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Volumn 70, Issue 5, 2010, Pages 1960-1969

A bax-mediated mechanism for obatoclax-induced apoptosis of cholangiocarcinoma cells

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C; OBATOCLAX; PROTEIN BAK; PROTEIN BAX; SHORT HAIRPIN RNA;

EID: 77950231711     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-3535     Document Type: Article
Times cited : (51)

References (42)
  • 1
    • 61449182121 scopus 로고    scopus 로고
    • Principles of cancer therapy: Oncogene and non-oncogene addiction
    • Luo J, Solimini NL, Elledge SJ. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 2009;136:823-837
    • (2009) Cell , vol.136 , pp. 823-837
    • Luo, J.1    Solimini, N.L.2    Elledge, S.J.3
  • 2
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 37549048249 scopus 로고    scopus 로고
    • The BCL-2 protein family: Opposing activities that mediate cell death
    • Youle RJ, Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 2008;9:47-59.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 5
    • 62849097807 scopus 로고    scopus 로고
    • Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim
    • Jabbour AM, Heraud JE, Daunt CP, et al. Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim. Cell Death Differ 2009;16:555-563
    • (2009) Cell Death Differ , vol.16 , pp. 555-563
    • Jabbour, A.M.1    Heraud, J.E.2    Daunt, C.P.3
  • 6
    • 38549145044 scopus 로고    scopus 로고
    • Diagnosing and exploiting cancer's addiction to blocks in apoptosis
    • Letai AG. Diagnosing and exploiting cancer's addiction to blocks in apoptosis. Nat Rev Cancer 2008;8:121-132
    • (2008) Nat Rev Cancer , vol.8 , pp. 121-132
    • Letai, A.G.1
  • 7
    • 44049083639 scopus 로고    scopus 로고
    • Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: A breakthrough in anticancer therapy?
    • Labi V, Grespi F, Baumgartner F, Villunger A. Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy? Cell Death Differ 2008;15:977-987
    • (2008) Cell Death Differ , vol.15 , pp. 977-987
    • Labi, V.1    Grespi, F.2    Baumgartner, F.3    Villunger, A.4
  • 8
    • 33750628289 scopus 로고    scopus 로고
    • Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
    • see comment
    • Konopleva M, Contractor R, Tsao T, et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia [see comment]. Cancer Cell 2006;10:375-388
    • (2006) Cancer Cell , vol.10 , pp. 375-388
    • Konopleva, M.1    Contractor, R.2    Tsao, T.3
  • 9
    • 33750834023 scopus 로고    scopus 로고
    • The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
    • see comment
    • van Delft MF, Wei AH, Mason KD, et al. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized [see comment]. Cancer Cell 2006;10:389-399
    • (2006) Cancer Cell , vol.10 , pp. 389-399
    • Van Delft, M.F.1    Wei, A.H.2    Mason, K.D.3
  • 10
    • 37649023004 scopus 로고    scopus 로고
    • Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
    • Nguyen M, Marcellus RC, Roulston A, et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A 2007;104:19512-19517
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 19512-19517
    • Nguyen, M.1    Marcellus, R.C.2    Roulston, A.3
  • 11
    • 33646354381 scopus 로고    scopus 로고
    • Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
    • see comment
    • Certo M, Del Gaizo Moore V, Nishino M, et al. Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members [see comment]. Cancer Cell 2006;9:351-365
    • (2006) Cancer Cell , vol.9 , pp. 351-365
    • Certo, M.1    Del Gaizo Moore, V.2    Nishino, M.3
  • 12
    • 33845994359 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737
    • Del Gaizo Moore V, Brown JR, Certo M, Love TM, Novina CD, Letai A. Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. J Clin Invest 2007;117:112-121
    • (2007) J Clin Invest , vol.117 , pp. 112-121
    • Del Gaizo Moore, V.1    Brown, J.R.2    Certo, M.3    Love, T.M.4    Novina, C.D.5    Letai, A.6
  • 13
    • 34547603628 scopus 로고    scopus 로고
    • BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents
    • Deng J, Carlson N, Takeyama K, Dal Cin P, Shipp M, Letai A. BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents. Cancer Cell 2007;12:171-185
    • (2007) Cancer Cell , vol.12 , pp. 171-185
    • Deng, J.1    Carlson, N.2    Takeyama, K.3    Dal Cin, P.4    Shipp, M.5    Letai, A.6
  • 14
    • 0030963602 scopus 로고    scopus 로고
    • Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
    • Hsu YT, Wolter KG, Youle RJ. Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. Proc Natl Acad Sci U S A 1997;94:3668-3672
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 3668-3672
    • Hsu, Y.T.1    Wolter, K.G.2    Youle, R.J.3
  • 15
    • 54549114986 scopus 로고    scopus 로고
    • BAX activation is initiated at a novel interaction site
    • see comment
    • Gavathiotis E, Suzuki M, Davis ML, et al. BAX activation is initiated at a novel interaction site [see comment]. Nature 2008;455:1076-1081
    • (2008) Nature , vol.455 , pp. 1076-1081
    • Gavathiotis, E.1    Suzuki, M.2    Davis, M.L.3
  • 16
    • 70449091753 scopus 로고    scopus 로고
    • Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis
    • see comment
    • Kim H, Tu HC, Ren D, et al. Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis [see comment]. Mol Cell 2009;36:487-499
    • (2009) Mol Cell , vol.36 , pp. 487-499
    • Kim, H.1    Tu, H.C.2    Ren, D.3
  • 17
    • 0032487582 scopus 로고    scopus 로고
    • Regulated targeting of BAX to mitochondria
    • Goping IS, Gross A, Lavoie JN, et al. Regulated targeting of BAX to mitochondria. J Cell Biol 1998;143:207-215
    • (1998) J Cell Biol , vol.143 , pp. 207-215
    • Goping, I.S.1    Gross, A.2    Lavoie, J.N.3
  • 18
    • 33745275877 scopus 로고    scopus 로고
    • Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on the incidence of intra- And extrahepatic cholangiocarcinoma in the United States
    • see comment
    • Welzel TM, McGlynn KA, Hsing AW, O'Brien TR, Pfeiffer RM. Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on the incidence of intra- and extrahepatic cholangiocarcinoma in the United States [see comment]. J Natl Cancer Inst 2006;98:873-875
    • (2006) J Natl Cancer Inst , vol.98 , pp. 873-875
    • Welzel, T.M.1    McGlynn, K.A.2    Hsing, A.W.3    O'Brien, T.R.4    Pfeiffer, R.M.5
  • 19
    • 20444452357 scopus 로고    scopus 로고
    • Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells
    • Kobayashi S, Werneburg NW, Bronk SF, Kaufmann SH, Gores GJ. Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells. Gastroenterology 2005;128:2054-2065
    • (2005) Gastroenterology , vol.128 , pp. 2054-2065
    • Kobayashi, S.1    Werneburg, N.W.2    Bronk, S.F.3    Kaufmann, S.H.4    Gores, G.J.5
  • 20
    • 0024363275 scopus 로고
    • A new human cholangiocellular carcinoma cell line (HuCC-T1) producing carbohydrate antigen 19/9 in serum-free medium
    • Miyagiwa M, Ichida T, Tokiwa T, Sato J, Sasaki H. A new human cholangiocellular carcinoma cell line (HuCC-T1) producing carbohydrate antigen 19/9 in serum-free medium. In vitro Cell Dev Biol 1989;25:503-510
    • (1989) In Vitro Cell Dev Biol , vol.25 , pp. 503-510
    • Miyagiwa, M.1    Ichida, T.2    Tokiwa, T.3    Sato, J.4    Sasaki, H.5
  • 21
    • 0023217304 scopus 로고
    • Establishment and characterization of a human combined hepatocholangio-carcinoma cell line and its heterologous transplantation in nude mice
    • Murakami T, Yano H, Maruiwa M, Sugihara S, Kojiro M. Establishment and characterization of a human combined hepatocholangio-carcinoma cell line and its heterologous transplantation in nude mice. Hepatology 1987;7:551-556
    • (1987) Hepatology , vol.7 , pp. 551-556
    • Murakami, T.1    Yano, H.2    Maruiwa, M.3    Sugihara, S.4    Kojiro, M.5
  • 22
    • 0021874928 scopus 로고
    • Biliary adenocarcinoma. Characterisation of three new human tumor cell lines
    • Knuth A, Gabbert H, Dippold W, et al. Biliary adenocarcinoma. Characterisation of three new human tumor cell lines. J Hepatol 1985;1:579-596
    • (1985) J Hepatol , vol.1 , pp. 579-596
    • Knuth, A.1    Gabbert, H.2    Dippold, W.3
  • 23
    • 28844448140 scopus 로고    scopus 로고
    • erbB-2/neu transformed rat cholangiocytes recapitulate key cellular and molecular features of human bile duct cancer
    • Lai GH, Zhang Z, Shen XN, et al. erbB-2/neu transformed rat cholangiocytes recapitulate key cellular and molecular features of human bile duct cancer. Gastroenterology 2005;129:2047-2057
    • (2005) Gastroenterology , vol.129 , pp. 2047-2057
    • Lai, G.H.1    Zhang, Z.2    Shen, X.N.3
  • 24
    • 42249110859 scopus 로고    scopus 로고
    • A novel "patient-like" model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines
    • Sirica AE, Zhang Z, Lai GH, et al. A novel "patient-like" model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines. Hepatology 2008;47:1178-1190
    • (2008) Hepatology , vol.47 , pp. 1178-1190
    • Sirica, A.E.1    Zhang, Z.2    Lai, G.H.3
  • 25
    • 53349097246 scopus 로고    scopus 로고
    • BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis
    • Mott JL, Bronk SF, Mesa RA, Kaufmann SH, Gores GJ. BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis. Mol Cancer Ther 2008;7:2339-2347
    • (2008) Mol Cancer Ther , vol.7 , pp. 2339-2347
    • Mott, J.L.1    Bronk, S.F.2    Mesa, R.A.3    Kaufmann, S.H.4    Gores, G.J.5
  • 26
    • 0041935939 scopus 로고    scopus 로고
    • Bethesda, MD: US NIH
    • Rasband WS. ImageJ. Bethesda, MD: US NIH; 1997-2008.
    • (1997) ImageJ
    • Rasband, W.S.1
  • 27
    • 35348948380 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand activates a lysosomal pathway of apoptosis that is regulated by Bcl-2 proteins
    • Werneburg NW, Guicciardi ME, Bronk SF, Kaufmann SH, Gores GJ. Tumor necrosis factor-related apoptosis-inducing ligand activates a lysosomal pathway of apoptosis that is regulated by Bcl-2 proteins. J Biol Chem 2007;282:28960-28970
    • (2007) J Biol Chem , vol.282 , pp. 28960-28970
    • Werneburg, N.W.1    Guicciardi, M.E.2    Bronk, S.F.3    Kaufmann, S.H.4    Gores, G.J.5
  • 28
    • 22344435528 scopus 로고    scopus 로고
    • Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor á-induced hepatocyte apoptosis
    • Guicciardi ME, Bronk SF, Werneburg NW, Yin XM, Gores GJ. Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor á-induced hepatocyte apoptosis. Gastroenterology 2005;129:269-284
    • (2005) Gastroenterology , vol.129 , pp. 269-284
    • Guicciardi, M.E.1    Bronk, S.F.2    Werneburg, N.W.3    Yin, X.M.4    Gores, G.J.5
  • 29
    • 33744948514 scopus 로고    scopus 로고
    • Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
    • Malhi H, Bronk SF, Werneburg NW, Gores GJ. Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J Biol Chem 2006;281:12093-12101
    • (2006) J Biol Chem , vol.281 , pp. 12093-12101
    • Malhi, H.1    Bronk, S.F.2    Werneburg, N.W.3    Gores, G.J.4
  • 30
    • 0033713002 scopus 로고    scopus 로고
    • Structure of Bax: Coregulation of dimer formation and intracellular localization
    • Suzuki M, Youle RJ, Tjandra N. Structure of Bax: coregulation of dimer formation and intracellular localization. Cell 2000;103:645-654
    • (2000) Cell , vol.103 , pp. 645-654
    • Suzuki, M.1    Youle, R.J.2    Tjandra, N.3
  • 31
    • 58849086028 scopus 로고    scopus 로고
    • BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells
    • Huang S, Okumura K, Sinicrope FA. BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells. Clin Cancer Res 2009;15:150-159
    • (2009) Clin Cancer Res , vol.15 , pp. 150-159
    • Huang, S.1    Okumura, K.2    Sinicrope, F.A.3
  • 32
    • 73149102791 scopus 로고    scopus 로고
    • Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2
    • Blechacz BR, Smoot RL, Bronk SF, Werneburg NW, Sirica AE, Gores GJ. Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2. Hepatology 2009;50:1861-1870
    • (2009) Hepatology , vol.50 , pp. 1861-1870
    • Blechacz, B.R.1    Smoot, R.L.2    Bronk, S.F.3    Werneburg, N.W.4    Sirica, A.E.5    Gores, G.J.6
  • 33
    • 33751513394 scopus 로고    scopus 로고
    • Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
    • see comment
    • Kim H, Rafiuddin-Shah M, Tu HC, et al. Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies [see comment]. Nat Cell Biol 2006;8:1348-1358
    • (2006) Nat Cell Biol , vol.8 , pp. 1348-1358
    • Kim, H.1    Rafiuddin-Shah, M.2    Tu, H.C.3
  • 34
    • 57149135309 scopus 로고    scopus 로고
    • Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax
    • see comment
    • Lovell JF, Billen LP, Bindner S, et al. Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax [see comment]. Cell 2008;135:1074-1084
    • (2008) Cell , vol.135 , pp. 1074-1084
    • Lovell, J.F.1    Billen, L.P.2    Bindner, S.3
  • 35
    • 58849164097 scopus 로고    scopus 로고
    • Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia
    • O'Brien SM, Claxton DF, Crump M, et al. Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia. Blood 2009;113:299-305.
    • (2009) Blood , vol.113 , pp. 299-305
    • O'Brien, S.M.1    Claxton, D.F.2    Crump, M.3
  • 36
    • 58149340656 scopus 로고    scopus 로고
    • A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies
    • Schimmer AD, O'Brien S, Kantarjian H, et al. A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies. Clin Cancer Res 2008;14:8295-8301
    • (2008) Clin Cancer Res , vol.14 , pp. 8295-8301
    • Schimmer, A.D.1    O'Brien, S.2    Kantarjian, H.3
  • 37
    • 63149129655 scopus 로고    scopus 로고
    • Bcl-2 inhibitors: Targeting mitochondrial apoptotic pathways in cancer therapy
    • Kang MH, Reynolds CP. Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. Clin Cancer Res 2009;15:1126-1132
    • (2009) Clin Cancer Res , vol.15 , pp. 1126-1132
    • Kang, M.H.1    Reynolds, C.P.2
  • 38
    • 33846964621 scopus 로고    scopus 로고
    • Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
    • see comment
    • Willis SN, Fletcher JI, Kaufmann T, et al. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak [see comment]. Science 2007;315:856-859
    • (2007) Science , vol.315 , pp. 856-859
    • Willis, S.N.1    Fletcher, J.I.2    Kaufmann, T.3
  • 39
    • 0035957653 scopus 로고    scopus 로고
    • Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
    • see comment
    • Wei MC, Zong WX, Cheng EH, et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death [see comment]. Science 2001;292:727-730
    • (2001) Science , vol.292 , pp. 727-730
    • Wei, M.C.1    Zong, W.X.2    Cheng, E.H.3
  • 40
    • 85047698445 scopus 로고    scopus 로고
    • Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis
    • Hemmati PG, Gillissen B, von Haefen C, et al. Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis. Oncogene 2002;21:3149-3161
    • (2002) Oncogene , vol.21 , pp. 3149-3161
    • Hemmati, P.G.1    Gillissen, B.2    Von Haefen, C.3
  • 41
    • 0035823558 scopus 로고    scopus 로고
    • A role for mitochondrial Bak in apoptotic response to anticancer drugs
    • Wang GQ, Gastman BR, Wieckowski E, et al. A role for mitochondrial Bak in apoptotic response to anticancer drugs. J Biol Chem 2001;276:34307-34317
    • (2001) J Biol Chem , vol.276 , pp. 34307-34317
    • Wang, G.Q.1    Gastman, B.R.2    Wieckowski, E.3
  • 42
    • 67549141546 scopus 로고    scopus 로고
    • Different forms of cell death induced by putative BCL2 inhibitors
    • Vogler M, Weber K, Dinsdale D, et al. Different forms of cell death induced by putative BCL2 inhibitors. Cell Death Differ 2009;16:1030-1039
    • (2009) Cell Death Differ , vol.16 , pp. 1030-1039
    • Vogler, M.1    Weber, K.2    Dinsdale, D.3


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