GATA-3 regulates the homeostasis and activation of CD8+ T cells

Journal of Immunology

Volumn 190, Issue 1, 2013, Pages 428-437

  Tai, Tzong Shyuan ^a   Pai, Sung Yun ^b,c   Ho, I Cheng ^a,d  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR GATA 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELL KILLING; CELL MATURATION; CELL SELECTION; CELL STIMULATION; CONTROLLED STUDY; HOMEOSTASIS; LYMPHADENOPATHY; MAJOR HISTOCOMPATIBILITY COMPLEX; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSGENE; TUMOR CELL;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; FEMALE; GATA3 TRANSCRIPTION FACTOR; HOMEOSTASIS; LYMPHOCYTE ACTIVATION; MALE; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC;

EID: 84871843151     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1201361     Document Type: Article

References (35)

1. Ho, I. C., P. Vorhees, N. Marin, B. K. Oakley, S. F. Tsai, S. H. Orkin, and J. M. Leiden. 1991. Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor a gene. EMBO J. 10: 1187-1192. (Pubitemid 21905580)
2. Ko, L. J., M. Yamamoto, M. W. Leonard, K. M. George, P. Ting, and J. D. Engel. 1991. Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer. Mol. Cell. Biol. 11: 2778-2784. (Pubitemid 21895658)
3. Ho, I. C., T. S. Tai, and S. Y. Pai. 2009. GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat. Rev. Immunol. 9: 125-135.
4. Hendriks, R. W., M. C. Nawijn, J. D. Engel, H. van Doorninck, F. Grosveld, and A. Karis. 1999. Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus. Eur. J. Immunol. 29: 1912-1918.
5. Ting, C. N., M. C. Olson, K. P. Barton, and J. M. Leiden. 1996. Transcription factor GATA-3 is required for development of the T-cell lineage. Nature 384: 474-478.
6. Hosoya, T., T. Kuroha, T. Moriguchi, D. Cummings, I. Maillard, K. C. Lim, and J. D. Engel. 2009. GATA-3 is required for early T lineage progenitor development. J. Exp. Med. 206: 2987-3000.
7. Taghon, T., M. A. Yui, and E. V. Rothenberg. 2007. Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3. Nat. Immunol. 8: 845-855. (Pubitemid 47099037)
8. Pai, S. Y., M. L. Truitt, C. N. Ting, J. M. Leiden, L. H. Glimcher, and I. C. Ho. 2003. Critical roles for transcription factor GATA-3 in thymocyte development. Immunity 19: 863-875.
9. + T cells. Nat. Immunol. 9: 1122-1130.
10. He, X., X. He, V. P. Dave, Y. Zhang, X. Hua, E. Nicolas, W. Xu, B. A. Roe, and D. J. Kappes. 2005. The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature 433: 826-833. (Pubitemid 40314886)
11. Sun, G., X. Liu, P. Mercado, S. R. Jenkinson, M. Kypriotou, L. Feigenbaum, P. Galéra, and R. Bosselut. 2005. The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection. Nat. Immunol. 6: 373-381. (Pubitemid 41716777)
12. Pai, S. Y., M. L. Truitt, and I. C. Ho. 2004. GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells. Proc. Natl. Acad. Sci. USA 101: 1993-1998.
13. Zhu, J., B. Min, J. Hu-Li, C. J. Watson, A. Grinberg, Q. Wang, N. Killeen, J. F. Urban, Jr., L. Guo, and W. E. Paul. 2004. Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Nat. Immunol. 5: 1157-1165. (Pubitemid 39549630)
14. Zheng, W. P., and R. A. Flavell. 1997. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89: 587-596.
15. Kurata, H., H. J. Lee, A. O'Garra, and N. Arai. 1999. Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells. Immunity 11: 677-688. (Pubitemid 30030707)
16. Ouyang, W., S. H. Ranganath, K. Weindel, D. Bhattacharya, T. L. Murphy, W. C. Sha, and K. M. Murphy. 1998. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 9: 745-755. (Pubitemid 28557602)
17. Zhu, J., J. Cote-Sierra, L. Guo, and W. E. Paul. 2003. Stat5 activation plays a critical role in Th2 differentiation. Immunity 19: 739-748. (Pubitemid 37490798)
18. Amsen, D., J. M. Blander, G. R. Lee, K. Tanigaki, T. Honjo, and R. A. Flavell. 2004. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 117: 515-526. (Pubitemid 38610236)
19. Yagi, R., J. Zhu, and W. E. Paul. 2011. An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation. Int. Immunol. 23: 415-420.
20. Omori, M., M. Yamashita, M. Inami, M. Ukai-Tadenuma, M. Kimura, Y. Nigo, H. Hosokawa, A. Hasegawa, M. Taniguchi, and T. Nakayama. 2003. CD8 T cell-specific downregulation of histone hyperacetylation and gene activation of the IL-4 gene locus by ROG, repressor of GATA. Immunity 19: 281-294. (Pubitemid 37011342)
21. Vernachio, J., M. Li, A. D. Donnenberg, and M. J. Soloski. 1989. Qa-2 expression in the adult murine thymus: a unique marker for a mature thymic subset. J. Immunol. 142: 48-56. (Pubitemid 19034721)
22. D'Souza, W. N., C. F. Chang, A. M. Fischer, M. Li, and S. M. Hedrick. 2008. The Erk2 MAPK regulates CD8 T cell proliferation and survival. J. Immunol. 181: 7617-7629.
23. Marth, J. D., D. B. Lewis, C. B. Wilson, M. E. Gearn, E. G. Krebs, and R. M. Perlmutter. 1987. Regulation of pp56lck during T-cell activation: functional implications for the src-like protein tyrosine kinases. EMBO J. 6: 2727-2734.
24. Paillard, F., and C. Vaquero. 1991. Down-regulation of lck mRNA by T cell activation involves transcriptional and post-transcriptional mechanisms. Nucleic Acids Res. 19: 4655-4661. (Pubitemid 21912846)
25. Wei, G., B. J. Abraham, R. Yagi, R. Jothi, K. Cui, S. Sharma, L. Narlikar, D. L. Northrup, Q. Tang, W. E. Paul, et al. 2011. Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity 35: 299-311.
26. Kim, P. J., S. Y. Pai, M. Brigl, G. S. Besra, J. Gumperz, and I. C. Ho. 2006. GATA-3 regulates the development and function of invariant NKT cells. J. Immunol. 177: 6650-6659. (Pubitemid 44715028)
27. + NKT cells. Eur. J. Immunol. 40: 2385-2390.
28. Wang, Y., M. A. Su, and Y. Y. Wan. 2011. An essential role of the transcription factor GATA-3 for the function of regulatory T cells. Immunity 35: 337-348.
29. + regulatory T cell fate during inflammation in mice. J. Clin. Invest. 121: 4503-4515.
30. Hsu, F. C., A. G. Pajerowski, M. Nelson-Holte, R. Sundsbak, and V. S. Shapiro. 2011. NKAP is required for T cell maturation and acquisition of functional competency. J. Exp. Med. 208: 1291-1304.
31. Schmidt-Supprian, M., G. Courtois, J. Tian, A. J. Coyle, A. Israël, K. Rajewsky, and M. Pasparakis. 2003. Mature T cells depend on signaling through the IKK complex. Immunity 19: 377-389. (Pubitemid 37153414)
32. Boursalian, T. E., and P. J. Fink. 2003. Mutation in fas ligand impairs maturation of thymocytes bearing moderate affinity T cell receptors. J. Exp. Med. 198: 349-360. (Pubitemid 36987860)
33. Vremec, D., J. Pooley, H. Hochrein, L. Wu, and K. Shortman. 2000. CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen. J. Immunol. 164: 2978-2986. (Pubitemid 30148956)
34. Shortman, K., and Y. J. Liu. 2002. Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 2: 151-161. (Pubitemid 37336516)
35. Mebius, R. E. 2003. Organogenesis of lymphoid tissues. Nat. Rev. Immunol. 3: 292-303. (Pubitemid 37328682)