYDRO-1H-CYCLOPROPA[4,5]PYRROLO[1,2-A]PYRAZINE; SIMMONS-SMITH CYCLOPROPANATION;

ANIMALS; BENZOPYRANS; BINDING SITES; BREAST NEOPLASMS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FEMALE; HALF-LIFE; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; MICE; MOLECULAR DYNAMICS SIMULATION; PROTEIN STRUCTURE, TERTIARY; PYRAZINES; PYRROLES; RNA, MESSENGER; STEREOISOMERISM; TRANSPLANTATION, HETEROLOGOUS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84882861205     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.07.020     Document Type: Article

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