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Volumn 6, Issue 2, 2011, Pages 125-129

Common toxicities of mammalian target of rapamycin inhibitors

Author keywords

Everolimus; mTOR inhibitors; Radaforolimus; Temsirolmus; Toxicity

Indexed keywords

AMIFOSTINE; ANTIOXIDANT; BENZOYL PEROXIDE; CARNOSINE; CLINDAMYCIN; CLOBETASOL; CORTICOSTEROID; DOXYCYCLINE; ERYTHROMYCIN; EVEROLIMUS; GEMFIBROZIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOTRETINOIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MINOCYCLINE; RAPAMYCIN; RETINOIC ACID; RIDAFOROLIMUS; TEMSIROLIMUS;

EID: 79960613394     PISSN: 17762596     EISSN: 1776260X     Source Type: Journal    
DOI: 10.1007/s11523-011-0174-9     Document Type: Review
Times cited : (93)

References (25)
  • 4
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
    • 18653228 10.1016/S0140-6736(08)61039-9 1:CAS:528:DC%2BD1cXps1GmsLY%3D
    • RJ Motzer B Escudier S Oudard, et al. 2008 Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial Lancet 372 449 456 18653228 10.1016/S0140-6736(08)61039-9 1:CAS:528:DC%2BD1cXps1GmsLY%3D
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 5
    • 43249086546 scopus 로고    scopus 로고
    • Phase i pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors
    • 18332470 10.1200/JCO.2007.14.0988
    • A O'Donnell S Faivre HA Burris III, et al. 2008 Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors J Clin Oncol 26 1588 1595 18332470 10.1200/JCO.2007.14.0988
    • (2008) J Clin Oncol , vol.26 , pp. 1588-1595
    • O'Donnell, A.1    Faivre, S.2    Burris Iii, H.A.3
  • 6
    • 63149129641 scopus 로고    scopus 로고
    • A phase i trial to determine the safety, tolerability, and maximum tolerated dose of deforolimus in patients with advanced malignancies
    • 19228743 10.1158/1078-0432.CCR-08-2076 1:CAS:528:DC%2BD1MXitVOktL8%3D
    • CM Hartford L Berk JW Loewry, et al. 2009 A phase I trial to determine the safety, tolerability, and maximum tolerated dose of deforolimus in patients with advanced malignancies Clin Cancer Res 15 1428 1434 19228743 10.1158/1078-0432.CCR-08-2076 1:CAS:528:DC%2BD1MXitVOktL8%3D
    • (2009) Clin Cancer Res , vol.15 , pp. 1428-1434
    • Hartford, C.M.1    Berk, L.2    Loewry, J.W.3
  • 9
    • 74549192779 scopus 로고    scopus 로고
    • Preliminary characterization of oral lesions associated with inhibitors of mammalian target of rapamycin in cancer patients
    • 19862817 1:CAS:528:DC%2BC3cXitFGiurw%3D
    • S Sonis N Treister S Chawla G Demetri F Haluska 2010 Preliminary characterization of oral lesions associated with inhibitors of mammalian target of rapamycin in cancer patients Cancer 116 210 215 19862817 1:CAS:528: DC%2BC3cXitFGiurw%3D
    • (2010) Cancer , vol.116 , pp. 210-215
    • Sonis, S.1    Treister, N.2    Chawla, S.3    Demetri, G.4    Haluska, F.5
  • 10
    • 77952905485 scopus 로고    scopus 로고
    • MTOR inhibitor-associated dermatologic and mucosal problems
    • 20236129 10.1111/j.1399-0012.2010.01232.x 1:CAS:528:DC%2BC3cXmtVSrsLs%3D
    • JM Campistol JW de Fijter SM Flechner, et al. 2010 mTOR inhibitor-associated dermatologic and mucosal problems Clin Transplant 24 149 156 20236129 10.1111/j.1399-0012.2010.01232.x 1:CAS:528:DC%2BC3cXmtVSrsLs%3D
    • (2010) Clin Transplant , vol.24 , pp. 149-156
    • Campistol, J.M.1    De Fijter, J.W.2    Flechner, S.M.3
  • 12
    • 33847743084 scopus 로고    scopus 로고
    • Clobetasol ameliorates aphthous ulceration in renal transplant patients on sirolimus
    • DOI 10.1111/j.1600-6143.2006.01678.x
    • P Chuang AJ Langone 2007 Clobetasol ameliorates aphthous ulceration in renal transplant patients on sirolimus Am J Transplant 7 714 717 17250555 10.1111/j.1600-6143.2006.01678.x 1:CAS:528:DC%2BD2sXjvFOhtLg%3D (Pubitemid 46376460)
    • (2007) American Journal of Transplantation , vol.7 , Issue.3 , pp. 714-717
    • Chuang, P.1    Langone, A.J.2
  • 15
    • 33746617583 scopus 로고    scopus 로고
    • Characterization of the lung toxicity of the cell cycle inhibitor temsirolimus
    • 10.1016/j.ejca.2006.03.015
    • I Duran LL Sui AM Oza, et al. 2004 Characterization of the lung toxicity of the cell cycle inhibitor temsirolimus Eur J Cancer 42 1875 1880 10.1016/j.ejca.2006.03.015
    • (2004) Eur J Cancer , vol.42 , pp. 1875-1880
    • Duran, I.1    Sui, L.L.2    Oza, A.M.3
  • 16
    • 74049151210 scopus 로고    scopus 로고
    • Comprehensive lung injury pathology induced by mTOR inhibitors
    • 19661024 10.1007/s12094-009-0394-y 1:CAS:528:DC%2BD1MXhtVygsLzO
    • G Aparicio MB Calvo V Medina, et al. 2009 Comprehensive lung injury pathology induced by mTOR inhibitors Clin Transl Oncol 11 499 510 19661024 10.1007/s12094-009-0394-y 1:CAS:528:DC%2BD1MXhtVygsLzO
    • (2009) Clin Transl Oncol , vol.11 , pp. 499-510
    • Aparicio, G.1    Calvo, M.B.2    Medina, V.3
  • 18
    • 0030066934 scopus 로고    scopus 로고
    • Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation
    • L Beretta AC Gingras YV Svitkin, et al. 1996 Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation EMBO J 15 658 664 8599949 1:CAS:528:DyaK28XhsV2gt7s%3D (Pubitemid 26044579)
    • (1996) EMBO Journal , vol.15 , Issue.3 , pp. 658-664
    • Beretta, L.1    Gingras, A.-C.2    Svitkin, Y.V.3    Hall, M.N.4    Sonenberg, N.5
  • 19
    • 0032730328 scopus 로고    scopus 로고
    • Opposite translational control of GLUT1 and GLUT4 glucose transporter mRNAs in response to insulin
    • 10551878 10.1074/jbc.274.46.33085 1:CAS:528:DyaK1MXntlygu7g%3D
    • C Taha Z Liu J Jin, et al. 1999 Opposite translational control of GLUT1 and GLUT4 glucose transporter mRNAs in response to insulin J Biol Chem 274 46 33085 33091 10551878 10.1074/jbc.274.46.33085 1:CAS:528:DyaK1MXntlygu7g%3D
    • (1999) J Biol Chem , vol.274 , Issue.46 , pp. 33085-33091
    • Taha, C.1    Liu, Z.2    Jin, J.3
  • 20
    • 51449096670 scopus 로고    scopus 로고
    • A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies
    • 18451242 10.1158/1078-0432.CCR-07-1372 1:CAS:528:DC%2BD1cXlsV2qurs%3D
    • DA Rizzieri E Feldman JF DiPersio, et al. 2008 A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies Clin Cancer Res 14 2756 2762 18451242 10.1158/1078-0432.CCR-07-1372 1:CAS:528:DC%2BD1cXlsV2qurs%3D
    • (2008) Clin Cancer Res , vol.14 , pp. 2756-2762
    • Rizzieri, D.A.1    Feldman, E.2    Dipersio, J.F.3
  • 22
    • 0032525253 scopus 로고    scopus 로고
    • Hyperlipidemia in renal transplant recipients treated with sirolimus (rapamycin)
    • DOI 10.1097/00007890-199805150-00023
    • C Brattstrom H Wilczek G Tyden, et al. 1998 Hyperlipidemia in renal transplant recipients treated with sirolimus (rapamycin) Transplantation 65 1272 1274 9603181 10.1097/00007890-199805150-00023 1:CAS:528:DyaK1cXjslSms78%3D (Pubitemid 28224351)
    • (1998) Transplantation , vol.65 , Issue.9 , pp. 1272-1274
    • Brattstrom, C.1    Wilczek, H.2    Tyden, G.3    Bottiger, Y.4    Sawe, J.5    Groth, C.-G.6
  • 23
    • 25444528711 scopus 로고    scopus 로고
    • Hypophosphatemia: An update on its etiology and treatment
    • DOI 10.1016/j.amjmed.2005.02.014, PII S0002934305001002
    • A Gaasbeek AE Meinders 2005 Hypophosphatemia: an update on its etiology and treatment Am J Med 118 1094 1101 16194637 10.1016/j.amjmed.2005.02.014 1:CAS:528:DC%2BD2MXhtVGrs7nP (Pubitemid 41362606)
    • (2005) American Journal of Medicine , vol.118 , Issue.10 , pp. 1094-1101
    • Gaasbeek, A.1    Meinders, A.E.2
  • 24
    • 0013297123 scopus 로고    scopus 로고
    • Torisel. Wyeth Pharmaceuticals Philadelphia
    • Torisel (2010) Package insert. Wyeth Pharmaceuticals, Philadelphia
    • (2010) Package Insert
  • 25
    • 0013297123 scopus 로고    scopus 로고
    • Afinitor. Novartis Pharmaceuticals Corporation East Hanover
    • Afinitor (2010) Package insert. Novartis Pharmaceuticals Corporation, East Hanover
    • (2010) Package Insert


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.