Identification of XAF1 as an antagonist of XIAP anti-caspase activity

Nature Cell Biology

Volumn 3, Issue 2, 2001, Pages 128-133

  Liston, Peter ^a   Fong, Wai Gin ^b   Kelly, N Lynn ^c   Toji, Shingo ^d   Miyazaki, Toshiaki ^d   Conte, Damiano ^b   Tamai, Katsuyuki ^a   Craig, Constance G ^c   McBurney, Michael W ^a   Korneluk, Robert G ^b,c  

^a OTTAWA REGIONAL CANCER CENTRE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c Aegera Oncology Inc   (Canada)

^d Medical & Biological Laboratories Co Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INHIBITOR; CASPASE INHIBITOR; PROTEIN X;

ARTICLE; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CELL PROTECTION; ENZYME ACTIVITY; ENZYME ANALYSIS; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY;

ADENOVIRIDAE; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CASPASES; CELL SURVIVAL; CULTURE MEDIA, SERUM-FREE; ENZYME INHIBITORS; ETOPOSIDE; GENES, REPORTER; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; PLASMIDS; PROTEINS; RECOMBINANT FUSION PROTEINS; TUMOR CELLS, CULTURED; TWO-HYBRID SYSTEM TECHNIQUES; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN; ZINC FINGERS;

INTRACISTERNAL A-PARTICLES;

EID: 0035156848     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/35055027     Document Type: Article

References (29)

1. The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy
2. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
3. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes
4. A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors
5. Cloning and expression of apoptosis inhibitory protein homologues that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors
6. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
7. X-linked IAP is a direct inhibitor of cell death proteases
8. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
9. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
10. A single BIR domain of XIAP sufficient for inhibiting caspases
11. Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation
12. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs
13. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases
14. Ubiquitin protein ligase activity of IAPs and their degradation in proteosomes in response to apoptotic stimuli
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16. IAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway
17. Activation of NF-Kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1
18. Expression and genetic analysis of XIAP associated factor 1 (XAF1) in cancer cell lines
19. Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells
20. Caspase activation is required for T cell proliferation
21. The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex
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24. The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID
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27. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome
28. Expression of inhibitor of apoptosis proteins (IAPs) in rat granulosa cells during ovarian follicular development and atresia
29. Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus