In situ analysis of interleukin-23- and interleukin-12-positive cells in the spine of patients with ankylosing spondylitis

Arthritis and Rheumatism

Volumn 65, Issue 6, 2013, Pages 1522-1529

  Appel, Heiner ^a   Maier, Rene ^a   Bleil, Janine ^a   Hempfing, Axel ^b   Loddenkemper, Christoph ^a   Schlichting, Uwe ^a   Syrbe, Uta ^a   Sieper, Joachim ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Werner Wicker Klinik   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 23; MYELOPEROXIDASE; TRYPTASE;

ANKYLOSING SPONDYLITIS; ARTICLE; B LYMPHOCYTE; BONE MARROW; CD3+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; MACROPHAGE; MAST CELL; OSTEOARTHRITIS; PRIORITY JOURNAL; SUBCHONDRAL BONE PLATE;

ADULT; AGED; CYTOKINES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-12; INTERLEUKIN-23; JOINTS; MACROPHAGES; MALE; MIDDLE AGED; SPINE; SPONDYLITIS, ANKYLOSING;

EID: 84878527072     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.37937     Document Type: Article

References (35)

1. Braun J, Sieper J,. Ankylosing spondylitis. Lancet 2007; 369: 1379-90. (Pubitemid 46590387)
2. Landewe R, Dougados M, Mielants H, van der Tempel H, van der Heijde D,. Physical function in ankylosing spondylitis is independently determined by both disease activity and radiographic damage of the spine. Ann Rheum Dis 2009; 68: 863-7.
3. Sieper J, Appel H, Braun J, Rudwaleit M,. Critical appraisal of assessment of structural damage in ankylosing spondylitis: implications for treatment outcomes [review]. Arthritis Rheum 2008; 58: 649-56. (Pubitemid 351364862)
4. Sieper J, Rudwaleit M, Khan MA, Braun J,. Concepts and epidemiology of spondyloarthritis. Best Pract Res Clin Rheumatol 2006; 20: 401-17. (Pubitemid 43843063)
5. Cruickshank B,. Pathology of ankylosing spondylitis. Clin Orthop Relat Res 1971; 74: 43-58.
6. Bywaters EGL, Olsen E,. A case of early ankylosing spondylitis with fatal secondary amyloidosis: demonstrated at the Royal Postgraduate Medical School. BMJ 1968; 2: 412-6.
7. Appel H, Kuhne M, Spiekermann S, Kohler D, Zacher J, Stein H, et al. Immunohistochemical analysis of hip arthritis in ankylosing spondylitis: evaluation of the bone-cartilage interface and subchondral bone marrow. Arthritis Rheum 2006; 54: 1805-13. (Pubitemid 43877930)
8. Braun J, Bollow M, Neure L, Seipelt E, Seyrekbasan F, Herbst H, et al. Use of immunohistologic and in situ hybridization techniques in the examination of sacroiliac joint biopsy specimens from patients with ankylosing spondylitis. Arthritis Rheum 1995; 38: 499-505.
9. Francois RJ, Gardner DL, Degrave EJ, Bywaters EG,. Histopathologic evidence that sacroiliitis in ankylosing spondylitis is not merely enthesitis: systematic study of specimens from patients and control subjects. Arthritis Rheum 2000; 43: 2011-24.
10. Savill DL,. The manubrio-sternal joint in ankylosing spondylitis. J Bone Joint Surg Br 1951; 33: 56-64.
11. Appel H, Kuhne M, Spiekermann S, Ebhardt H, Groszdanovic Z, Kohler D, et al. Immunohistologic analysis of zygapophyseal joints in patients with ankylosing spondylitis. Arthritis Rheum 2006; 54: 2845-51. (Pubitemid 44497763)
12. Appel H, Loddenkemper C, Grozdanovic Z, Ebhardt H, Dreimann M, Hempfing A, et al. Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis. Arthritis Res Ther 2006; 8: R143.
13. Appel H, Maier R, Loddenkemper C, Kayser R, Meier O, Hempfing A, et al. Immunohistochemical analysis of osteoblasts in zygapophyseal joints of patients with ankylosing spondylitis reveal repair mechanisms similar to osteoarthritis. J Rheumatol 2010; 37: 823-8.
14. Appel H, Sieper J,. Spondyloarthritis at the crossroads of imaging, pathology, and structural damage in the era of biologics. Curr Rheumatol Rep 2008; 10: 356-63.
15. + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005; 6: 1123-32. (Pubitemid 41541790)
16. Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005; 6: 1133-41. (Pubitemid 41541791)
17. Weaver CT, Hatton RD, Mangan PR, Harrington LE,. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 2007; 25: 821-52. (Pubitemid 46697925)
18. Dardalhon V, Korn T, Kuchroo VK, Anderson AC,. Role of Th1 and Th17 cells in organ-specific autoimmunity. J Autoimmun 2008; 31: 252-6.
19. Wellcome Trust Case Control Consortium, Australo-Anglo-American Spondylitis Consortium (TASC), Burton PR, Clayton DG, Cardon LR, Craddock N, et al. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007; 39: 1329-37. (Pubitemid 350041542)
20. Pointon JJ, Harvey D, Karaderi T, Appleton LH, Farrar C, Stone MA, et al. Elucidating the chromosome 9 association with AS: CARD9 is a candidate gene [published erratum appears in Genes Immun 2011;12:319-20]. Genes Immun 2010; 11: 490-6.
21. Danoy P, Pryce K, Hadler J, Bradbury LA, Farrar C, Pointon J, et al. Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease. PLoS Genet 2010; 6: e1001195.
22. Mei Y, Pan F, Gao J, Ge R, Duan Z, Zeng Z, et al. Increased serum IL-17 and IL-23 in the patient with ankylosing spondylitis. Clin Rheumatol 2011; 30: 269-73.
23. Romero-Sanchez C, Jaimes DA, Londono J, De Avila J, Castellanos JE, Bello JM, et al. Association between Th-17 cytokine profile and clinical features in patients with spondyloarthritis. Clin Exp Rheumatol 2011; 29: 828-34.
24. - entheseal resident T cells. Nat Med 2012; 18: 1069-76.
25. Resnick D, Niwayama G,. Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Radiology 1976; 119: 559-68.
26. + cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response. Arthritis Res Therapy 2011; 13: R95.
27. Colbert RA, DeLay ML, Klenk EI, Layh-Schmitt G,. From HLA-B27 to spondyloarthritis: a journey through the ER. Immunol Rev 2010; 233: 181-202.
28. Chen L, Wei XQ, Evans B, Jiang W, Aeschlimann D,. IL-23 promotes osteoclast formation by up-regulation of receptor activator of NF-κB (RANK) expression in myeloid precursor cells. Eur J Immunol 2008; 38: 2845-54.
29. Zeng L, Lindstrom MJ, Smith JA,. Ankylosing spondylitis macrophage production of higher levels of interleukin-23 in response to lipopolysaccharide without induction of a significant unfolded protein response. Arthritis Rheum 2011; 63: 3807-17.
30. Fichtner-Feigl S, Strober W, Geissler EK, Schlitt HJ,. Cytokines mediating the induction of chronic colitis and colitis-associated fibrosis. Mucosal Immunol 2008; 1 Suppl 1: S24-7.
31. Gasse P, Riteau N, Vacher R, Michel ML, Fautrel A, di Padova F, et al. IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis. PLoS One 2011; 6: e23185.
32. Adamopoulos IE, Tessmer M, Chao CC, Adda S, Gorman D, Petro M, et al. IL-23 is critical for induction of arthritis, osteoclast formation, and maintenance of bone mass. J Immunol 2011; 187: 951-9.
33. Li X, Kim KW, Cho ML, Ju JH, Kang CM, Oh HJ, et al. IL-23 induces receptor activator of NF-κB ligand expression in fibroblast-like synoviocytes via STAT3 and NF-κB signal pathways. Immunol Lett 2010; 127: 100-7.
34. Ciccia F, Bombardieri M, Principato A, Giardina A, Tripodo C, Porcasi R, et al. Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis. Arthritis Rheum 2009; 60: 955-65.
35. Quinn JM, Sims NA, Saleh H, Mirosa D, Thompson K, Bouralexis S, et al. IL-23 inhibits osteoclastogenesis indirectly through lymphocytes and is required for the maintenance of bone mass in mice. J Immunol 2008; 181: 5720-9.