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Volumn 12, Issue 3, 2016, Pages 169-182

Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; AMINO ACID; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE IV; CYCLIC AMP; FINGOLIMOD; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; KYNURENINE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; METFORMIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOLIPID ANTIBODY; PLACEBO; PROTEIN KINASE B; PROTEIN KINASE LKB1; RAPAMYCIN; PROTEIN KINASE INHIBITOR; TARGET OF RAPAMYCIN KINASE;

EID: 84959209910     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2015.172     Document Type: Review
Times cited : (269)

References (243)
  • 1
    • 0016724057 scopus 로고
    • Rapamycin AY 22 989), a new antifungal antibiotic i taxonomy of the producing streptomycete and isolation of the active principle
    • Vezina C., Kudelski A., & Sehgal S. N. Rapamycin (AY 22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J. Antibiot. (Tokyo) 28, 721-726 (1975
    • (1975) J. Antibiot. (Tokyo , vol.28 , pp. 721-726
    • Vezina, C.1    Kudelski, A.2    Sehgal, S.N.3
  • 2
    • 0027197865 scopus 로고
    • Rapamycin: In vitro profile of a new immunosuppressive macrolide
    • Sehgal S. N., & Bansback C. C. Rapamycin: in vitro profile of a new immunosuppressive macrolide. Ann. NY Acad. Sci. 685, 58-67 (1993
    • (1993) Ann. NY Acad. Sci , vol.685 , pp. 58-67
    • Sehgal, S.N.1    Bansback, C.C.2
  • 3
    • 0025073524 scopus 로고
    • Rapamycin in experimental renal allografts in dogs and pigs
    • Collier D. S. J., et al. Rapamycin in experimental renal allografts in dogs and pigs. Transplant. Proc. 22, 1674-1675 (1990
    • (1990) Transplant. Proc , vol.22 , pp. 1674-1675
    • Collier, D.S.J.1
  • 4
    • 0024976525 scopus 로고
    • Rapamycin for immunosuppression in organ allografting
    • Calne R. Y., et al. Rapamycin for immunosuppression in organ allografting. Lancet 334, 227 (1989
    • (1989) Lancet , vol.334 , pp. 227
    • Calne, R.Y.1
  • 5
    • 0028107540 scopus 로고
    • Rapamycin prolongs survival and arrests pathophysiologic changes in murine systemic lupus erythematosus
    • Warner L. M., Adams L. M., & Sehgal S. N. Rapamycin prolongs survival and arrests pathophysiologic changes in murine systemic lupus erythematosus. Arthritis Rheum. 37, 289-297 (1994
    • (1994) Arthritis Rheum , vol.37 , pp. 289-297
    • Warner, L.M.1    Adams, L.M.2    Sehgal, S.N.3
  • 6
    • 33749345289 scopus 로고    scopus 로고
    • Rapamycin reduces disease activity and normalizes T cell activation-induced calcium fluxing in patients with systemic lupus erythematosus
    • Fernandez D., Bonilla E., Mirza N., Niland B., & Perl A. Rapamycin reduces disease activity and normalizes T cell activation-induced calcium fluxing in patients with systemic lupus erythematosus. Arthritis Rheum. 54, 2983-2988 (2006
    • (2006) Arthritis Rheum , vol.54 , pp. 2983-2988
    • Fernandez, D.1    Bonilla, E.2    Mirza, N.3    Niland, B.4    Perl, A.5
  • 7
    • 77955351696 scopus 로고    scopus 로고
    • Mammalian target of rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis
    • Cejka D., et al. Mammalian target of rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis. Arthritis Rheum. 62, 2294-2302 (2010
    • (2010) Arthritis Rheum , vol.62 , pp. 2294-2302
    • Cejka, D.1
  • 8
    • 47949110435 scopus 로고    scopus 로고
    • Everolimus in patients with rheumatoid arthritis receiving concomitant methotrexate: A 3 month, double-blind, randomised, placebo-controlled, parallel-group, proof of concept study
    • Bruyn G. A. W., et al. Everolimus in patients with rheumatoid arthritis receiving concomitant methotrexate: a 3 month, double-blind, randomised, placebo-controlled, parallel-group, proof of concept study. Ann. Rheum. Dis. 67, 1090-1095 (2008
    • (2008) Ann. Rheum. Dis , vol.67 , pp. 1090-1095
    • Bruyn, G.A.W.1
  • 9
  • 10
    • 84892918737 scopus 로고    scopus 로고
    • A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of sjögrens syndrome
    • Shah M., et al. A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögrens syndrome. J. Control. Release 171, 269-279 (2013
    • (2013) J. Control. Release , vol.171 , pp. 269-279
    • Shah, M.1
  • 11
    • 84919913137 scopus 로고    scopus 로고
    • Failed degradation of JunB contributes to overproduction of type i collagen and development of dermal fibrosis in patients with systemic sclerosis
    • Ponticos M., et al. Failed degradation of JunB contributes to overproduction of type I collagen and development of dermal fibrosis in patients with systemic sclerosis. Arthritis Rheumatol. 67, 243-253 (2015
    • (2015) Arthritis Rheumatol , vol.67 , pp. 243-253
    • Ponticos, M.1
  • 12
    • 84899987036 scopus 로고    scopus 로고
    • Effects of the immunosuppressant rapamycin on the expression of human α2 I) collagen and matrix metalloproteinase 1 genes in scleroderma dermal fibroblasts
    • Tamaki Z., et al. Effects of the immunosuppressant rapamycin on the expression of human α2(I) collagen and matrix metalloproteinase 1 genes in scleroderma dermal fibroblasts. J. Dermatol. Sci. 74, 251-259 (2014
    • (2014) J. Dermatol. Sci , vol.74 , pp. 251-259
    • Tamaki, Z.1
  • 13
    • 77955349716 scopus 로고    scopus 로고
    • Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis
    • Yoshizaki A., et al. Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis. Arthritis Rheum. 62, 2476-2487 (2010
    • (2010) Arthritis Rheum , vol.62 , pp. 2476-2487
    • Yoshizaki, A.1
  • 14
    • 84921413874 scopus 로고    scopus 로고
    • MTOR inhibition rescues osteopenia in mice with systemic sclerosis
    • Chen C., et al. mTOR inhibition rescues osteopenia in mice with systemic sclerosis. J. Exp. Med. 212, 73-91 (2015
    • (2015) J. Exp. Med , vol.212 , pp. 73-91
    • Chen, C.1
  • 15
    • 73249139173 scopus 로고    scopus 로고
    • Rapamycin versus methotrexate in early diffuse systemic sclerosis: Results from a randomized, single-blind pilot study
    • Su T. I., et al. Rapamycin versus methotrexate in early diffuse systemic sclerosis: results from a randomized, single-blind pilot study. Arthritis Rheum. 60, 3821-3830 (2009
    • (2009) Arthritis Rheum , vol.60 , pp. 3821-3830
    • Su, T.I.1
  • 16
    • 72449156000 scopus 로고    scopus 로고
    • Sirolimus-eluting stent implantation for ostial stenosis of left main coronary artery after Bentall operation in aortitis syndrome
    • Terasawa A., et al. Sirolimus-eluting stent implantation for ostial stenosis of left main coronary artery after Bentall operation in aortitis syndrome. J. Cardiol. 55, 147-150 (2010
    • (2010) J. Cardiol , vol.55 , pp. 147-150
    • Terasawa, A.1
  • 17
    • 20444413105 scopus 로고    scopus 로고
    • Sirolimus-eluting stent for in stent restenosis of left main coronary artery in Takayasu arteritis
    • Furukawa Y., et al. Sirolimus-eluting stent for in stent restenosis of left main coronary artery in Takayasu arteritis. Circ. J. 69, 752-755 (2005
    • (2005) Circ. J. , vol.69 , pp. 752-755
    • Furukawa, Y.1
  • 19
    • 0036324991 scopus 로고    scopus 로고
    • Sirolimus lowers myeloperoxidase and p ANCA titers in a pediatric patient before kidney transplantation
    • Constantinescu A. R., Liang M., & Laskow D. A. Sirolimus lowers myeloperoxidase and p ANCA titers in a pediatric patient before kidney transplantation. Am. J. Kidney Dis. 40, 407-410 (2002
    • (2002) Am. J. Kidney Dis , vol.40 , pp. 407-410
    • Constantinescu, A.R.1    Liang, M.2    Laskow, D.A.3
  • 20
    • 84925729192 scopus 로고    scopus 로고
    • Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes
    • Lopez De Figueroa P., Lotz M. K., Blanco F. J., & Carames B. Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes. Arthritis Rheum. 67, 966-976 (2015
    • (2015) Arthritis Rheum , vol.67 , pp. 966-976
    • Lopez De Figueroa, P.1    Lotz, M.K.2    Blanco, F.J.3    Carames, B.4
  • 21
    • 84896629473 scopus 로고    scopus 로고
    • Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program
    • Chauvin C., et al. Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program. Oncogene 33, 474-483 (2014
    • (2014) Oncogene , vol.33 , pp. 474-483
    • Chauvin, C.1
  • 22
    • 0033153166 scopus 로고    scopus 로고
    • Regulation of 4E BP1 phosphorylation: A novel two step mechanism
    • Gingras A. C., et al. Regulation of 4E BP1 phosphorylation: a novel two step mechanism. Genes Dev. 13, 1422-1437 (1999
    • (1999) Genes Dev , vol.13 , pp. 1422-1437
    • Gingras, A.C.1
  • 24
    • 84876488191 scopus 로고    scopus 로고
    • MTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6
    • Nazio F., et al. MTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6. Nat. Cell. Biol. 15, 406-416 (2013
    • (2013) Nat. Cell. Biol , vol.15 , pp. 406-416
    • Nazio, F.1
  • 25
    • 84856800302 scopus 로고    scopus 로고
    • Role of AMPK-mTOR Ulk1/2 in the regulation of autophagy: Cross talk, shortcuts, and feedbacks
    • Alers S., Loffler A. S., Wesselborg S., & Stork B. Role of AMPK-mTOR Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. Mol. Cell. Biol. 32, 2-11 (2012
    • (2012) Mol. Cell. Biol , vol.32 , pp. 2-11
    • Alers, S.1    Loffler, A.S.2    Wesselborg, S.3    Stork, B.4
  • 26
    • 80555143078 scopus 로고    scopus 로고
    • MTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H+-ATPase
    • Zoncu R., et al. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H+-ATPase. Science 334, 678-683 (2011
    • (2011) Science , vol.334 , pp. 678-683
    • Zoncu, R.1
  • 27
    • 84878357685 scopus 로고    scopus 로고
    • A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1
    • Bar-Peled L., et al. A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science 340, 1100-1106 (2013
    • (2013) Science , vol.340 , pp. 1100-1106
    • Bar-Peled, L.1
  • 28
    • 28244469041 scopus 로고    scopus 로고
    • Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex
    • Sarbassov D. D., & Sabatini D. M. Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex. J. Biol. Chem. 280, 39505-39509 (2005
    • (2005) J. Biol. Chem , vol.280 , pp. 39505-39509
    • Sarbassov, D.D.1    Sabatini, D.M.2
  • 29
    • 84882800242 scopus 로고    scopus 로고
    • Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells
    • Thedieck K., et al. Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells. Cell 154, 859-874 (2013
    • (2013) Cell , vol.154 , pp. 859-874
    • Thedieck, K.1
  • 30
    • 61449084536 scopus 로고    scopus 로고
    • Activation of mTOR controls the loss of TCRζ in lupus T cells through HRES 1/Rab4 regulated lysosomal degradation
    • Fernandez D. R., et al. Activation of mTOR controls the loss of TCRζ in lupus T cells through HRES 1/Rab4 regulated lysosomal degradation. J. Immunol. 182, 2063-2073 (2009
    • (2009) J. Immunol , vol.182 , pp. 2063-2073
    • Fernandez, D.R.1
  • 31
    • 60149091189 scopus 로고    scopus 로고
    • Regulation of translation initiation in eukaryotes: Mechanisms and biological targets
    • Sonenberg N., & Hinnebusch A. G. Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell 136, 731-745 (2009
    • (2009) Cell , vol.136 , pp. 731-745
    • Sonenberg, N.1    Hinnebusch, A.G.2
  • 32
    • 45849105156 scopus 로고    scopus 로고
    • The Rag GTPases bind Raptor and mediate amino acid signaling to mTORC1
    • Sancak Y., et al. The Rag GTPases bind Raptor and mediate amino acid signaling to mTORC1. Science 320, 1496-1501 (2008
    • (2008) Science , vol.320 , pp. 1496-1501
    • Sancak, Y.1
  • 33
    • 0037007014 scopus 로고    scopus 로고
    • FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction
    • Desai B. N., Myers B. R., & Schreiber S. L. FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. Proc. Natl Acad. Sci. USA 99, 4319-4324 (2002
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 4319-4324
    • Desai, B.N.1    Myers, B.R.2    Schreiber, S.L.3
  • 34
    • 77952036652 scopus 로고    scopus 로고
    • Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells
    • Shor B., et al. Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells. J. Biol. Chem. 285, 15380-15392 (2010
    • (2010) J. Biol. Chem , vol.285 , pp. 15380-15392
    • Shor, B.1
  • 35
    • 77953512889 scopus 로고    scopus 로고
    • MTOR binds to the promoters of RNA polymerase I-and III-transcribed genes
    • Tsang C. K., Liu H., & Zheng X. S. mTOR binds to the promoters of RNA polymerase I-and III-transcribed genes. Cell Cycle 9, 953-957 (2010
    • (2010) Cell Cycle , vol.9 , pp. 953-957
    • Tsang, C.K.1    Liu, H.2    Zheng, X.S.3
  • 36
    • 46249127490 scopus 로고    scopus 로고
    • Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of huntington disease
    • Ravikumar B., Imarisio S., Sarkar S., OKane C. J., & Rubinsztein D. C. Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease. J. Cell. Sci. 121, 1649-1660 (2008
    • (2008) J. Cell. Sci , vol.121 , pp. 1649-1660
    • Ravikumar, B.1    Imarisio, S.2    Sarkar, S.3    Okane, C.J.4    Rubinsztein, D.C.5
  • 37
    • 80054978956 scopus 로고    scopus 로고
    • Rab5 and class III phosphoinositide 3 kinase Vps34 are involved in hepatitis C virus NS4B induced autophagy
    • Su W. C., et al. Rab5 and class III phosphoinositide 3 kinase Vps34 are involved in hepatitis C virus NS4B induced autophagy. J. Virol. 85, 10561-10571 (2011
    • (2011) J. Virol , vol.85 , pp. 10561-10571
    • Su, W.C.1
  • 38
    • 79251534395 scopus 로고    scopus 로고
    • Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes
    • Jia W., Pua H. H., Li Q. J., & He Y. W. Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. J. Immunol. 186, 1564-1574 (2011
    • (2011) J. Immunol , vol.186 , pp. 1564-1574
    • Jia, W.1    Pua, H.H.2    Li, Q.J.3    He, Y.W.4
  • 39
    • 3242877218 scopus 로고    scopus 로고
    • Rab7 is required for the normal progression of the autophagic pathway in mammalian cells
    • Gutierrez M. G., Munafo D. B., Beron W., & Colombo M. I. Rab7 is required for the normal progression of the autophagic pathway in mammalian cells. J. Cell Sci. 117, 2687-2697 (2004
    • (2004) J. Cell Sci , vol.117 , pp. 2687-2697
    • Gutierrez, M.G.1    Munafo, D.B.2    Beron, W.3    Colombo, M.I.4
  • 41
    • 84881126185 scopus 로고    scopus 로고
    • HRES 1/RAB4 mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE
    • Caza T. N., et al. HRES 1/RAB4 mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE. Ann. Rheum. Dis. 73, 1887-1897 (2014
    • (2014) Ann. Rheum. Dis , vol.73 , pp. 1887-1897
    • Caza, T.N.1
  • 42
    • 84896762116 scopus 로고    scopus 로고
    • HRES 1/Rab4 promotes the formation of LC3+ autophagosomes and the accumulation of mitochondria during autophagy
    • Talaber G., et al. HRES 1/Rab4 promotes the formation of LC3+ autophagosomes and the accumulation of mitochondria during autophagy. PLoS ONE 9, e84392 (2014
    • (2014) Plos One , vol.9 , pp. e84392
    • Talaber, G.1
  • 43
    • 84977563446 scopus 로고    scopus 로고
    • HRES 1/Rab4 lupus susceptibility gene selectively regulates mammalian target of rapamycin complexes 1 and 2 in T lymphocytes
    • Telarico T., et al. HRES 1/Rab4 lupus susceptibility gene selectively regulates mammalian target of rapamycin complexes 1 and 2 in T lymphocytes. Arthritis Rheum. Abstr. 63 (Suppl. 10), 2358 (2011
    • (2011) Arthritis Rheum. Abstr , vol.63 , Issue.SUPPL10 , pp. 2358
    • Telarico, T.1
  • 44
    • 10344232033 scopus 로고    scopus 로고
    • The p85α subunit of phosphatidylinositol 3? Kinase binds to and stimulates the GTPase activity of Rab proteins
    • Chamberlain M. D., Berry T. R., Pastor M. C., & Anderson D. H. The p85α subunit of phosphatidylinositol 3? kinase binds to and stimulates the GTPase activity of Rab proteins. J. Biol. Chem. 279, 48607-48614 (2004
    • (2004) J. Biol. Chem , vol.279 , pp. 48607-48614
    • Chamberlain, M.D.1    Berry, T.R.2    Pastor, M.C.3    Anderson, D.H.4
  • 45
    • 47049095900 scopus 로고    scopus 로고
    • Disrupted RabGAP function of the p85 subunit of phosphatidylinositol 3 kinase results in cell transformation
    • Chamberlain M. D., et al. Disrupted RabGAP function of the p85 subunit of phosphatidylinositol 3 kinase results in cell transformation. J. Biol. Chem. 283, 15861-15868 (2008
    • (2008) J. Biol. Chem , vol.283 , pp. 15861-15868
    • Chamberlain, M.D.1
  • 46
    • 77954542938 scopus 로고    scopus 로고
    • Deregulation of Rab5 and Rab4 proteins in p85R274A-expressing cells alters PDGFR trafficking
    • Chamberlain M. D., et al. Deregulation of Rab5 and Rab4 proteins in p85R274A-expressing cells alters PDGFR trafficking. Cell. Signal. 22, 1562-1575 (2010
    • (2010) Cell. Signal , vol.22 , pp. 1562-1575
    • Chamberlain, M.D.1
  • 47
    • 17744380195 scopus 로고    scopus 로고
    • Association of impaired phosphatidylinositol 3 kinase activity in glut1 containing vesicles with malinsertion of glucose transporters into the plasma membrane of fibroblasts from a patient with severe insulin resistance and clinical features of werner syndrome
    • Kausch C., et al. Association of impaired phosphatidylinositol 3 kinase activity in GLUT1 containing vesicles with malinsertion of glucose transporters into the plasma membrane of fibroblasts from a patient with severe insulin resistance and clinical features of Werner syndrome. J. Clin. Endocrin. Metab. 85, 905-918 (2000
    • (2000) J. Clin. Endocrin. Metab , vol.85 , pp. 905-918
    • Kausch, C.1
  • 48
    • 84872272443 scopus 로고    scopus 로고
    • Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT RUVBL1/2 complex
    • Kim S. G., et al. Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT RUVBL1/2 complex. Mol. Cell 49, 172-185 (2013
    • (2013) Mol. Cell , vol.49 , pp. 172-185
    • Kim, S.G.1
  • 49
    • 17844380477 scopus 로고    scopus 로고
    • Spatiotemporal regulation of MyD88-IRF 7 signalling for robust type i interferon induction
    • Honda K., et al. Spatiotemporal regulation of MyD88-IRF 7 signalling for robust type I interferon induction. Nature 434, 1035-1040 (2005
    • (2005) Nature , vol.434 , pp. 1035-1040
    • Honda, K.1
  • 50
    • 84874242408 scopus 로고    scopus 로고
    • Matched and mismatched metabolic fuels in lymphocyte function
    • Caro-Maldonado A., Gerriets V. A., & Rathmell J. C. Matched and mismatched metabolic fuels in lymphocyte function. Semin. Immunol. 24, 405-413 (2012
    • (2012) Semin. Immunol , vol.24 , pp. 405-413
    • Caro-Maldonado, A.1    Gerriets, V.A.2    Rathmell, J.C.3
  • 51
    • 79952985551 scopus 로고    scopus 로고
    • The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
    • Delgoffe G. M., et al. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat. Immunol. 12, 295-304 (2011
    • (2011) Nat. Immunol , vol.12 , pp. 295-304
    • Delgoffe, G.M.1
  • 52
    • 84883761914 scopus 로고    scopus 로고
    • Rapamycin unbalances the polarization of human macrophages to M1
    • Mercalli A., et al. Rapamycin unbalances the polarization of human macrophages to M1. Immunology 140, 179-190 (2013
    • (2013) Immunology , vol.140 , pp. 179-190
    • Mercalli, A.1
  • 53
    • 84907363576 scopus 로고    scopus 로고
    • TSC1 controls macrophage polarization to prevent inflammatory disease
    • Zhu L., et al. TSC1 controls macrophage polarization to prevent inflammatory disease. Nat. Commun. 5, 4696 (2014
    • (2014) Nat. Commun , vol.5 , pp. 4696
    • Zhu, L.1
  • 54
    • 84861818332 scopus 로고    scopus 로고
    • CMV late phase-induced mTOR activation is essential for efficient virus replication in polarized human macrophages
    • Poglitsch M., et al. CMV late phase-induced mTOR activation is essential for efficient virus replication in polarized human macrophages. Am. J. Transplant. 12, 1458-1468 (2012
    • (2012) Am. J. Transplant , vol.12 , pp. 1458-1468
    • Poglitsch, M.1
  • 55
    • 84922356976 scopus 로고    scopus 로고
    • PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage
    • Vasheghani F., et al. PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage. Ann. Rheum. Dis. 74, 569-578 (2015
    • (2015) Ann. Rheum. Dis , vol.74 , pp. 569-578
    • Vasheghani, F.1
  • 56
    • 84876535307 scopus 로고    scopus 로고
    • Attention deficit and hyperactivity disorder scores are elevated and respond to NAC treatment in patients with SLE
    • Garcia R. J., et al. Attention deficit and hyperactivity disorder scores are elevated and respond to NAC treatment in patients with SLE. Arthritis Rheum. 65, 1313-1318 (2013
    • (2013) Arthritis Rheum , vol.65 , pp. 1313-1318
    • Garcia, R.J.1
  • 57
    • 0036440779 scopus 로고    scopus 로고
    • Regulation of mammalian translation factors by nutrients
    • Proud C. G. Regulation of mammalian translation factors by nutrients. Eur. J. Biochem. 269, 5338-5349 (2002
    • (2002) Eur. J. Biochem , vol.269 , pp. 5338-5349
    • Proud, C.G.1
  • 58
    • 84864931233 scopus 로고    scopus 로고
    • Glutaminolysis activates Rag-mTORC1 signaling
    • Duran R., et al. Glutaminolysis activates Rag-mTORC1 signaling. Mol. Cell 47, 349-358 (2012
    • (2012) Mol. Cell , vol.47 , pp. 349-358
    • Duran, R.1
  • 59
    • 84922727084 scopus 로고    scopus 로고
    • Differential regulation of mTORC1 by leucine and glutamine
    • Jewell J. L., et al. Differential regulation of mTORC1 by leucine and glutamine. Science 347, 194-198 (2015
    • (2015) Science , vol.347 , pp. 194-198
    • Jewell, J.L.1
  • 60
    • 84941022225 scopus 로고    scopus 로고
    • Comprehensive metabolome analyses reveal N acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: Implications for activation of the mechanistic target of rapamycin
    • Perl A., et al. Comprehensive metabolome analyses reveal N acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin. Metabolomics 11, 1157-1174 (2015
    • (2015) Metabolomics , vol.11 , pp. 1157-1174
    • Perl, A.1
  • 61
    • 77955483125 scopus 로고    scopus 로고
    • Activation of a metabolic gene regulatory network downstream of mTOR complex 1
    • Duvel K., et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol. Cell 39, 171-183 (2010
    • (2010) Mol. Cell , vol.39 , pp. 171-183
    • Duvel, K.1
  • 62
    • 84883501150 scopus 로고    scopus 로고
    • HIF 1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
    • Semenza G. L. HIF 1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. J. Clin. Invest. 123, 3664-3671 (2013
    • (2013) J. Clin. Invest , vol.123 , pp. 3664-3671
    • Semenza, G.L.1
  • 63
    • 84893873953 scopus 로고    scopus 로고
    • SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF 1 α dependent glycolysis
    • Liu G., et al. SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF 1 α dependent glycolysis. Cancer Res. 74, 727-737 (2014
    • (2014) Cancer Res , vol.74 , pp. 727-737
    • Liu, G.1
  • 64
    • 84874995247 scopus 로고    scopus 로고
    • Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1
    • Ben-Sahra I., Howell J. J., Asara J. M., & Manning B. D. Stimulation of De novo pyrimidine synthesis by growth signaling through mTOR and S6K1. Science 339, 1323-1328 (2013
    • (2013) Science , vol.339 , pp. 1323-1328
    • Ben-Sahra, I.1    Howell, J.J.2    Asara, J.M.3    Manning, B.D.4
  • 65
    • 84901019405 scopus 로고    scopus 로고
    • Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells
    • Sun Y., et al. Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells. Cell Death Dis. 5, e1231 (2014
    • (2014) Cell Death Dis , vol.5 , pp. e1231
    • Sun, Y.1
  • 67
    • 84922264746 scopus 로고    scopus 로고
    • MTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD
    • De Joussineau C., et al. mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD). Hum. Mol. Genet. 23, 5418-5428 (2014
    • (2014) Hum. Mol. Genet , vol.23 , pp. 5418-5428
    • De Joussineau, C.1
  • 68
    • 84859060800 scopus 로고    scopus 로고
    • Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain
    • Yoo S. E., et al. Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain. Free Radic. Biol. Med. 52, 1820-1827 (2012
    • (2012) Free Radic. Biol. Med , vol.52 , pp. 1820-1827
    • Yoo, S.E.1
  • 69
    • 80053250328 scopus 로고    scopus 로고
    • CAMP inhibits mammalian target of rapamycin complex 1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity
    • Xie J., et al. CAMP inhibits mammalian target of rapamycin complex 1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity. Cell. Signal. 23, 1927-1935 (2011
    • (2011) Cell. Signal , vol.23 , pp. 1927-1935
    • Xie, J.1
  • 70
    • 84865633655 scopus 로고    scopus 로고
    • N acetylcysteine reduces disease activity by blocking mTOR in T cells of lupus patients
    • Lai Z. W., et al. N acetylcysteine reduces disease activity by blocking mTOR in T cells of lupus patients. Arthritis Rheum. 64, 2937-2946 (2012
    • (2012) Arthritis Rheum , vol.64 , pp. 2937-2946
    • Lai, Z.W.1
  • 71
    • 67650096912 scopus 로고    scopus 로고
    • Enhancing CD8 T cell memory by modulating fatty acid metabolism
    • Pearce E. L., et al. Enhancing CD8 T cell memory by modulating fatty acid metabolism. Nature 460, 103-107 (2009
    • (2009) Nature , vol.460 , pp. 103-107
    • Pearce, E.L.1
  • 72
    • 79953172571 scopus 로고    scopus 로고
    • Cutting edge: Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
    • Michalek R. D., et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J. Immunol. 186, 3299-3303 (2011
    • (2011) J. Immunol , vol.186 , pp. 3299-3303
    • Michalek, R.D.1
  • 73
    • 0038218405 scopus 로고    scopus 로고
    • Sphingosine-1 phosphate: An enigmatic signalling lipid
    • Spiegel S., & Milstien S. Sphingosine-1 phosphate: an enigmatic signalling lipid. Nat. Rev. Mol. Cell. Biol. 4, 397-407 (2003
    • (2003) Nat. Rev. Mol. Cell. Biol , vol.4 , pp. 397-407
    • Spiegel, S.1    Milstien, S.2
  • 74
    • 52949108813 scopus 로고    scopus 로고
    • The alliance of sphingosine-1 phosphate and its receptors in immunity
    • Rivera J., Proia R. L., & Olivera A. The alliance of sphingosine-1 phosphate and its receptors in immunity. Nat. Rev. Immunol. 8, 753-763 (2008
    • (2008) Nat. Rev. Immunol , vol.8 , pp. 753-763
    • Rivera, J.1    Proia, R.L.2    Olivera, A.3
  • 75
    • 1642580757 scopus 로고    scopus 로고
    • Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    • Matloubian M., et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427, 355-360 (2004
    • (2004) Nature , vol.427 , pp. 355-360
    • Matloubian, M.1
  • 76
    • 67649185215 scopus 로고    scopus 로고
    • The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt- mTOR
    • Liu G., et al. The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt- mTOR. Nat. Immunol. 10, 769-777 (2009
    • (2009) Nat. Immunol , vol.10 , pp. 769-777
    • Liu, G.1
  • 77
    • 77958151145 scopus 로고    scopus 로고
    • The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells
    • Liu G., Yang K., Burns S., Shrestha S., & Chi H. The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells. Nat. Immunol. 11, 1047-1056 (2010
    • (2010) Nat. Immunol , vol.11 , pp. 1047-1056
    • Liu, G.1    Yang, K.2    Burns, S.3    Shrestha, S.4    Chi, H.5
  • 78
    • 84897092283 scopus 로고    scopus 로고
    • Ceramide inhibits insulin-stimulated Akt phosphorylation through activation of Rheb/mTORC1/S6K signaling in skeletal muscle
    • Hsieh C. T., Chuang J. H., Yang W. C., Yin Y., & Lin Y. Ceramide inhibits insulin-stimulated Akt phosphorylation through activation of Rheb/mTORC1/S6K signaling in skeletal muscle. Cell. Signal. 26, 1400-1408 (2014
    • (2014) Cell. Signal , vol.26 , pp. 1400-1408
    • Hsieh, C.T.1    Chuang, J.H.2    Yang, W.C.3    Yin, Y.4    Lin, Y.5
  • 79
    • 80052736325 scopus 로고    scopus 로고
    • Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway
    • Yoshida S., et al. Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway. J. Biol. Chem. 286, 32651-32660 (2011
    • (2011) J. Biol. Chem , vol.286 , pp. 32651-32660
    • Yoshida, S.1
  • 80
    • 0023897684 scopus 로고
    • Type i phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3 phosphate
    • Whitman M., Downes C. P., Keeler M., Keller T., & Cantley L. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3 phosphate. Nature 332, 644-646 (1988
    • (1988) Nature , vol.332 , pp. 644-646
    • Whitman, M.1    Downes, C.P.2    Keeler, M.3    Keller, T.4    Cantley, L.5
  • 82
    • 84859117806 scopus 로고    scopus 로고
    • Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
    • Lamming D. W., et al. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 335, 1638-1643 (2012
    • (2012) Science , vol.335 , pp. 1638-1643
    • Lamming, D.W.1
  • 83
    • 84930184555 scopus 로고    scopus 로고
    • PI3K C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling
    • Braccini L., et al. PI3K C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling. Nat. Commun. 6, 7400 (2015
    • (2015) Nat. Commun , vol.6 , pp. 7400
    • Braccini, L.1
  • 84
    • 84872586081 scopus 로고    scopus 로고
    • Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy
    • Kim J., et al. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152, 290-303 (2013
    • (2013) Cell , vol.152 , pp. 290-303
    • Kim, J.1
  • 86
    • 84945333827 scopus 로고    scopus 로고
    • A 50 year-old woman with cowden syndrome and joint pains
    • Sagar V., Bond J. R., & Chowdhary V. R. A 50 year-old woman with Cowden syndrome and joint pains. Arthritis Care Res. 67, 1604-1608 (2015
    • (2015) Arthritis Care Res , vol.67 , pp. 1604-1608
    • Sagar, V.1    Bond, J.R.2    Chowdhary, V.R.3
  • 87
    • 84929942277 scopus 로고    scopus 로고
    • Systemic lupus erythematosus in a patient with PTEN hamartoma tumour syndrome
    • Lee T., Le E. N., Glass D. A., Bowen C. D., & Dominguez A. R. Systemic lupus erythematosus in a patient with PTEN hamartoma tumour syndrome. Brit. J. Dermatol. 170, 990-992 (2014
    • (2014) Brit. J. Dermatol , vol.170 , pp. 990-992
    • Lee, T.1    Le, E.N.2    Glass, D.A.3    Bowen, C.D.4    Dominguez, A.R.5
  • 88
    • 84922930171 scopus 로고    scopus 로고
    • Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses
    • Shrestha S., et al. Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses. Nat. Immunol. 16, 178-187 (2015
    • (2015) Nat. Immunol , vol.16 , pp. 178-187
    • Shrestha, S.1
  • 89
    • 84922917657 scopus 로고    scopus 로고
    • Control of PI3 kinase in Treg cells maintains homeostasis and lineage stability
    • Huynh A., et al. Control of PI3 kinase in Treg cells maintains homeostasis and lineage stability. Nat. Immunol. 16, 188-196 (2015
    • (2015) Nat. Immunol , vol.16 , pp. 188-196
    • Huynh, A.1
  • 90
    • 84922918343 scopus 로고    scopus 로고
    • PTENtiating autoimmunity through Treg cell deregulation
    • Ray J. P., & Craft J. PTENtiating autoimmunity through Treg cell deregulation. Nat. Immunol. 16, 139-140 (2015
    • (2015) Nat. Immunol , vol.16 , pp. 139-140
    • Ray, J.P.1    Craft, J.2
  • 91
    • 84927152610 scopus 로고    scopus 로고
    • Defective PTEN regulation contributes to B cell hyperresponsiveness in systemic lupus erythematosus
    • 246ra99
    • Wu X. N., et al. Defective PTEN regulation contributes to B cell hyperresponsiveness in systemic lupus erythematosus. Sci. Transl. Med. 6, 246ra99 (2014
    • (2014) Sci. Transl. Med , vol.6
    • Wu, X.N.1
  • 92
    • 84918522184 scopus 로고    scopus 로고
    • Loss of phosphatase and tensin homolog (PTEN) in myeloid cells controls inflammatory bone destruction by regulating the osteoclastogenic potential of myeloid cells
    • Bluml S., et al. Loss of phosphatase and tensin homolog (PTEN) in myeloid cells controls inflammatory bone destruction by regulating the osteoclastogenic potential of myeloid cells. Ann. Rheum. Dis. 74, 227-233 (2015
    • (2015) Ann. Rheum. Dis , vol.74 , pp. 227-233
    • Bluml, S.1
  • 93
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K., Zhu T., & Guan K. L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577-590 (2003
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 94
    • 42949139481 scopus 로고    scopus 로고
    • AMPK phosphorylation of Raptor mediates a metabolic checkpoint
    • Gwinn D. M., et al. AMPK phosphorylation of Raptor mediates a metabolic checkpoint. Mol. Cell 30, 214-226 (2008
    • (2008) Mol. Cell , vol.30 , pp. 214-226
    • Gwinn, D.M.1
  • 95
    • 0031717105 scopus 로고    scopus 로고
    • The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
    • Hardie D. G., Carling D., & Carlson M. The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Ann. Rev. Biochem. 67, 821-855 (1998
    • (1998) Ann. Rev. Biochem , vol.67 , pp. 821-855
    • Hardie, D.G.1    Carling, D.2    Carlson, M.3
  • 96
    • 84888794082 scopus 로고    scopus 로고
    • AMPKα1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling
    • Carroll K. C., Viollet B., & Suttles J. AMPKα1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling. J. Leukoc. Biol. 94, 1113-1121 (2013
    • (2013) J. Leukoc. Biol , vol.94 , pp. 1113-1121
    • Carroll, K.C.1    Viollet, B.2    Suttles, J.3
  • 97
    • 84880331368 scopus 로고    scopus 로고
    • ULK1 induces autophagy by phosphorylating Beclin 1 and activating VPS34 lipid kinase
    • Russell R. C., et al. ULK1 induces autophagy by phosphorylating Beclin 1 and activating VPS34 lipid kinase. Nat. Cell Biol. 15, 741-750 (2013
    • (2013) Nat. Cell Biol , vol.15 , pp. 741-750
    • Russell, R.C.1
  • 98
    • 84875999344 scopus 로고    scopus 로고
    • Metformin downregulates TH17 cells differentiation and attenuates murine autoimmune arthritis
    • Kang K. Y., et al. Metformin downregulates TH17 cells differentiation and attenuates murine autoimmune arthritis. Int. Immunopharmacol. 16, 85-92 (2013
    • (2013) Int. Immunopharmacol , vol.16 , pp. 85-92
    • Kang, K.Y.1
  • 99
    • 67650074206 scopus 로고    scopus 로고
    • MTOR regulates memory CD8 T cell differentiation
    • Araki K., et al. mTOR regulates memory CD8 T cell differentiation. Nature 460, 108-112 (2009
    • (2009) Nature , vol.460 , pp. 108-112
    • Araki, K.1
  • 100
    • 74649085700 scopus 로고    scopus 로고
    • The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T bet and eomesodermin
    • Rao R. R., Li Q., Odunsi K., & Shrikant P. A. The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T bet and eomesodermin. Immunity 32, 67-78 (2010
    • (2010) Immunity , vol.32 , pp. 67-78
    • Rao, R.R.1    Li, Q.2    Odunsi, K.3    Shrikant, P.A.4
  • 101
    • 66949173728 scopus 로고    scopus 로고
    • The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
    • Delgoffe G. M., et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 30, 832-844 (2009
    • (2009) Immunity , vol.30 , pp. 832-844
    • Delgoffe, G.M.1
  • 102
    • 78650188983 scopus 로고    scopus 로고
    • An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness
    • Procaccini C., et al. An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity 33, 929-941 (2010
    • (2010) Immunity , vol.33 , pp. 929-941
    • Procaccini, C.1
  • 103
    • 84881192927 scopus 로고    scopus 로고
    • MTORC1 couples immune signals and metabolic programming to establish Treg-cell function
    • Zeng H., et al. mTORC1 couples immune signals and metabolic programming to establish Treg-cell function. Nature 499, 485-490 (2013
    • (2013) Nature , vol.499 , pp. 485-490
    • Zeng, H.1
  • 104
    • 84885448124 scopus 로고    scopus 로고
    • Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells
    • Yang Z., Fujii H., Mohan S. V., Goronzy J. J., & Weyand C. M. Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells. J. Exp. Med. 210, 2119-2134 (2013
    • (2013) J. Exp. Med , vol.210 , pp. 2119-2134
    • Yang, Z.1    Fujii, H.2    Mohan, S.V.3    Goronzy, J.J.4    Weyand, C.M.5
  • 106
    • 84899562139 scopus 로고    scopus 로고
    • Mechanistic taret of rapamycin complex 1 expands TH17 and IL 4+ double negative T cells and contracts regulatory T cells in systemic lupus erythematosus
    • Kato H., & Perl A. Mechanistic taret of rapamycin complex 1 expands TH17 and IL 4+ double negative T cells and contracts regulatory T cells in systemic lupus erythematosus. J. Immunol. 192, 4134-4144 (2014
    • (2014) J. Immunol , vol.192 , pp. 4134-4144
    • Kato, H.1    Perl, A.2
  • 107
    • 77953720799 scopus 로고    scopus 로고
    • MTOR signaling: A central pathway to pathogenesis in systemic lupus erythematosus?
    • Fernandez D. R., & Perl A. mTOR signaling: a central pathway to pathogenesis in systemic lupus erythematosus? Discov. Med. 9, 173-178 (2010
    • (2010) Discov. Med , vol.9 , pp. 173-178
    • Fernandez, D.R.1    Perl, A.2
  • 108
    • 80053286823 scopus 로고    scopus 로고
    • Abnormalities of T cell signaling in systemic lupus erythematosus
    • Moulton V. R., & Tsokos G. C. Abnormalities of T cell signaling in systemic lupus erythematosus. Arth. Res. Ther. 13, 207 (2010
    • (2010) Arth. Res. Ther , vol.13 , pp. 207
    • Moulton, V.R.1    Tsokos, G.C.2
  • 109
    • 84883375256 scopus 로고    scopus 로고
    • MTOR activation triggers IL 4 production and necrotic death of double-negative T cells in patients with systemic lupus eryhthematosus
    • Lai Z. W., et al. mTOR activation triggers IL 4 production and necrotic death of double-negative T cells in patients with systemic lupus eryhthematosus. J. Immunol. 191, 2236-2246 (2013
    • (2013) J. Immunol , vol.191 , pp. 2236-2246
    • Lai, Z.W.1
  • 110
    • 84949097466 scopus 로고    scopus 로고
    • MTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging
    • Perl A. mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging. Ann. NY Acad. Sci. 1346, 33-44 (2015
    • (2015) Ann. NY Acad. Sci , vol.1346 , pp. 33-44
    • Perl, A.1
  • 111
    • 84871843151 scopus 로고    scopus 로고
    • GATA 3 regulates the homeostasis and activation of CD8+ T cells
    • Tai T. S., Pai S. Y., & Ho I. C. GATA 3 regulates the homeostasis and activation of CD8+ T cells. J. Immunol. 190, 428-437 (2013
    • (2013) J. Immunol , vol.190 , pp. 428-437
    • Tai, T.S.1    Pai, S.Y.2    Ho, I.C.3
  • 112
    • 79959770321 scopus 로고    scopus 로고
    • Rapamycin-sensitive signals control TCR/CD28 driven Ifng Il4 and Foxp3 transcription and promoter region methylation
    • Tomasoni R., et al. Rapamycin-sensitive signals control TCR/CD28 driven Ifng, Il4 and Foxp3 transcription and promoter region methylation. Eur. J. Immunol. 41, 2086-2096 (2011
    • (2011) Eur. J. Immunol , vol.41 , pp. 2086-2096
    • Tomasoni, R.1
  • 113
    • 0034327735 scopus 로고    scopus 로고
    • Human double-negative T cells in systemic lupus erythematosus provide help for IgG and are restricted by CD1c
    • Sieling P. A., et al. Human double-negative T cells in systemic lupus erythematosus provide help for IgG and are restricted by CD1c. J. Immunol. 165, 5338-5344 (2000
    • (2000) J. Immunol , vol.165 , pp. 5338-5344
    • Sieling, P.A.1
  • 114
    • 0024341842 scopus 로고
    • T cell receptor α/β expressing double-negative (CD4-/CD8-) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis
    • Shivakumar S., Tsokos G. C., & Datta S. K. T cell receptor α/β expressing double-negative (CD4-/CD8-) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis. J. Immunol. 143, 103-112 (1989
    • (1989) J. Immunol , vol.143 , pp. 103-112
    • Shivakumar, S.1    Tsokos, G.C.2    Datta, S.K.3
  • 115
    • 84860879231 scopus 로고    scopus 로고
    • Ksp1 kinase regulates autophagy via the target of rapamycin complex 1 (TORC1) pathway
    • Umekawa M., & Klionsky D. J. Ksp1 kinase regulates autophagy via the target of rapamycin complex 1 (TORC1) pathway. J. Biol. Chem. 287, 16300-16310 (2012
    • (2012) J. Biol. Chem , vol.287 , pp. 16300-16310
    • Umekawa, M.1    Klionsky, D.J.2
  • 116
    • 58149279490 scopus 로고    scopus 로고
    • ICOS-dependent extrafollicular helper T cells elicit IgG production via IL 21 in systemic autoimmunity
    • Odegard J. M., et al. ICOS-dependent extrafollicular helper T cells elicit IgG production via IL 21 in systemic autoimmunity. J. Exp. Med. 205, 2873-2886 (2008
    • (2008) J. Exp. Med , vol.205 , pp. 2873-2886
    • Odegard, J.M.1
  • 117
    • 84884367704 scopus 로고    scopus 로고
    • Circulating TFH subset distribution is strongly affected in lupus patients with an active disease
    • Le Coz C., et al. Circulating TFH subset distribution is strongly affected in lupus patients with an active disease. PLoS ONE 8, e75319 (2013
    • (2013) Plos One , vol.8 , pp. e75319
    • Le Coz, C.1
  • 119
    • 34547687662 scopus 로고    scopus 로고
    • Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus
    • Wu T., et al. Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus. J. Clin. Invest. 117, 2186-2196 (2007
    • (2007) J. Clin. Invest , vol.117 , pp. 2186-2196
    • Wu, T.1
  • 120
    • 79551471312 scopus 로고    scopus 로고
    • The PI3K/Akt/mTOR pathway is activated in murine lupus nephritis and downregulated by rapamycin
    • Stylianou K., et al. The PI3K/Akt/mTOR pathway is activated in murine lupus nephritis and downregulated by rapamycin. Nephrol. Dial. Transplant. 26, 498-508 (2011
    • (2011) Nephrol. Dial. Transplant , vol.26 , pp. 498-508
    • Stylianou, K.1
  • 121
    • 0020436689 scopus 로고
    • The 1982 revised criteria for the classification of systemic lupus erythematosus
    • Tan E. M., et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 25, 1271-1277 (1982
    • (1982) Arthritis Rheum , vol.25 , pp. 1271-1277
    • Tan, E.M.1
  • 122
    • 0031229830 scopus 로고    scopus 로고
    • Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus
    • Hochberg M. C. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 40, 1725 (1997
    • (1997) Arthritis Rheum , vol.40 , pp. 1725
    • Hochberg, M.C.1
  • 123
    • 84864470206 scopus 로고    scopus 로고
    • Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus
    • Petri M., et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum. 64, 2677-2686 (2012
    • (2012) Arthritis Rheum , vol.64 , pp. 2677-2686
    • Petri, M.1
  • 124
    • 33344458573 scopus 로고    scopus 로고
    • International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS
    • Miyakis S., et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J. Thromb. Haemost. 4, 295-306 (2006
    • (2006) J. Thromb. Haemost , vol.4 , pp. 295-306
    • Miyakis, S.1
  • 125
    • 84904581191 scopus 로고    scopus 로고
    • Inhibition of the mTORC pathway in the antiphospholipid syndrome
    • Canaud G., et al. Inhibition of the mTORC pathway in the antiphospholipid syndrome. N. Engl. J. Med. 371, 303-312 (2014
    • (2014) N. Engl. J. Med , vol.371 , pp. 303-312
    • Canaud, G.1
  • 126
    • 84928634094 scopus 로고    scopus 로고
    • Oxidative stress and Treg depletion in lupus patients with anti-phospholipid syndrome
    • Lai Z. W., Marchena-Mendez I., & Perl A. Oxidative stress and Treg depletion in lupus patients with anti-phospholipid syndrome. Clin. Immunol. 158, 148-152 (2015
    • (2015) Clin. Immunol , vol.158 , pp. 148-152
    • Lai, Z.W.1    Marchena-Mendez, I.2    Perl, A.3
  • 127
    • 84902161920 scopus 로고    scopus 로고
    • Increased mitochondrial electron transport chain activity at complex i is regulated by N acetylcysteine in lymphocytes of patients with systemic lupus erythematosus
    • Doherty E., Oaks Z., & Perl A. Increased mitochondrial electron transport chain activity at complex I is regulated by N acetylcysteine in lymphocytes of patients with systemic lupus erythematosus. Antiox. Redox Signal. 21, 56-65 (2014
    • (2014) Antiox. Redox Signal , vol.21 , pp. 56-65
    • Doherty, E.1    Oaks, Z.2    Perl, A.3
  • 128
    • 84928641864 scopus 로고    scopus 로고
    • Normalization of CD4+ T cell metabolism reverses lupus
    • 274ra18
    • Yin Y., et al. Normalization of CD4+ T cell metabolism reverses lupus. Sci. Transl. Med. 7, 274ra18 (2015
    • (2015) Sci. Transl. Med , vol.7
    • Yin, Y.1
  • 129
    • 67651007563 scopus 로고    scopus 로고
    • Prevention of hepatocarcinogenesis and acetaminophen-induced liver failure in transaldolase-deficient mice by N acetylcysteine
    • Hanczko R., et al. Prevention of hepatocarcinogenesis and acetaminophen-induced liver failure in transaldolase-deficient mice by N acetylcysteine. J. Clin. Invest. 119, 1546-1557 (2009
    • (2009) J. Clin. Invest , vol.119 , pp. 1546-1557
    • Hanczko, R.1
  • 130
    • 79960221714 scopus 로고    scopus 로고
    • Oxidative stress, inflammation and carcinogenesis are controlled through the pentose phosphate pathway by transaldolase
    • Perl A., Hanczko R., Telarico T., Oaks Z., & Landas S. Oxidative stress, inflammation and carcinogenesis are controlled through the pentose phosphate pathway by transaldolase. Trends Mol. Med. 7, 395-403 (2011
    • (2011) Trends Mol. Med , vol.7 , pp. 395-403
    • Perl, A.1    Hanczko, R.2    Telarico, T.3    Oaks, Z.4    Landas, S.5
  • 131
    • 84935043505 scopus 로고    scopus 로고
    • The PI3K/Akt/PTEN/mTOR pathway: A fruitful target for inducing cell death in rheumatoid arthritis?
    • Malemud C. J. The PI3K/Akt/PTEN/mTOR pathway: a fruitful target for inducing cell death in rheumatoid arthritis? Future Med. Chem. 7, 1137-1147 (2015
    • (2015) Future Med. Chem , vol.7 , pp. 1137-1147
    • Malemud, C.J.1
  • 132
    • 33747789572 scopus 로고    scopus 로고
    • Age related CD8+ T cell clonal expansions express elevated levels of CD122 and CD127 and display defects in perceiving homeostatic signals
    • Messaoudi I., Warner J., & Nikolich-Zugich J. Age related CD8+ T cell clonal expansions express elevated levels of CD122 and CD127 and display defects in perceiving homeostatic signals. J. Immunol. 177, 2784-2792 (2006
    • (2006) J. Immunol , vol.177 , pp. 2784-2792
    • Messaoudi, I.1    Warner, J.2    Nikolich-Zugich, J.3
  • 133
    • 77956633322 scopus 로고    scopus 로고
    • MTOR regulates the invasive properties of synovial fibroblasts in rheumatoid arthritis
    • Laragione T., & Gulko P. S. mTOR regulates the invasive properties of synovial fibroblasts in rheumatoid arthritis. Mol. Med. 16, 352-358 (2010
    • (2010) Mol. Med , vol.16 , pp. 352-358
    • Laragione, T.1    Gulko, P.S.2
  • 134
    • 79955559622 scopus 로고    scopus 로고
    • Interleukin-17 induced proliferation of fibroblast-like synovial cells is mTOR dependent
    • Saxena A., Raychaudhuri S. K., & Raychaudhuri S. P. Interleukin-17 induced proliferation of fibroblast-like synovial cells is mTOR dependent. Arthritis Rheum. 63, 1465-1466 (2011
    • (2011) Arthritis Rheum , vol.63 , pp. 1465-1466
    • Saxena, A.1    Raychaudhuri, S.K.2    Raychaudhuri, S.P.3
  • 135
    • 84929962351 scopus 로고    scopus 로고
    • Biomarkers for diagnosis, monitoring of progression, and treatment responses in ankylosing spondylitis and axial spondyloarthritis
    • Reveille J. D. Biomarkers for diagnosis, monitoring of progression, and treatment responses in ankylosing spondylitis and axial spondyloarthritis. Clin. Rheumatol. 34, 1009-1018 (2015
    • (2015) Clin. Rheumatol , vol.34 , pp. 1009-1018
    • Reveille, J.D.1
  • 136
    • 84879691837 scopus 로고    scopus 로고
    • Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci
    • International Genetics of Ankylosing Spondylitis Consortium (IGAS), et al.
    • International Genetics of Ankylosing Spondylitis Consortium (IGAS), et al. Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat. Genet. 45, 730-738 (2013
    • (2013) Nat. Genet , vol.45 , pp. 730-738
  • 137
    • 84940107646 scopus 로고    scopus 로고
    • ERAP2 is associated with ankylosing spondylitis in HLA B27 positive and HLA B27 negative patients
    • Robinson P. C., et al. ERAP2 is associated with ankylosing spondylitis in HLA B27 positive and HLA B27 negative patients. Ann. Rheum. Dis. 74, 1627-1629 (2015
    • (2015) Ann. Rheum. Dis , vol.74 , pp. 1627-1629
    • Robinson, P.C.1
  • 138
    • 79960899377 scopus 로고    scopus 로고
    • Interaction between ERAP1 and HLA B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA B27 in disease susceptibility
    • Evans D. M., et al. Interaction between ERAP1 and HLA B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA B27 in disease susceptibility. Nat. Genet. 43, 761-767 (2011
    • (2011) Nat. Genet , vol.43 , pp. 761-767
    • Evans, D.M.1
  • 139
    • 84878527072 scopus 로고    scopus 로고
    • In situ analysis of interleukin 23 and interleukin 12 positive cells in the spine of patients with ankylosing spondylitis
    • Appel H., et al. In situ analysis of interleukin 23 and interleukin 12 positive cells in the spine of patients with ankylosing spondylitis. Arthritis Rheum. 65, 1522-1529 (2013
    • (2013) Arthritis Rheum , vol.65 , pp. 1522-1529
    • Appel, H.1
  • 140
    • 84878810703 scopus 로고    scopus 로고
    • Aberrant expression of microRNAs in T cells from patients with ankylosing spondylitis contributes to the immunopathogenesis
    • Lai N. S., et al. Aberrant expression of microRNAs in T cells from patients with ankylosing spondylitis contributes to the immunopathogenesis. Clin. Exp. Immunol. 173, 47-57 (2013
    • (2013) Clin. Exp. Immunol , vol.173 , pp. 47-57
    • Lai, N.S.1
  • 141
    • 84910020383 scopus 로고    scopus 로고
    • MicroRNA let 7i induced autophagy to protect T cell from apoptosis by targeting IGF1R
    • Hou C., Zhu M., Sun M., & Lin Y. MicroRNA let 7i induced autophagy to protect T cell from apoptosis by targeting IGF1R. Biochem. Biophys. Res. Commun. 453, 728-734 (2014
    • (2014) Biochem. Biophys. Res. Commun , vol.453 , pp. 728-734
    • Hou, C.1    Zhu, M.2    Sun, M.3    Lin, Y.4
  • 142
    • 0029096649 scopus 로고
    • Insulin-like growth factor induces phosphorylation of immunoreactive insulin receptor substrate and its association with phosphatidylinositol 3 kinase in human thymocytes
    • Kooijman R., Lauf J. J., Kappers A. C., & Rijkers G. T. Insulin-like growth factor induces phosphorylation of immunoreactive insulin receptor substrate and its association with phosphatidylinositol 3 kinase in human thymocytes. J. Exp. Med. 182, 593-597 (1995
    • (1995) J. Exp. Med , vol.182 , pp. 593-597
    • Kooijman, R.1    Lauf, J.J.2    Kappers, A.C.3    Rijkers, G.T.4
  • 143
    • 0028960852 scopus 로고
    • Differential expression of type i insulin like growth factor receptors in different stages of human T cells
    • Kooijman R., Scholtens L. E., Rijkers G. T., & Zegers B. J. Differential expression of type I insulin like growth factor receptors in different stages of human T cells. Eur. J. Immunol. 25, 931-935 (1995
    • (1995) Eur. J. Immunol , vol.25 , pp. 931-935
    • Kooijman, R.1    Scholtens, L.E.2    Rijkers, G.T.3    Zegers, B.J.4
  • 144
    • 84907992169 scopus 로고    scopus 로고
    • Up regulation of fatty acid oxidation in the ligament as a contributing factor of ankylosing spondylitis: A comparative proteomic study
    • Xu W. D., et al. Up regulation of fatty acid oxidation in the ligament as a contributing factor of ankylosing spondylitis: a comparative proteomic study. J. Proteom. 113, 57-72 (2015
    • (2015) J. Proteom , vol.113 , pp. 57-72
    • Xu, W.D.1
  • 145
    • 84922410788 scopus 로고    scopus 로고
    • Inhibition of interleukin 17, interleukin 23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis
    • Mease P. J. Inhibition of interleukin 17, interleukin 23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis. Curr. Opin. Rheumatol. 27, 127-133 (2015
    • (2015) Curr. Opin. Rheumatol , vol.27 , pp. 127-133
    • Mease, P.J.1
  • 146
    • 0345659216 scopus 로고    scopus 로고
    • A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis
    • Helms C., et al. A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. Nat. Genet. 35, 349-356 (2003
    • (2003) Nat. Genet , vol.35 , pp. 349-356
    • Helms, C.1
  • 147
    • 84865409069 scopus 로고    scopus 로고
    • IL 22 induced cell proliferation is regulated by PI3K/Akt/mTOR signaling cascade
    • Mitra A., Raychaudhuri S. K., & Raychaudhuri S. P. IL 22 induced cell proliferation is regulated by PI3K/Akt/mTOR signaling cascade. Cytokine 60, 38-42 (2012
    • (2012) Cytokine , vol.60 , pp. 38-42
    • Mitra, A.1    Raychaudhuri, S.K.2    Raychaudhuri, S.P.3
  • 148
    • 84937252297 scopus 로고    scopus 로고
    • Analysis of programmed death 1 in patients with psoriatic arthritis
    • Peled M., et al. Analysis of programmed death 1 in patients with psoriatic arthritis. Inflammation 38, 1573-1579 (2015
    • (2015) Inflammation , vol.38 , pp. 1573-1579
    • Peled, M.1
  • 149
    • 0030912133 scopus 로고    scopus 로고
    • Rapamycin (sirolimus) inhibits proliferating cell nuclear antigen expression and blocks cell cycle in the G1 phase in human keratinocyte stem cells
    • Javier A. F., et al. Rapamycin (sirolimus) inhibits proliferating cell nuclear antigen expression and blocks cell cycle in the G1 phase in human keratinocyte stem cells. J. Clin. Invest. 99, 2094-2099 (1997
    • (1997) J. Clin. Invest , vol.99 , pp. 2094-2099
    • Javier, A.F.1
  • 150
    • 84879955291 scopus 로고    scopus 로고
    • Mammalian target of rapamycin and its downstream signalling components are activated in psoriatic skin
    • Buerger C., Malisiewicz B., Eiser A., Hardt K., & Boehncke W. H. Mammalian target of rapamycin and its downstream signalling components are activated in psoriatic skin. Br. J. Dermatol. 169, 156-159 (2013
    • (2013) Br. J. Dermatol , vol.169 , pp. 156-159
    • Buerger, C.1    Malisiewicz, B.2    Eiser, A.3    Hardt, K.4    Boehncke, W.H.5
  • 151
    • 53949113624 scopus 로고    scopus 로고
    • Reactive oxygen species in tumor necrosis factor-α activated primary human keratinocytes: Implications for psoriasis and inflammatory skin disease
    • Young C. N., et al. Reactive oxygen species in tumor necrosis factor-α activated primary human keratinocytes: implications for psoriasis and inflammatory skin disease. J. Invest. Dermatol. 128, 2606-2614 (2008
    • (2008) J. Invest. Dermatol , vol.128 , pp. 2606-2614
    • Young, C.N.1
  • 152
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • Wynn T. A. Cellular and molecular mechanisms of fibrosis. J. Pathol. 214, 199-210 (2008
    • (2008) J. Pathol , vol.214 , pp. 199-210
    • Wynn, T.A.1
  • 153
    • 28544450380 scopus 로고    scopus 로고
    • Transforming growth factor β activation of phosphatidylinositol 3 kinase is independent of smad2 and smad3 and regulates fibroblast responses via p21 activated kinase 2
    • Wilkes M. C., et al. Transforming growth factor β activation of phosphatidylinositol 3 kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21 activated kinase 2. Cancer Res. 65, 10431-10440 (2005
    • (2005) Cancer Res , vol.65 , pp. 10431-10440
    • Wilkes, M.C.1
  • 154
    • 58249106743 scopus 로고    scopus 로고
    • Distinct roles for mammalian target of rapamycin complexes in the fibroblast response to transforming growth factor β
    • Rahimi R. A., et al. Distinct roles for mammalian target of rapamycin complexes in the fibroblast response to transforming growth factor β. Cancer Res. 69, 84-93 (2009
    • (2009) Cancer Res , vol.69 , pp. 84-93
    • Rahimi, R.A.1
  • 155
    • 84940789259 scopus 로고    scopus 로고
    • Rictor/mTORC2 signaling mediates TGFβ1 induced fibroblast activation and kidney fibrosis
    • Li J., et al. Rictor/mTORC2 signaling mediates TGFβ1 induced fibroblast activation and kidney fibrosis. Kidney Int. 88, 515-527 (2015
    • (2015) Kidney Int , vol.88 , pp. 515-527
    • Li, J.1
  • 157
    • 84907707647 scopus 로고    scopus 로고
    • Mechanical activation of mammalian target of rapamycin pathway is required for cartilage development
    • Guan Y., Yang X., Yang W., Charbonneau C., & Chen Q. Mechanical activation of mammalian target of rapamycin pathway is required for cartilage development. FASEB J. 28, 4470-4481 (2014
    • (2014) FASEB J. , vol.28 , pp. 4470-4481
    • Guan, Y.1    Yang, X.2    Yang, W.3    Charbonneau, C.4    Chen, Q.5
  • 158
    • 80053900670 scopus 로고    scopus 로고
    • Autophagy and cartilage homeostasis mechanisms in joint health, aging and osteoarthritis
    • Lotz M., & Carames B. Autophagy and cartilage homeostasis mechanisms in joint health, aging and osteoarthritis. Nat. Rev. Rheumatol. 7, 579-587 (2011
    • (2011) Nat. Rev. Rheumatol , vol.7 , pp. 579-587
    • Lotz, M.1    Carames, B.2
  • 159
    • 84935036182 scopus 로고    scopus 로고
    • Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis
    • Zhang Y., et al. Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis. Ann. Rheum. Dis. 74, 1432-1440 (2015
    • (2015) Ann. Rheum. Dis , vol.74 , pp. 1432-1440
    • Zhang, Y.1
  • 160
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • Harrison D. E., et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460, 392-395 (2009
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1
  • 161
    • 0028239893 scopus 로고
    • RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
    • Sabatini D. M., Erdjument-Bromage H., Lui M., Tempst P., & Snyder S. H. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 78, 35-43 (1994
    • (1994) Cell , vol.78 , pp. 35-43
    • Sabatini, D.M.1    Erdjument-Bromage, H.2    Lui, M.3    Tempst, P.4    Snyder, S.H.5
  • 162
    • 84864568658 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov
    • Clinical Trials.gov [Online
  • 164
    • 65549145048 scopus 로고    scopus 로고
    • An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
    • Thoreen C. C., et al. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J. Biol. Chem. 284, 8023-8032 (2009
    • (2009) J. Biol. Chem , vol.284 , pp. 8023-8032
    • Thoreen, C.C.1
  • 165
    • 33751162384 scopus 로고    scopus 로고
    • Therapeutic targets: MTOR and related pathways
    • Dancey J. E. Therapeutic targets: mTOR and related pathways. Cancer Biol. Ther. 5, 1065-1073 (2006
    • (2006) Cancer Biol. Ther , vol.5 , pp. 1065-1073
    • Dancey, J.E.1
  • 166
    • 84925501455 scopus 로고    scopus 로고
    • Treatment-related fatigue with everolimus and temsirolimus in patients with cancer meta-analysis of clinical trials
    • Peng L., Zhou Y., Ye X., & Zhao Q. Treatment-related fatigue with everolimus and temsirolimus in patients with cancer meta-analysis of clinical trials. Tumor Biol. 36, 643-654 (2014
    • (2014) Tumor Biol , vol.36 , pp. 643-654
    • Peng, L.1    Zhou, Y.2    Ye, X.3    Zhao, Q.4
  • 167
    • 84865562515 scopus 로고    scopus 로고
    • Phase i safety, pharmacokinetic, and pharmacodynamic study of the oral phosphatidylinositol-3 kinase and mTOR inhibitor BGT226 in patients with advanced solid tumors
    • Markman B., et al. Phase I safety, pharmacokinetic, and pharmacodynamic study of the oral phosphatidylinositol-3 kinase and mTOR inhibitor BGT226 in patients with advanced solid tumors. Ann. Oncol. 23, 2399-2408 (2012
    • (2012) Ann. Oncol , vol.23 , pp. 2399-2408
    • Markman, B.1
  • 168
    • 0035956972 scopus 로고    scopus 로고
    • FKBP12, the 12 kDa FK506 binding protein, is a physiologic regulator of the cell cycle
    • Aghdasi B., et al. FKBP12, the 12 kDa FK506 binding protein, is a physiologic regulator of the cell cycle. Proc. Natl Acad. Sci. USA 98, 2425-2430 (2001
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 2425-2430
    • Aghdasi, B.1
  • 169
    • 0030692139 scopus 로고    scopus 로고
    • All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae
    • Dolinski K., Muir S., Cardenas M., & Heitman J. All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA 94, 13093-13098 (1997
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 13093-13098
    • Dolinski, K.1    Muir, S.2    Cardenas, M.3    Heitman, J.4
  • 170
    • 77953218866 scopus 로고    scopus 로고
    • Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue
    • Houde V. P., et al. Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue. Diabetes 59, 1338-1348 (2010
    • (2010) Diabetes , vol.59 , pp. 1338-1348
    • Houde, V.P.1
  • 171
    • 42449104351 scopus 로고    scopus 로고
    • MTOR inhibition by rapamycin prevents β cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
    • Fraenkel M., et al. mTOR inhibition by rapamycin prevents β cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes. Diabetes 57, 945-957 (2008
    • (2008) Diabetes , vol.57 , pp. 945-957
    • Fraenkel, M.1
  • 172
    • 84875331396 scopus 로고    scopus 로고
    • Duration of rapamycin treatment has differential effects on metabolism in mice
    • Fang Y., et al. Duration of rapamycin treatment has differential effects on metabolism in mice. Cell. Metab. 17, 456-462 (2013
    • (2013) Cell. Metab , vol.17 , pp. 456-462
    • Fang, Y.1
  • 174
    • 80053083941 scopus 로고    scopus 로고
    • The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile
    • Wang B. T., et al. The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile. Proc. Natl Acad. Sci. USA 108, 15201-15206 (2011
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 15201-15206
    • Wang, B.T.1
  • 175
    • 35948936095 scopus 로고    scopus 로고
    • Prevention of murine lupus disease in (NZB × NZW)F1 mice by sirolimus treatment
    • Ramos-Barron A., et al. Prevention of murine lupus disease in (NZB × NZW)F1 mice by sirolimus treatment. Lupus 16, 775-781 (2007
    • (2007) Lupus , vol.16 , pp. 775-781
    • Ramos-Barron, A.1
  • 176
    • 58549107810 scopus 로고    scopus 로고
    • Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice
    • Lui S. L., et al. Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice. Nephrol. Dial. Transplant. 23, 2768-2776 (2008
    • (2008) Nephrol. Dial. Transplant , vol.23 , pp. 2768-2776
    • Lui, S.L.1
  • 177
    • 84868138682 scopus 로고    scopus 로고
    • Proliferation signal inhibitors in the treatment of lupus nephritis: Preliminary experience
    • Yap D. Y., Ma M. K., Tang C. S., & Chan T. M. Proliferation signal inhibitors in the treatment of lupus nephritis: preliminary experience. Nephrology (Carlton) 17, 676-680 (2012
    • (2012) Nephrology (Carlton , vol.17 , pp. 676-680
    • Yap, D.Y.1    Ma, M.K.2    Tang, C.S.3    Chan, T.M.4
  • 178
    • 84938215789 scopus 로고    scopus 로고
    • US National Library of Medicine. NCT00779194
    • US National Library of Medicine. NCT00779194. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/results?term=NCT00779194 (2015
    • (2015) ClinicalTrials.gov [Online
  • 179
    • 0034786155 scopus 로고    scopus 로고
    • Efficacy of sirolimus (rapamycin) administered concomitantly with a subtherapeutic dose of cyclosporin in the treatment of severe psoriasis: A randomized controlled trial
    • Reitamo S., et al. Efficacy of sirolimus (rapamycin) administered concomitantly with a subtherapeutic dose of cyclosporin in the treatment of severe psoriasis: a randomized controlled trial. Brit. J. Dermatol. 145, 438-445 (2001
    • (2001) Brit. J. Dermatol , vol.145 , pp. 438-445
    • Reitamo, S.1
  • 180
    • 0037388451 scopus 로고    scopus 로고
    • Pathogenic T cells in murine lupus exhibit spontaneous signaling activity through phosphatidylinositol 3 kinase and mitogen-activated protein kinase pathways
    • Niculescu F., et al. Pathogenic T cells in murine lupus exhibit spontaneous signaling activity through phosphatidylinositol 3 kinase and mitogen-activated protein kinase pathways. Arthritis Rheum. 48, 1071-1079 (2003
    • (2003) Arthritis Rheum , vol.48 , pp. 1071-1079
    • Niculescu, F.1
  • 181
    • 24744449495 scopus 로고    scopus 로고
    • PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
    • Barber D. F., et al. PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus. Nat. Med. 11, 933-935 (2005
    • (2005) Nat. Med , vol.11 , pp. 933-935
    • Barber, D.F.1
  • 182
    • 80052667108 scopus 로고    scopus 로고
    • Enhanced phosphoinositide 3 kinase δ activity is a frequent event in systemic lupus erythematosus that confers resistance to activation-induced T cell death
    • Suarez-Fueyo A., Barber D. F., Martinez-Ara J., Zea Mendoza A. C., & Carrera A. C. Enhanced phosphoinositide 3 kinase δ activity is a frequent event in systemic lupus erythematosus that confers resistance to activation-induced T cell death. J. Immunol. 187, 2376-2385 (2011
    • (2011) J. Immunol , vol.187 , pp. 2376-2385
    • Suarez-Fueyo, A.1    Barber, D.F.2    Martinez-Ara, J.3    Zea Mendoza, A.C.4    Carrera, A.C.5
  • 183
    • 84904250196 scopus 로고    scopus 로고
    • Inhibition of PI3Kγ reduces kidney infiltration by macrophages and ameliorates systemic lupus in the mouse
    • Suarez-Fueyo A., et al. Inhibition of PI3Kγ reduces kidney infiltration by macrophages and ameliorates systemic lupus in the mouse. J. Immunol. 193, 544-554 (2014
    • (2014) J. Immunol , vol.193 , pp. 544-554
    • Suarez-Fueyo, A.1
  • 184
    • 84940107593 scopus 로고    scopus 로고
    • Leptin and NAP2 promote mesenchymal stem cell senescence through activation of PI3K/Akt pathway in patients with systemic lupus erythematosus
    • Chen H., et al. Leptin and NAP2 promote mesenchymal stem cell senescence through activation of PI3K/Akt pathway in patients with systemic lupus erythematosus. Arthritis Rheumatol. 67, 2383-2393 (2015
    • (2015) Arthritis Rheumatol , vol.67 , pp. 2383-2393
    • Chen, H.1
  • 185
    • 84860114297 scopus 로고    scopus 로고
    • PI3 kinase δ is a key regulator of synoviocyte function in rheumatoid arthritis
    • Bartok B., et al. PI3 kinase δ is a key regulator of synoviocyte function in rheumatoid arthritis. Am. J. Pathol. 180, 1906-1916 (2012
    • (2012) Am. J. Pathol , vol.180 , pp. 1906-1916
    • Bartok, B.1
  • 186
    • 84887171398 scopus 로고    scopus 로고
    • Oxidative stress in the pathology and treatment of systemic lupus erythematosus
    • Perl A. Oxidative stress in the pathology and treatment of systemic lupus erythematosus. Nat. Rev. Rheumatol. 9, 674-686 (2013
    • (2013) Nat. Rev. Rheumatol , vol.9 , pp. 674-686
    • Perl, A.1
  • 187
    • 0037100275 scopus 로고    scopus 로고
    • Persistent mitochondrial hyperpolarization, increased reactive oxygen intermediate production, and cytoplasmic alkalinization characterize altered IL 10 signaling in patients with systemic lupus erythematosus
    • Gergely P. J., et al. Persistent mitochondrial hyperpolarization, increased reactive oxygen intermediate production, and cytoplasmic alkalinization characterize altered IL 10 signaling in patients with systemic lupus erythematosus. J. Immunol. 169, 1092-1101 (2002
    • (2002) J. Immunol , vol.169 , pp. 1092-1101
    • Gergely, P.J.1
  • 189
    • 84884333427 scopus 로고    scopus 로고
    • Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing
    • Gehrke N., et al. Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing. Immunity 39, 482-495 (2013
    • (2013) Immunity , vol.39 , pp. 482-495
    • Gehrke, N.1
  • 190
    • 13844296394 scopus 로고    scopus 로고
    • Modification of lupus-associated 60 kDa Ro protein with the lipid oxidation product 4 hydroxy-2 nonenal increases antigenicity and facilitates epitope spreading
    • Scofield R. H., et al. Modification of lupus-associated 60 kDa Ro protein with the lipid oxidation product 4 hydroxy-2 nonenal increases antigenicity and facilitates epitope spreading. Free Radic. Biol. Med. 38, 719-728 (2005
    • (2005) Free Radic. Biol. Med , vol.38 , pp. 719-728
    • Scofield, R.H.1
  • 191
    • 77958585820 scopus 로고    scopus 로고
    • Identification of a lipid peroxidation product as the source of oxidation-specific epitopes recognized by anti-DNA autoantibodies
    • Otaki N., et al. Identification of a lipid peroxidation product as the source of oxidation-specific epitopes recognized by anti-DNA autoantibodies. J. Biol. Chem. 285, 33834-33842 (2010
    • (2010) J. Biol. Chem , vol.285 , pp. 33834-33842
    • Otaki, N.1
  • 192
    • 0036161789 scopus 로고    scopus 로고
    • Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus
    • Gergely P. J., et al. Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus. Arthritis Rheum. 46, 175-190 (2002
    • (2002) Arthritis Rheum , vol.46 , pp. 175-190
    • Gergely, P.J.1
  • 193
    • 79952637812 scopus 로고    scopus 로고
    • Association between T lymphocyte sub-sets apoptosis and peripheral blood mononuclear cells oxidative stress in systemic lupus erythematosus
    • Shah D., Aggarwal A., Bhatnagar A., Kiran R., & Wanchu A. Association between T lymphocyte sub-sets apoptosis and peripheral blood mononuclear cells oxidative stress in systemic lupus erythematosus. Free Radic. Res. 45, 559-567 (2011
    • (2011) Free Radic. Res , vol.45 , pp. 559-567
    • Shah, D.1    Aggarwal, A.2    Bhatnagar, A.3    Kiran, R.4    Wanchu, A.5
  • 194
    • 77649184355 scopus 로고    scopus 로고
    • Oxidative stress in systemic lupus erythematosus: Relationship to TH1 cytokine and disease activity
    • Shah D., Kiran R., Wanchu A., & Bhatnagar A. Oxidative stress in systemic lupus erythematosus: relationship to TH1 cytokine and disease activity. Immunol. Lett. 129, 7-12 (2010
    • (2010) Immunol. Lett , vol.129 , pp. 7-12
    • Shah, D.1    Kiran, R.2    Wanchu, A.3    Bhatnagar, A.4
  • 195
    • 84855181178 scopus 로고    scopus 로고
    • Deranged bioenergetics and defective redox capacity in T lymphocytes and neutrophils are related to cellular dysfunction and increased oxidative stress in patients with active systemic lupus erythematosus
    • Li K. J., et al. Deranged bioenergetics and defective redox capacity in T lymphocytes and neutrophils are related to cellular dysfunction and increased oxidative stress in patients with active systemic lupus erythematosus. Clin. Dev. Immunol. 2012, 548516 (2012
    • (2012) Clin. Dev. Immunol , vol.2012 , pp. 548516
    • Li, K.J.1
  • 196
    • 0036391946 scopus 로고    scopus 로고
    • Oxidative stress is involved in the heat stress-induced downregulation of TCRζ chain expression and TCR/CD3 mediated [Ca2+]i response in human T lymphocytes
    • Nambiar M. P., et al. Oxidative stress is involved in the heat stress-induced downregulation of TCRζ chain expression and TCR/CD3 mediated [Ca2+]i response in human T lymphocytes. Cell. Immunol. 215, 151-161 (2002
    • (2002) Cell. Immunol , vol.215 , pp. 151-161
    • Nambiar, M.P.1
  • 197
    • 0035059028 scopus 로고    scopus 로고
    • Antioxidants suppress mortality in the female NZB × NZW F1 mouse model of systemic lupus erythematosus (SLE
    • Suwannaroj S., Lagoo A., Keisler D., & McMurray R. W. Antioxidants suppress mortality in the female NZB × NZW F1 mouse model of systemic lupus erythematosus (SLE). Lupus 10, 258-265 (2001
    • (2001) Lupus , vol.10 , pp. 258-265
    • Suwannaroj, S.1    Lagoo, A.2    Keisler, D.3    McMurray, R.W.4
  • 198
    • 33845564894 scopus 로고    scopus 로고
    • Conjugated linoleic acid enhances glutathione synthesis and attenuates pathological signs in MRL/MpJ-Faslpr mice
    • Bergamo P., et al. Conjugated linoleic acid enhances glutathione synthesis and attenuates pathological signs in MRL/MpJ-Faslpr mice. J. Lipid Res. 47, 2382-2391 (2006
    • (2006) J. Lipid Res , vol.47 , pp. 2382-2391
    • Bergamo, P.1
  • 199
    • 34249877687 scopus 로고    scopus 로고
    • Phase 2 enzyme induction by conjugated linoleic acid improves lupus-associated oxidative stress
    • Bergamo P., Maurano F., & Rossi M. Phase 2 enzyme induction by conjugated linoleic acid improves lupus-associated oxidative stress. Free Radic. Biol. Med. 43, 71-79 (2007
    • (2007) Free Radic. Biol. Med , vol.43 , pp. 71-79
    • Bergamo, P.1    Maurano, F.2    Rossi, M.3
  • 200
    • 0031042638 scopus 로고    scopus 로고
    • Glutathione deficiency is associated with impaired survival in HIV disease
    • Herzenberg L. A., et al. Glutathione deficiency is associated with impaired survival in HIV disease. Proc. Natl Acad. Sci. USA 94, 1967-1972 (1997
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 1967-1972
    • Herzenberg, L.A.1
  • 201
    • 0030696635 scopus 로고    scopus 로고
    • Effect of N acetylcysteine on human diaphragm strength and fatigability
    • Travaline J. M., et al. Effect of N acetylcysteine on human diaphragm strength and fatigability. Am. J. Resp. Crit. Care Med. 156, 1567-1571 (1997
    • (1997) Am. J. Resp. Crit. Care Med , vol.156 , pp. 1567-1571
    • Travaline, J.M.1
  • 202
    • 28144459814 scopus 로고    scopus 로고
    • High-dose acetylcysteine in idiopathic pulmonary fibrosis
    • Demedts M., et al. High-dose acetylcysteine in idiopathic pulmonary fibrosis. N. Engl. J. Med. 353, 2229-2242 (2005
    • (2005) N. Engl. J. Med , vol.353 , pp. 2229-2242
    • Demedts, M.1
  • 203
    • 0032525253 scopus 로고    scopus 로고
    • Hyperlipidemia in renal transplant recipients treated with sirolimus (rapamycin
    • Brattstrom C., et al. Hyperlipidemia in renal transplant recipients treated with sirolimus (rapamycin). Transplantation 65, 1272-1274 (1998
    • (1998) Transplantation , vol.65 , pp. 1272-1274
    • Brattstrom, C.1
  • 204
    • 84878965833 scopus 로고    scopus 로고
    • Incidence and risk of treatment-related mortality with mTOR inhibitors everolimus and temsirolimus in cancer patients: A meta-analysis
    • Qi W. X., Huang Y. J., Yao Y., Shen Z., & Min D. L. Incidence and risk of treatment-related mortality with mTOR inhibitors everolimus and temsirolimus in cancer patients: a meta-analysis. PLoS ONE 8, e65166 (2013
    • (2013) Plos One , vol.8 , pp. e65166
    • Qi, W.X.1    Huang, Y.J.2    Yao, Y.3    Shen, Z.4    Min, D.L.5
  • 205
    • 0034815697 scopus 로고    scopus 로고
    • Mortality and causes of death in systemic lupus erythematosus
    • Trager J., & Ward M. M. Mortality and causes of death in systemic lupus erythematosus. Curr. Opin. Rheumatol. 13, 345-351 (2001
    • (2001) Curr. Opin. Rheumatol , vol.13 , pp. 345-351
    • Trager, J.1    Ward, M.M.2
  • 206
    • 84860718879 scopus 로고    scopus 로고
    • Evaluating oxidative stress in human cardiovascular disease: Methodological aspects and considerations
    • Lee R., Margaritis M., Channon K. M., & Antoniades C. Evaluating oxidative stress in human cardiovascular disease: methodological aspects and considerations. Curr. Med. Chem. 19, 2504-2520 (2012
    • (2012) Curr. Med. Chem , vol.19 , pp. 2504-2520
    • Lee, R.1    Margaritis, M.2    Channon, K.M.3    Antoniades, C.4
  • 207
    • 0037465546 scopus 로고    scopus 로고
    • The antioxidant acetylcysteine reduces cardiovascular events in patients with end-stage renal failure
    • Tepel M., Van Der Giet M., Statz M., Jankowski J., & Zidek W. The antioxidant acetylcysteine reduces cardiovascular events in patients with end-stage renal failure. Circulation 107, 992-995 (2003
    • (2003) Circulation , vol.107 , pp. 992-995
    • Tepel, M.1    Van Der Giet, M.2    Statz, M.3    Jankowski, J.4    Zidek, W.5
  • 208
    • 84920504512 scopus 로고    scopus 로고
    • MTOR: A pharmacologic target for autophagy regulation
    • Kim Y. C., & Guan K. L. mTOR: a pharmacologic target for autophagy regulation. J. Clin. Invest. 125, 25-32 (2015
    • (2015) J. Clin. Invest , vol.125 , pp. 25-32
    • Kim, Y.C.1    Guan, K.L.2
  • 209
    • 84983410554 scopus 로고    scopus 로고
    • Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation
    • Yan H., Zhou H. F., Hu Y., & Pham C. T. Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation. J. Rheum. Dis. Treat. 1, 5 (2015
    • (2015) J. Rheum. Dis. Treat , vol.1 , pp. 5
    • Yan, H.1    Zhou, H.F.2    Hu, Y.3    Pham, C.T.4
  • 210
    • 84896295961 scopus 로고    scopus 로고
    • MTOR inhibition: A promising strategy for stabilization of atherosclerotic plaques
    • Martinet W., De Loof H., & De Meyer G. R. mTOR inhibition: a promising strategy for stabilization of atherosclerotic plaques. Atherosclerosis 233, 601-607 (2014
    • (2014) Atherosclerosis , vol.233 , pp. 601-607
    • Martinet, W.1    De Loof, H.2    De Meyer, G.R.3
  • 211
    • 78650926104 scopus 로고    scopus 로고
    • Novel heterozygous mutations in TALDO1 gene causing transaldolase deficiency and early infantile liver failure
    • Balasubramaniam S., et al. Novel heterozygous mutations in TALDO1 gene causing transaldolase deficiency and early infantile liver failure. J. Pediatr. Gastroenterol. Nutr. 52, 113-116 (2011
    • (2011) J. Pediatr. Gastroenterol. Nutr , vol.52 , pp. 113-116
    • Balasubramaniam, S.1
  • 212
    • 84869208878 scopus 로고    scopus 로고
    • Regulation of autophagy and its associated cell death by sphingolipid rheostat: Reciprocal role of ceramide and sphingosine 1 phosphate in the mammalian target of rapamycin pathway
    • Taniguchi M., et al. Regulation of autophagy and its associated cell death by sphingolipid rheostat: reciprocal role of ceramide and sphingosine 1 phosphate in the mammalian target of rapamycin pathway. J. Biol. Chem. 287, 39898-39910 (2012
    • (2012) J. Biol. Chem , vol.287 , pp. 39898-39910
    • Taniguchi, M.1
  • 213
    • 78049480679 scopus 로고    scopus 로고
    • Fingolimod (FTY720): Discovery and development of an oral drug to treat multiple sclerosis
    • Brinkmann V., et al. Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat. Rev. Drug Discov. 9, 883-897 (2010
    • (2010) Nat. Rev. Drug Discov , vol.9 , pp. 883-897
    • Brinkmann, V.1
  • 214
    • 0036228891 scopus 로고    scopus 로고
    • Effects of FTY720 in MRL-lpr/lpr mice: Therapeutic potential in systemic lupus erythematosus
    • Okazaki H., et al. Effects of FTY720 in MRL-lpr/lpr mice: therapeutic potential in systemic lupus erythematosus. J. Rheumatol. 29, 707-716 (2002
    • (2002) J. Rheumatol , vol.29 , pp. 707-716
    • Okazaki, H.1
  • 215
    • 55249113624 scopus 로고    scopus 로고
    • Prolonged survival and reduced renal injury in MRL/lpr mice treated with a novel sphingosine-1 P receptor agonist
    • Wenderfer S. E., Stepkowski S. M., & Braun M. C. Prolonged survival and reduced renal injury in MRL/lpr mice treated with a novel sphingosine-1 P receptor agonist. Kidney Int. 74, 1319-1326 (2008
    • (2008) Kidney Int , vol.74 , pp. 1319-1326
    • Wenderfer, S.E.1    Stepkowski, S.M.2    Braun, M.C.3
  • 216
    • 84899760423 scopus 로고    scopus 로고
    • CaMK4 dependent activation of AKT/mTOR and CREM α underlies autoimmunity-associated TH17 imbalance
    • Koga T., et al. CaMK4 dependent activation of AKT/mTOR and CREM α underlies autoimmunity-associated TH17 imbalance. J. Clin. Invest. 124, 2234-2245 (2014
    • (2014) J. Clin. Invest , vol.124 , pp. 2234-2245
    • Koga, T.1
  • 217
    • 84911999334 scopus 로고    scopus 로고
    • KN 93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3+ regulatory T cells in MRL/lpr mice
    • Koga T., et al. KN 93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3+ regulatory T cells in MRL/lpr mice. Autoimmunity 47, 445-450 (2014
    • (2014) Autoimmunity , vol.47 , pp. 445-450
    • Koga, T.1
  • 218
    • 79551680278 scopus 로고    scopus 로고
    • Inhibition of calcium/calmodulin-dependent protein kinase type IV results in suppression of autoimmunity and organ pathology in lupus-prone mice
    • Ichinose K., Juang Y. T., Crispin J. C., Kis-Toth K., & Tsokos G. C. Inhibition of calcium/calmodulin-dependent protein kinase type IV results in suppression of autoimmunity and organ pathology in lupus-prone mice. Arthritis Rheum. 63, 523-529 (2011
    • (2011) Arthritis Rheum , vol.63 , pp. 523-529
    • Ichinose, K.1    Juang, Y.T.2    Crispin, J.C.3    Kis-Toth, K.4    Tsokos, G.C.5
  • 219
    • 76649084540 scopus 로고    scopus 로고
    • Calcium/calmodulin-dependent protein kinase II (CaMKII) regulates tumour necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated apoptosis of fibroblast-like synovial cells (FLS) by phosphorylation of Akt
    • Fujikawa K., et al. Calcium/calmodulin-dependent protein kinase II (CaMKII) regulates tumour necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated apoptosis of fibroblast-like synovial cells (FLS) by phosphorylation of Akt. Clin. Exp. Rheumatol. 27, 952-957 (2009
    • (2009) Clin. Exp. Rheumatol , vol.27 , pp. 952-957
    • Fujikawa, K.1
  • 220
    • 77950452018 scopus 로고    scopus 로고
    • Expression and regulation of HIF 1α in macrophages under inflammatory conditions; Significant reduction of VEGF by CaMKII inhibitor
    • Westra J., et al. Expression and regulation of HIF 1α in macrophages under inflammatory conditions; significant reduction of VEGF by CaMKII inhibitor. BMC Musculoskelet. Disord. 11, 61 (2010
    • (2010) BMC Musculoskelet. Disord , vol.11 , pp. 61
    • Westra, J.1
  • 221
    • 84869208408 scopus 로고    scopus 로고
    • Positive crosstalk between arginase II and S6K1 in vascular endothelial inflammation and aging
    • Yepuri G., et al. Positive crosstalk between arginase II and S6K1 in vascular endothelial inflammation and aging. Aging Cell 11, 1005-1016 (2012
    • (2012) Aging Cell , vol.11 , pp. 1005-1016
    • Yepuri, G.1
  • 222
    • 84922355342 scopus 로고    scopus 로고
    • ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis
    • Xiong Y., et al. ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis. Autophagy 10, 2223-2238 (2014
    • (2014) Autophagy , vol.10 , pp. 2223-2238
    • Xiong, Y.1
  • 223
    • 0038585135 scopus 로고    scopus 로고
    • Protective effect of the immunosuppressant sirolimus against aortic atherosclerosis in apo e deficient mice
    • Elloso M. M., et al. Protective effect of the immunosuppressant sirolimus against aortic atherosclerosis in apo E deficient mice. Am. J. Transplant. 3, 562-569 (2003
    • (2003) Am. J. Transplant , vol.3 , pp. 562-569
    • Elloso, M.M.1
  • 224
    • 0031052874 scopus 로고    scopus 로고
    • Age-specific incidence rates of myocardial infarction and angina in women with systemic lupus erythematosus: Comparison with the Framingham study
    • Manzi S., et al. Age-specific incidence rates of myocardial infarction and angina in women with systemic lupus erythematosus: comparison with the Framingham study. Am. J. Epidemiol. 145, 408-415 (1997
    • (1997) Am. J. Epidemiol , vol.145 , pp. 408-415
    • Manzi, S.1
  • 225
    • 84940116967 scopus 로고    scopus 로고
    • Rheumatoid arthritis, anti-ccp positivity, and cardiovascular disease risk in the womens health initiative
    • Mackey R. H., et al. Rheumatoid arthritis, anti-CCP positivity, and cardiovascular disease risk in the Womens Health Initiative. Arthritis Rheumatol. 67, 2311-2322 (2015
    • (2015) Arthritis Rheumatol , vol.67 , pp. 2311-2322
    • Mackey, R.H.1
  • 226
    • 57149096904 scopus 로고    scopus 로고
    • Risk of cardiovascular mortality in patients with rheumatoid arthritis: A meta-analysis of observational studies
    • Avina-Zubieta J. A., et al. Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies. Arthritis Care Res. 59, 1690-1697 (2008
    • (2008) Arthritis Care Res , vol.59 , pp. 1690-1697
    • Avina-Zubieta, J.A.1
  • 227
    • 79960613394 scopus 로고    scopus 로고
    • Common toxicities of mammalian target of rapamycin inhibitors
    • Soefje S. A., Karnad A., & Brenner A. J. Common toxicities of mammalian target of rapamycin inhibitors. Target. Oncol. 6, 125-129 (2011
    • (2011) Target. Oncol , vol.6 , pp. 125-129
    • Soefje, S.A.1    Karnad, A.2    Brenner, A.J.3
  • 228
    • 0036745041 scopus 로고    scopus 로고
    • Frequency of infection in patients with rheumatoid arthritis compared with controls: A population-based study
    • Doran M. F., Crowson C. S., Pond G. R., OFallon W. M., & Gabriel S. E. Frequency of infection in patients with rheumatoid arthritis compared with controls: a population-based study. Arthritis Rheum. 46, 2287-2293 (2002
    • (2002) Arthritis Rheum , vol.46 , pp. 2287-2293
    • Doran, M.F.1    Crowson, C.S.2    Pond, G.R.3    Ofallon, W.M.4    Gabriel, S.E.5
  • 229
    • 84939209556 scopus 로고    scopus 로고
    • Methotrexate promotes platelet apoptosis via JNK-mediated mitochondrial damage: Alleviation by N acetylcysteine and N acetylcysteine amide
    • Paul M., et al. Methotrexate promotes platelet apoptosis via JNK-mediated mitochondrial damage: alleviation by N acetylcysteine and N acetylcysteine amide. PLoS ONE 10, e0127558 (2015
    • (2015) Plos One , vol.10 , pp. e0127558
    • Paul, M.1
  • 230
    • 84877965001 scopus 로고    scopus 로고
    • Regulation of mTORC1 and its impact on gene expression at a glance
    • Laplante M., & Sabatini D. M. Regulation of mTORC1 and its impact on gene expression at a glance. J. Cell Sci. 126, 1713-1719 (2013
    • (2013) J. Cell Sci , vol.126 , pp. 1713-1719
    • Laplante, M.1    Sabatini, D.M.2
  • 231
    • 43249109614 scopus 로고    scopus 로고
    • Rapamycin prevents the development of nephritis in lupus-prone NZB/W F1 mice
    • Lui S. L., et al. Rapamycin prevents the development of nephritis in lupus-prone NZB/W F1 mice. Lupus 17, 305-313 (2008
    • (2008) Lupus , vol.17 , pp. 305-313
    • Lui, S.L.1
  • 232
    • 84910130591 scopus 로고    scopus 로고
    • Akt-dependent enhanced migratory capacity of TH17 cells from children with lupus nephritis
    • Kshirsagar S., et al. Akt-dependent enhanced migratory capacity of TH17 cells from children with lupus nephritis. J. Immunol. 193, 4895-4903 (2014
    • (2014) J. Immunol , vol.193 , pp. 4895-4903
    • Kshirsagar, S.1
  • 233
    • 84936967028 scopus 로고    scopus 로고
    • Rapamycin ameliorates IgA nephropathy via cell cycle-dependent mechanisms
    • Tian J., Wang Y., Liu X., Zhou X., & Li R. Rapamycin ameliorates IgA nephropathy via cell cycle-dependent mechanisms. Exp. Biol. Med. (Maywood) 240, 936-945 (2015
    • (2015) Exp. Biol. Med. (Maywood , vol.240 , pp. 936-945
    • Tian, J.1    Wang, Y.2    Liu, X.3    Zhou, X.4    Li, R.5
  • 234
    • 80155192344 scopus 로고    scopus 로고
    • Low-dose sirolimus combined with angiotensin-converting enzyme inhibitor and statin stabilizes renal function and reduces glomerular proliferation in poor prognosis iga nephropathy
    • Cruzado J. M., et al. Low-dose sirolimus combined with angiotensin-converting enzyme inhibitor and statin stabilizes renal function and reduces glomerular proliferation in poor prognosis IgA nephropathy. Nephrol. Dial. Transplant. 26, 3596-3602 (2011
    • (2011) Nephrol. Dial. Transplant , vol.26 , pp. 3596-3602
    • Cruzado, J.M.1
  • 235
    • 84911443008 scopus 로고    scopus 로고
    • Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain
    • Zou Y., et al. Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain. J. Neurosci. 34, 15764-15778 (2014
    • (2014) J. Neurosci , vol.34 , pp. 15764-15778
    • Zou, Y.1
  • 236
    • 84929512343 scopus 로고    scopus 로고
    • Everolimus in patients with severe pulmonary hypertension: A safety and efficacy pilot trial
    • Seyfarth H. J., Hammerschmidt S., Halank M., Neuhaus P., & Wirtz H. R. Everolimus in patients with severe pulmonary hypertension: a safety and efficacy pilot trial. Pulm. Circ. 3, 632-638 (2013
    • (2013) Pulm. Circ , vol.3 , pp. 632-638
    • Seyfarth, H.J.1    Hammerschmidt, S.2    Halank, M.3    Neuhaus, P.4    Wirtz, H.R.5
  • 237
    • 84891947565 scopus 로고    scopus 로고
    • MTOR signaling cascade in psoriatic disease: Double kinase mTOR inhibitor a novel therapeutic target
    • Raychaudhuri S. K., & Raychaudhuri S. P. mTOR signaling cascade in psoriatic disease: double kinase mTOR inhibitor a novel therapeutic target. Indian J. Dermatol. 59, 67-70 (2014
    • (2014) Indian J. Dermatol , vol.59 , pp. 67-70
    • Raychaudhuri, S.K.1    Raychaudhuri, S.P.2
  • 238
    • 84947017376 scopus 로고    scopus 로고
    • Dual mTOR inhibition is required to prevent TGF β mediated fibrosis: Implications for scleroderma
    • Mitra A., et al. Dual mTOR inhibition is required to prevent TGF β mediated fibrosis: implications for scleroderma. J. Invest. Dermatol. 135, 2873-2876 (2015
    • (2015) J. Invest. Dermatol , vol.135 , pp. 2873-2876
    • Mitra, A.1
  • 239
    • 79961123240 scopus 로고    scopus 로고
    • Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis
    • Biniecka M., et al. Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis. Arth. Rheum. 63, 2172-2182 (2011
    • (2011) Arth. Rheum , vol.63 , pp. 2172-2182
    • Biniecka, M.1
  • 242
    • 59449099980 scopus 로고    scopus 로고
    • Treatment strategies for a rheumatoid arthritis patient with interstitial lung disease
    • Kelly C., & Saravanan V. Treatment strategies for a rheumatoid arthritis patient with interstitial lung disease. Exp. Opin. Pharmacother. 9, 3221-3230 (2008
    • (2008) Exp. Opin. Pharmacother , vol.9 , pp. 3221-3230
    • Kelly, C.1    Saravanan, V.2
  • 243
    • 84907228811 scopus 로고    scopus 로고
    • Metformin attenuates experimental autoimmune arthritis through reciprocal regulation of TH17/Treg balance and osteoclastogenesis
    • Son H. J., et al. Metformin attenuates experimental autoimmune arthritis through reciprocal regulation of TH17/Treg balance and osteoclastogenesis. Mediators Inflamm. 2014, 973986 (2014
    • (2014) Mediators Inflamm , vol.2014 , pp. 973986
    • Son, H.J.1


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