Identification of chelerythrine as an inhibitor of BclXL function

Journal of Biological Chemistry

Volumn 278, Issue 23, 2003, Pages 20453-20456

  Chan, Shing Leng ^a   Lee, Mei Chin ^a   Tan, Kuan Onn ^a   Yang, Lay Kien ^b   Lee, Alex S Y ^b   Flotow, Horst ^b   Fu, Nai Yang ^a   Butler, Mark S ^b   Soejarto, Doel D ^c   Buss, Antony D ^b   Yu, Victor C ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b MerLion Pharmaceuticals Pte Ltd   (Singapore)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; EXTRACTION; PROTEINS; STRUCTURE (COMPOSITION);

CHELERYTHRINE;

BIOCHEMISTRY;

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CHELERYTHRINE; CYTOCHROME C; ETOPOSIDE; NATURAL PRODUCT; PROTEIN BAK; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN INHIBITOR; PROTEIN KINASE C INHIBITOR; STAUROSPORINE;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN TARGETING;

ALKALOIDS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BENZOPHENANTHRIDINES; CYTOCHROME C GROUP; ENZYME INHIBITORS; ETOPOSIDE; GENE EXPRESSION; HUMANS; MEMBRANE PROTEINS; MITOCHONDRIA; MOLECULAR MIMICRY; NUCLEIC ACID SYNTHESIS INHIBITORS; PHENANTHRIDINES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; STAUROSPORINE; TUMOR CELLS, CULTURED;

MAMMALIA;

EID: 0038081194     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C300138200     Document Type: Article

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