메뉴 건너뛰기




Volumn 27, Issue 2, 2015, Pages 127-133

Inhibition of interleukin-17, interleukin-23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis

Author keywords

biologics; interleukin 17; interleukin 23; psoriasis; psoriatic arthritis

Indexed keywords

BRODALUMAB; GUSELKUMAB; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 23; IXEKIZUMAB; SECUKINUMAB; TILDRAKIZUMAB; TUMOR NECROSIS FACTOR INHIBITOR; USTEKINUMAB; IMMUNOSUPPRESSIVE AGENT;

EID: 84922410788     PISSN: 10408711     EISSN: 15316963     Source Type: Journal    
DOI: 10.1097/BOR.0000000000000147     Document Type: Review
Times cited : (156)

References (33)
  • 1
    • 0027215897 scopus 로고
    • CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene
    • Rouvier E, Luciani MF, Mattei MG, et al. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J Immunol 1993; 150:5445-5456.
    • (1993) J Immunol , vol.150 , pp. 5445-5456
    • Rouvier, E.1    Luciani, M.F.2    Mattei, M.G.3
  • 2
    • 84886067284 scopus 로고    scopus 로고
    • Th17 cells and IL-17 a-focus on immunopathogenesis and immunotherapeutics
    • van den Berg WB, McInnes IB. Th17 cells and IL-17 a-focus on immunopathogenesis and immunotherapeutics. Semin Arthritis Rheum 2013; 43:158-170.
    • (2013) Semin Arthritis Rheum , vol.43 , pp. 158-170
    • Van Den Berg, W.B.1    McInnes, I.B.2
  • 3
    • 69349093225 scopus 로고    scopus 로고
    • Interleukin-17 and type 17 helper T cells
    • Miossec P, Korn T, Kuchroo VK. Interleukin-17 and type 17 helper T cells. N Engl J Med 2009; 361:888-898.
    • (2009) N Engl J Med , vol.361 , pp. 888-898
    • Miossec, P.1    Korn, T.2    Kuchroo, V.K.3
  • 4
    • 84894239179 scopus 로고    scopus 로고
    • The interleukin-17 pathway in psoriasis and psoriatic arthritis: Disease pathogenesis and possibilities of treatment
    • Frleta M, Siebert S, McInnes IB. The interleukin-17 pathway in psoriasis and psoriatic arthritis: disease pathogenesis and possibilities of treatment. Curr Rheumatol Rep 2014; 16:414.
    • (2014) Curr Rheumatol Rep , vol.16 , pp. 414
    • Frleta, M.1    Siebert, S.2    McInnes, I.B.3
  • 5
    • 84876292569 scopus 로고    scopus 로고
    • Effect of IL-17A blockade with secukinumab in autoimmune diseases
    • Patel DD, Lee DM, Kolbinger F, et al. Effect of IL-17A blockade with secukinumab in autoimmune diseases. Ann Rheum Dis 2013; 72 (Suppl 2): ii116-ii123.
    • (2013) Ann Rheum Dis , vol.72 , pp. ii116-ii123
    • Patel, D.D.1    Lee, D.M.2    Kolbinger, F.3
  • 6
    • 84863697312 scopus 로고    scopus 로고
    • IL-23 induces spondyloarthropathy by acting on ROR-gammat CD3CD4-CD8- entheseal resident T cells
    • Sherlock JP, Joyce-Shaikh B, Turner SP, et al. IL-23 induces spondyloarthropathy by acting on ROR-gammat CD3CD4-CD8- entheseal resident T cells. Nat Med 2012; 18:1069-1076.
    • (2012) Nat Med , vol.18 , pp. 1069-1076
    • Sherlock, J.P.1    Joyce-Shaikh, B.2    Turner, S.P.3
  • 7
    • 84863669568 scopus 로고    scopus 로고
    • Primed for inflammation: Enthesis-resident T cells
    • Lories RJ, McInnes IB. Primed for inflammation: enthesis-resident T cells. Nat Med 2012; 18:1018-1019.
    • (2012) Nat Med , vol.18 , pp. 1018-1019
    • Lories, R.J.1    McInnes, I.B.2
  • 8
    • 67449128733 scopus 로고    scopus 로고
    • The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): Validation and final selection
    • Rudwaleit M, van der Heijde D, Landewe R, et al. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis 2009; 68:777-783.
    • (2009) Ann Rheum Dis , vol.68 , pp. 777-783
    • Rudwaleit, M.1    Van Der Heijde, D.2    Landewe, R.3
  • 10
    • 84879503193 scopus 로고    scopus 로고
    • Role of IL-17 in psoriasis and psoriatic arthritis
    • Raychaudhuri SP. Role of IL-17 in psoriasis and psoriatic arthritis. Clin Rev Allergy Immunol 2013; 44:183-193.
    • (2013) Clin Rev Allergy Immunol , vol.44 , pp. 183-193
    • Raychaudhuri, S.P.1
  • 11
    • 49449115544 scopus 로고    scopus 로고
    • Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides
    • Jandus C, Bioley G, Rivals JP, et al. Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides. Arthritis Rheum 2008; 58:2307-2317.
    • (2008) Arthritis Rheum , vol.58 , pp. 2307-2317
    • Jandus, C.1    Bioley, G.2    Rivals, J.P.3
  • 12
    • 84896313565 scopus 로고    scopus 로고
    • The IL-23/IL-17 axis in psoriatic arthritis
    • Suzuki E, Mellins ED, Gershwin ME, et al. The IL-23/IL-17 axis in psoriatic arthritis. Autoimmun Rev 2014; 13 (4-5):496-502.
    • (2014) Autoimmun Rev , vol.13 , Issue.4-5 , pp. 496-502
    • Suzuki, E.1    Mellins, E.D.2    Gershwin, M.E.3
  • 13
    • 84877603562 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab in patients with rheumatoid arthritis: A phase II, dose-finding, doubleblind, randomised, placebo controlled study
    • Genovese MC, Durez P, Richards HB, et al. Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, doubleblind, randomised, placebo controlled study. Ann Rheum Dis 2013; 72: 863-869.
    • (2013) Ann Rheum Dis , vol.72 , pp. 863-869
    • Genovese, M.C.1    Durez, P.2    Richards, H.B.3
  • 14
    • 43449139402 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
    • Papp KA, Langley RG, Lebwohl M, et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2). Lancet 2008; 371:1675-1684.
    • (2008) Lancet , vol.371 , pp. 1675-1684
    • Papp, K.A.1    Langley, R.G.2    Lebwohl, M.3
  • 15
    • 84883134297 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial
    • McInnes IB, Kavanaugh A, Gottlieb AB, et al. Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial. Lancet 2013; 382:780-789.
    • (2013) Lancet , vol.382 , pp. 780-789
    • McInnes, I.B.1    Kavanaugh, A.2    Gottlieb, A.B.3
  • 16
    • 84899991797 scopus 로고    scopus 로고
    • Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional nonbiological and biological antitumour necrosis factor therapy: 6-month and 1-year results of the phase 3, multicentre, double-blind, placebo-controlled, randomised PSUMMIT 2 trial
    • Ritchlin C, Rahman P, Kavanaugh A, et al. Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional nonbiological and biological antitumour necrosis factor therapy: 6-month and 1-year results of the phase 3, multicentre, double-blind, placebo-controlled, randomised PSUMMIT 2 trial. Ann Rheum Dis 2014; 73:990-999.
    • (2014) Ann Rheum Dis , vol.73 , pp. 990-999
    • Ritchlin, C.1    Rahman, P.2    Kavanaugh, A.3
  • 17
    • 84899922972 scopus 로고    scopus 로고
    • Ustekinumab, an anti-IL-12/23 p40 monoclonal antibody, inhibits radiographic progression in patients with active psoriatic arthritis: Results of an integrated analysis of radiographic data from the phase 3, multicentre, randomised, double-blind, placebo-controlled PSUMMIT-1 and PSUMMIT-2 trials
    • Kavanaugh A, Ritchlin C, Rahman P, et al. Ustekinumab, an anti-IL-12/23 p40 monoclonal antibody, inhibits radiographic progression in patients with active psoriatic arthritis: results of an integrated analysis of radiographic data from the phase 3, multicentre, randomised, double-blind, placebo-controlled PSUMMIT-1 and PSUMMIT-2 trials. Ann Rheum Dis 2014; 73:1000-1006.
    • (2014) Ann Rheum Dis , vol.73 , pp. 1000-1006
    • Kavanaugh, A.1    Ritchlin, C.2    Rahman, P.3
  • 18
    • 84896810693 scopus 로고    scopus 로고
    • Ustekinumab for the treatment of patients with active ankylosing spondylitis: Results of a 28-week, prospective, open-label, proof-of-concept study (TOPAS)
    • Podubbnyy D, Callhoff J, Listing J, et al. Ustekinumab for the treatment of patients with active ankylosing spondylitis: results of a 28-week, prospective, open-label, proof-of-concept study (TOPAS). Arthritis Rheumatol 2013; 65 (10 (Suppl)):S766.
    • (2013) Arthritis Rheumatol , vol.65 , Issue.10 , pp. S766
    • Podubbnyy, D.1    Callhoff, J.2    Listing, J.3
  • 19
    • 84904545875 scopus 로고    scopus 로고
    • Secukinumab in plaque psoriasis - Results of two phase 3 trials
    • Langley RG, Elewski BE, Lebwohl M, et al. Secukinumab in plaque psoriasis - results of two phase 3 trials. N Engl J Med 2014; 371:326-338.
    • (2014) N Engl J Med , vol.371 , pp. 326-338
    • Langley, R.G.1    Elewski, B.E.2    Lebwohl, M.3
  • 20
    • 84922411329 scopus 로고    scopus 로고
    • Secukinumab, a human anti-interleukin- 17A monoclonal antibody, improves active psoriatic arthritis and inhibits radiographic progression: Efficacy and safety data from a phase 3 randomized, multicenter, double-blind, placebo-controlled study
    • Abstract 953
    • Mease P, McInnes I, Kirkham B, et al. Secukinumab, a human anti-interleukin- 17A monoclonal antibody, improves active psoriatic arthritis and inhibits radiographic progression: efficacy and safety data from a phase 3 randomized, multicenter, double-blind, placebo-controlled study. Arthritis Rheum 2014; 66 (Suppl):S423. Abstract 953.
    • (2014) Arthritis Rheum , vol.66 , pp. S423
    • Mease, P.1    McInnes, I.2    Kirkham, B.3
  • 21
    • 84922405577 scopus 로고    scopus 로고
    • Secukinumab, a monoclonal antibody to interleukin-17A, provides significant and sustained inhibition of joint structural damage in active psoriatic arthritis regardless of prior TNF inhibitors or concomitant methotrexate: A phase 3 randomized, double-blind, placebo-cotrolled sudy
    • Abstract 954
    • van der Heijde D, Landewe R, Mease P, et al. Secukinumab, a monoclonal antibody to interleukin-17A, provides significant and sustained inhibition of joint structural damage in active psoriatic arthritis regardless of prior TNF inhibitors or concomitant methotrexate: a phase 3 randomized, double-blind, placebo-cotrolled sudy. Arthritis Rheum 2014; 66 (Suppl):S424. Abstract 954.
    • (2014) Arthritis Rheum , vol.66 , pp. S424
    • Van Der Heijde, D.1    Landewe, R.2    Mease, P.3
  • 22
    • 84922401347 scopus 로고    scopus 로고
    • Secukinumab, a human anti-interleukin- 17A monoclonal antibody, improves active psoriatic arthritis: 24-week efficacy and safety data from a phase 3 randomized, multicenter, double-blind, placebo-controlled study using subcutaneous dosing
    • Boston, MA, USA
    • McInnes IB, Mease P, Kirkham B, et al. Secukinumab, a human anti-interleukin- 17A monoclonal antibody, improves active psoriatic arthritis: 24-week efficacy and safety data from a phase 3 randomized, multicenter, double-blind, placebo-controlled study using subcutaneous dosing. Late breaking oral presentation at: ACR/ARHP Annual Meeting, Boston, MA, USA, 2014. Presentation number L1.
    • (2014) Late Breaking Oral Presentation At: ACR/ARHP Annual Meeting
    • McInnes, I.B.1    Mease, P.2    Kirkham, B.3
  • 23
    • 84922411378 scopus 로고    scopus 로고
    • Secukinumab, a monoclonal antibody to interleukin-17A, significantly improves signs and symptoms of active ankylosing spondylitis: Results of a 52-week phase 3 randomized placebo-controlled trial with intravenous loading and subcutaneous maintenance dosing
    • Abstract 819
    • Baeten D, Braun J, Baraliakos X, et al. Secukinumab, a monoclonal antibody to interleukin-17A, significantly improves signs and symptoms of active ankylosing spondylitis: results of a 52-week phase 3 randomized placebo-controlled trial with intravenous loading and subcutaneous maintenance dosing. Arthritis Rheum 2014; 66 (Suppl):S360. Abstract 819.
    • (2014) Arthritis Rheum , vol.66 , pp. S360
    • Baeten, D.1    Braun, J.2    Baraliakos, X.3
  • 24
    • 84922407071 scopus 로고    scopus 로고
    • Secukinumab, a monoclonal antibody to interleukin-17A, significantly improves signs and symptoms of active ankylosing spondylitis: Results of a phase 3, randomized, placebo-controlled trial with subcutaneous loading and maintenance dosing
    • Abstract 536
    • Sieper J, Braun J, Baraliakos X, et al. Secukinumab, a monoclonal antibody to interleukin-17A, significantly improves signs and symptoms of active ankylosing spondylitis: results of a phase 3, randomized, placebo-controlled trial with subcutaneous loading and maintenance dosing. Arthritis Rheum 2014; 66 (Suppl):S232. Abstract 536.
    • (2014) Arthritis Rheum , vol.66 , pp. S232
    • Sieper, J.1    Braun, J.2    Baraliakos, X.3
  • 25
    • 84859073115 scopus 로고    scopus 로고
    • Antiinterleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis
    • Leonardi C, Matheson R, Zachariae C, et al. Antiinterleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N Engl J Med 2012; 366:1190-1199.
    • (2012) N Engl J Med , vol.366 , pp. 1190-1199
    • Leonardi, C.1    Matheson, R.2    Zachariae, C.3
  • 26
    • 84903478179 scopus 로고    scopus 로고
    • A phase II randomized study of subcutaneous ixekizumab, an antiinterleukin-17 monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor necrosis factor inhibitors
    • Genovese MC, Greenwald M, Cho CS, et al. A phase II randomized study of subcutaneous ixekizumab, an antiinterleukin-17 monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor necrosis factor inhibitors. Arthritis Rheum 2014; 66:1693-1704.
    • (2014) Arthritis Rheum , vol.66 , pp. 1693-1704
    • Genovese, M.C.1    Greenwald, M.2    Cho, C.S.3
  • 27
    • 84859017988 scopus 로고    scopus 로고
    • Brodalumab, an antiinterleukin-17- receptor antibody for psoriasis
    • Papp KA, Leonardi C, Menter A, et al. Brodalumab, an antiinterleukin-17- receptor antibody for psoriasis. N Engl J Med 2012; 366:1181-1189.
    • (2012) N Engl J Med , vol.366 , pp. 1181-1189
    • Papp, K.A.1    Leonardi, C.2    Menter, A.3
  • 28
    • 84902209516 scopus 로고    scopus 로고
    • Brodalumab, an anti-IL17RA monoclonal antibody, in psoriatic arthritis
    • Mease PJ, Genovese MC, Greenwald MW, et al. Brodalumab, an anti-IL17RA monoclonal antibody, in psoriatic arthritis. N Engl J Med 2014; 370:2295-2306.
    • (2014) N Engl J Med , vol.370 , pp. 2295-2306
    • Mease, P.J.1    Genovese, M.C.2    Greenwald, M.W.3
  • 29
    • 84886226230 scopus 로고    scopus 로고
    • A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis
    • Martin DA, Churchill M, Flores-Suarez L, et al. A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis. Arthritis Res Ther 2013; 15:R164.
    • (2013) Arthritis Res Ther , vol.15 , pp. R164
    • Martin, D.A.1    Churchill, M.2    Flores-Suarez, L.3
  • 30
    • 84887412452 scopus 로고    scopus 로고
    • A randomized, double-blind, placebocontrolled, multiple-dose study to evaluate the safety, tolerability, and efficacy of brodalumab (AMG827) in subjects with rheumatoid arthritis and an inadequate response to methotrexate (abstract 831)
    • Pavelka K, Chon Y, Newmark R, et al. A randomized, double-blind, placebocontrolled, multiple-dose study to evaluate the safety, tolerability, and efficacy of brodalumab (AMG827) in subjects with rheumatoid arthritis and an inadequate response to methotrexate (abstract 831). Arthritis Rheum 2012; 64
    • (2012) Arthritis Rheum , vol.64
    • Pavelka, K.1    Chon, Y.2    Newmark, R.3
  • 31
    • 84897146802 scopus 로고    scopus 로고
    • Guselkumab (an IL-23-specific mAb) demonstrates clinical and molecular response in patients with moderate-tosevere psoriasis
    • Sofen H, Smith S, Matheson RT, et al. Guselkumab (an IL-23-specific mAb) demonstrates clinical and molecular response in patients with moderate-tosevere psoriasis. J Allergy Clin Immunol 2014; 133:1032-1040.
    • (2014) J Allergy Clin Immunol , vol.133 , pp. 1032-1040
    • Sofen, H.1    Smith, S.2    Matheson, R.T.3
  • 32
    • 84901029678 scopus 로고    scopus 로고
    • Systematic review of interleukin-12, interleukin-17, and interleukin-23 pathway inhibitors for the treatment of moderate-to-severe chronic plaque psoriasis: Ustekinumab, briakinumab, tildrakizumab, guselkumab, secukinumab, ixekizumab, and brodalumab
    • Tausend W, Downing C, Tyring S. Systematic review of interleukin-12, interleukin-17, and interleukin-23 pathway inhibitors for the treatment of moderate-to-severe chronic plaque psoriasis: ustekinumab, briakinumab, tildrakizumab, guselkumab, secukinumab, ixekizumab, and brodalumab. J Cutan Med Surg 2014; 18:156-169. An excellent review of emerging therapies along the TH17 pathway.
    • (2014) J Cutan Med Surg , vol.18 , pp. 156-169
    • Tausend, W.1    Downing, C.2    Tyring, S.3
  • 33
    • 84905588626 scopus 로고    scopus 로고
    • New and emerging therapies in psoriasis
    • Leonardi CL, Gordon KB. New and emerging therapies in psoriasis. Semin Cutan Med Surg 2014; 33 (Suppl 2):S37-S41.
    • (2014) Semin Cutan Med Surg , vol.33 , pp. S37-S41
    • Leonardi, C.L.1    Gordon, K.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.