Novobiocin: Redesigning a DNA gyrase inhibitor for selective inhibition of Hsp90

Journal of the American Chemical Society

Volumn 128, Issue 48, 2006, Pages 15529-15536

  Burlison, Joseph A ^a   Neckers, Len ^a,b   Smith, Andrew B ^c   Maxwell, Anthony ^c   Blagg, Brian S J ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c JOHN INNES CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; DEGRADATION; DNA; ENZYME INHIBITION; HYDROXYLATION; MOLECULAR STRUCTURE;

COUMERMYCIN; DESHYDROXY NOVOBIOCIN (DHN1); GYRASE; NOVOBIOCIN;

ANTIBIOTICS;

3' DESCARBAMOYL 4 DESHYDROXYNOVOBIOCIN; 4 DESHYDROXYNOVOBIOCIN; ADENOSINE TRIPHOSPHATE; ANTIBIOTIC AGENT; CARBAMIC ACID; CLOROBIOCIN; COUMAMYCIN; COUMAMYCIN A1; COUMARIN; DNA TOPOISOMERASE (ATP HYDROLYSING); GELDANAMYCIN; GYRASE INHIBITOR; HEAT SHOCK PROTEIN 90; HYDROXYL GROUP; NATURAL PRODUCT; NOVOBIOCIN; RADICICOL;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG CLASSIFICATION; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; PROTEIN DEGRADATION; STRUCTURE ACTIVITY RELATION;

BINDING SITES; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SURVIVAL; DNA GYRASE; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MOLECULAR STRUCTURE; NOVOBIOCIN; PROTEIN FOLDING; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 33845306864     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja065793p     Document Type: Article

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