BI-97C1, an optically pure apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/Leukemia-2 (Bcl-2) family proteins

Journal of Medicinal Chemistry

Volumn 53, Issue 10, 2010, Pages 4166-4176

  Wei, Jun ^a   Stebbins, John L ^a   Kitada, Shinichi ^a   Dash, Rupesh ^b   Placzek, William ^a   Rega, Michele F ^a   Wu, Bainan ^a   Cellitti, Jason ^a   Zhai, Dayong ^a   Yang, Li ^a   Dahl, Russell ^a   Fisher, Paul B ^b   Reed, John C ^a   Pellecchia, Maurizio ^a  

^a BURNHAM INSTITUTE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1',6,6',7,7' HEXAHYDROXY 3,3' DIMETHYL N5 (2 PHENYLPROPYL) N5 (2 PHENOPROPYL) 2,2' BINAPHTHYL 5,5' DICARBOXAMIDE; 1,1',6,6',7,7' HEXAHYDROXY 3,3' DIMETHYL N5 (2 PHENYLPROPYL) N5 (2 PHENYLPROPYL) 2,2' BINAPHTHYL 5,5' DICARBOXAMIDE; APOPTOSIS INHIBITOR; BCL2 RELATED PROTEIN A1; BI 97C1; GOSSYPOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; B CELL LYMPHOMA; CANCER CELL CULTURE; CANCER INHIBITION; CANCER THERAPY; CARBON NUCLEAR MAGNETIC RESONANCE; CELL VIABILITY; CYTOTOXICITY; DENATURING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; DIASTEREOISOMER; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IC 50; IN VIVO STUDY; LUNG CANCER; MOUSE; NONHUMAN; PROSTATE CANCER; PROTON NUCLEAR MAGNETIC RESONANCE; TRANSGENIC MOUSE; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING, COMPETITIVE; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG SCREENING ASSAYS, ANTITUMOR; FLUORESCENCE POLARIZATION; GOSSYPOL; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, TRANSGENIC; MODELS, MOLECULAR; NEOPLASM TRANSPLANTATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-BCL-2; STEREOISOMERISM; TRANSPLANTATION, HETEROLOGOUS;

EID: 77952719306     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1001265     Document Type: Article

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