Phosphofructokinase deficiency impairs atp generation, autophagy, and redox balance in rheumatoid arthritis T cells

Journal of Experimental Medicine

Volumn 210, Issue 10, 2013, Pages 2119-2134

  Yang, Zhen ^a   Fujii, Hiroshi ^b   Mohan, Shalini V ^a   Goronzy, Jorg J ^a   Weyand, Cornelia M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 PHOSPHOFRUCTO 2 KINASE; 6 PHOSPHOFRUCTOKINASE; ADENOSINE TRIPHOSPHATE; FRUCTOSE 2,6 BISPHOSPHATASE; GLUCOSE; GLYCOLYTIC ENZYME; PENTOSE PHOSPHATE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ADULT; APOPTOSIS; ARTICLE; AUTOPHAGY; BIOSYNTHESIS; CD4+ T LYMPHOCYTE; CELL ACTIVITY; CELL AGING; CELL ENERGY; CELL FATE; CELL FUNCTION; CELL LINE; CELL METABOLISM; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME INDUCTION; FEMALE; GENE OVEREXPRESSION; GENE SILENCING; GLYCOLYSIS; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; PENTOSE PHOSPHATE CYCLE; PHOSPHOFRUCTOKINASE DEFICIENCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS;

ADENOSINE TRIPHOSPHATE; ADULT; APOPTOSIS; ARTHRITIS, RHEUMATOID; AUTOPHAGY; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; GENE EXPRESSION; GENE SILENCING; GLUCOSE; GLYCOLYSIS; HUMANS; MALE; MIDDLE AGED; OXIDATION-REDUCTION; PENTOSE PHOSPHATE PATHWAY; PHOSPHOFRUCTOKINASE-2; T-LYMPHOCYTE SUBSETS;

EID: 84885448124     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20130252     Document Type: Article

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