Signal transducer and activator of transcription 3 (STAT3) mediates amino acid inhibition of insulin ignaling through serine 727 phosphorylation

Journal of Biological Chemistry

Volumn 284, Issue 51, 2009, Pages 35425-35432

  Kim, Jeong Ho ^a   Yoon, Mee Sup ^a   Chen, Jie ^a,b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION MECHANISMS; AKT PHOSPHORYLATION; CELLULAR LEVELS; GLYCOGEN SYNTHESIS; HEPATIC CELLS; HEPG2 CELLS; HUMAN HEPATOCARCINOMA; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN SIGNALING; MAMMALIAN TARGET; OVER-EXPRESSION; PLASMA CONCENTRATION; PRIMARY HEPATOCYTES; RAPAMYCIN; SIGNAL TRANSDUCERS; TARGET GENES; TYPE II; WILD TYPES;

AMINATION; AMINES; CHEMICAL ACTIVATION; INSULIN; MAMMALS; NUTRIENTS; ORGANIC ACIDS; PHOSPHORYLATION; SIGNALING; TRANSCRIPTION;

AMINO ACIDS;

MAMMALIAN TARGET OF RAPAMYCIN; SERINE; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TYROSINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; ENZYME REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WILD TYPE;

AMINO ACID SUBSTITUTION; AMINO ACIDS; ANIMALS; DIABETES MELLITUS, TYPE 2; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HEP G2 CELLS; HEPATOCYTES; HUMANS; INSULIN; INSULIN RESISTANCE; MUTATION, MISSENSE; PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

MAMMALIA;

EID: 72149126863     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.051516     Document Type: Article

References (45)

1. Must, A., Spadano, J., Coakley, E. H., Field, A. E., Colditz, G., and Dietz, W. H. (1999) JAMA 282, 1523-1529
2. Um, S. H., D'Alessio, D., and Thomas, G. (2006) Cell Metab. 3, 393-402
3. Linn, T., Santosa, B., Grönemeyer, D., Aygen, S., Scholz, N., Busch, M., and Bretzel, R. G. (2000) Diabetologia 43, 1257-1265
4. Schulze, M. B., Manson, J. E., Willett, W. C., and Hu, F. B. (2003) Diabetologia 46, 1465-1473
5. Adibi, S. A. (1968) J. Appl. Physiol. 25, 52-57
6. Felig, P., Marliss, E., and Cahill, G. F., Jr. (1969) N. Engl. J. Med. 281, 811-816
7. Felig, P., Marliss, E., and Cahill, G. F., Jr. (1970) N. Engl. J. Med. 282, 166
8. Felig, P., Wahren, J., Hendler, R., and Brundin, T. (1974) J. Clin. Invest. 53, 582-590
9. Krebs, M., Krssak, M., Bernroider, E., Anderwald, C., Brehm, A., Meyerspeer, M., Nowotny, P., Roth, E., Waldhäusl, W., and Roden, M. (2002) Diabetes 51, 599-605
10. Newgard, C. B., An, J., Bain, J. R., Muehlbauer, M. J., Stevens, R. D., Lien, L. F., Haqq, A. M., Shah, S. H., Arlotto, M., Slentz, C. A., Rochon, J., Gallup, D., Ilkayeva, O., Wenner, B. R., Yancy, W. S., Jr., Eisenson, H., Musante, G., Surwit, R. S., Millington, D. S., Butler, M. D., and Svetkey, L. P. (2009) Cell Metab. 9, 311-326
11. Tremblay, F., Lavigne, C., Jacques, H., and Marette, A. (2007) Annu. Rev. Nutr. 27, 293-310
12. Calò, V., Migliavacca, M., Bazan, V., Macaluso, M., Buscemi, M., Gebbia, N., and Russo, A. (2003) J. Cell. Physiol. 197, 157-168
13. Wen, Z., Zhong, Z., and Darnell, J. E., Jr. (1995) Cell 82, 241-250
14. Decker, T., and Kovarik, P. (2000) Oncogene 19, 2628-2637
15. Rajan, P., Panchision, D. M., Newell, L. F., and McKay, R. D. (2003) J. Cell Biol. 161, 911-921
16. Yokogami, K., Wakisaka, S., Avruch, J., and Reeves, S. A. (2000) Curr. Biol. 10, 47-50
17. Kim, J. H., Kim, J. E., Liu, H. Y., Cao, W., and Chen, J. (2008) J. Biol. Chem. 283, 708-715
18. Krebs, D. L., and Hilton, D. J. (2000) J. Cell Sci. 113, 2813-2819
19. Krebs, D. L., and Hilton, D. J. (2003) Sci STKE 2003, PE6
20. Ueki, K., Kondo, T., and Kahn, C. R. (2004) Mol. Cell. Biol. 24, 5434-5446
21. Torisu, T., Sato, N., Yoshiga, D., Kobayashi, T., Yoshioka, T., Mori, H., Iida, M., and Yoshimura, A. (2007) Genes Cells 12, 143-154
22. Howard, J. K., and Flier, J. S. (2006) Trends Endocrinol. Metab. 17, 365-371
23. Klover, P. J., Zimmers, T. A., Koniaris, L. G., and Mooney, R. A. (2003) Diabetes 52, 2784-2789
24. Senn, J. J., Klover, P. J., Nowak, I. A., Zimmers, T. A., Koniaris, L. G., Furlanetto, R. W., and Mooney, R. A. (2003) J. Biol. Chem. 278, 13740-13746
25. Sarbassov, D. D., Ali, S. M., and Sabatini, D. M. (2005) Curr. Opin. Cell Biol. 17, 596-603
26. Hay, N., and Sonenberg, N. (2004) Genes Dev. 18, 1926-1945
27. Baum, J. I., O'Connor, J. C., Seyler, J. E., Anthony, T. G., Freund, G. G., and Layman, D. K. (2005) Am. J. Physiol. Endocrinol Metab. 288, E86-E91
28. Tremblay, F., Krebs, M., Dombrowski, L., Brehm, A., Bernroider, E., Roth, E., Nowotny, P., Waldhäusl, W., Marette, A., and Roden, M. (2005) Diabetes 54, 2674-2684
29. Iiboshi, Y., Papst, P. J., Kawasome, H., Hosoi, H., Abraham, R. T., Houghton, P. J., and Terada, N. (1999) J. Biol. Chem. 274, 1092-1099
30. Hara, K., Yonezawa, K., Weng, Q. P., Kozlowski, M. T., Belham, C., and Avruch, J. (1998) J. Biol. Chem. 273, 14484-14494
31. Takano, A., Usui, I., Haruta, T., Kawahara, J., Uno, T., Iwata, M., and Kobayashi, M. (2001) Mol. Cell. Biol. 21, 5050-5062
32. Tremblay, F., and Marette, A. (2001) J. Biol. Chem. 276, 38052-38060
33. Patti, M. E., Brambilla, E., Luzi, L., Landaker, E. J., and Kahn, C. R. (1998) J. Clin. Invest. 101, 1519-1529
34. Tremblay, F., Brûlé, S., Um, S. H., Li, Y., Masuda, K., Roden, M., Sun, X. J., Krebs, M., Polakiewicz, R. D., Thomas, G., and Marette, A. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 14056-14061
35. Sarbassov, D. D., Guertin, D. A., Ali, S. M., and Sabatini, D. M. (2005) Science 307, 1098-1101
36. Senn, J. J., Klover, P. J., Nowak, I. A., and Mooney, R. A. (2002) Diabetes 51, 3391-3399
37. Klover, P. J., Clementi, A. H., and Mooney, R. A. (2005) Endocrinology 146, 3417-3427
38. Moh, A., Zhang, W., Yu, S., Wang, J., Xu, X., Li, J., and Fu, X. Y. (2008) Diabetes 57, 1227-1235
39. Peterson, R. T., Beal, P. A., Comb, M. J., and Schreiber, S. L. (2000) J. Biol. Chem. 275, 7416-7423
40. Schuringa, J. J., Schepers, H., Vellenga, E., and Kruijer, W. (2001) FEBS Lett. 495, 71-76
41. Androutsellis-Theotokis, A., Leker, R. R., Soldner, F., Hoeppner, D. J., Ravin, R., Poser, S. W., Rueger, M. A., Bae, S. K., Kittappa, R., and McKay, R. D. (2006) Nature 442, 823-826
42. Liu, H., Ma, Y., Cole, S. M., Zander, C., Chen, K. H., Karras, J., and Pope, R. M. (2003) Blood 102, 344-352
43. Qin, H. R., Kim, H. J., Kim, J. Y., Hurt, E. M., Klarmann, G. J., Kawasaki, B. T., Duhagon Serrat, M. A., and Farrar, W. L. (2008) Cancer Res. 68, 7736-7741
44. Inoue, H., Ogawa, W., Ozaki, M., Haga, S., Matsumoto, M., Furukawa, K., Hashimoto, N., Kido, Y., Mori, T., Sakaue, H., Teshigawara, K., Jin, S., Iguchi, H., Hiramatsu, R., LeRoith, D., Takeda, K., Akira, S., and Kasuga, M. (2004) Nat. Med. 10, 168-174
45. Inoue, H., Ogawa, W., Asakawa, A., Okamoto, Y., Nishizawa, A., Matsumoto, M., Teshigawara, K., Matsuki, Y., Watanabe, E., Hiramatsu, R., Notohara, K., Katayose, K., Okamura, H., Kahn, C. R., Noda, T., Takeda, K., Akira, S., Inui, A., and Kasuga, M. (2006) Cell Metab. 3, 267-275