Association of impaired phosphatidylinositol 3-kinase activity in GLUT1-containing vesicles with malinsertion of glucose transporters into the plasma membrane of fibroblasts from a patient with severe insulin resistance and clinical features of Werner syndrome

Journal of Clinical Endocrinology and Metabolism

Volumn 85, Issue 2, 2000, Pages 905-918

  Kausch, Christiana ^a   Hamann, Andreas ^b   Uphues, Ingo ^d   Niendorf, Axel ^c   Müller Wieland, Dirk ^e   Joost, Hans Georg ^f   Algenstaedt, Petra ^c   Dreyer, Manfred ^g   Rüdiger, Hugo W ^h   Häring, Hans Ulrich ^a   Eckel, Jürgen ^d   Matthaei, Stephan ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF HAMBURG   (Germany)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e UNIVERSITY OF COLOGNE   (Germany)

^f RWTH AACHEN UNIVERSITY   (Germany)

^g Krankenhaus Bethanien   (Germany)

^h UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 1; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL KINASE; PROTEIN P85; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CASE REPORT; CELL CULTURE; CELL MEMBRANE; CLINICAL FEATURE; CONTROLLED STUDY; DNA STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROBLAST; GENE OVEREXPRESSION; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INSULIN RESISTANCE; MALE; MEMBRANE VESICLE; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WERNER SYNDROME;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADULT; AFFINITY LABELS; AZIDES; BASE SEQUENCE; CELL MEMBRANE; DISACCHARIDES; DNA, COMPLEMENTARY; FIBROBLASTS; GLUCOSE TRANSPORTER TYPE 1; GLYCOSIDES; HUMANS; INSULIN RESISTANCE; ISOENZYMES; MONOSACCHARIDE TRANSPORT PROTEINS; PROPYLAMINES; RAB GTP-BINDING PROTEINS; RECEPTOR, INSULIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; SUBCELLULAR FRACTIONS; WERNER SYNDROME;

EID: 17744380195     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.85.2.905     Document Type: Article

References (60)

1. Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane
2. Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site
3. Subcellular localization and trafficking of the GLUT4 glucose transporter isoform in insulin-responsive cells
4. The metabolic regulation and vesicular transport of GLUT4, the major insulin-responsive glucose transporter
5. Pathogenesis of insulin resistance and hyperglycemia in non-insulin-dependent diabetes mellitus
6. Pathogenesis of NIDDM: A balanced overview
7. Pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus: Candidates for signal transmitter defect causing insulin resistance of skeletal muscle
8. Insulin resistance and disease
9. Hormonal regulation of glucose transport
10. The role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus
11. Mechanisms of impaired insulin action in isolated adipocytes from obese and diabetic subjects
12. Decreased in vivo glucose uptake but normal expression of GLUT1 and GLUT4 in skeletal muscle of diabetic rats
13. Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM
14. Banting lecture: Insulin action, diabetogenes, and the cause of type II diabetes
15. The insulin signaling system
16. New frontiers in insulin receptor substrate signaling
17. Causes of insulin resistance
18. Insulin action and the insulin signaling network
19. Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine tyrosine kinase
20. The structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
21. Human skeletal muscle insulin receptor substrate-1: Characterization of the cDNA, gene an chromosomal localization
22. The IRS-1 signaling system
23. The IRS-1 signaling system
24. The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains
25. Phosphatidylinositol 3-kinase is activated by association with IRS-1 during insulin stimulation
26. IRS-1 activates phosphatidylinositol 3′-kinase by associating with src homology 2 domains of p85
27. Phosphatidylinositol 3-kinase
28. Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI 3-kinase
29. Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor wortmannin
30. Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes
31. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis and glucose transporter translocation
32. Effects of wortmannin on increased glucose transport by insulin and norepinephrine in primary culture of brown adipocytes
33. Phosphatidylinositol 3-kinase activity is requiered for insulin-stimulated glucose transport but not for Ras activation in CHO cells
34. Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane
35. Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site
36. From receptor to transporter: Insulin signalling to glucose transport
37. A new familial syndrome with impaired function of three related peptide growth factors
38. Single-step method of RNA isolation by acid guanidiniumthiocyanate-phenol-chloroform extraction
39. DNA sequencing with chain-terminating inhibitors
40. Insulin-mediated pseudoacromegaly in a patient with severe insulin resistance: Association of defective insulin-stimulated glucose transport with impaired phosphatidylinositol 3-kinase activity in fibroblasts
41. Insulin stimulation of phosphatidylinositol 3-kinase and association with insulin receptor substrate-1 in liver and muscle of the intact rat
42. Preparation and properties of plasma membrane and endoplasmic reticulum fragments from isolated rat fat cells
43. Biogenesis of endoplasmatic reticulum membranes. Synthesis of constitutive microsomal enzymes in developing rat hepatocyte
44. Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site
45. Exofacial photolabelling of the human erythrocyte glucose transporter with an azitrifiuoroethylbenzoyl-substituted bis mannose
46. Chronic treatment with insulin selectively down-regulates cell-surface glucose transporters in 3T3-L1 adipocytes
47. Insulin-induced translocation of the glucose transporter GLUT4 in cardiac muscle: Studies on the role of small-molecular-mass GTP-binding proteins
48. Activation of phosphatidylinositol 3-kinase by insulin
49. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
50. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
51. Sequence and structure of a human glucose transporter
52. 1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for Ras activation in CHO cells
53. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
54. Impaired activation of phosphoinositide 3-kinase by insulin in fibroblasts from patients with severe insulin resistance and pseudoacromegaly
55. Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle
56. Insulin-mediated targeting of phosphatidylinositol 3-kinase to GLUT4-containmg vesicles
57. Rab proteins and the road maps for intracellular transport
58. Insulin and okadaic acid induce Rab4 redistribution in adipocytes