메뉴 건너뛰기




Volumn 180, Issue 5, 2012, Pages 1906-1916

PI3 kinase δ is a key regulator of synoviocyte function in rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN PEROXIDE; INK 007; INTERLEUKIN 1; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE DELTA; PHOSPHATIDYLINOSITOL 3 KINASE DELTA BETA; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

EID: 84860114297     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2012.01.030     Document Type: Article
Times cited : (95)

References (65)
  • 1
    • 70449368599 scopus 로고    scopus 로고
    • PI3K isoforms as drug targets in inflammatory diseases: Lessons from pharmacological and genetic strategies
    • S.J. Harris, J.G. Foster, S.G. Ward PI3K isoforms as drug targets in inflammatory diseases: lessons from pharmacological and genetic strategies Curr Opin Investig Drugs 10 2009 1151 1162
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 1151-1162
    • Harris, S.J.1    Foster, J.G.2    Ward, S.G.3
  • 2
    • 33847239467 scopus 로고    scopus 로고
    • PI3K delta and PI3K gamma: Partners in crime in inflammation in rheumatoid arthritis and beyond?
    • C. Rommel, M. Camps, H. Ji PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? Nat Rev Immunol 7 2007 191 201
    • (2007) Nat Rev Immunol , vol.7 , pp. 191-201
    • Rommel, C.1    Camps, M.2    Ji, H.3
  • 3
    • 77049088525 scopus 로고    scopus 로고
    • Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: A prototype for new anti-inflammatory drugs
    • O. Williams, B.T. Houseman, E.J. Kunkel, B. Aizenstein, R. Hoffman, Z.A. Knight, K.M. Shokat Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs Chem Biol 17 2010 123 134
    • (2010) Chem Biol , vol.17 , pp. 123-134
    • Williams, O.1    Houseman, B.T.2    Kunkel, E.J.3    Aizenstein, B.4    Hoffman, R.5    Knight, Z.A.6    Shokat, K.M.7
  • 12
    • 0037695593 scopus 로고    scopus 로고
    • Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex
    • S.T. Jou, N. Carpino, Y. Takahashi, R. Piekorz, J.R. Chao, D. Wang, J.N. Ihle Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex Mol Cell Biol 22 2002 8580 8591
    • (2002) Mol Cell Biol , vol.22 , pp. 8580-8591
    • Jou, S.T.1    Carpino, N.2    Takahashi, Y.3    Piekorz, R.4    Chao, J.R.5    Wang, D.6    Ihle, J.N.7
  • 14
    • 0034635221 scopus 로고    scopus 로고
    • Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction
    • Z. Li, H. Jiang, W. Xie, Z. Zhang, A.V. Smrcka, D. Wu Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction Science 287 2000 1046 1049
    • (2000) Science , vol.287 , pp. 1046-1049
    • Li, Z.1    Jiang, H.2    Xie, W.3    Zhang, Z.4    Smrcka, A.V.5    Wu, D.6
  • 17
    • 79151475516 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase delta (PI3Kdelta) in leukocyte signaling and function
    • W.P. Fung-Leung Phosphoinositide 3-kinase delta (PI3Kdelta) in leukocyte signaling and function Cell Signal 23 2011 603 608
    • (2011) Cell Signal , vol.23 , pp. 603-608
    • Fung-Leung, W.P.1
  • 18
    • 73249125200 scopus 로고    scopus 로고
    • Fibroblast-like synoviocytes: Key effector cells in rheumatoid arthritis
    • B. Bartok, G.S. Firestein Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis Immunol Rev 233 2010 233 255
    • (2010) Immunol Rev , vol.233 , pp. 233-255
    • Bartok, B.1    Firestein, G.S.2
  • 19
    • 0025847243 scopus 로고
    • Cytokines in chronic inflammatory arthritis VI Analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and tumor necrosis factor-alpha
    • J.M. Alvaro-Gracia, N.J. Zvaifler, C.B. Brown, K. Kaushansky, G.S. Firestein Cytokines in chronic inflammatory arthritis VI Analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and tumor necrosis factor-alpha J Immunol 146 1991 3365 3371
    • (1991) J Immunol , vol.146 , pp. 3365-3371
    • Alvaro-Gracia, J.M.1    Zvaifler, N.J.2    Brown, C.B.3    Kaushansky, K.4    Firestein, G.S.5
  • 21
    • 77957258073 scopus 로고    scopus 로고
    • Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha
    • M. Sun, P. Hillmann, B.T. Hofmann, J.R. Hart, P.K. Vogt Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha Proc Natl Acad Sci USA 107 2010 15547 15552
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 15547-15552
    • Sun, M.1    Hillmann, P.2    Hofmann, B.T.3    Hart, J.R.4    Vogt, P.K.5
  • 28
    • 1542784431 scopus 로고    scopus 로고
    • Expression and activation of mitogen-activated protein kinase kinases-3 and -6 in rheumatoid arthritis
    • M. Chabaud-Riou, G.S. Firestein Expression and activation of mitogen-activated protein kinase kinases-3 and -6 in rheumatoid arthritis Am J Pathol 164 2004 177 184
    • (2004) Am J Pathol , vol.164 , pp. 177-184
    • Chabaud-Riou, M.1    Firestein, G.S.2
  • 30
    • 61849126233 scopus 로고    scopus 로고
    • Fine tuning the immune response with PI3K
    • D.A. Fruman, G. Bismuth Fine tuning the immune response with PI3K Immunol Rev 228 2009 253 272
    • (2009) Immunol Rev , vol.228 , pp. 253-272
    • Fruman, D.A.1    Bismuth, G.2
  • 32
    • 21644446058 scopus 로고    scopus 로고
    • Unmet needs in rheumatoid arthritis
    • L. Moreland Unmet needs in rheumatoid arthritis Arthritis Res Ther 3 7 Suppl 2005 S2 S8
    • (2005) Arthritis Res Ther , vol.3 , Issue.SUPPL. 7
    • Moreland, L.1
  • 33
    • 77950290250 scopus 로고    scopus 로고
    • Kinase inhibitors: A new approach to rheumatoid arthritis treatment
    • S. Cohen, R. Fleischmann Kinase inhibitors: a new approach to rheumatoid arthritis treatment Curr Opin Rheumatol 22 2010 330 335
    • (2010) Curr Opin Rheumatol , vol.22 , pp. 330-335
    • Cohen, S.1    Fleischmann, R.2
  • 34
    • 35648969120 scopus 로고    scopus 로고
    • Primer: Signal transduction in rheumatic disease-a clinician's guide
    • S.E. Sweeney, G.S. Firestein Primer: signal transduction in rheumatic disease-a clinician's guide Nat Clin Pract Rheumatol 3 2007 651 660
    • (2007) Nat Clin Pract Rheumatol , vol.3 , pp. 651-660
    • Sweeney, S.E.1    Firestein, G.S.2
  • 35
    • 77649160181 scopus 로고    scopus 로고
    • PI3K inhibition in inflammation: Toward tailored therapies for specific diseases
    • A. Ghigo, F. Damilano, L. Braccini, E. Hirsch PI3K inhibition in inflammation: toward tailored therapies for specific diseases Bioessays 32 2010 185 196
    • (2010) Bioessays , vol.32 , pp. 185-196
    • Ghigo, A.1    Damilano, F.2    Braccini, L.3    Hirsch, E.4
  • 36
    • 0033574429 scopus 로고    scopus 로고
    • Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase
    • L. Bi, I. Okabe, D.J. Bernard, A. Wynshaw-Boris, R.L. Nussbaum Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase J Biol Chem 274 1999 10963 10968
    • (1999) J Biol Chem , vol.274 , pp. 10963-10968
    • Bi, L.1    Okabe, I.2    Bernard, D.J.3    Wynshaw-Boris, A.4    Nussbaum, R.L.5
  • 37
    • 0036185944 scopus 로고    scopus 로고
    • Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase
    • L. Bi, I. Okabe, D.J. Bernard, R.L. Nussbaum Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase Mamm Genome 13 2002 169 172
    • (2002) Mamm Genome , vol.13 , pp. 169-172
    • Bi, L.1    Okabe, I.2    Bernard, D.J.3    Nussbaum, R.L.4
  • 38
    • 30444439101 scopus 로고    scopus 로고
    • Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: Comparative analysis of genetic and pharmacologic interference with p110delta function in B cells
    • A. Bilancio, K. Okkenhaug, M. Camps, J.L. Emery, T. Ruckle, C. Rommel, B. Vanhaesebroeck Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells Blood 107 2006 642 650
    • (2006) Blood , vol.107 , pp. 642-650
    • Bilancio, A.1    Okkenhaug, K.2    Camps, M.3    Emery, J.L.4    Ruckle, T.5    Rommel, C.6    Vanhaesebroeck, B.7
  • 39
    • 62849114529 scopus 로고    scopus 로고
    • Regulation of phosphoinositide 3-kinase expression in health and disease
    • K. Kok, B. Geering, B. Vanhaesebroeck Regulation of phosphoinositide 3-kinase expression in health and disease Trends Biochem Sci 34 2009 115 127
    • (2009) Trends Biochem Sci , vol.34 , pp. 115-127
    • Kok, K.1    Geering, B.2    Vanhaesebroeck, B.3
  • 41
    • 34548029399 scopus 로고    scopus 로고
    • Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo
    • L. Liu, K.D. Puri, J.M. Penninger, P. Kubes Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo Blood 110 2007 1191 1198
    • (2007) Blood , vol.110 , pp. 1191-1198
    • Liu, L.1    Puri, K.D.2    Penninger, J.M.3    Kubes, P.4
  • 42
    • 0035895375 scopus 로고    scopus 로고
    • New responsibilities for the PI3K regulatory subunit p85 alpha
    • K. Okkenhaug, B. Vanhaesebroeck New responsibilities for the PI3K regulatory subunit p85 alpha Sci STKE 2001 2001 pe1
    • (2001) Sci STKE , vol.2001 , pp. 1
    • Okkenhaug, K.1    Vanhaesebroeck, B.2
  • 43
    • 14144250240 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice
    • S.M. Brachmann, K. Ueki, J.A. Engelman, R.C. Kahn, L.C. Cantley Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice Mol Cell Biol 25 2005 1596 1607
    • (2005) Mol Cell Biol , vol.25 , pp. 1596-1607
    • Brachmann, S.M.1    Ueki, K.2    Engelman, J.A.3    Kahn, R.C.4    Cantley, L.C.5
  • 45
    • 15444370901 scopus 로고    scopus 로고
    • Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes
    • T. Inoue, D. Hammaker, D.L. Boyle, G.S. Firestein Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes J Immunol 174 2005 4301 4306
    • (2005) J Immunol , vol.174 , pp. 4301-4306
    • Inoue, T.1    Hammaker, D.2    Boyle, D.L.3    Firestein, G.S.4
  • 47
    • 33645827963 scopus 로고    scopus 로고
    • Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model
    • K.S. Lee, H.K. Lee, J.S. Hayflick, Y.C. Lee, K.D. Puri Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model FASEB J 20 2006 455 465
    • (2006) FASEB J , vol.20 , pp. 455-465
    • Lee, K.S.1    Lee, H.K.2    Hayflick, J.S.3    Lee, Y.C.4    Puri, K.D.5
  • 48
    • 77951667667 scopus 로고    scopus 로고
    • A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease
    • J.A. Marwick, G. Caramori, P. Casolari, F. Mazzoni, P.A. Kirkham, I.M. Adcock, K.F. Chung, A. Papi A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease J Allergy Clin Immunol 125 2010 1146 1153
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1146-1153
    • Marwick, J.A.1    Caramori, G.2    Casolari, P.3    Mazzoni, F.4    Kirkham, P.A.5    Adcock, I.M.6    Chung, K.F.7    Papi, A.8
  • 51
    • 47049113462 scopus 로고    scopus 로고
    • Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils
    • T.M. Randis, K.D. Puri, H. Zhou, T.G. Diacovo Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils Eur J Immunol 38 2008 1215 1224
    • (2008) Eur J Immunol , vol.38 , pp. 1215-1224
    • Randis, T.M.1    Puri, K.D.2    Zhou, H.3    Diacovo, T.G.4
  • 52
    • 0034944752 scopus 로고    scopus 로고
    • Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt
    • H.G. Zhang, Y. Wang, J.F. Xie, X. Liang, D. Liu, P. Yang, H.C. Hsu, R.B. Ray, J.D. Mountz Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt Arthritis Rheum 44 2001 1555 1567
    • (2001) Arthritis Rheum , vol.44 , pp. 1555-1567
    • Zhang, H.G.1    Wang, Y.2    Xie, J.F.3    Liang, X.4    Liu, D.5    Yang, P.6    Hsu, H.C.7    Ray, R.B.8    Mountz, J.D.9
  • 53
    • 78651315431 scopus 로고    scopus 로고
    • Mechanisms related to NO-induced motility in differentiated rat aortic smooth muscle cells
    • Q. Pu, D. Zhuang, S. Thakran, A. Hassid Mechanisms related to NO-induced motility in differentiated rat aortic smooth muscle cells Am J Physiol Heart Circ Physiol 300 2011 H101 H108
    • (2011) Am J Physiol Heart Circ Physiol , vol.300
    • Pu, Q.1    Zhuang, D.2    Thakran, S.3    Hassid, A.4
  • 59
    • 54449095043 scopus 로고    scopus 로고
    • Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport
    • J. Wang, Z.A. Knight, D. Fiedler, O. Williams, K.M. Shokat, D. Pearce Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport Am J Physiol Renal Physiol 295 2008 F843 F850
    • (2008) Am J Physiol Renal Physiol , vol.295
    • Wang, J.1    Knight, Z.A.2    Fiedler, D.3    Williams, O.4    Shokat, K.M.5    Pearce, D.6
  • 60
    • 18144416502 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces rheumatoid arthritis synovial fibroblast proliferation through mitogen-activated protein kinases and phosphatidylinositol 3-kinase/Akt
    • J. Morel, R. Audo, M. Hahne, B. Combe Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces rheumatoid arthritis synovial fibroblast proliferation through mitogen-activated protein kinases and phosphatidylinositol 3-kinase/Akt J Biol Chem 280 2005 15709 15718
    • (2005) J Biol Chem , vol.280 , pp. 15709-15718
    • Morel, J.1    Audo, R.2    Hahne, M.3    Combe, B.4
  • 61
    • 79551698224 scopus 로고    scopus 로고
    • Akt activity protects rheumatoid synovial fibroblasts from Fas-induced apoptosis by inhibition of Bid cleavage
    • S. Garcia, M. Liz, J.J. Gomez-Reino, C. Conde Akt activity protects rheumatoid synovial fibroblasts from Fas-induced apoptosis by inhibition of Bid cleavage Arthritis Res Ther 12 2010 R33
    • (2010) Arthritis Res Ther , vol.12 , pp. 33
    • Garcia, S.1    Liz, M.2    Gomez-Reino, J.J.3    Conde, C.4
  • 62
    • 69049110871 scopus 로고    scopus 로고
    • The pleiotropic effect of TRAIL on tumor-like synovial fibroblasts from rheumatoid arthritis patients is mediated by caspases
    • R. Audo, B. Combe, B. Coulet, J. Morel, M. Hahne The pleiotropic effect of TRAIL on tumor-like synovial fibroblasts from rheumatoid arthritis patients is mediated by caspases Cell Death Differ 16 2009 1227 1237
    • (2009) Cell Death Differ , vol.16 , pp. 1227-1237
    • Audo, R.1    Combe, B.2    Coulet, B.3    Morel, J.4    Hahne, M.5
  • 63
    • 34447299716 scopus 로고    scopus 로고
    • The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN
    • E.A. Papakonstanti, A.J. Ridley, B. Vanhaesebroeck The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN EMBO J 26 2007 3050 3061
    • (2007) EMBO J , vol.26 , pp. 3050-3061
    • Papakonstanti, E.A.1    Ridley, A.J.2    Vanhaesebroeck, B.3
  • 64
    • 33750459743 scopus 로고    scopus 로고
    • A selective inhibitor of the p110delta isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16
    • C. Billottet, V.L. Grandage, R.E. Gale, A. Quattropani, C. Rommel, B. Vanhaesebroeck, A. Khwaja A selective inhibitor of the p110delta isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16 Oncogene 25 2006 6648 6659
    • (2006) Oncogene , vol.25 , pp. 6648-6659
    • Billottet, C.1    Grandage, V.L.2    Gale, R.E.3    Quattropani, A.4    Rommel, C.5    Vanhaesebroeck, B.6    Khwaja, A.7
  • 65
    • 84860213415 scopus 로고    scopus 로고
    • Isoform selective induction of human p100d PI3K expression by TNFa: Identification of a new and inducible PI3KCD promoter
    • 10.1042/BJ20112214
    • M.A. Whitehead, M. Bombardieri, C. Pitzalis, Vanhaesebroeck Isoform selective induction of human p100d PI3K expression by TNFa: identification of a new and inducible PI3KCD promoter Biochem J 2012 10.1042/BJ20112214
    • (2012) Biochem J
    • Whitehead, M.A.1    Bombardieri, M.2    Pitzalis, C.3    Vanhaesebroeck4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.