Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation

Journal of Biological Chemistry

Volumn 287, Issue 13, 2012, Pages 10224-10235

  Doi, Kenichiro ^a   Li, Rongshi ^c   Sung, Shen Shu ^a   Wu, Hongwei ^d   Liu, Yan ^c   Manieri, Wanda ^c   Krishnegowda, Gowdahalli ^a   Awwad, Andy ^b   Dewey, Alden ^b   Liu, Xin ^b   Amin, Shantu ^a,b   Cheng, Chunwei ^e   Qin, Yong ^e   Schonbrunn, Ernst ^c   Daughdrill, Gary ^d   Loughran, Thomas P ^b   Sebti, Said ^c   Wang, Hong Gang ^a,b  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b PENN STATE CANCER INSTITUTE   (United States)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF SOUTH FLORIDA   (United States)

^e SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY;

ABT-263; APOPTOTIC; BCL-2 FAMILY; DRUG TARGETS; HIGH AFFINITY; ORALLY ACTIVE; POTENT INHIBITOR; PROTEASOMAL DEGRADATION; SMALL MOLECULES; SPECIFIC INHIBITORS;

DISEASES;

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; ANTINEOPLASTIC AGENT; BIM PROTEIN; MARITOCLAX; PROTEIN BCL XL; PROTEIN MCL 1; PROTEINASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER RESISTANCE; CHEMOSENSITIZATION; CONTROLLED STUDY; DOWN REGULATION; DRUG DETERMINATION; DRUG EFFICACY; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME DEGRADATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING;

EID: 84858957737     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.334532     Document Type: Article

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